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gi-side-effects

Page 9 of 18 · 416 questions tagged gi-side-effects.

416 questions · sorted by votes · page 9 of 18

21 votes5 answers17k views
What is the reported incidence of dizziness on ecnoglutide in REDEFINE-1?

The specifics, since they change the answer: dizziness · ecnoglutide · REDEFINE-1. I have the document in front of me and I can read the numbers. What I cannot do is…

gi-side-effects
gi-side-effects

The gastrointestinal cluster as a whole - nausea, vomiting, diarrhoea, constipation, reflux, early satiety - with trial incidence rates, dropout…

416 questions
clinical-trials
clinical-trials

Reading the primary literature properly: estimands, intention-to-treat versus per-protocol, confidence intervals, absolute versus relative…

913 questions
nausea
nausea

The dominant tolerability signal in every trial of the class: incidence, timing relative to a dose step, duration, and the distinction between…

346 questions
renal-outcomes
renal-outcomes

Kidney endpoints: the FLOW composite, eGFR slope as an endpoint, albuminuria regression, and why an early eGFR dip is expected rather than alarming.

14 questions
asked by felix_araya 17k · 6 months ago
21 votes5 answers17k views
What does TRIUMPH-3 tell me about nausea at the 8 mg dose?

For reference: TRIUMPH-3 · nausea · 8 mg. I have the document in front of me and I can read the numbers. What I cannot do is interpret them. I am reasonably…

clinical-trials
clinical-trials

Reading the primary literature properly: estimands, intention-to-treat versus per-protocol, confidence intervals, absolute versus relative…

913 questions
gi-side-effects
gi-side-effects

The gastrointestinal cluster as a whole - nausea, vomiting, diarrhoea, constipation, reflux, early satiety - with trial incidence rates, dropout…

416 questions
titration
titration

Stepwise dose increases over weeks, why the label schedules exist at all, and what tolerability-driven deviation from a schedule looks like in…

444 questions
asked by Dr_Nadia_Farsi 90k · 15 months ago
21 votes0 answers15k views
Does reflux at week five of a GLP-1 receptor agonist usually resolve without a dose change?

For reference: reflux · five · a GLP-1 receptor agonist. I have read the obvious sources and they disagree with each other, so I would rather ask people who have…

gi-side-effects
gi-side-effects

The gastrointestinal cluster as a whole - nausea, vomiting, diarrhoea, constipation, reflux, early satiety - with trial incidence rates, dropout…

416 questions
titration
titration

Stepwise dose increases over weeks, why the label schedules exist at all, and what tolerability-driven deviation from a schedule looks like in…

444 questions
nausea
nausea

The dominant tolerability signal in every trial of the class: incidence, timing relative to a dose step, duration, and the distinction between…

346 questions
asked by dermot_kiely 14k · 9 months ago
21 votes 5 answers14k views
Is injection-site erythema on orforglipron dose-dependent or dose-rate dependent?

What I have: injection-site erythema · orforglipron. I can predict the outcome but I cannot explain it, which means I will get the next case wrong. I would like to…

nausea
nausea

The dominant tolerability signal in every trial of the class: incidence, timing relative to a dose step, duration, and the distinction between…

346 questions
titration
titration

Stepwise dose increases over weeks, why the label schedules exist at all, and what tolerability-driven deviation from a schedule looks like in…

444 questions
gi-side-effects
gi-side-effects

The gastrointestinal cluster as a whole - nausea, vomiting, diarrhoea, constipation, reflux, early satiety - with trial incidence rates, dropout…

416 questions
asked by lipid_panel_q 44k · 2.0 years ago
21 votes 5 answers10k views
What does SURPASS-2 tell me about reflux at the 10 mg dose?

