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dosing-math

Page 16 of 34 · 811 questions tagged dosing-math.

811 questions · sorted by votes · page 16 of 34

20 votes4 answers44k views
Is 2.5 mg/mL a sensible working concentration for liraglutide, or should I go lower?

Conditions: 2.5 mg/mL · liraglutide. I would like the axes of comparison first and the recommendation second. I have tried the first option and it works; the question…

diluent-volume
diluent-volume

Choosing how much diluent to add, which is really a question about what you want your measurement resolution to be. Larger volumes buy you…

308 questions
reconstitution
reconstitution

Taking a lyophilised vial to a solution of known concentration: choice of diluent, volume selection, how to add liquid without shearing the cake,…

330 questions
dosing-math
dosing-math

The arithmetic itself: milligrams to millilitres to insulin units, concentration after reconstitution, dose per draw, and vial-days per vial. Show…

811 questions
asked by ivo_paunovic 15k · 2.3 years ago
20 votes 5 answers35k views
How many units on a low-dead-space syringe is a 30 mg dose at 2.5 mg/mL?

Concretely: a low-dead-space syringe · 30 mg · 2.5 mg/mL. I want the working, not the result — I need to be able to redo it with different numbers. I care about the…

dosing-math
dosing-math

The arithmetic itself: milligrams to millilitres to insulin units, concentration after reconstitution, dose per draw, and vial-days per vial. Show…

811 questions
insulin-syringe
insulin-syringe

U-100 and U-40 insulin syringes as measuring instruments. A U-100 syringe is graduated in insulin units where 100 units equals 1 mL, so one unit…

268 questions
reconstitution
reconstitution

Taking a lyophilised vial to a solution of known concentration: choice of diluent, volume selection, how to add liquid without shearing the cake,…

330 questions
asked by w_okoye 40k · 2.3 years ago
20 votes 5 answers34k views
How does retatrutide at 15 mg weekly compare on cost per milligram across routes?

Stated plainly: retatrutide · 15 mg. I have worked this out and I would like someone to find the error, because I suspect there is one. My working so far, for the…

cost-analysis
cost-analysis

Cost arithmetic done honestly: cost per milligram after dead-space loss, list versus net price, comparing a multi-dose vial to a fixed-dose pen,…

261 questions
vendor-comparison
vendor-comparison

Side-by-side comparison of suppliers on measurable axes - independently confirmed purity and content, lead time, cold-chain handling,…

351 questions
dosing-math
dosing-math

The arithmetic itself: milligrams to millilitres to insulin units, concentration after reconstitution, dose per draw, and vial-days per vial. Show…

811 questions
asked by h_pergande 86k · 19 months ago
20 votes 5 answers31k views
If I reconstitute a 60 mg vial with 5 mL of bacteriostatic water, what concentration do I end up with?

Stated plainly: 60 mg · 5 mL · bacteriostatic water. The units are where I keep going wrong, so please be explicit about them. I have sanity-checked the order of…

reconstitution
reconstitution

Taking a lyophilised vial to a solution of known concentration: choice of diluent, volume selection, how to add liquid without shearing the cake,…

330 questions
diluent-volume
diluent-volume

Choosing how much diluent to add, which is really a question about what you want your measurement resolution to be. Larger volumes buy you…

308 questions
dosing-math
dosing-math

The arithmetic itself: milligrams to millilitres to insulin units, concentration after reconstitution, dose per draw, and vial-days per vial. Show…

811 questions
asked by swab_and_wait 15k · 19 months ago
20 votes 5 answers30k views
How many weeks to steady state for survodutide on a weekly schedule?

This matters because it predicts what a related molecule should do. Please show the division. I want to check my own against yours. I would like the general form as…

glp1-mechanism
glp1-mechanism

Receptor-level pharmacology: GLP-1R as a class B GPCR, cAMP and PKA signalling, biased agonism, internalisation and resensitisation, and the…

175 questions
titration
titration

Stepwise dose increases over weeks, why the label schedules exist at all, and what tolerability-driven deviation from a schedule looks like in…

444 questions
dosing-math
dosing-math

The arithmetic itself: milligrams to millilitres to insulin units, concentration after reconstitution, dose per draw, and vial-days per vial. Show…

811 questions
asked by amara_nwachukwu 41k · 21 months ago
20 votes5 answers30k views
Is 4 mg/mL a sensible working concentration for liraglutide, or should I go lower?

