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nausea

Page 13 of 15 · 346 questions tagged nausea.

346 questions · sorted by votes · page 13 of 15

8 votes 5 answers4.4k views
Does nausea at week ten of retatrutide usually resolve without a dose change?

Conditions: nausea · ten · retatrutide. I have done this once and I suspect I got away with it rather than got it right. For context: I keep records of every batch,…

gi-side-effects
gi-side-effects

The gastrointestinal cluster as a whole - nausea, vomiting, diarrhoea, constipation, reflux, early satiety - with trial incidence rates, dropout…

416 questions
titration
titration

Stepwise dose increases over weeks, why the label schedules exist at all, and what tolerability-driven deviation from a schedule looks like in…

444 questions
nausea
nausea

The dominant tolerability signal in every trial of the class: incidence, timing relative to a dose step, duration, and the distinction between…

346 questions
constipation
constipation

Slowed transit as a consequence of delayed gastric emptying and reduced intake: incidence figures, fibre and hydration evidence, and why it often…

14 questions
asked by haze_check 17k · 10 months ago
7 votes 5 answers17k views
What did the placebo arm of PIONEER-4 report for dizziness?

What I am working with: PIONEER-4 · dizziness. I would like help reading this properly rather than being told what conclusion to reach. I have the full report…

clinical-trials
clinical-trials

Reading the primary literature properly: estimands, intention-to-treat versus per-protocol, confidence intervals, absolute versus relative…

913 questions
gi-side-effects
gi-side-effects

The gastrointestinal cluster as a whole - nausea, vomiting, diarrhoea, constipation, reflux, early satiety - with trial incidence rates, dropout…

416 questions
nausea
nausea

The dominant tolerability signal in every trial of the class: incidence, timing relative to a dose step, duration, and the distinction between…

346 questions
asked by forty_two_c 43k · 15 months ago
7 votes0 answers4.1k views
Is injection-site erythema on dulaglutide dose-dependent or dose-rate dependent?

Numbers first: injection-site erythema · dulaglutide. I can predict the outcome but I cannot explain it, which means I will get the next case wrong. I would like to…

nausea
nausea

The dominant tolerability signal in every trial of the class: incidence, timing relative to a dose step, duration, and the distinction between…

346 questions
titration
titration

Stepwise dose increases over weeks, why the label schedules exist at all, and what tolerability-driven deviation from a schedule looks like in…

444 questions
gi-side-effects
gi-side-effects

The gastrointestinal cluster as a whole - nausea, vomiting, diarrhoea, constipation, reflux, early satiety - with trial incidence rates, dropout…

416 questions
asked by juliette_farnese 12k · 11 months ago
7 votes0 answers3.4k views
Does holding at 20 mg for eight weeks before escalating reduce early satiety?

What I am working with: 20 mg · eight weeks · early satiety. The empirical answer seems settled. The explanation does not. If the honest answer is that nobody knows,…

titration
titration

Stepwise dose increases over weeks, why the label schedules exist at all, and what tolerability-driven deviation from a schedule looks like in…

444 questions
nausea
nausea

The dominant tolerability signal in every trial of the class: incidence, timing relative to a dose step, duration, and the distinction between…

346 questions
dose-escalation
dose-escalation

The decision to move up a step: what evidence supports a four-week interval, what happens when you compress it, and how trial protocols handled…

88 questions
asked by fresh_bac 13k · 15 months ago
7 votes2 answers2.6k views
Does reflux at week nine of mazdutide usually resolve without a dose change?

The specifics, since they change the answer: reflux · nine · mazdutide. I want a method I can write down and repeat, not a rule of thumb. I would rather over-engineer…

gi-side-effects
gi-side-effects

The gastrointestinal cluster as a whole - nausea, vomiting, diarrhoea, constipation, reflux, early satiety - with trial incidence rates, dropout…

416 questions
titration
titration

Stepwise dose increases over weeks, why the label schedules exist at all, and what tolerability-driven deviation from a schedule looks like in…

444 questions
nausea
nausea

The dominant tolerability signal in every trial of the class: incidence, timing relative to a dose step, duration, and the distinction between…

346 questions
asked by sinead_gaffney 14k · 5 months ago
7 votes0 answers875 views
Does holding at a lower dose for longer reduce total side-effect burden?

