PeptideStack
5.2kquestions
20kanswers
220users

Why does aggregation accelerate at room temperature rather than proceeding linearly?

Asked 17 Oct 2025Modified 9 months agoViewed 3.9k times
6

The specifics, since they change the answer: aggregation · room temperature.

I keep seeing this stated as a fact with no explanation attached, and unexplained facts make me suspicious.

My background is quantitative but not chemical, so I can follow an equation more easily than a hand-wave.

Why does this happen, and what would falsify the usual explanation?

peptide-stability
peptide-stability

The chemistry of peptide degradation: deamidation, oxidation, hydrolysis, aggregation and fibrillation, and how temperature, pH, ionic strength,…

908 questions
storage
storage

Storage conditions and their evidence base: minus twenty degrees for powder, refrigerated for solution, protection from light, and what the…

701 questions
hplc
hplc

Reverse-phase high-performance liquid chromatography, the workhorse purity method. Column chemistry, mobile-phase choice, gradient slope,…

503 questions
shareeditfollowflag
LW
askedlinnea_wahlberg17k2717 Oct 2025
3Same situation here, so I will follow this one. – w_okoye 2 months ago
4Is the material lyophilised or already in solution? Completely different answer. – lyoph_cake 3 months ago
add a comment

No answers yet

This question has not been answered. It has been viewed 3.9k times, which suggests the question is of interest and the answer is not obvious. If you can answer it with a source or a worked calculation, it will be read. See how to ask and answer.
Sponsored

Sigma-Aldrich - Certified Reference Materials

Analytical standards and reagents with traceable certificates. Every quantitative result you read inherits the accuracy of the standard behind it.

Shop standards

Your answer

Ask PeptideStack is a static archive. Posting is closed, but the norms are worth stating: answer the question that was asked, show your working, cite the trial or the certificate, and say plainly where the evidence runs out.

Not medical advice. Research-use-only compounds are not approved for human use.