What I am working with: SURPASS-2 · reflux · 10 mg. I would like help reading this properly rather than being told what conclusion to reach. I have the full report…

clinical-trials
clinical-trials

Reading the primary literature properly: estimands, intention-to-treat versus per-protocol, confidence intervals, absolute versus relative…

913 questions
gi-side-effects
gi-side-effects

The gastrointestinal cluster as a whole - nausea, vomiting, diarrhoea, constipation, reflux, early satiety - with trial incidence rates, dropout…

416 questions
titration
titration

Stepwise dose increases over weeks, why the label schedules exist at all, and what tolerability-driven deviation from a schedule looks like in…

444 questions
asked by grainne_ahearn 13k · 3 months ago
21 votes 1 answer8.3k views
Is reflux on retatrutide dose-dependent or dose-rate dependent?

What I have: reflux · retatrutide. I suspect the usual explanation for this is wrong, or at least incomplete. I am aware this may have a boring answer. I would still…

nausea
nausea

The dominant tolerability signal in every trial of the class: incidence, timing relative to a dose step, duration, and the distinction between…

346 questions
titration
titration

Stepwise dose increases over weeks, why the label schedules exist at all, and what tolerability-driven deviation from a schedule looks like in…

444 questions
gi-side-effects
gi-side-effects

The gastrointestinal cluster as a whole - nausea, vomiting, diarrhoea, constipation, reflux, early satiety - with trial incidence rates, dropout…

416 questions
asked by hana_petrikova 19k · 5 months ago
21 votes0 answers6.7k views
What does STEP 8 tell me about nausea at the 30 mg dose?

The specifics, since they change the answer: STEP 8 · nausea · 30 mg. I want to understand what this actually establishes, as opposed to what it is being used to…

clinical-trials
clinical-trials

Reading the primary literature properly: estimands, intention-to-treat versus per-protocol, confidence intervals, absolute versus relative…

913 questions
gi-side-effects
gi-side-effects

The gastrointestinal cluster as a whole - nausea, vomiting, diarrhoea, constipation, reflux, early satiety - with trial incidence rates, dropout…

416 questions
titration
titration

Stepwise dose increases over weeks, why the label schedules exist at all, and what tolerability-driven deviation from a schedule looks like in…

444 questions
asked by lucia_marchetti 18k · 4 months ago
21 votes 5 answers6.1k views
What does SOUL tell me about headache at the 2 mg dose?

For reference: SOUL · headache · 2 mg. I want to understand what this actually establishes, as opposed to what it is being used to imply. My concern is that I am…

clinical-trials
clinical-trials

Reading the primary literature properly: estimands, intention-to-treat versus per-protocol, confidence intervals, absolute versus relative…

913 questions
gi-side-effects
gi-side-effects

The gastrointestinal cluster as a whole - nausea, vomiting, diarrhoea, constipation, reflux, early satiety - with trial incidence rates, dropout…

416 questions
titration
titration

Stepwise dose increases over weeks, why the label schedules exist at all, and what tolerability-driven deviation from a schedule looks like in…

444 questions
asked by cake_intact 18k · 2 months ago
21 votes0 answers4.8k views
Does hair thinning at week four of survodutide usually resolve without a dose change?

Setup, so nobody has to ask: hair thinning · four · survodutide. This is a procedural question rather than a theoretical one, and I would like the procedure rather…

gi-side-effects
gi-side-effects

The gastrointestinal cluster as a whole - nausea, vomiting, diarrhoea, constipation, reflux, early satiety - with trial incidence rates, dropout…

416 questions
titration
titration

Stepwise dose increases over weeks, why the label schedules exist at all, and what tolerability-driven deviation from a schedule looks like in…

444 questions
nausea
nausea

The dominant tolerability signal in every trial of the class: incidence, timing relative to a dose step, duration, and the distinction between…

346 questions
asked by tare_weight 47k · 10 months ago
20 votes 4 answers37k views
What did the placebo arm of SURMOUNT-5 report for injection-site erythema?

