Reading the primary literature properly: estimands, intention-to-treat versus per-protocol, confidence intervals, absolute versus relative effects, and why headline percentages differ between two papers describing the same trial.
Started tirzepatide in February. Nothing unusual until early June, when the shedding started, and it is now substantial: handfuls in the shower, hair on the pillow,…
Every summary I read says nausea is "the most common adverse event" and then quotes a single percentage, usually without saying which trial, which dose or which…
I am going to have to stop, not by choice: my supply arrangement is ending and the alternative is not affordable for me long term. I have gone from 108 kg to 79 kg…
The phrase "food noise" is used constantly and I have never seen it defined precisely. My own experience of it was extremely specific and I would like to know what it…
I am five months in, down 16 kg, and flattened. Not sleepy, exactly. More that everything costs more than it used to: stairs, conversations, training sessions I used…
The claim that "about a quarter of what you lose on these drugs is muscle" gets repeated everywhere and I have never once seen it sourced. I am 14 weeks into…
I started semaglutide for weight and something I did not expect happened: I stopped drinking, more or less by accident. I was on four or five drinks most evenings for…
The specifics, since they change the answer: vomiting · survodutide · TRIUMPH-3. I have the document in front of me and I can read the numbers. What I cannot do is…
Details up front: TRIUMPH-1 · dulaglutide. I would rather be corrected now than propagate something wrong. I am specifically not interested in a testimonial; I am…
The specifics, since they change the answer: SURPASS-3 · survodutide. I have the document in front of me and I can read the numbers. What I cannot do is interpret…
For reference: SELECT · survodutide. I want to understand what this actually establishes, as opposed to what it is being used to imply. My concern is that I am being…
What I have: mazdutide · room temperature. I am asking for verification rather than opinion, ideally with something I can read myself. It is possible the evidence…
For reference: SURPASS-2 · semaglutide. I have the document in front of me and I can read the numbers. What I cannot do is interpret them. I am reasonably comfortable…
Details up front: PIONEER-4 · dulaglutide. This is presented as though it settles something, and I am not convinced it does. I have two documents that appear to…
The particulars: liraglutide · minus 20 °C. I would like to know whether this claim survives contact with evidence. If the answer is "nobody has tested that", I would…
The clinician who ordered the panel was not concerned; I would still like to understand it. Please show the division. I want to check my own against yours. I would…
The case in front of me: ecnoglutide · 2–8 °C. The claim is plausible, which is exactly why I want to check it. I am able to read a paper if someone points me at one.…
Conditions: FLOW · 2 mg. I would like to know the limits of what can be inferred from this. What I am trying to avoid is over-reading a single result, which I have…
Conditions: constipation · liraglutide · PIONEER-4. The figures are clear enough; the question is what they mean and what they do not. I can supply the numbers if the…
Setup, so nobody has to ask: STEP 1 · a GLP-1 receptor agonist. This has the shape of a fact but I cannot find its origin. What I found instead were three secondary…
What I am working with: three weeks · mazdutide. This is asserted often enough that I assumed it was established, and then I went looking for the source. I have…
The case in front of me: semaglutide · liraglutide. These are treated as interchangeable and I do not think they are. If both are acceptable I would like to know…
This came up because two published schedules for the same agent differ. I would like to know the limits of what can be inferred from this. What I am trying to avoid…
Details up front: SOUL · 40 mg. I can parse the result. I am less sure what it licenses me to conclude. I have deliberately not looked at anyone else’s interpretation…
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