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coa

Page 20 of 32 · 749 questions tagged coa.

749 questions · sorted by votes · page 20 of 32

15 votes3 answers19k views
How do I reconcile 99.1% from Janoshik with 96.4% from the supplier?

What I have: 99.1% · Janoshik · 96.4%. I have a result I cannot explain, and I would rather diagnose it than guess. I have checked the obvious explanations and…

purity
purity

Purity as chromatographic area per cent - the fraction of detected material that is your target peak. It says nothing about how much material is…

788 questions
batch-testing
batch-testing

Testing at the batch or lot level: sampling plans, how many vials from a lot need testing to say anything about the lot, and the difference…

865 questions
coa
coa

Certificates of analysis: what fields a useful one carries, how to tell a real analytical report from a marketing document, batch and lot…

749 questions
asked by Dr_Idris_Coulibaly 40k · 15 months ago
15 votes 5 answers17k views
What does 97.6% purity on a C4 column actually tell me about an orforglipron vial?

Concretely: 97.6% · a C4 column · orforglipron. The figures are clear enough; the question is what they mean and what they do not. I can supply the numbers if the…

hplc
hplc

Reverse-phase high-performance liquid chromatography, the workhorse purity method. Column chemistry, mobile-phase choice, gradient slope,…

466 questions
purity
purity

Purity as chromatographic area per cent - the fraction of detected material that is your target peak. It says nothing about how much material is…

788 questions
coa
coa

Certificates of analysis: what fields a useful one carries, how to tell a real analytical report from a marketing document, batch and lot…

749 questions
asked by pip_okonjo 11k · 10 months ago
15 votes5 answers14k views
How does QSC compare to Nantong Guangyuan Chemical on documentation quality?

Stated plainly: QSC · Nantong Guangyuan Chemical. I suspect the honest answer is that it depends, in which case I would like to know on what. Assume I can obtain…

vendor-comparison
vendor-comparison

Side-by-side comparison of suppliers on measurable axes - independently confirmed purity and content, lead time, cold-chain handling,…

351 questions
coa
coa

Certificates of analysis: what fields a useful one carries, how to tell a real analytical report from a marketing document, batch and lot…

749 questions
vendor-vetting
vendor-vetting

Evaluating a supplier on evidence rather than reputation: testing history across batches, whether certificates are batch-specific, how failures…

436 questions
asked by mateo_iglesias 16k · 6 months ago
15 votes5 answers14k views
Has anyone independently verified a QST tirzepatide batch COA?

Conditions: QST · tirzepatide. The claim is plausible, which is exactly why I want to check it. I am able to read a paper if someone points me at one. Can anyone…

vendor-vetting
vendor-vetting

Evaluating a supplier on evidence rather than reputation: testing history across batches, whether certificates are batch-specific, how failures…

436 questions
coa
coa

Certificates of analysis: what fields a useful one carries, how to tell a real analytical report from a marketing document, batch and lot…

749 questions
batch-testing
batch-testing

Testing at the batch or lot level: sampling plans, how many vials from a lot need testing to say anything about the lot, and the difference…

865 questions
asked by ayo_fadipe 19k · 2.2 years ago
15 votes 5 answers14k views
What does a 503A pharmacy need to prepare retatrutide lawfully?

The pharmacy is accredited and I have verified that on the accreditor register. I have read the primary source rather than the summary, which has left me with more…

pharmacy-503a
pharmacy-503a

Section 503A traditional compounding pharmacies specifically: patient-specific prescriptions, accreditation such as PCAB and ACHC, USP 797…

17 questions
compounding
compounding

Compounded preparations: what a 503A and a 503B facility may legally prepare and when, base versus salt forms, beyond-use dating under USP…

61 questions
coa
coa

Certificates of analysis: what fields a useful one carries, how to tell a real analytical report from a marketing document, batch and lot…

749 questions
asked by bufferline42 49k · 21 months ago
15 votes0 answers14k views
How do I write up a VendorInvestigate result on survodutide so it is useful to others?

For reference: VendorInvestigate · survodutide. I have read the obvious sources and they disagree with each other, so I would rather ask people who have actually done…

batch-testing
batch-testing

Testing at the batch or lot level: sampling plans, how many vials from a lot need testing to say anything about the lot, and the difference…

865 questions
coa
coa

Certificates of analysis: what fields a useful one carries, how to tell a real analytical report from a marketing document, batch and lot…

749 questions
harm-reduction
harm-reduction

Reducing avoidable risk where a decision has already been made: independent verification before use, sterility practice, dose arithmetic checked…

445 questions
asked by Dr_Elias_Weiss 46k · 15 months ago
15 votes 3 answers13k views
How do I reconcile 96.8% from PeptideMeter with 96.4% from the supplier?