Setup, so nobody has to ask: SURMOUNT-5 · injection-site erythema. I have read the primary source rather than the summary, which has left me with more questions. I…

clinical-trials
clinical-trials

Reading the primary literature properly: estimands, intention-to-treat versus per-protocol, confidence intervals, absolute versus relative…

913 questions
gi-side-effects
gi-side-effects

The gastrointestinal cluster as a whole - nausea, vomiting, diarrhoea, constipation, reflux, early satiety - with trial incidence rates, dropout…

416 questions
nausea
nausea

The dominant tolerability signal in every trial of the class: incidence, timing relative to a dose step, duration, and the distinction between…

346 questions
asked by claudia_ferrante 46k · 2.0 years ago
20 votes 5 answers28k views
What did the placebo arm of STEP 2 report for reflux?

The case in front of me: STEP 2 · reflux. I would like to know the limits of what can be inferred from this. What I am trying to avoid is over-reading a single…

clinical-trials
clinical-trials

Reading the primary literature properly: estimands, intention-to-treat versus per-protocol, confidence intervals, absolute versus relative…

913 questions
gi-side-effects
gi-side-effects

The gastrointestinal cluster as a whole - nausea, vomiting, diarrhoea, constipation, reflux, early satiety - with trial incidence rates, dropout…

416 questions
nausea
nausea

The dominant tolerability signal in every trial of the class: incidence, timing relative to a dose step, duration, and the distinction between…

346 questions
asked by Dr_Otto_Lindqvist 38k · 23 months ago
20 votes 5 answers23k views
What did the placebo arm of SURMOUNT-OSA report for reflux?

Setup, so nobody has to ask: SURMOUNT-OSA · reflux. I have read the primary source rather than the summary, which has left me with more questions. I understand the…

clinical-trials
clinical-trials

Reading the primary literature properly: estimands, intention-to-treat versus per-protocol, confidence intervals, absolute versus relative…

913 questions
gi-side-effects
gi-side-effects

The gastrointestinal cluster as a whole - nausea, vomiting, diarrhoea, constipation, reflux, early satiety - with trial incidence rates, dropout…

416 questions
nausea
nausea

The dominant tolerability signal in every trial of the class: incidence, timing relative to a dose step, duration, and the distinction between…

346 questions
asked by swab_and_wait 15k · 9 months ago
20 votes5 answers19k views
What does SOUL tell me about injection-site erythema at the 10 mg dose?

What I am working with: SOUL · injection-site erythema · 10 mg. I have read the primary source rather than the summary, which has left me with more questions. I…

clinical-trials
clinical-trials

Reading the primary literature properly: estimands, intention-to-treat versus per-protocol, confidence intervals, absolute versus relative…

913 questions
gi-side-effects
gi-side-effects

The gastrointestinal cluster as a whole - nausea, vomiting, diarrhoea, constipation, reflux, early satiety - with trial incidence rates, dropout…

416 questions
titration
titration

Stepwise dose increases over weeks, why the label schedules exist at all, and what tolerability-driven deviation from a schedule looks like in…

444 questions
vomiting
vomiting

Emesis as a reported adverse event: trial incidence, its relationship to dose escalation rate, dehydration risk, and when it stops being a…

14 questions
asked by eoin_mcgarry 16k · 7 months ago
20 votes 5 answers19k views
What does SOUL tell me about reflux at the 40 mg dose?

Setup, so nobody has to ask: SOUL · reflux · 40 mg. I would like help reading this properly rather than being told what conclusion to reach. I have the full report…

clinical-trials
clinical-trials

Reading the primary literature properly: estimands, intention-to-treat versus per-protocol, confidence intervals, absolute versus relative…

913 questions
gi-side-effects
gi-side-effects

The gastrointestinal cluster as a whole - nausea, vomiting, diarrhoea, constipation, reflux, early satiety - with trial incidence rates, dropout…

416 questions
titration
titration

Stepwise dose increases over weeks, why the label schedules exist at all, and what tolerability-driven deviation from a schedule looks like in…

444 questions
asked by marta_szymanska 17k · 2.4 years ago
20 votes 3 answers13k views
Does fibre help or worsen constipation at very low intake?

