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content-assay

Page 19 of 19 · 438 questions tagged content-assay.

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438 questions · sorted by votes · page 19 of 19

2 votes0 answers2.6k views
What counter-ion should I expect on a QST oral semaglutide lot?

Concretely: QST · oral semaglutide. I would like to know the limits of what can be inferred from this. What I am trying to avoid is over-reading a single result,…

acetate-content
acetate-content

Counter-ion content, most often acetate or trifluoroacetate, and why it matters: the counter-ion and residual water are part of the gross mass you…

87 questionspurity
purity

Purity as chromatographic area per cent - the fraction of detected material that is your target peak. It says nothing about how much material is…

788 questionscontent-assay
content-assay

Quantified content: how many milligrams of peptide are actually in the vial, measured against a calibrated reference standard. A separate test…

438 questionsasked by tadhg_o_riordan 14k · 14 months ago
2 votes0 answers1.6k views
Why did two ERP lots of mazdutide differ on content assay?

Setup, so nobody has to ask: ERP · mazdutide. I noticed this today and I have not touched anything since, in case the state is diagnostic. I have not discarded…

batch-testing
batch-testing

Testing at the batch or lot level: sampling plans, how many vials from a lot need testing to say anything about the lot, and the difference…

865 questionscontent-assay
content-assay

Quantified content: how many milligrams of peptide are actually in the vial, measured against a calibrated reference standard. A separate test…

438 questionsvendor-vetting
vendor-vetting

Evaluating a supplier on evidence rather than reputation: testing history across batches, whether certificates are batch-specific, how failures…

436 questionsasked by samir_bennani 13k · 18 months ago
2 votes0 answers819 views
Would you accept 96.4% on ecnoglutide from KP without a content assay?

For reference: 96.4% · ecnoglutide · KP. I would like to define my thresholds before I have a result, for obvious reasons. I want a plan with explicit stopping rules,…

purity
purity

Purity as chromatographic area per cent - the fraction of detected material that is your target peak. It says nothing about how much material is…

788 questionscontent-assay
content-assay

Quantified content: how many milligrams of peptide are actually in the vial, measured against a calibrated reference standard. A separate test…

438 questionsvendor-vetting
vendor-vetting

Evaluating a supplier on evidence rather than reputation: testing history across batches, whether certificates are batch-specific, how failures…

436 questionsasked by sasha_ferreira 15k · 37 days ago
2 votes0 answers791 views
Does tirzepatide adsorb measurably to the vial wall at 1 mg/mL?

The specifics, since they change the answer: tirzepatide · 1 mg/mL. I would like the arithmetic checked rather than the conclusion asserted. I have deliberately not…

peptide-stability
peptide-stability

The chemistry of peptide degradation: deamidation, oxidation, hydrolysis, aggregation and fibrillation, and how temperature, pH, ionic strength,…

832 questionscontent-assay
content-assay

Quantified content: how many milligrams of peptide are actually in the vial, measured against a calibrated reference standard. A separate test…

438 questionsstorage
storage

Storage conditions and their evidence base: minus twenty degrees for powder, refrigerated for solution, protection from light, and what the…

646 questionsasked by gunnar_isaksen 16k · 7 months ago
2 votes0 answers693 views
Would you accept 99.4% on orforglipron from GGPeps without a content assay?

What I have: 99.4% · orforglipron · GGPeps. I would rather over-plan the first cycle and simplify later. I am prepared to do the work if someone can tell me which…

purity
purity

Purity as chromatographic area per cent - the fraction of detected material that is your target peak. It says nothing about how much material is…

788 questionscontent-assay
content-assay

Quantified content: how many milligrams of peptide are actually in the vial, measured against a calibrated reference standard. A separate test…

438 questionsvendor-vetting
vendor-vetting

Evaluating a supplier on evidence rather than reputation: testing history across batches, whether certificates are batch-specific, how failures…

436 questionsasked by nynke_dekker 18k · 3 months ago
1 vote 5 answers5k views
Does aggregation of a GLP-1 receptor agonist at 30 °C show up as a loss of content or of purity?

Setup, so nobody has to ask: aggregation · a GLP-1 receptor agonist · 30 °C. The empirical answer seems settled. The explanation does not. If the honest answer is…

peptide-stability
peptide-stability

The chemistry of peptide degradation: deamidation, oxidation, hydrolysis, aggregation and fibrillation, and how temperature, pH, ionic strength,…

832 questionscontent-assay
content-assay

Quantified content: how many milligrams of peptide are actually in the vial, measured against a calibrated reference standard. A separate test…

438 questionspurity
purity

Purity as chromatographic area per cent - the fraction of detected material that is your target peak. It says nothing about how much material is…

788 questionsasked by cap_the_luer 15k · 6 months ago