My records go back to the first dose with dates, so I can reconstruct the timeline exactly. I keep seeing this stated as a fact with no explanation attached, and…

titration
titration

Stepwise dose increases over weeks, why the label schedules exist at all, and what tolerability-driven deviation from a schedule looks like in…

444 questions
nausea
nausea

The dominant tolerability signal in every trial of the class: incidence, timing relative to a dose step, duration, and the distinction between…

346 questions
gi-side-effects
gi-side-effects

The gastrointestinal cluster as a whole - nausea, vomiting, diarrhoea, constipation, reflux, early satiety - with trial incidence rates, dropout…

416 questions
hair-loss
hair-loss

Telogen effluvium following rapid weight loss versus a drug-attributable effect: the timing signature that distinguishes them, protein and…

14 questions
asked by gel_pack_warm 13k · 22 days ago
6 votes 5 answers28k views
Does fatigue at week nine of a GLP-1 receptor agonist usually resolve without a dose change?

The particulars: fatigue · nine · a GLP-1 receptor agonist. I have read the obvious sources and they disagree with each other, so I would rather ask people who have…

gi-side-effects
gi-side-effects

The gastrointestinal cluster as a whole - nausea, vomiting, diarrhoea, constipation, reflux, early satiety - with trial incidence rates, dropout…

416 questions
titration
titration

Stepwise dose increases over weeks, why the label schedules exist at all, and what tolerability-driven deviation from a schedule looks like in…

444 questions
nausea
nausea

The dominant tolerability signal in every trial of the class: incidence, timing relative to a dose step, duration, and the distinction between…

346 questions
gallbladder
gallbladder

Cholelithiasis and cholecystitis risk during rapid weight loss and on treatment: how much is attributable to the rate of loss versus to the drug,…

14 questions
asked by ilaria_bertone 43k · 2.0 years ago
6 votes 5 answers26k views
What did the placebo arm of TRIUMPH-3 report for constipation?

The particulars: TRIUMPH-3 · constipation. I have the document in front of me and I can read the numbers. What I cannot do is interpret them. I am reasonably…

clinical-trials
clinical-trials

Reading the primary literature properly: estimands, intention-to-treat versus per-protocol, confidence intervals, absolute versus relative…

913 questions
gi-side-effects
gi-side-effects

The gastrointestinal cluster as a whole - nausea, vomiting, diarrhoea, constipation, reflux, early satiety - with trial incidence rates, dropout…

416 questions
nausea
nausea

The dominant tolerability signal in every trial of the class: incidence, timing relative to a dose step, duration, and the distinction between…

346 questions
constipation
constipation

Slowed transit as a consequence of delayed gastric emptying and reduced intake: incidence figures, fibre and hydration evidence, and why it often…

14 questions
asked by swab_and_wait 15k · 2.0 years ago
6 votes 4 answers21k views
What is the reported incidence of reflux on semaglutide in TRIUMPH-1?

The particulars: reflux · semaglutide · TRIUMPH-1. I want to understand what this actually establishes, as opposed to what it is being used to imply. My concern is…

gi-side-effects
gi-side-effects

The gastrointestinal cluster as a whole - nausea, vomiting, diarrhoea, constipation, reflux, early satiety - with trial incidence rates, dropout…

416 questions
clinical-trials
clinical-trials

Reading the primary literature properly: estimands, intention-to-treat versus per-protocol, confidence intervals, absolute versus relative…

913 questions
nausea
nausea

The dominant tolerability signal in every trial of the class: incidence, timing relative to a dose step, duration, and the distinction between…

346 questions
asked by forty_units 14k · 2.1 years ago
6 votes 5 answers18k views
What did the placebo arm of STEP 1 report for early satiety?

