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dosing-math

Page 3 of 34 · 811 questions tagged dosing-math.

811 questions · sorted by votes · page 3 of 34

37 votes5 answers34k views
Why does a U-40 insulin syringe read differently from the volume I thought I drew at 5 mg/mL?

Conditions: a U-40 insulin syringe · 5 mg/mL. I think I have a problem. I am not yet sure whether it is a real problem or a measurement artefact. I want to know…

insulin-syringe
insulin-syringe

U-100 and U-40 insulin syringes as measuring instruments. A U-100 syringe is graduated in insulin units where 100 units equals 1 mL, so one unit…

268 questions
dead-space
dead-space

The volume trapped in the syringe hub and needle after the plunger bottoms out. It is small in absolute terms and large as a fraction of a small…

110 questions
dosing-math
dosing-math

The arithmetic itself: milligrams to millilitres to insulin units, concentration after reconstitution, dose per draw, and vial-days per vial. Show…

811 questions
asked by aine_mulcahy 35k · 16 months ago
37 votes 3 answers29k views
How many units on a U-100 insulin syringe is a 10 mg dose at 2 mg/mL?

Details up front: a U-100 insulin syringe · 10 mg · 2 mg/mL. This should be a straightforward calculation and I keep getting two different answers. The numbers are…

dosing-math
dosing-math

The arithmetic itself: milligrams to millilitres to insulin units, concentration after reconstitution, dose per draw, and vial-days per vial. Show…

811 questions
insulin-syringe
insulin-syringe

U-100 and U-40 insulin syringes as measuring instruments. A U-100 syringe is graduated in insulin units where 100 units equals 1 mL, so one unit…

268 questions
reconstitution
reconstitution

Taking a lyophilised vial to a solution of known concentration: choice of diluent, volume selection, how to add liquid without shearing the cake,…

330 questions
asked by e_dziedzic 87k · 16 months ago
37 votes5 answers24k views
Why do two papers on SURMOUNT-4 report different headline figures?

I have three data points across nine months, which I hope is enough to see a trend. I understand the observation; what I do not understand is the mechanism behind it.…

clinical-trials
clinical-trials

Reading the primary literature properly: estimands, intention-to-treat versus per-protocol, confidence intervals, absolute versus relative…

913 questions
dosing-math
dosing-math

The arithmetic itself: milligrams to millilitres to insulin units, concentration after reconstitution, dose per draw, and vial-days per vial. Show…

811 questions
semaglutide
semaglutide

A GLP-1 receptor agonist with a fatty-acid-acylated backbone and a roughly one-week half-life, marketed for type 2 diabetes and for weight…

360 questions
asked by ekaterina_volk 16k · 2.2 years ago
37 votes0 answers19k views
Can I reconstitute cagrilintide at 4 mg/mL and still measure a small dose accurately?

Numbers first: cagrilintide · 4 mg/mL. This is a planning question. I know what my options are; I do not know how to weigh them. What I want is the minimum viable…

diluent-volume
diluent-volume

Choosing how much diluent to add, which is really a question about what you want your measurement resolution to be. Larger volumes buy you…

308 questions
insulin-syringe
insulin-syringe

U-100 and U-40 insulin syringes as measuring instruments. A U-100 syringe is graduated in insulin units where 100 units equals 1 mL, so one unit…

268 questions
dosing-math
dosing-math

The arithmetic itself: milligrams to millilitres to insulin units, concentration after reconstitution, dose per draw, and vial-days per vial. Show…

811 questions
asked by bridget_nyathi 16k · 23 months ago
36 votes 5 answers67k views
How many units on a low-dead-space syringe is a 15 mg dose at 10 mg/mL?

Stated plainly: a low-dead-space syringe · 15 mg · 10 mg/mL. I have worked this out and I would like someone to find the error, because I suspect there is one. My…

dosing-math
dosing-math

The arithmetic itself: milligrams to millilitres to insulin units, concentration after reconstitution, dose per draw, and vial-days per vial. Show…

811 questions
insulin-syringe
insulin-syringe

U-100 and U-40 insulin syringes as measuring instruments. A U-100 syringe is graduated in insulin units where 100 units equals 1 mL, so one unit…

268 questions
reconstitution
reconstitution

Taking a lyophilised vial to a solution of known concentration: choice of diluent, volume selection, how to add liquid without shearing the cake,…

330 questions
asked by otto_brenner 19k · 2.0 years ago
36 votes5 answers45k views
How many units on a low-dead-space syringe is a 4 mg dose at 1 mg/mL?