I have kept a symptom diary against dose dates, which turns out to have been the useful thing. Both of these get recommended confidently by different people, which…

constipation
constipation

Slowed transit as a consequence of delayed gastric emptying and reduced intake: incidence figures, fibre and hydration evidence, and why it often…

14 questions
nutrition
nutrition

Eating on a suppressed appetite: hitting nutritional targets inside a small energy budget, micronutrient risk, meal structure, and what the trial…

92 questions
gi-side-effects
gi-side-effects

The gastrointestinal cluster as a whole - nausea, vomiting, diarrhoea, constipation, reflux, early satiety - with trial incidence rates, dropout…

416 questions
asked by seven_day_half 16k · 9 months ago
20 votes 5 answers13k views
What does ATTAIN-1 tell me about dizziness at the 60 mg dose?

The case in front of me: ATTAIN-1 · dizziness · 60 mg. I would like to know the limits of what can be inferred from this. What I am trying to avoid is over-reading a…

clinical-trials
clinical-trials

Reading the primary literature properly: estimands, intention-to-treat versus per-protocol, confidence intervals, absolute versus relative…

913 questions
gi-side-effects
gi-side-effects

The gastrointestinal cluster as a whole - nausea, vomiting, diarrhoea, constipation, reflux, early satiety - with trial incidence rates, dropout…

416 questions
titration
titration

Stepwise dose increases over weeks, why the label schedules exist at all, and what tolerability-driven deviation from a schedule looks like in…

444 questions
asked by charge_state_3 39k · 5 months ago
20 votes5 answers13k views
What does SURPASS-3 tell me about injection-site erythema at the 5 mg dose?

The case in front of me: SURPASS-3 · injection-site erythema · 5 mg. I would like to know the limits of what can be inferred from this. What I am trying to avoid is…

clinical-trials
clinical-trials

Reading the primary literature properly: estimands, intention-to-treat versus per-protocol, confidence intervals, absolute versus relative…

913 questions
gi-side-effects
gi-side-effects

The gastrointestinal cluster as a whole - nausea, vomiting, diarrhoea, constipation, reflux, early satiety - with trial incidence rates, dropout…

416 questions
titration
titration

Stepwise dose increases over weeks, why the label schedules exist at all, and what tolerability-driven deviation from a schedule looks like in…

444 questions
asked by Dr_Colm_Fitzhenry 85k · 2.0 years ago
20 votes0 answers6.9k views
What does TRIUMPH-3 tell me about early satiety at the 30 mg dose?

The specifics, since they change the answer: TRIUMPH-3 · early satiety · 30 mg. I have the document in front of me and I can read the numbers. What I cannot do is…

clinical-trials
clinical-trials

Reading the primary literature properly: estimands, intention-to-treat versus per-protocol, confidence intervals, absolute versus relative…

913 questions
gi-side-effects
gi-side-effects

The gastrointestinal cluster as a whole - nausea, vomiting, diarrhoea, constipation, reflux, early satiety - with trial incidence rates, dropout…

416 questions
titration
titration

Stepwise dose increases over weeks, why the label schedules exist at all, and what tolerability-driven deviation from a schedule looks like in…

444 questions
asked by kofi_mensah 12k · 10 months ago
20 votes0 answers5.6k views
What is the reported incidence of constipation on mazdutide in STEP 2?

Setup, so nobody has to ask: constipation · mazdutide · STEP 2. I have read the primary source rather than the summary, which has left me with more questions. I…

gi-side-effects
gi-side-effects

The gastrointestinal cluster as a whole - nausea, vomiting, diarrhoea, constipation, reflux, early satiety - with trial incidence rates, dropout…

416 questions
clinical-trials
clinical-trials

Reading the primary literature properly: estimands, intention-to-treat versus per-protocol, confidence intervals, absolute versus relative…

913 questions
nausea
nausea

The dominant tolerability signal in every trial of the class: incidence, timing relative to a dose step, duration, and the distinction between…

346 questions
asked by fiadh_cronin 14k · 11 months ago
20 votes 3 answers3.6k views
What did TRIUMPH-3 do with participants who could not tolerate a step?

