Page 6 of 15 · 360 questions tagged semaglutide.
Every trial in metabolic dysfunction-associated steatohepatitis reports two co-primary endpoints with oddly constructed names: "resolution of steatohepatitis without…
The specifics, since they change the answer: PIONEER-4 · ecnoglutide. Somebody stated this to me confidently and I would like to check it before repeating it. I would…
The missed-dose instructions in this class are close to each other but not identical, and I cannot work out whether the differences are pharmacology or arbitrary.…
Setup, so nobody has to ask: retatrutide · liraglutide. Both of these get recommended confidently by different people, which suggests neither is obviously right. My…
Details up front: SURMOUNT-2 · orforglipron. This is presented as though it settles something, and I am not convinced it does. I have two documents that appear to…
Conditions: FLOW · liraglutide. I want to know whether there is evidence behind this or only repetition. I have checked the obvious registries and monographs without…
The specifics, since they change the answer: SURMOUNT-1 · survodutide. Somebody stated this to me confidently and I would like to check it before repeating it. I…
What I have: STEP 3 · orforglipron. I am asking for verification rather than opinion, ideally with something I can read myself. It is possible the evidence exists and…
REDEFINE 1 reported mean weight loss of about 22.7% for CagriSema at 68 weeks, which as far as I can tell is the largest figure any phase 3 obesity trial has…
Numbers first: mazdutide · cagrilintide. I want to know what the trade-off actually is rather than which option is fashionable. I would rather have a defensible…
The particulars: tirzepatide · retatrutide. I am trying to choose between two options that are usually discussed as though only one exists. I am not optimising for…
Concretely: survodutide · survodutide. These are treated as interchangeable and I do not think they are. If both are acceptable I would like to know that, so I can…
Details up front: a GLP-1 receptor agonist · retatrutide. I want to know what the trade-off actually is rather than which option is fashionable. I would rather have a…
The specifics, since they change the answer: STEP 1 · survodutide. I want to understand what this actually establishes, as opposed to what it is being used to imply.…
Conditions: FLOW · oral semaglutide. The figures are clear enough; the question is what they mean and what they do not. I can supply the numbers if the specifics…
Concretely: TRIUMPH-1 · liraglutide. I would like to know the limits of what can be inferred from this. What I am trying to avoid is over-reading a single result,…
Setup, so nobody has to ask: SURPASS-2 · cagrilintide. I have read the primary source rather than the summary, which has left me with more questions. I understand the…
I have the full paper rather than the abstract, and the supplementary appendix. I understand the observation; what I do not understand is the mechanism behind it. I…
Numbers first: mazdutide · mazdutide. I have used one of these for a while and I am considering switching, which requires a reason. What I care about is…
The specifics, since they change the answer: SOUL · ecnoglutide. I would like to know whether this claim survives contact with evidence. If the answer is "nobody has…
What I am working with: SELECT · mazdutide. I would like help reading this properly rather than being told what conclusion to reach. I have the full report including…
Stated plainly: retatrutide · survodutide. I suspect the honest answer is that it depends, in which case I would like to know on what. Assume I can obtain either…
Concretely: PIONEER-1 · tirzepatide. The figures are clear enough; the question is what they mean and what they do not. I can supply the numbers if the specifics…
Details up front: SURMOUNT-1 · dulaglutide. I would rather be corrected now than propagate something wrong. I am specifically not interested in a testimonial; I am…