Stated plainly: a low-dead-space syringe · 4 mg · 1 mg/mL. The units are where I keep going wrong, so please be explicit about them. I have sanity-checked the order…

dosing-math
dosing-math

The arithmetic itself: milligrams to millilitres to insulin units, concentration after reconstitution, dose per draw, and vial-days per vial. Show…

811 questions
insulin-syringe
insulin-syringe

U-100 and U-40 insulin syringes as measuring instruments. A U-100 syringe is graduated in insulin units where 100 units equals 1 mL, so one unit…

268 questions
reconstitution
reconstitution

Taking a lyophilised vial to a solution of known concentration: choice of diluent, volume selection, how to add liquid without shearing the cake,…

330 questions
asked by tadhg_o_riordan 14k · 20 months ago
36 votes 5 answers42k views
Is 10 mg/mL a sensible working concentration for liraglutide, or should I go lower?

The case in front of me: 10 mg/mL · liraglutide. These are treated as interchangeable and I do not think they are. If both are acceptable I would like to know that,…

diluent-volume
diluent-volume

Choosing how much diluent to add, which is really a question about what you want your measurement resolution to be. Larger volumes buy you…

308 questions
reconstitution
reconstitution

Taking a lyophilised vial to a solution of known concentration: choice of diluent, volume selection, how to add liquid without shearing the cake,…

330 questions
dosing-math
dosing-math

The arithmetic itself: milligrams to millilitres to insulin units, concentration after reconstitution, dose per draw, and vial-days per vial. Show…

811 questions
asked by ahmed_zerouali 19k · 2.2 years ago
36 votes0 answers23k views
Does splitting a 10 mg weekly dose of oral semaglutide across two administrations change anything?

The case in front of me: 10 mg · oral semaglutide. I want to know whether this is a real physical effect or an artefact of how it is measured. What prompted the…

split-dosing
split-dosing

Dividing a weekly dose across more than one administration. Questions here concern the pharmacokinetic rationale, whether the peak-to-trough ratio…

39 questions
dosing-math
dosing-math

The arithmetic itself: milligrams to millilitres to insulin units, concentration after reconstitution, dose per draw, and vial-days per vial. Show…

811 questions
glp1-mechanism
glp1-mechanism

Receptor-level pharmacology: GLP-1R as a class B GPCR, cAMP and PKA signalling, biased agonism, internalisation and resensitisation, and the…

175 questions
asked by birk_nordahl 20k · 2.2 years ago
36 votes 3 answers19k views
If HbA1c is a 90-day average, what does a 0.5-point fall actually mean in glucose?

My HbA1c went from 7.4% to 6.9% over four months on semaglutide. Everyone tells me half a point is good. Nobody has told me what half a point is , in units I can…

a1c
a1c

Glycated haemoglobin as a ninety-day glycaemic average: what a change of half a point means, why it lags, and the conditions under which it…

108 questions
bloodwork
bloodwork

Laboratory monitoring: which panels are worth ordering, sensible intervals, reference-range versus optimal-range arguments, and how to read a…

284 questions
dosing-math
dosing-math

The arithmetic itself: milligrams to millilitres to insulin units, concentration after reconstitution, dose per draw, and vial-days per vial. Show…

811 questions
t2dm
t2dm

Type 2 diabetes: glycaemic endpoints, the SURPASS and SUSTAIN programmes, dose ranges licensed for diabetes versus obesity, and interaction with…

20 questions
asked by p_mkhize 41k · 21 months ago
36 votes 5 answers19k views
What is the dead-space loss per draw with a 27G needle at 8 mg/mL?

