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How do I compare QYB and QST on lead time to Canada?

Asked 11 Jul 2024Modified 23 months agoViewed 39k times
This question was closed as primarily opinion-based.Closed 20 Aug 2024. Answers already posted are preserved; new answers are not accepted. Questions here need a factual basis on which they can be answered.
28

The specifics, since they change the answer: QYB · QST · Canada.

The comparison I want does not seem to exist anywhere in a form I can evaluate.

I have read the arguments for each and they do not engage with each other.

Which axes does this decision turn on?

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CH
askedcal_hennessy17k2711 Jul 2024

2 Answers

Sorted by votes
31

Answer first: comparing suppliers is only meaningful if the comparison holds the laboratory, the method and the compound constant, and most published comparisons hold none of them.

Sample size matters. One order each is an anecdote about six vials; three orders each over a year is the beginning of a comparison.

Cost per milligram, adjusted honestly

StepValueNote
Vial price, 10 mg nominal£34.00As advertised
Nominal cost per mg£3.4034 ÷ 10
Measured content9.2 mgIndependent content assay
Cost per actual mg£3.7034 ÷ 9.2
Dead-space loss, 20 draws4 %80 µL of a 2 mL fill
Cost per delivered mg£3.853.70 ÷ 0.96
First vial, with £110 assay£14.85Testing dominates a single vial

The part that matters: lead time and lane behaviour are supplier properties too and are easier to compare than analytical ones, because they need no laboratory at all.

Inter-laboratory spread on identical peptide material is routinely half a per cent to a per cent by RP-HPLC, which is the noise floor for any cross-laboratory comparison.

Price per milligram of measured peptide, not per milligram of label claim.

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answeredb_delacroix43k3810 Sept 2024
2Adding a vote because this deserves more of them. – tare_weight 8 months ago
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22

The short version: same compound, same laboratory, same method, ideally same week — otherwise you are comparing laboratories rather than suppliers.

Content is the more discriminating measurement than purity for supplier comparison, because purity clusters tightly among competent suppliers and content does not.

Compare documentation on a fixed checklist rather than by impression: lot specificity, method section, chromatogram availability, quantified content, water and counter-ion figures, and whether the code is on the vial.

The ratings on this site are a community opinion average on a ten-point scale and are not reconciled with any other community's figures.

Name the laboratory and the dates or the comparison cannot be reproduced.

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answeredorla_sheridan18k2730 Aug 2024
3Small correction: carriage amortises across the order, which changes small-order economics entirely. – petra_hovland 4 months ago
4Is there a sensible order size where independent testing stops being a large surcharge? – RP_C18 6 months ago
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