For reference: 96.8% · PeptideMeter · 96.4%. An unexpected observation, and I would like a differential rather than reassurance. The conditions were within what I…

purity
purity

Purity as chromatographic area per cent - the fraction of detected material that is your target peak. It says nothing about how much material is…

788 questions
batch-testing
batch-testing

Testing at the batch or lot level: sampling plans, how many vials from a lot need testing to say anything about the lot, and the difference…

865 questions
coa
coa

Certificates of analysis: what fields a useful one carries, how to tell a real analytical report from a marketing document, batch and lot…

749 questions
asked by lucia_marchetti 18k · 11 months ago
15 votes2 answers12k views
Would you re-test orforglipron after two weeks at 37 °C, or accept the original certificate?

Setup, so nobody has to ask: orforglipron · two weeks · 37 °C. I am trying to build something sustainable rather than something thorough that I will abandon. I have…

batch-testing
batch-testing

Testing at the batch or lot level: sampling plans, how many vials from a lot need testing to say anything about the lot, and the difference…

865 questions
peptide-stability
peptide-stability

The chemistry of peptide degradation: deamidation, oxidation, hydrolysis, aggregation and fibrillation, and how temperature, pH, ionic strength,…

832 questions
coa
coa

Certificates of analysis: what fields a useful one carries, how to tell a real analytical report from a marketing document, batch and lot…

749 questions
asked by halvard_ness 42k · 9 months ago
15 votes 5 answers12k views
What does a 98.2% purity with a sampling plan attached let me conclude?

What I am working with: 98.2% · sampling plan. I would like help reading this properly rather than being told what conclusion to reach. I have the full report…

purity
purity

Purity as chromatographic area per cent - the fraction of detected material that is your target peak. It says nothing about how much material is…

788 questions
coa
coa

Certificates of analysis: what fields a useful one carries, how to tell a real analytical report from a marketing document, batch and lot…

749 questions
hplc
hplc

Reverse-phase high-performance liquid chromatography, the workhorse purity method. Column chemistry, mobile-phase choice, gradient slope,…

466 questions
asked by pascal_thibault 13k · 23 months ago
15 votes0 answers11k views
What accept/reject threshold would you set for orforglipron before seeing the result?

I am comparing a supplier certificate against an independent result on the same lot. I am trying to build something sustainable rather than something thorough that I…

batch-testing
batch-testing

Testing at the batch or lot level: sampling plans, how many vials from a lot need testing to say anything about the lot, and the difference…

865 questions
harm-reduction
harm-reduction

Reducing avoidable risk where a decision has already been made: independent verification before use, sterility practice, dose arithmetic checked…

445 questions
coa
coa

Certificates of analysis: what fields a useful one carries, how to tell a real analytical report from a marketing document, batch and lot…

749 questions
asked by birk_nordahl 20k · 18 months ago
15 votes 4 answers9.6k views
How does GL Biochem compare to Hubei Jianxiang Bioscience on documentation quality?

The particulars: GL Biochem · Hubei Jianxiang Bioscience. The comparison I want does not seem to exist anywhere in a form I can evaluate. I have read the arguments…

vendor-comparison
vendor-comparison

Side-by-side comparison of suppliers on measurable axes - independently confirmed purity and content, lead time, cold-chain handling,…

351 questions
coa
coa

Certificates of analysis: what fields a useful one carries, how to tell a real analytical report from a marketing document, batch and lot…

749 questions
vendor-vetting
vendor-vetting

Evaluating a supplier on evidence rather than reputation: testing history across batches, whether certificates are batch-specific, how failures…

436 questions
asked by jana_horakova 15k · 3 months ago
15 votes 5 answers7.9k views
How does TFC compare to Zhuhai Kerui Biotechnology on documentation quality?

Concretely: TFC · Zhuhai Kerui Biotechnology. These are treated as interchangeable and I do not think they are. If both are acceptable I would like to know that, so I…

vendor-comparison
vendor-comparison

Side-by-side comparison of suppliers on measurable axes - independently confirmed purity and content, lead time, cold-chain handling,…

351 questions
coa
coa

Certificates of analysis: what fields a useful one carries, how to tell a real analytical report from a marketing document, batch and lot…

749 questions
vendor-vetting
vendor-vetting

Evaluating a supplier on evidence rather than reputation: testing history across batches, whether certificates are batch-specific, how failures…

436 questions
asked by area_percent 13k · 6 months ago
15 votes 5 answers7.7k views
Does QSC issue lot-specific documentation, or a batch certificate?