Conditions: 4 mg/mL · liraglutide. These are treated as interchangeable and I do not think they are. If both are acceptable I would like to know that, so I can stop…

diluent-volume
diluent-volume

Choosing how much diluent to add, which is really a question about what you want your measurement resolution to be. Larger volumes buy you…

308 questions
reconstitution
reconstitution

Taking a lyophilised vial to a solution of known concentration: choice of diluent, volume selection, how to add liquid without shearing the cake,…

330 questions
dosing-math
dosing-math

The arithmetic itself: milligrams to millilitres to insulin units, concentration after reconstitution, dose per draw, and vial-days per vial. Show…

811 questions
asked by kirsi_lahtinen 45k · 19 months ago
20 votes5 answers29k views
Does splitting a 60 mg weekly dose of a GLP-1 receptor agonist across two administrations change anything?

Setup, so nobody has to ask: 60 mg · a GLP-1 receptor agonist. The empirical answer seems settled. The explanation does not. If the honest answer is that nobody…

split-dosing
split-dosing

Dividing a weekly dose across more than one administration. Questions here concern the pharmacokinetic rationale, whether the peak-to-trough ratio…

39 questions
dosing-math
dosing-math

The arithmetic itself: milligrams to millilitres to insulin units, concentration after reconstitution, dose per draw, and vial-days per vial. Show…

811 questions
glp1-mechanism
glp1-mechanism

Receptor-level pharmacology: GLP-1R as a class B GPCR, cAMP and PKA signalling, biased agonism, internalisation and resensitisation, and the…

175 questions
asked by thabo_maseko 20k · 15 months ago
20 votes0 answers24k views
Is 2.5 mg in 3 mL of 0.9% sodium chloride a sensible presentation for cagrilintide?

The case in front of me: 2.5 mg · 3 mL · 0.9% sodium chloride · cagrilintide. The failure mode I am trying to avoid is making this decision emotionally. I have twelve…

diluent-volume
diluent-volume

Choosing how much diluent to add, which is really a question about what you want your measurement resolution to be. Larger volumes buy you…

308 questions
reconstitution
reconstitution

Taking a lyophilised vial to a solution of known concentration: choice of diluent, volume selection, how to add liquid without shearing the cake,…

330 questions
dosing-math
dosing-math

The arithmetic itself: milligrams to millilitres to insulin units, concentration after reconstitution, dose per draw, and vial-days per vial. Show…

811 questions
asked by syringe_ninety 15k · 2.2 years ago
20 votes 5 answers22k views
What is the arithmetic to convert 60 mg in 2 mL into units on a U-100 scale?

What I am working with: 60 mg · 2 mL. The units are where I keep going wrong, so please be explicit about them. I have sanity-checked the order of magnitude and it…

dosing-math
dosing-math

The arithmetic itself: milligrams to millilitres to insulin units, concentration after reconstitution, dose per draw, and vial-days per vial. Show…

811 questions
insulin-syringe
insulin-syringe

U-100 and U-40 insulin syringes as measuring instruments. A U-100 syringe is graduated in insulin units where 100 units equals 1 mL, so one unit…

268 questions
reconstitution
reconstitution

Taking a lyophilised vial to a solution of known concentration: choice of diluent, volume selection, how to add liquid without shearing the cake,…

330 questions
asked by unit_math 13k · 11 months ago
20 votes5 answers18k views
What is the dead-space loss per draw with a 18G drawing needle at 2.5 mg/mL?

