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storage

Page 15 of 27 · 646 questions tagged storage.

646 questions · sorted by votes · page 15 of 27

18 votes 2 answers9.1k views
What happens to cagrilintide after sixteen weeks at 30 °C in solution?

Numbers first: cagrilintide · sixteen weeks · 30 °C. I suspect the usual explanation for this is wrong, or at least incomplete. I am aware this may have a boring…

peptide-stability
peptide-stability

The chemistry of peptide degradation: deamidation, oxidation, hydrolysis, aggregation and fibrillation, and how temperature, pH, ionic strength,…

832 questions
storage
storage

Storage conditions and their evidence base: minus twenty degrees for powder, refrigerated for solution, protection from light, and what the…

646 questions
shelf-life
shelf-life

How long a preparation remains within specification: labelled expiry for a sealed lyophilised vial, beyond-use dating after reconstitution, and…

301 questions
asked by sinead_gaffney 14k · 13 months ago
18 votes 5 answers8.9k views
How long does oral semaglutide stay within specification at 4 °C once reconstituted?

The particulars: oral semaglutide · 4 °C. I have read the obvious sources and they disagree with each other, so I would rather ask people who have actually done this.…

peptide-stability
peptide-stability

The chemistry of peptide degradation: deamidation, oxidation, hydrolysis, aggregation and fibrillation, and how temperature, pH, ionic strength,…

832 questions
storage
storage

Storage conditions and their evidence base: minus twenty degrees for powder, refrigerated for solution, protection from light, and what the…

646 questions
shelf-life
shelf-life

How long a preparation remains within specification: labelled expiry for a sealed lyophilised vial, beyond-use dating after reconstitution, and…

301 questions
asked by ekaterina_volk 16k · 2 months ago
18 votes0 answers8.4k views
What happens to orforglipron after two weeks at 30 °C in solution?

Setup, so nobody has to ask: orforglipron · two weeks · 30 °C. The empirical answer seems settled. The explanation does not. If the honest answer is that nobody…

peptide-stability
peptide-stability

The chemistry of peptide degradation: deamidation, oxidation, hydrolysis, aggregation and fibrillation, and how temperature, pH, ionic strength,…

832 questions
storage
storage

Storage conditions and their evidence base: minus twenty degrees for powder, refrigerated for solution, protection from light, and what the…

646 questions
shelf-life
shelf-life

How long a preparation remains within specification: labelled expiry for a sealed lyophilised vial, beyond-use dating after reconstitution, and…

301 questions
asked by olu_babatunde 14k · 22 months ago
18 votes5 answers7.8k views
What is the thermal exposure on a Suzhou to Canada lane in summer?

What I am working with: Suzhou · Canada. I have read the primary source rather than the summary, which has left me with more questions. I understand the headline. I…

cold-chain
cold-chain

Keeping material within a temperature window from manufacture to use: phase-change packs versus dry ice, thermal mass, transit-lane temperature…

524 questions
international-shipping
international-shipping

Cross-border movement of research material: transit lanes and their thermal profiles, tracked versus untracked, declaration accuracy, and what…

427 questions
storage
storage

Storage conditions and their evidence base: minus twenty degrees for powder, refrigerated for solution, protection from light, and what the…

646 questions
asked by colm_dunphy 16k · 8 months ago
18 votes 5 answers7.6k views
How long does cagrilintide stay within specification at 2–8 °C once reconstituted?

Details up front: cagrilintide · 2–8 °C. I can find plenty of assertions about this and almost no reasoning, which is usually a sign that nobody has checked. Assume…

peptide-stability
peptide-stability

The chemistry of peptide degradation: deamidation, oxidation, hydrolysis, aggregation and fibrillation, and how temperature, pH, ionic strength,…

832 questions
storage
storage

Storage conditions and their evidence base: minus twenty degrees for powder, refrigerated for solution, protection from light, and what the…

646 questions
shelf-life
shelf-life

How long a preparation remains within specification: labelled expiry for a sealed lyophilised vial, beyond-use dating after reconstitution, and…

301 questions
asked by sinead_gaffney 14k · 43 days ago
18 votes0 answers7.3k views
Does liraglutide adsorb measurably to the vial wall at 4 mg/mL?

The particulars: liraglutide · 4 mg/mL. I would like the arithmetic checked rather than the conclusion asserted. I have deliberately not used an online calculator…

peptide-stability
peptide-stability

The chemistry of peptide degradation: deamidation, oxidation, hydrolysis, aggregation and fibrillation, and how temperature, pH, ionic strength,…

832 questions
content-assay
content-assay

Quantified content: how many milligrams of peptide are actually in the vial, measured against a calibrated reference standard. A separate test…

438 questions
storage
storage

Storage conditions and their evidence base: minus twenty degrees for powder, refrigerated for solution, protection from light, and what the…

646 questions
asked by ravi_pillai 16k · 5 months ago
18 votes 5 answers4.5k views
Does fibrillation dominate for survodutide held at 2–8 °C?