Details up front: STEP 1 · early satiety. I can parse the result. I am less sure what it licenses me to conclude. I have deliberately not looked at anyone else’s…

clinical-trials
clinical-trials

Reading the primary literature properly: estimands, intention-to-treat versus per-protocol, confidence intervals, absolute versus relative…

913 questions
gi-side-effects
gi-side-effects

The gastrointestinal cluster as a whole - nausea, vomiting, diarrhoea, constipation, reflux, early satiety - with trial incidence rates, dropout…

416 questions
nausea
nausea

The dominant tolerability signal in every trial of the class: incidence, timing relative to a dose step, duration, and the distinction between…

346 questions
asked by oona_kekkonen 16k · 22 months ago
6 votes5 answers17k views
Does injection-site erythema at week five of liraglutide usually resolve without a dose change?

Numbers first: injection-site erythema · five · liraglutide. I would like to understand the steps well enough to explain them to someone else. I have access to a…

gi-side-effects
gi-side-effects

The gastrointestinal cluster as a whole - nausea, vomiting, diarrhoea, constipation, reflux, early satiety - with trial incidence rates, dropout…

416 questions
titration
titration

Stepwise dose increases over weeks, why the label schedules exist at all, and what tolerability-driven deviation from a schedule looks like in…

444 questions
nausea
nausea

The dominant tolerability signal in every trial of the class: incidence, timing relative to a dose step, duration, and the distinction between…

346 questions
asked by felix_araya 17k · 21 months ago
6 votes 5 answers15k views
Does holding at 50 mg for ten weeks before escalating reduce injection-site erythema?

For reference: 50 mg · ten weeks · injection-site erythema. I understand the observation; what I do not understand is the mechanism behind it. I have read the two…

titration
titration

Stepwise dose increases over weeks, why the label schedules exist at all, and what tolerability-driven deviation from a schedule looks like in…

444 questions
nausea
nausea

The dominant tolerability signal in every trial of the class: incidence, timing relative to a dose step, duration, and the distinction between…

346 questions
dose-escalation
dose-escalation

The decision to move up a step: what evidence supports a four-week interval, what happens when you compress it, and how trial protocols handled…

88 questions
asked by pieter_maas 22k · 19 months ago
6 votes5 answers8.1k views
Does holding at 4 mg for three weeks before escalating reduce reflux?

The particulars: 4 mg · three weeks · reflux. I would like the mechanism, because I want to be able to reason about the cases nobody has written about. I have tried…

titration
titration

Stepwise dose increases over weeks, why the label schedules exist at all, and what tolerability-driven deviation from a schedule looks like in…

444 questions
nausea
nausea

The dominant tolerability signal in every trial of the class: incidence, timing relative to a dose step, duration, and the distinction between…

346 questions
dose-escalation
dose-escalation

The decision to move up a step: what evidence supports a four-week interval, what happens when you compress it, and how trial protocols handled…

88 questions
asked by two_two_micron 15k · 5 months ago
6 votes5 answers7.9k views
What did the placebo arm of ESSENCE report for early satiety?

The particulars: ESSENCE · early satiety. I have the document in front of me and I can read the numbers. What I cannot do is interpret them. I am reasonably…

clinical-trials
clinical-trials

Reading the primary literature properly: estimands, intention-to-treat versus per-protocol, confidence intervals, absolute versus relative…

913 questions
gi-side-effects
gi-side-effects

The gastrointestinal cluster as a whole - nausea, vomiting, diarrhoea, constipation, reflux, early satiety - with trial incidence rates, dropout…

416 questions
nausea
nausea

The dominant tolerability signal in every trial of the class: incidence, timing relative to a dose step, duration, and the distinction between…

346 questions
asked by cal_hennessy 14k · 7 months ago
6 votes 5 answers7.1k views
Does reflux at week three of liraglutide usually resolve without a dose change?