Details up front: an 18G drawing needle · 2.5 mg/mL. This should be a straightforward calculation and I keep getting two different answers. The numbers are arbitrary;…

dead-space
dead-space

The volume trapped in the syringe hub and needle after the plunger bottoms out. It is small in absolute terms and large as a fraction of a small…

110 questions
insulin-syringe
insulin-syringe

U-100 and U-40 insulin syringes as measuring instruments. A U-100 syringe is graduated in insulin units where 100 units equals 1 mL, so one unit…

268 questions
dosing-math
dosing-math

The arithmetic itself: milligrams to millilitres to insulin units, concentration after reconstitution, dose per draw, and vial-days per vial. Show…

811 questions
asked by nynke_dekker 18k · 18 months ago
20 votes 3 answers17k views
Air bubbles versus dead space — are they the same loss, and does back-loading or an air flush recover anything?

I have started to suspect I have been conflating two different problems. When I draw and see a bubble in the barrel, I tap it up and expel it and redraw. When I read…

dead-space
dead-space

The volume trapped in the syringe hub and needle after the plunger bottoms out. It is small in absolute terms and large as a fraction of a small…

110 questions
insulin-syringe
insulin-syringe

U-100 and U-40 insulin syringes as measuring instruments. A U-100 syringe is graduated in insulin units where 100 units equals 1 mL, so one unit…

268 questions
injection-technique
injection-technique

Technique questions: angle, pinch versus flat, aspiration, injection speed, air bubbles, and the handling steps that determine whether you deliver…

90 questions
dosing-math
dosing-math

The arithmetic itself: milligrams to millilitres to insulin units, concentration after reconstitution, dose per draw, and vial-days per vial. Show…

811 questions
asked by rhian_prydderch 44k · 5 months ago
20 votes5 answers17k views
Is 20 mg weekly a defensible maintenance dose for a GLP-1 receptor agonist?

Setup, so nobody has to ask: 20 mg · a GLP-1 receptor agonist. I am trying to build something sustainable rather than something thorough that I will abandon. I have…

maintenance-dose
maintenance-dose

Staying put: the lowest dose that holds a result, the difference between the maximum studied dose and the maximum useful dose, and what the…

44 questions
clinical-trials
clinical-trials

Reading the primary literature properly: estimands, intention-to-treat versus per-protocol, confidence intervals, absolute versus relative…

913 questions
dosing-math
dosing-math

The arithmetic itself: milligrams to millilitres to insulin units, concentration after reconstitution, dose per draw, and vial-days per vial. Show…

811 questions
asked by gradient_slope 41k · 21 months ago
20 votes 5 answers15k views
If I reconstitute a 15 mg vial with 0.5 mL of phosphate-buffered diluent, what concentration do I end up with?

For reference: 15 mg · 0.5 mL · phosphate-buffered diluent. I would rather understand the derivation than memorise the outcome. Two people I asked gave two answers…

reconstitution
reconstitution

Taking a lyophilised vial to a solution of known concentration: choice of diluent, volume selection, how to add liquid without shearing the cake,…

330 questions
diluent-volume
diluent-volume

Choosing how much diluent to add, which is really a question about what you want your measurement resolution to be. Larger volumes buy you…

308 questions
dosing-math
dosing-math

The arithmetic itself: milligrams to millilitres to insulin units, concentration after reconstitution, dose per draw, and vial-days per vial. Show…

811 questions
asked by RP_C18 85k · 8 months ago
20 votes 5 answers15k views
Can I reconstitute semaglutide at 2 mg/mL and still measure a small dose accurately?

Conditions: semaglutide · 2 mg/mL. The failure mode I am trying to avoid is making this decision emotionally. I have twelve months in view and I would like the plan…

diluent-volume
diluent-volume

Choosing how much diluent to add, which is really a question about what you want your measurement resolution to be. Larger volumes buy you…

308 questions
insulin-syringe
insulin-syringe

U-100 and U-40 insulin syringes as measuring instruments. A U-100 syringe is graduated in insulin units where 100 units equals 1 mL, so one unit…

268 questions
dosing-math
dosing-math

The arithmetic itself: milligrams to millilitres to insulin units, concentration after reconstitution, dose per draw, and vial-days per vial. Show…

811 questions
asked by ellis_thorne 17k · 5 months ago
20 votes 5 answers14k views
How many vial-days does a 10 mg vial give at 5 mg/mL on a weekly schedule?

