A once-daily GLP-1 receptor agonist and the compound that established the class. Still relevant for its shorter half-life, its paediatric and cardiovascular data, and as a comparator arm in almost every later trial.
The US labelling for several drugs in this class carries a boxed warning about thyroid C-cell tumours, and it is stated fairly starkly — tumours in both rats and…
Native GLP-1 has a plasma half-life measured in minutes. Semaglutide has one measured in days, and the difference is usually explained in one sentence about a fatty…
I have looked for a randomised comparison of dosing frequency within a single molecule in this class and cannot find one. Every phase 3 trial I can find fixed the…
The particulars: liraglutide · SURMOUNT-4. I would like the mechanism, because I want to be able to reason about the cases nobody has written about. I have tried to…
Stated plainly: retatrutide · ATTAIN-1. The empirical answer seems settled. The explanation does not. If the honest answer is that nobody knows, I would rather hear…
Conditions: ecnoglutide · retatrutide. I would like the axes of comparison first and the recommendation second. I have tried the first option and it works; the…
What I have: TRIUMPH-3 · orforglipron. I would rather be corrected now than propagate something wrong. I am specifically not interested in a testimonial; I am…
What I am working with: FLOW · mazdutide. I would like help reading this properly rather than being told what conclusion to reach. I have the full report including…
Details up front: a GLP-1 receptor agonist · survodutide. I have used one of these for a while and I am considering switching, which requires a reason. What I care…
For reference: STEP 8 · survodutide. Somebody stated this to me confidently and I would like to check it before repeating it. I would accept a well-reasoned negative…
Numbers first: STEP 8 · dulaglutide. This is presented as though it settles something, and I am not convinced it does. I have two documents that appear to disagree,…
I would like to know how much of this is established and how much is a reasonable story. I want to know what the trade-off actually is rather than which option is…
The case in front of me: ESSENCE · oral semaglutide. The claim is plausible, which is exactly why I want to check it. I am able to read a paper if someone points me…
My background is chemistry rather than physiology, which may explain where I am stuck. I want the working, not the result — I need to be able to redo it with…
Analytical standards and reagents with traceable certificates. Every quantitative result you read inherits the accuracy of the standard behind it.
Shop standards