The lot number on the vial matches the certificate, which at least rules out the easy problem. I would like help reading this properly rather than being told what…

batch-testing
batch-testing

Testing at the batch or lot level: sampling plans, how many vials from a lot need testing to say anything about the lot, and the difference…

865 questions
coa
coa

Certificates of analysis: what fields a useful one carries, how to tell a real analytical report from a marketing document, batch and lot…

749 questions
vendor-vetting
vendor-vetting

Evaluating a supplier on evidence rather than reputation: testing history across batches, whether certificates are batch-specific, how failures…

436 questions
asked by void_volume 13k · 14 months ago
15 votes 5 answers7.1k views
Has anyone independently verified a Homopeptide liraglutide batch COA?

Conditions: Homopeptide · liraglutide. The claim is plausible, which is exactly why I want to check it. I am able to read a paper if someone points me at one. Can…

vendor-vetting
vendor-vetting

Evaluating a supplier on evidence rather than reputation: testing history across batches, whether certificates are batch-specific, how failures…

436 questions
coa
coa

Certificates of analysis: what fields a useful one carries, how to tell a real analytical report from a marketing document, batch and lot…

749 questions
batch-testing
batch-testing

Testing at the batch or lot level: sampling plans, how many vials from a lot need testing to say anything about the lot, and the difference…

865 questions
asked by fill_volume 13k · 3 months ago
15 votes 4 answers7k views
How do I set an accept/reject threshold before I see the result?

This is my second independent submission on material from the same supplier. This is a planning question. I know what my options are; I do not know how to weigh them.…

batch-testing
batch-testing

Testing at the batch or lot level: sampling plans, how many vials from a lot need testing to say anything about the lot, and the difference…

865 questions
harm-reduction
harm-reduction

Reducing avoidable risk where a decision has already been made: independent verification before use, sterility practice, dose arithmetic checked…

445 questions
coa
coa

Certificates of analysis: what fields a useful one carries, how to tell a real analytical report from a marketing document, batch and lot…

749 questions
asked by label_claim 11k · 15 months ago
15 votes4 answers6.3k views
How do I reconcile 99.1% from PeptideMeter with 97.9% from the supplier?

The specifics, since they change the answer: 99.1% · PeptideMeter · 97.9%. Something has gone wrong and I would like to know how badly before I decide what to do.…

purity
purity

Purity as chromatographic area per cent - the fraction of detected material that is your target peak. It says nothing about how much material is…

788 questions
batch-testing
batch-testing

Testing at the batch or lot level: sampling plans, how many vials from a lot need testing to say anything about the lot, and the difference…

865 questions
coa
coa

Certificates of analysis: what fields a useful one carries, how to tell a real analytical report from a marketing document, batch and lot…

749 questions
asked by bea_castellanos 47k · 3 months ago
15 votes 2 answers6.2k views
How many vials from an HJ lot should I send for a sterility test?

Conditions: HJ · a sterility test. Please show the division. I want to check my own against yours. I would like the general form as well as the specific number, so I…

batch-testing
batch-testing

Testing at the batch or lot level: sampling plans, how many vials from a lot need testing to say anything about the lot, and the difference…

865 questions
coa
coa

Certificates of analysis: what fields a useful one carries, how to tell a real analytical report from a marketing document, batch and lot…

749 questions
cost-analysis
cost-analysis

Cost arithmetic done honestly: cost per milligram after dead-space loss, list versus net price, comparing a multi-dose vial to a fixed-dose pen,…

261 questions
asked by kirsi_lahtinen 45k · 3 months ago
15 votes 5 answers5k views
What does a 98.4% purity with a batch certificate attached let me conclude?

What I am working with: 98.4% · batch certificate. I have read the primary source rather than the summary, which has left me with more questions. I understand the…

purity
purity

Purity as chromatographic area per cent - the fraction of detected material that is your target peak. It says nothing about how much material is…

788 questions
coa
coa

Certificates of analysis: what fields a useful one carries, how to tell a real analytical report from a marketing document, batch and lot…

749 questions
hplc
hplc

Reverse-phase high-performance liquid chromatography, the workhorse purity method. Column chemistry, mobile-phase choice, gradient slope,…

466 questions
asked by mass_shift_18 14k · 2 months ago
15 votes0 answers5k views
Would you re-test ecnoglutide after four weeks at 4 °C, or accept the original certificate?

