A dual GIP and GLP-1 receptor agonist. Questions here cover the SURPASS and SURMOUNT programmes, the practical differences from a pure GLP-1 agonist, dose ladders that go to 15 mg, and why the GIP arm makes the side-effect profile behave differently.
The claim that "about a quarter of what you lose on these drugs is muscle" gets repeated everywhere and I have never once seen it sourced. I am 14 weeks into…
Anovulatory for most of my adult life with PCOS, told repeatedly that conception would be difficult and would need assistance. Five months into treatment, having lost…
Details up front: TRIUMPH-1 · dulaglutide. I would rather be corrected now than propagate something wrong. I am specifically not interested in a testimonial; I am…
Setup, so nobody has to ask: STEP 1 · a GLP-1 receptor agonist. This has the shape of a fact but I cannot find its origin. What I found instead were three secondary…
The case in front of me: semaglutide · liraglutide. These are treated as interchangeable and I do not think they are. If both are acceptable I would like to know…
Second wave of shedding, nine months in, and I have been told by two people in strong terms that switching from tirzepatide to semaglutide will fix it because…
Details up front: SURMOUNT-2 · dulaglutide. I am asking for verification rather than opinion, ideally with something I can read myself. It is possible the evidence…
Conditions: ATTAIN-1 · tirzepatide. I want to know whether there is evidence behind this or only repetition. I have checked the obvious registries and monographs…
Stated plainly: dulaglutide · semaglutide. I suspect the honest answer is that it depends, in which case I would like to know on what. Assume I can obtain either…
The particulars: SURPASS-3 · ecnoglutide. Somebody stated this to me confidently and I would like to check it before repeating it. I would accept a well-reasoned…
Conditions: SURMOUNT-5 · oral semaglutide. I want to know whether there is evidence behind this or only repetition. I have checked the obvious registries and…
What I have: a GLP-1 receptor agonist · cagrilintide. I have used one of these for a while and I am considering switching, which requires a reason. What I care about…
Details up front: cagrilintide · liraglutide. I have used one of these for a while and I am considering switching, which requires a reason. What I care about is…
What I have: SURMOUNT-OSA · orforglipron. I would rather be corrected now than propagate something wrong. I am specifically not interested in a testimonial; I am…
Setup, so nobody has to ask: STEP 4 · mazdutide. This is asserted often enough that I assumed it was established, and then I went looking for the source. I have…
Setup, so nobody has to ask: STEP 4 · a GLP-1 receptor agonist. This has the shape of a fact but I cannot find its origin. What I found instead were three secondary…
Conditions: semaglutide · retatrutide. These are treated as interchangeable and I do not think they are. If both are acceptable I would like to know that, so I can…
Setup, so nobody has to ask: STEP 3 · a GLP-1 receptor agonist. This has the shape of a fact but I cannot find its origin. What I found instead were three secondary…
Setup, so nobody has to ask: ESSENCE · a GLP-1 receptor agonist. This is asserted often enough that I assumed it was established, and then I went looking for the…
What I am working with: retatrutide · retatrutide. I suspect the honest answer is that it depends, in which case I would like to know on what. Assume I can obtain…
Stated plainly: orforglipron · mazdutide. I suspect the honest answer is that it depends, in which case I would like to know on what. Assume I can obtain either…
Setup, so nobody has to ask: ATTAIN-1 · cagrilintide. This has the shape of a fact but I cannot find its origin. What I found instead were three secondary sources all…
For reference: oral semaglutide · liraglutide. The comparison I want does not seem to exist anywhere in a form I can evaluate. I have read the arguments for each and…
I have been reading the prescribing information for several agents in this class side by side and something bothers me. The ladders themselves are completely…
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