Details up front: reflux · three · liraglutide. I can find plenty of assertions about this and almost no reasoning, which is usually a sign that nobody has checked.…

gi-side-effects
gi-side-effects

The gastrointestinal cluster as a whole - nausea, vomiting, diarrhoea, constipation, reflux, early satiety - with trial incidence rates, dropout…

416 questions
titration
titration

Stepwise dose increases over weeks, why the label schedules exist at all, and what tolerability-driven deviation from a schedule looks like in…

444 questions
nausea
nausea

The dominant tolerability signal in every trial of the class: incidence, timing relative to a dose step, duration, and the distinction between…

346 questions
asked by syringe_ninety 15k · 7 months ago
6 votes 5 answers7.1k views
Is dizziness on dulaglutide dose-dependent or dose-rate dependent?

What I have: dizziness · dulaglutide. I suspect the usual explanation for this is wrong, or at least incomplete. I am aware this may have a boring answer. I would…

nausea
nausea

The dominant tolerability signal in every trial of the class: incidence, timing relative to a dose step, duration, and the distinction between…

346 questions
titration
titration

Stepwise dose increases over weeks, why the label schedules exist at all, and what tolerability-driven deviation from a schedule looks like in…

444 questions
gi-side-effects
gi-side-effects

The gastrointestinal cluster as a whole - nausea, vomiting, diarrhoea, constipation, reflux, early satiety - with trial incidence rates, dropout…

416 questions
asked by day_seven_trough 11k · 4 months ago
6 votes4 answers4.2k views
Does early satiety at week six of semaglutide usually resolve without a dose change?

Stated plainly: early satiety · six · semaglutide. This is a procedural question rather than a theoretical one, and I would like the procedure rather than the theory.…

gi-side-effects
gi-side-effects

The gastrointestinal cluster as a whole - nausea, vomiting, diarrhoea, constipation, reflux, early satiety - with trial incidence rates, dropout…

416 questions
titration
titration

Stepwise dose increases over weeks, why the label schedules exist at all, and what tolerability-driven deviation from a schedule looks like in…

444 questions
nausea
nausea

The dominant tolerability signal in every trial of the class: incidence, timing relative to a dose step, duration, and the distinction between…

346 questions
asked by per_haugen 18k · 9 months ago
6 votes0 answers1.4k views
What did the placebo arm of SUSTAIN-6 report for early satiety?

The particulars: SUSTAIN-6 · early satiety. I have the document in front of me and I can read the numbers. What I cannot do is interpret them. I am reasonably…

clinical-trials
clinical-trials

Reading the primary literature properly: estimands, intention-to-treat versus per-protocol, confidence intervals, absolute versus relative…

913 questions
gi-side-effects
gi-side-effects

The gastrointestinal cluster as a whole - nausea, vomiting, diarrhoea, constipation, reflux, early satiety - with trial incidence rates, dropout…

416 questions
nausea
nausea

The dominant tolerability signal in every trial of the class: incidence, timing relative to a dose step, duration, and the distinction between…

346 questions
pcos
pcos

Polycystic ovary syndrome: insulin resistance as the shared mechanism, ovulatory and menstrual outcomes reported on treatment, androgen changes,…

14 questions
asked by hana_petrikova 19k · 5 months ago
5 votes5 answers25k views
Does holding at 2.5 mg for twelve weeks before escalating reduce constipation?

Concretely: 2.5 mg · twelve weeks · constipation. I want to know whether this is a real physical effect or an artefact of how it is measured. What prompted the…

titration
titration

Stepwise dose increases over weeks, why the label schedules exist at all, and what tolerability-driven deviation from a schedule looks like in…

444 questions
nausea
nausea

The dominant tolerability signal in every trial of the class: incidence, timing relative to a dose step, duration, and the distinction between…

346 questions
dose-escalation
dose-escalation

The decision to move up a step: what evidence supports a four-week interval, what happens when you compress it, and how trial protocols handled…

88 questions
asked by thabo_maseko 20k · 2.1 years ago
5 votes 5 answers21k views
Does headache at week two of retatrutide usually resolve without a dose change?