Concretely: a 27G needle · 8 mg/mL. I want the working, not the result — I need to be able to redo it with different numbers. I care about the precision as well as…

dead-space
dead-space

The volume trapped in the syringe hub and needle after the plunger bottoms out. It is small in absolute terms and large as a fraction of a small…

110 questions
insulin-syringe
insulin-syringe

U-100 and U-40 insulin syringes as measuring instruments. A U-100 syringe is graduated in insulin units where 100 units equals 1 mL, so one unit…

268 questions
dosing-math
dosing-math

The arithmetic itself: milligrams to millilitres to insulin units, concentration after reconstitution, dose per draw, and vial-days per vial. Show…

811 questions
asked by Dr_Marek_Zielinski 39k · 16 months ago
35 votes5 answers62k views
How many units on a 0.3 mL insulin syringe is a 2.5 mg dose at 8 mg/mL?

What I have: a 0.3 mL insulin syringe · 2.5 mg · 8 mg/mL. This should be a straightforward calculation and I keep getting two different answers. The numbers are…

dosing-math
dosing-math

The arithmetic itself: milligrams to millilitres to insulin units, concentration after reconstitution, dose per draw, and vial-days per vial. Show…

811 questions
insulin-syringe
insulin-syringe

U-100 and U-40 insulin syringes as measuring instruments. A U-100 syringe is graduated in insulin units where 100 units equals 1 mL, so one unit…

268 questions
reconstitution
reconstitution

Taking a lyophilised vial to a solution of known concentration: choice of diluent, volume selection, how to add liquid without shearing the cake,…

330 questions
asked by aine_mulcahy 35k · 2.0 years ago
35 votes5 answers60k views
If an oral semaglutide dose is missed by ten days, does the ladder reset?

The specifics, since they change the answer: oral semaglutide · ten days. I have read the obvious sources and they disagree with each other, so I would rather ask…

missed-dose
missed-dose

What the label instructions for a missed weekly dose are, why they differ between agents, and what the pharmacokinetics say about drift in an…

41 questions
titration
titration

Stepwise dose increases over weeks, why the label schedules exist at all, and what tolerability-driven deviation from a schedule looks like in…

444 questions
dosing-math
dosing-math

The arithmetic itself: milligrams to millilitres to insulin units, concentration after reconstitution, dose per draw, and vial-days per vial. Show…

811 questions
asked by one_ml_bac 12k · 2.1 years ago
35 votes 5 answers57k views
How do I get 25 units out of a vial reconstituted to 4 mg/mL without guessing?

Details up front: 25 units · 4 mg/mL. I can find plenty of assertions about this and almost no reasoning, which is usually a sign that nobody has checked. Assume no…

insulin-syringe
insulin-syringe

U-100 and U-40 insulin syringes as measuring instruments. A U-100 syringe is graduated in insulin units where 100 units equals 1 mL, so one unit…

268 questions
dosing-math
dosing-math

The arithmetic itself: milligrams to millilitres to insulin units, concentration after reconstitution, dose per draw, and vial-days per vial. Show…

811 questions
diluent-volume
diluent-volume

Choosing how much diluent to add, which is really a question about what you want your measurement resolution to be. Larger volumes buy you…

308 questions
asked by leonid_marchuk 15k · 2.1 years ago
35 votes 5 answers52k views
How many units on a 0.5 mL insulin syringe is a 30 mg dose at 10 mg/mL?

Concretely: a 0.5 mL insulin syringe · 30 mg · 10 mg/mL. I want the working, not the result — I need to be able to redo it with different numbers. I care about the…

dosing-math
dosing-math

The arithmetic itself: milligrams to millilitres to insulin units, concentration after reconstitution, dose per draw, and vial-days per vial. Show…

811 questions
insulin-syringe
insulin-syringe

U-100 and U-40 insulin syringes as measuring instruments. A U-100 syringe is graduated in insulin units where 100 units equals 1 mL, so one unit…

268 questions
reconstitution
reconstitution

Taking a lyophilised vial to a solution of known concentration: choice of diluent, volume selection, how to add liquid without shearing the cake,…

330 questions
asked by dmitri_savchuk 17k · 19 months ago
35 votes 5 answers50k views
How do I convert the SURMOUNT-5 hazard ratio into an absolute risk reduction?

