How comparable are dulaglutide and semaglutide on the evidence available?

Asked 15 Aug 2024Modified 23 months agoViewed 29k times

Stated plainly: dulaglutide · semaglutide.

I suspect the honest answer is that it depends, in which case I would like to know on what.

Assume I can obtain either option without difficulty, so availability is not the deciding factor.

Under what conditions does the answer flip?

Reading the primary literature properly: estimands, intention-to-treat versus per-protocol, confidence intervals, absolute versus relative…

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semaglutide

A GLP-1 receptor agonist with a fatty-acid-acylated backbone and a roughly one-week half-life, marketed for type 2 diabetes and for weight…

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tirzepatide

A dual GIP and GLP-1 receptor agonist. Questions here cover the SURPASS and SURMOUNT programmes, the practical differences from a pure GLP-1…

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askedbufferline4249k13815 Aug 2024

6I would add a sentence about sterility here, since it is the thing people skip. – fiadh_cronin 6 days ago

5The placebo-arm figure is the part everyone omits. – Dr_Colm_Fitzhenry 8 months ago

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This question has not been answered. It has been viewed 29k times, which suggests the question is of interest and the answer is not obvious. If you can answer it with a source or a worked calculation, it will be read. See how to ask and answer.

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Ask PeptideStack is a static archive. Posting is closed, but the norms are worth stating: answer the question that was asked, show your working, cite the trial or the certificate, and say plainly where the evidence runs out.

Not medical advice. Research-use-only compounds are not approved for human use.

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30 Is FLOW a fair comparison of orforglipron against its comparator arm?18 Is SURMOUNT-1 a fair comparison of a GLP-1 receptor agonist against its comparator arm?25 How comparable are a GLP-1 receptor agonist and semaglutide on the evidence available?13 Is PIONEER-1 a fair comparison of mazdutide against its comparator arm?

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Independent HPLC, identity and content testing. Chromatograms included with every report.

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