The case in front of me: ecnoglutide · four weeks · 4 °C. The failure mode I am trying to avoid is making this decision emotionally. I have twelve months in view and…

batch-testing
batch-testing

Testing at the batch or lot level: sampling plans, how many vials from a lot need testing to say anything about the lot, and the difference…

865 questions
peptide-stability
peptide-stability

The chemistry of peptide degradation: deamidation, oxidation, hydrolysis, aggregation and fibrillation, and how temperature, pH, ionic strength,…

832 questions
coa
coa

Certificates of analysis: what fields a useful one carries, how to tell a real analytical report from a marketing document, batch and lot…

749 questions
asked by tare_weight 47k · 3 months ago
15 votes5 answers4.8k views
What does Janoshik verification of Bachem Holding (Suzhou) actually cover?

What I have: Janoshik · Bachem Holding (Suzhou). I can parse the result. I am less sure what it licenses me to conclude. I have deliberately not looked at anyone…

vendor-investigate
vendor-investigate

VendorInvestigate, an independent vendor review and verification service. Use this tag for questions about its verification criteria, what a…

41 questions
vendor-vetting
vendor-vetting

Evaluating a supplier on evidence rather than reputation: testing history across batches, whether certificates are batch-specific, how failures…

436 questions
coa
coa

Certificates of analysis: what fields a useful one carries, how to tell a real analytical report from a marketing document, batch and lot…

749 questions
asked by hana_petrikova 19k · 3 months ago
15 votes 2 answers3.9k views
How do I reconcile 98.2% from PeptideMeter with 99.4% from the supplier?

The specifics, since they change the answer: 98.2% · PeptideMeter · 99.4%. Something has gone wrong and I would like to know how badly before I decide what to do.…

purity
purity

Purity as chromatographic area per cent - the fraction of detected material that is your target peak. It says nothing about how much material is…

788 questions
batch-testing
batch-testing

Testing at the batch or lot level: sampling plans, how many vials from a lot need testing to say anything about the lot, and the difference…

865 questions
coa
coa

Certificates of analysis: what fields a useful one carries, how to tell a real analytical report from a marketing document, batch and lot…

749 questions
asked by mass_shift_18 14k · 5 months ago
15 votes5 answers2.9k views
Has anyone independently verified a BCH mazdutide batch COA?

Stated plainly: BCH · mazdutide. This has the shape of a fact but I cannot find its origin. What I found instead were three secondary sources all citing each other.…

vendor-vetting
vendor-vetting

Evaluating a supplier on evidence rather than reputation: testing history across batches, whether certificates are batch-specific, how failures…

436 questions
coa
coa

Certificates of analysis: what fields a useful one carries, how to tell a real analytical report from a marketing document, batch and lot…

749 questions
batch-testing
batch-testing

Testing at the batch or lot level: sampling plans, how many vials from a lot need testing to say anything about the lot, and the difference…

865 questions
asked by rune_thoresen 14k · 34 days ago
14 votes 5 answers28k views
What does a 503A pharmacy need to prepare ecnoglutide lawfully?

This is a United States plan; I appreciate the answer is jurisdiction-specific. The figures are clear enough; the question is what they mean and what they do not. I…

pharmacy-503a
pharmacy-503a

Section 503A traditional compounding pharmacies specifically: patient-specific prescriptions, accreditation such as PCAB and ACHC, USP 797…

17 questions
compounding
compounding

Compounded preparations: what a 503A and a 503B facility may legally prepare and when, base versus salt forms, beyond-use dating under USP…

61 questions
coa
coa

Certificates of analysis: what fields a useful one carries, how to tell a real analytical report from a marketing document, batch and lot…

749 questions
asked by oona_kekkonen 16k · 17 months ago
14 votes 5 answers26k views
Is a sampling plan from QSC sufficient basis to skip independent testing?

What I have: sampling plan · QSC. This is a planning question. I know what my options are; I do not know how to weigh them. What I want is the minimum viable version,…

coa
coa

Certificates of analysis: what fields a useful one carries, how to tell a real analytical report from a marketing document, batch and lot…

749 questions
batch-testing
batch-testing

Testing at the batch or lot level: sampling plans, how many vials from a lot need testing to say anything about the lot, and the difference…

865 questions
harm-reduction
harm-reduction

Reducing avoidable risk where a decision has already been made: independent verification before use, sterility practice, dose arithmetic checked…

445 questions
asked by tobias_reint 19k · 2.1 years ago