I have three data points across nine months, which I hope is enough to see a trend. I would like the arithmetic checked rather than the conclusion asserted. I have…

cardiovascular
cardiovascular

Cardiovascular outcomes: the SELECT major-adverse-event result, SOUL, SUSTAIN 6 and REWIND, how to convert a hazard ratio into an absolute risk…

111 questions
clinical-trials
clinical-trials

Reading the primary literature properly: estimands, intention-to-treat versus per-protocol, confidence intervals, absolute versus relative…

913 questions
dosing-math
dosing-math

The arithmetic itself: milligrams to millilitres to insulin units, concentration after reconstitution, dose per draw, and vial-days per vial. Show…

811 questions
asked by area_percent 13k · 22 months ago
35 votes5 answers47k views
Is 50 mg in 2.5 mL of phosphate-buffered diluent a sensible presentation for orforglipron?

The specifics, since they change the answer: 50 mg · 2.5 mL · phosphate-buffered diluent · orforglipron. I am at the decision point and I would rather think it…

diluent-volume
diluent-volume

Choosing how much diluent to add, which is really a question about what you want your measurement resolution to be. Larger volumes buy you…

308 questions
reconstitution
reconstitution

Taking a lyophilised vial to a solution of known concentration: choice of diluent, volume selection, how to add liquid without shearing the cake,…

330 questions
dosing-math
dosing-math

The arithmetic itself: milligrams to millilitres to insulin units, concentration after reconstitution, dose per draw, and vial-days per vial. Show…

811 questions
asked by marta_okonkwo 87k · 23 months ago
35 votes5 answers40k views
How many vial-days does a 30 mg vial give at 6.67 mg/mL on a weekly schedule?

Details up front: 30 mg · 6.67 mg/mL. I can do the algebra. I am not confident about the conversion factors. If there is a standard way to lay this out, I would…

dosing-math
dosing-math

The arithmetic itself: milligrams to millilitres to insulin units, concentration after reconstitution, dose per draw, and vial-days per vial. Show…

811 questions
cost-analysis
cost-analysis

Cost arithmetic done honestly: cost per milligram after dead-space loss, list versus net price, comparing a multi-dose vial to a fixed-dose pen,…

261 questions
diluent-volume
diluent-volume

Choosing how much diluent to add, which is really a question about what you want your measurement resolution to be. Larger volumes buy you…

308 questions
asked by siobhan_deasy 16k · 22 months ago
35 votes 5 answers39k views
How many units on a U-40 insulin syringe is a 30 mg dose at 4 mg/mL?

Conditions: a U-40 insulin syringe · 30 mg · 4 mg/mL. I want the working, not the result — I need to be able to redo it with different numbers. I care about the…

dosing-math
dosing-math

The arithmetic itself: milligrams to millilitres to insulin units, concentration after reconstitution, dose per draw, and vial-days per vial. Show…

811 questions
insulin-syringe
insulin-syringe

U-100 and U-40 insulin syringes as measuring instruments. A U-100 syringe is graduated in insulin units where 100 units equals 1 mL, so one unit…

268 questions
reconstitution
reconstitution

Taking a lyophilised vial to a solution of known concentration: choice of diluent, volume selection, how to add liquid without shearing the cake,…

330 questions
asked by rosa_mendieta 13k · 17 months ago
35 votes5 answers38k views
If I reconstitute a 10 mg vial with 2.5 mL of 0.9% sodium chloride, what concentration do I end up with?

The case in front of me: 10 mg · 2.5 mL · 0.9% sodium chloride. Please show the division. I want to check my own against yours. I would like the general form as well…

reconstitution
reconstitution

Taking a lyophilised vial to a solution of known concentration: choice of diluent, volume selection, how to add liquid without shearing the cake,…

330 questions
diluent-volume
diluent-volume

Choosing how much diluent to add, which is really a question about what you want your measurement resolution to be. Larger volumes buy you…

308 questions
dosing-math
dosing-math

The arithmetic itself: milligrams to millilitres to insulin units, concentration after reconstitution, dose per draw, and vial-days per vial. Show…

811 questions
asked by mateo_iglesias 16k · 16 months ago
35 votes 5 answers37k views
Is 8 mg weekly a defensible maintenance dose for orforglipron?