The case in front of me: headache · two · retatrutide. I have done this once and I suspect I got away with it rather than got it right. For context: I keep records of…

gi-side-effects
gi-side-effects

The gastrointestinal cluster as a whole - nausea, vomiting, diarrhoea, constipation, reflux, early satiety - with trial incidence rates, dropout…

416 questions
titration
titration

Stepwise dose increases over weeks, why the label schedules exist at all, and what tolerability-driven deviation from a schedule looks like in…

444 questions
nausea
nausea

The dominant tolerability signal in every trial of the class: incidence, timing relative to a dose step, duration, and the distinction between…

346 questions
asked by meniscus_film 34k · 19 months ago
5 votes 5 answers17k views
Is headache on mazdutide dose-dependent or dose-rate dependent?

Stated plainly: headache · mazdutide. I keep seeing this stated as a fact with no explanation attached, and unexplained facts make me suspicious. My background is…

nausea
nausea

The dominant tolerability signal in every trial of the class: incidence, timing relative to a dose step, duration, and the distinction between…

346 questions
titration
titration

Stepwise dose increases over weeks, why the label schedules exist at all, and what tolerability-driven deviation from a schedule looks like in…

444 questions
gi-side-effects
gi-side-effects

The gastrointestinal cluster as a whole - nausea, vomiting, diarrhoea, constipation, reflux, early satiety - with trial incidence rates, dropout…

416 questions
hair-loss
hair-loss

Telogen effluvium following rapid weight loss versus a drug-attributable effect: the timing signature that distinguishes them, protein and…

14 questions
asked by bounty_hunter_q 18k · 22 months ago
5 votes 5 answers15k views
What did the placebo arm of SURMOUNT-5 report for reflux?

Setup, so nobody has to ask: SURMOUNT-5 · reflux. I would like help reading this properly rather than being told what conclusion to reach. I have the full report…

clinical-trials
clinical-trials

Reading the primary literature properly: estimands, intention-to-treat versus per-protocol, confidence intervals, absolute versus relative…

913 questions
gi-side-effects
gi-side-effects

The gastrointestinal cluster as a whole - nausea, vomiting, diarrhoea, constipation, reflux, early satiety - with trial incidence rates, dropout…

416 questions
nausea
nausea

The dominant tolerability signal in every trial of the class: incidence, timing relative to a dose step, duration, and the distinction between…

346 questions
asked by pierce_count 15k · 23 months ago
5 votes 5 answers9.4k views
Does holding at 2.5 mg for four weeks before escalating reduce early satiety?

Conditions: 2.5 mg · four weeks · early satiety. This is one of those things that everyone repeats and nobody derives. This matters practically, not just…

titration
titration

Stepwise dose increases over weeks, why the label schedules exist at all, and what tolerability-driven deviation from a schedule looks like in…

444 questions
nausea
nausea

The dominant tolerability signal in every trial of the class: incidence, timing relative to a dose step, duration, and the distinction between…

346 questions
dose-escalation
dose-escalation

The decision to move up a step: what evidence supports a four-week interval, what happens when you compress it, and how trial protocols handled…

88 questions
asked by assay_blank 39k · 2.2 years ago
5 votes 5 answers5.2k views
What did the placebo arm of SURMOUNT-OSA report for hair thinning?

Numbers first: SURMOUNT-OSA · hair thinning. This is presented as though it settles something, and I am not convinced it does. I have two documents that appear to…

clinical-trials
clinical-trials

Reading the primary literature properly: estimands, intention-to-treat versus per-protocol, confidence intervals, absolute versus relative…

913 questions
gi-side-effects
gi-side-effects

The gastrointestinal cluster as a whole - nausea, vomiting, diarrhoea, constipation, reflux, early satiety - with trial incidence rates, dropout…

416 questions
nausea
nausea

The dominant tolerability signal in every trial of the class: incidence, timing relative to a dose step, duration, and the distinction between…

346 questions
asked by ten_mg_vial 16k · 8 months ago