Concretely: 10 mg · 5 mg/mL. I want the working, not the result — I need to be able to redo it with different numbers. I care about the precision as well as the value…

dosing-math
dosing-math

The arithmetic itself: milligrams to millilitres to insulin units, concentration after reconstitution, dose per draw, and vial-days per vial. Show…

811 questions
cost-analysis
cost-analysis

Cost arithmetic done honestly: cost per milligram after dead-space loss, list versus net price, comparing a multi-dose vial to a fixed-dose pen,…

261 questions
diluent-volume
diluent-volume

Choosing how much diluent to add, which is really a question about what you want your measurement resolution to be. Larger volumes buy you…

308 questions
asked by rhian_prydderch 44k · 9 months ago
20 votes 5 answers14k views
What is the arithmetic to convert 2 mg in 1 mL into units on a U-100 scale?

Numbers first: 2 mg · 1 mL. I can do the algebra. I am not confident about the conversion factors. If there is a standard way to lay this out, I would rather learn…

dosing-math
dosing-math

The arithmetic itself: milligrams to millilitres to insulin units, concentration after reconstitution, dose per draw, and vial-days per vial. Show…

811 questions
insulin-syringe
insulin-syringe

U-100 and U-40 insulin syringes as measuring instruments. A U-100 syringe is graduated in insulin units where 100 units equals 1 mL, so one unit…

268 questions
reconstitution
reconstitution

Taking a lyophilised vial to a solution of known concentration: choice of diluent, volume selection, how to add liquid without shearing the cake,…

330 questions
asked by retest_please 13k · 18 months ago
20 votes 5 answers14k views
What does SURPASS-2 report at the 4 mg dose level?

Setup, so nobody has to ask: SURPASS-2 · 4 mg. I would like help reading this properly rather than being told what conclusion to reach. I have the full report…

clinical-trials
clinical-trials

Reading the primary literature properly: estimands, intention-to-treat versus per-protocol, confidence intervals, absolute versus relative…

913 questions
dosing-math
dosing-math

The arithmetic itself: milligrams to millilitres to insulin units, concentration after reconstitution, dose per draw, and vial-days per vial. Show…

811 questions
titration
titration

Stepwise dose increases over weeks, why the label schedules exist at all, and what tolerability-driven deviation from a schedule looks like in…

444 questions
asked by cake_collapsed 13k · 14 months ago
20 votes3 answers9.5k views
How many units on a U-40 insulin syringe is a 2 mg dose at 6.67 mg/mL?

Concretely: a U-40 insulin syringe · 2 mg · 6.67 mg/mL. Please show the division. I want to check my own against yours. I would like the general form as well as the…

dosing-math
dosing-math

The arithmetic itself: milligrams to millilitres to insulin units, concentration after reconstitution, dose per draw, and vial-days per vial. Show…

811 questions
insulin-syringe
insulin-syringe

U-100 and U-40 insulin syringes as measuring instruments. A U-100 syringe is graduated in insulin units where 100 units equals 1 mL, so one unit…

268 questions
reconstitution
reconstitution

Taking a lyophilised vial to a solution of known concentration: choice of diluent, volume selection, how to add liquid without shearing the cake,…

330 questions
asked by Dr_Ilse_Vandenberg 78k · 4 months ago
20 votes0 answers9.3k views
How many vial-days does a 5 mg vial give at 3.33 mg/mL on a weekly schedule?

Stated plainly: 5 mg · 3.33 mg/mL. The units are where I keep going wrong, so please be explicit about them. I have sanity-checked the order of magnitude and it seems…

dosing-math
dosing-math

The arithmetic itself: milligrams to millilitres to insulin units, concentration after reconstitution, dose per draw, and vial-days per vial. Show…

811 questions
cost-analysis
cost-analysis

Cost arithmetic done honestly: cost per milligram after dead-space loss, list versus net price, comparing a multi-dose vial to a fixed-dose pen,…

261 questions
diluent-volume
diluent-volume

Choosing how much diluent to add, which is really a question about what you want your measurement resolution to be. Larger volumes buy you…

308 questions
asked by sample_id 17k · 10 months ago
20 votes0 answers8.7k views
How does retatrutide at 50 mg weekly compare on cost per milligram across routes?