This came up because two published schedules for the same agent differ. I have read the primary source rather than the summary, which has left me with more questions.…

titration
titration

Stepwise dose increases over weeks, why the label schedules exist at all, and what tolerability-driven deviation from a schedule looks like in…

444 questions
clinical-trials
clinical-trials

Reading the primary literature properly: estimands, intention-to-treat versus per-protocol, confidence intervals, absolute versus relative…

913 questions
gi-side-effects
gi-side-effects

The gastrointestinal cluster as a whole - nausea, vomiting, diarrhoea, constipation, reflux, early satiety - with trial incidence rates, dropout…

416 questions
asked by w_okoye 40k · 2 months ago
19 votes 5 answers51k views
What did the placebo arm of REDEFINE-1 report for early satiety?

The particulars: REDEFINE-1 · early satiety. I have the document in front of me and I can read the numbers. What I cannot do is interpret them. I am reasonably…

clinical-trials
clinical-trials

Reading the primary literature properly: estimands, intention-to-treat versus per-protocol, confidence intervals, absolute versus relative…

913 questions
gi-side-effects
gi-side-effects

The gastrointestinal cluster as a whole - nausea, vomiting, diarrhoea, constipation, reflux, early satiety - with trial incidence rates, dropout…

416 questions
nausea
nausea

The dominant tolerability signal in every trial of the class: incidence, timing relative to a dose step, duration, and the distinction between…

346 questions
asked by teodora_ilic 15k · 2.3 years ago
19 votes 5 answers28k views
What is the reported incidence of vomiting on survodutide in STEP 3?

The particulars: vomiting · survodutide · STEP 3. I want to understand what this actually establishes, as opposed to what it is being used to imply. My concern is…

gi-side-effects
gi-side-effects

The gastrointestinal cluster as a whole - nausea, vomiting, diarrhoea, constipation, reflux, early satiety - with trial incidence rates, dropout…

416 questions
clinical-trials
clinical-trials

Reading the primary literature properly: estimands, intention-to-treat versus per-protocol, confidence intervals, absolute versus relative…

913 questions
nausea
nausea

The dominant tolerability signal in every trial of the class: incidence, timing relative to a dose step, duration, and the distinction between…

346 questions
asked by tabular_nums 47k · 2.0 years ago
19 votes0 answers25k views
Does fatigue at week five of a GLP-1 receptor agonist usually resolve without a dose change?

For reference: fatigue · five · a GLP-1 receptor agonist. I want a method I can write down and repeat, not a rule of thumb. I would rather over-engineer this than…

gi-side-effects
gi-side-effects

The gastrointestinal cluster as a whole - nausea, vomiting, diarrhoea, constipation, reflux, early satiety - with trial incidence rates, dropout…

416 questions
titration
titration

Stepwise dose increases over weeks, why the label schedules exist at all, and what tolerability-driven deviation from a schedule looks like in…

444 questions
nausea
nausea

The dominant tolerability signal in every trial of the class: incidence, timing relative to a dose step, duration, and the distinction between…

346 questions
asked by carys_meredith 17k · 23 months ago
19 votes 3 answers18k views
Does early satiety at week six of dulaglutide usually resolve without a dose change?

Concretely: early satiety · six · dulaglutide. I am trying to do this correctly the first time rather than learn it by getting it wrong. I have already made one…

gi-side-effects
gi-side-effects

The gastrointestinal cluster as a whole - nausea, vomiting, diarrhoea, constipation, reflux, early satiety - with trial incidence rates, dropout…

416 questions
titration
titration

Stepwise dose increases over weeks, why the label schedules exist at all, and what tolerability-driven deviation from a schedule looks like in…

444 questions
nausea
nausea

The dominant tolerability signal in every trial of the class: incidence, timing relative to a dose step, duration, and the distinction between…

346 questions
asked by meniscus_film 34k · 10 months ago