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Does racemisation dominate for orforglipron held at minus 20 °C?

Asked 18 Jun 2025Modified 13 months agoViewed 12k times
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Numbers first: racemisation · orforglipron · minus 20 °C.

I suspect the usual explanation for this is wrong, or at least incomplete.

I am aware this may have a boring answer. I would still like the boring answer stated clearly.

So what is the mechanism, and how well established is it?

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askedmeniscus_film34k3818 Jun 2025
Good answer, but the confidence interval in the cited trial is wider than implied. – RP_C18 4 months ago
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