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How do I tell early satiety from an energy deficit on 900 kcal a day?

Asked 12 Oct 2024Modified 19 months agoViewed 16k times
5

Conditions: early satiety · 900 kcal.

I think I have a problem. I am not yet sure whether it is a real problem or a measurement artefact.

I want to know whether this is recoverable or whether the honest answer is to write it off.

How do I distinguish the benign explanation from the one that matters?

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CO
askedcoldbox941k13812 Oct 2024

5 Answers

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97

Start with what 900 kcal a day leaves you room for, because at that intake the deficit is a live competing explanation rather than a footnote. Protein is 4 kcal per gram, so 100 g costs 400 kcal — 44 per cent of the entire day's energy — and everything else has to come out of the remaining 500. A day that misses protein at 900 kcal has missed it by a wide margin, and early satiety that tracks those days is a nutrition signal. Then separate the two by timing: a dose effect is periodic and phase-locked to the injection or to an increase, and a deficit effect is monotonic and gets worse the longer the intake stays at 900. Log intake, protein and early satiety on the same daily row for a fortnight and the two patterns separate without any further cleverness. Nothing here is medical advice.

If it persists at an adequate intake, it needs blood work rather than more speculation.

Three days of honest weighed intake usually settles this. Estimated intake in this situation is systematically wrong and usually wrong in the direction that hides the problem.

Carbohydrate intake specifically affects training performance and perceived energy at a given total intake, which is why very low carbohydrate approaches feel worse in the gym at matched energy.

Nothing here is medical advice.

Abrupt onset points away from the deficit and towards something else.

edited 24 Dec 2024 by rhian_prydderch — added a caveat about sampling

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RP
answeredrhian_prydderch23k2723 Dec 2024
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64

Put another way, this is the complaint with the widest differential and the one most often attributed too quickly.

Hypothyroidism, sleep apnoea, depression and anaemia all present as fatigue and all become more likely rather than less in this population, so attribution to the compound should be a diagnosis of exclusion.

To be exact about it, sleep quality often changes during rapid weight loss in both directions, and sleep debt produces fatigue that no amount of dietary adjustment will fix.

Attributing a symptom with a wide differential to the most recent change is a common and expensive error.

Sleep is a variable here too, and no amount of eating fixes sleep debt.

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SL
answeredsian_llewellyn65k1474 Jan 2025
3Worth flagging that this presents differently in people who titrated faster than the label. – j_wierzbicki 10 months ago
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47

Start with the actual intake, because a substantially suppressed appetite produces deficits far larger than intended and fatigue is the first symptom.

Iron deficiency is common, particularly in menstruating women, and low intake plus a reduced red-meat share makes it more likely. Ferritin is the test, and it is an acute-phase reactant so it needs interpreting alongside CRP.

Fatigue that appeared abruptly, rather than gradually with the deficit, is a different pattern and points away from intake.

Self-reported intake underestimates measured intake by twenty per cent or more in doubly labelled water comparisons.

Research-use compounds are not approved for human use.

Check fluid and sodium before anything more exotic.

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SL
answeredsian_llewellyn65k1471 Dec 2024
8Does the tolerance develop at the same rate for the daily agents? – lukas_sedlacek 2 months ago
7Small correction: the discontinuation rate in the trials is lower than most people assume. – plate_count_9k 12 days ago
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38

Dehydration and low sodium intake produce fatigue that is indistinguishable subjectively and much easier to fix.

Dehydration from reduced fluid intake alongside reduced food intake produces headache, lethargy and postural dizziness, and is the cheapest thing on the list to correct.

Sleep restriction produces measurable decrements in subjective energy and in training performance independently of energy intake.

If it persists at an adequate intake, get bloods rather than more theories.

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AZ
answeredahmed_zerouali15k1712 Dec 2024
1

Answering this needs to know the size of the deficit, since fatigue tracks it closely and predictably.

A deficit beyond about a thousand kilocalories a day reliably produces fatigue, reduced training performance and reduced spontaneous movement. With appetite suppressed, deficits of that size arrive by accident rather than by plan.

Energy deficits above roughly a thousand kilocalories a day are associated with measurable reductions in resting metabolic rate, spontaneous activity and subjective energy in controlled studies.

Weigh three days of intake honestly. That answers this most of the time.

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CF
answeredclaudia_ferrante22k279 Nov 2024
I have seen this misattributed to the compound twice when it was the deficit. – ekaterina_volk 4 months ago
8Adding for future readers: fluids between meals rather than with them made a real difference. – j_wierzbicki 2 months ago
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Your answer

Ask PeptideStack is a static archive. Posting is closed, but the norms are worth stating: answer the question that was asked, show your working, cite the trial or the certificate, and say plainly where the evidence runs out.

Not medical advice. Research-use-only compounds are not approved for human use.