Numbers first: 8 mg · orforglipron. This is a planning question. I know what my options are; I do not know how to weigh them. What I want is the minimum viable…

maintenance-dose
maintenance-dose

Staying put: the lowest dose that holds a result, the difference between the maximum studied dose and the maximum useful dose, and what the…

44 questions
clinical-trials
clinical-trials

Reading the primary literature properly: estimands, intention-to-treat versus per-protocol, confidence intervals, absolute versus relative…

913 questions
dosing-math
dosing-math

The arithmetic itself: milligrams to millilitres to insulin units, concentration after reconstitution, dose per draw, and vial-days per vial. Show…

811 questions
subcutaneous
subcutaneous

Subcutaneous administration as a route: absorption kinetics from abdomen versus thigh versus upper arm, tissue depth, and why site rotation…

14 questions
asked by t_oyelaran 41k · 2.4 years ago
35 votes5 answers37k views
If a tirzepatide dose is missed by ten days, does the ladder reset?

The particulars: tirzepatide · ten days. I have read the obvious sources and they disagree with each other, so I would rather ask people who have actually done this.…

missed-dose
missed-dose

What the label instructions for a missed weekly dose are, why they differ between agents, and what the pharmacokinetics say about drift in an…

41 questions
titration
titration

Stepwise dose increases over weeks, why the label schedules exist at all, and what tolerability-driven deviation from a schedule looks like in…

444 questions
dosing-math
dosing-math

The arithmetic itself: milligrams to millilitres to insulin units, concentration after reconstitution, dose per draw, and vial-days per vial. Show…

811 questions
asked by g_paskevicius 44k · 16 months ago
35 votes 2 answers36k views
How many vial-days does a 4 mg vial give at 1 mg/mL on a weekly schedule?

For reference: 4 mg · 1 mg/mL. I would like the arithmetic checked rather than the conclusion asserted. I have deliberately not used an online calculator because I…

dosing-math
dosing-math

The arithmetic itself: milligrams to millilitres to insulin units, concentration after reconstitution, dose per draw, and vial-days per vial. Show…

811 questions
cost-analysis
cost-analysis

Cost arithmetic done honestly: cost per milligram after dead-space loss, list versus net price, comparing a multi-dose vial to a fixed-dose pen,…

261 questions
diluent-volume
diluent-volume

Choosing how much diluent to add, which is really a question about what you want your measurement resolution to be. Larger volumes buy you…

308 questions
asked by rae_oyelowo 21k · 23 months ago
35 votes2 answers36k views
What is the dead-space loss per draw with a 31G needle at 1 mg/mL?

The particulars: a 31G needle · 1 mg/mL. I would like the arithmetic checked rather than the conclusion asserted. I have deliberately not used an online calculator…

dead-space
dead-space

The volume trapped in the syringe hub and needle after the plunger bottoms out. It is small in absolute terms and large as a fraction of a small…

110 questions
insulin-syringe
insulin-syringe

U-100 and U-40 insulin syringes as measuring instruments. A U-100 syringe is graduated in insulin units where 100 units equals 1 mL, so one unit…

268 questions
dosing-math
dosing-math

The arithmetic itself: milligrams to millilitres to insulin units, concentration after reconstitution, dose per draw, and vial-days per vial. Show…

811 questions
asked by swab_and_wait 15k · 21 months ago
35 votes0 answers34k views
How do I get 40 units out of a vial reconstituted to 1 mg/mL without guessing?

For reference: 40 units · 1 mg/mL. I want a method I can write down and repeat, not a rule of thumb. I would rather over-engineer this than discover a problem later,…

insulin-syringe
insulin-syringe

U-100 and U-40 insulin syringes as measuring instruments. A U-100 syringe is graduated in insulin units where 100 units equals 1 mL, so one unit…

268 questions
dosing-math
dosing-math

The arithmetic itself: milligrams to millilitres to insulin units, concentration after reconstitution, dose per draw, and vial-days per vial. Show…

811 questions
diluent-volume
diluent-volume

Choosing how much diluent to add, which is really a question about what you want your measurement resolution to be. Larger volumes buy you…

308 questions
asked by two_point_four 14k · 21 months ago