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Is a Karl Fischer water content test worth paying for on top of a purity figure for liraglutide?

Asked 3 Jul 2025Modified 13 months agoViewed 12k times
19

The case in front of me: a Karl Fischer water content test · liraglutide.

I want to decide this in advance so that I am not deciding it under pressure later.

Assume I will follow the plan I write down, so I would like it to be a good one.

What should I decide now, and what should I defer?

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Quantified content: how many milligrams of peptide are actually in the vial, measured against a calibrated reference standard. A separate test…

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260 questionswater-content
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Residual moisture in a lyophilised solid, measured by Karl Fischer titration or loss on drying. It drives both the mass balance on a content assay…

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liraglutide

A once-daily GLP-1 receptor agonist and the compound that established the class. Still relevant for its shorter half-life, its paediatric and…

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askedanouk_desmet16k383 Jul 2025

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