What I am working with: retatrutide · 50 mg. The units are where I keep going wrong, so please be explicit about them. I have sanity-checked the order of magnitude…

cost-analysis
cost-analysis

Cost arithmetic done honestly: cost per milligram after dead-space loss, list versus net price, comparing a multi-dose vial to a fixed-dose pen,…

261 questions
vendor-comparison
vendor-comparison

Side-by-side comparison of suppliers on measurable axes - independently confirmed purity and content, lead time, cold-chain handling,…

351 questions
dosing-math
dosing-math

The arithmetic itself: milligrams to millilitres to insulin units, concentration after reconstitution, dose per draw, and vial-days per vial. Show…

811 questions
asked by ben_akintola 14k · 20 months ago
20 votes 5 answers8.4k views
How do I compute the +3 charge state m/z for a peptide of 4113.6 Da?

What I am working with: +3 · 4113.6 Da. I have worked this out and I would like someone to find the error, because I suspect there is one. My working so far, for the…

mass-spec
mass-spec

Mass spectrometry for identity confirmation: electrospray ionisation, multiple charge states, monoisotopic versus average mass, deconvolution, and…

38 questions
dosing-math
dosing-math

The arithmetic itself: milligrams to millilitres to insulin units, concentration after reconstitution, dose per draw, and vial-days per vial. Show…

811 questions
purity
purity

Purity as chromatographic area per cent - the fraction of detected material that is your target peak. It says nothing about how much material is…

788 questions
asked by thabo_maseko 20k · 5 months ago
20 votes 1 answer7.7k views
How many vial-days does a 2 mg vial give at 6.67 mg/mL on a weekly schedule?

What I have: 2 mg · 6.67 mg/mL. I can do the algebra. I am not confident about the conversion factors. If there is a standard way to lay this out, I would rather…

dosing-math
dosing-math

The arithmetic itself: milligrams to millilitres to insulin units, concentration after reconstitution, dose per draw, and vial-days per vial. Show…

811 questions
cost-analysis
cost-analysis

Cost arithmetic done honestly: cost per milligram after dead-space loss, list versus net price, comparing a multi-dose vial to a fixed-dose pen,…

261 questions
diluent-volume
diluent-volume

Choosing how much diluent to add, which is really a question about what you want your measurement resolution to be. Larger volumes buy you…

308 questions
asked by tenth_of_a_unit 40k · 3 months ago
20 votes 5 answers6.4k views
Why do two papers on SURPASS-2 report different headline figures?

This is a question about interpretation, not about whether to act — I will take action questions elsewhere. This is one of those things that everyone repeats and…

clinical-trials
clinical-trials

Reading the primary literature properly: estimands, intention-to-treat versus per-protocol, confidence intervals, absolute versus relative…

913 questions
dosing-math
dosing-math

The arithmetic itself: milligrams to millilitres to insulin units, concentration after reconstitution, dose per draw, and vial-days per vial. Show…

811 questions
semaglutide
semaglutide

A GLP-1 receptor agonist with a fatty-acid-acylated backbone and a roughly one-week half-life, marketed for type 2 diabetes and for weight…

360 questions
asked by colm_dunphy 16k · 16 days ago
20 votes 5 answers6.1k views
What does ESSENCE report at the 4 mg dose level?

Setup, so nobody has to ask: ESSENCE · 4 mg. I have read the primary source rather than the summary, which has left me with more questions. I understand the headline.…

clinical-trials
clinical-trials

Reading the primary literature properly: estimands, intention-to-treat versus per-protocol, confidence intervals, absolute versus relative…

913 questions
dosing-math
dosing-math

The arithmetic itself: milligrams to millilitres to insulin units, concentration after reconstitution, dose per draw, and vial-days per vial. Show…

811 questions
titration
titration

Stepwise dose increases over weeks, why the label schedules exist at all, and what tolerability-driven deviation from a schedule looks like in…

444 questions
asked by olu_babatunde 14k · 26 days ago