What did the placebo arm of STEP 2 report for constipation?

Asked 19 Feb 2026Modified 5 months agoViewed 2.3k times

The particulars: STEP 2 · constipation.

I have the document in front of me and I can read the numbers. What I cannot do is interpret them.

I am reasonably comfortable with statistics and completely uncomfortable with chromatography, or vice versa.

What is the correct interpretation, and what is the common misreading?

Reading the primary literature properly: estimands, intention-to-treat versus per-protocol, confidence intervals, absolute versus relative…

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gi-side-effects

The gastrointestinal cluster as a whole - nausea, vomiting, diarrhoea, constipation, reflux, early satiety - with trial incidence rates, dropout…

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The dominant tolerability signal in every trial of the class: incidence, timing relative to a dose step, duration, and the distinction between…

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askedgel_pack_warm13k1819 Feb 2026

Worth flagging that this changed in 2025, so older answers on the site are out of date. – Dr_Jonas_Halvorsen 5 months ago

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