The specifics, since they change the answer: fibrillation · survodutide · 2–8 °C. I understand the observation; what I do not understand is the mechanism behind it. I…

peptide-stability
peptide-stability

The chemistry of peptide degradation: deamidation, oxidation, hydrolysis, aggregation and fibrillation, and how temperature, pH, ionic strength,…

832 questions
storage
storage

Storage conditions and their evidence base: minus twenty degrees for powder, refrigerated for solution, protection from light, and what the…

646 questions
hplc
hplc

Reverse-phase high-performance liquid chromatography, the workhorse purity method. Column chemistry, mobile-phase choice, gradient slope,…

466 questions
asked by second_lot 11k · 3 months ago
18 votes0 answers4.4k views
Is 2–8 °C an acceptable storage condition for lyophilised dulaglutide?

Numbers first: 2–8 °C · dulaglutide. I would rather be corrected now than propagate something wrong. I am specifically not interested in a testimonial; I am…

storage
storage

Storage conditions and their evidence base: minus twenty degrees for powder, refrigerated for solution, protection from light, and what the…

646 questions
peptide-stability
peptide-stability

The chemistry of peptide degradation: deamidation, oxidation, hydrolysis, aggregation and fibrillation, and how temperature, pH, ionic strength,…

832 questions
shelf-life
shelf-life

How long a preparation remains within specification: labelled expiry for a sealed lyophilised vial, beyond-use dating after reconstitution, and…

301 questions
asked by ekaterina_volk 16k · 9 months ago
17 votes 5 answers34k views
Does hydrolysis dominate for orforglipron held at 37 °C?

Details up front: hydrolysis · orforglipron · 37 °C. I can predict the outcome but I cannot explain it, which means I will get the next case wrong. I would like to…

peptide-stability
peptide-stability

The chemistry of peptide degradation: deamidation, oxidation, hydrolysis, aggregation and fibrillation, and how temperature, pH, ionic strength,…

832 questions
storage
storage

Storage conditions and their evidence base: minus twenty degrees for powder, refrigerated for solution, protection from light, and what the…

646 questions
hplc
hplc

Reverse-phase high-performance liquid chromatography, the workhorse purity method. Column chemistry, mobile-phase choice, gradient slope,…

466 questions
asked by assay_blank 39k · 2.2 years ago
17 votes 5 answers32k views
What is the thermal exposure on a Qingdao to South Africa lane in summer?

The particulars: Qingdao · South Africa. I have the document in front of me and I can read the numbers. What I cannot do is interpret them. I am reasonably…

cold-chain
cold-chain

Keeping material within a temperature window from manufacture to use: phase-change packs versus dry ice, thermal mass, transit-lane temperature…

524 questions
international-shipping
international-shipping

Cross-border movement of research material: transit lanes and their thermal profiles, tracked versus untracked, declaration accuracy, and what…

427 questions
storage
storage

Storage conditions and their evidence base: minus twenty degrees for powder, refrigerated for solution, protection from light, and what the…

646 questions
asked by juliette_farnese 12k · 20 months ago
17 votes5 answers29k views
How many freeze-thaw cycles will oral semaglutide at 4 mg/mL tolerate?

The particulars: oral semaglutide · 4 mg/mL. I have read the obvious sources and they disagree with each other, so I would rather ask people who have actually done…

freeze-thaw
freeze-thaw

What repeated freezing does to a peptide in solution: ice-crystal shear at the growing front, freeze-concentration of solutes, pH shifts as buffer…

55 questions
peptide-stability
peptide-stability

The chemistry of peptide degradation: deamidation, oxidation, hydrolysis, aggregation and fibrillation, and how temperature, pH, ionic strength,…

832 questions
storage
storage

Storage conditions and their evidence base: minus twenty degrees for powder, refrigerated for solution, protection from light, and what the…

646 questions
asked by swab_and_wait 15k · 2.1 years ago
17 votes 5 answers19k views
Does aggregation dominate for cagrilintide held at 30 °C?

Stated plainly: aggregation · cagrilintide · 30 °C. I keep seeing this stated as a fact with no explanation attached, and unexplained facts make me suspicious. My…

peptide-stability
peptide-stability

The chemistry of peptide degradation: deamidation, oxidation, hydrolysis, aggregation and fibrillation, and how temperature, pH, ionic strength,…

832 questions
storage
storage

Storage conditions and their evidence base: minus twenty degrees for powder, refrigerated for solution, protection from light, and what the…

646 questions
hplc
hplc

Reverse-phase high-performance liquid chromatography, the workhorse purity method. Column chemistry, mobile-phase choice, gradient slope,…

466 questions
asked by one_ml_bac 12k · 13 months ago
17 votes 3 answers18k views
How long does liraglutide stay within specification at 2–8 °C once reconstituted?

The particulars: liraglutide · 2–8 °C. I have read the obvious sources and they disagree with each other, so I would rather ask people who have actually done this. I…

peptide-stability
peptide-stability

The chemistry of peptide degradation: deamidation, oxidation, hydrolysis, aggregation and fibrillation, and how temperature, pH, ionic strength,…

832 questions
storage
storage

Storage conditions and their evidence base: minus twenty degrees for powder, refrigerated for solution, protection from light, and what the…

646 questions
shelf-life
shelf-life

How long a preparation remains within specification: labelled expiry for a sealed lyophilised vial, beyond-use dating after reconstitution, and…

301 questions
asked by ellis_thorne 17k · 21 months ago
17 votes5 answers13k views
What happens to a GLP-1 receptor agonist after sixteen weeks at 40 °C in solution?

What I have: a GLP-1 receptor agonist · sixteen weeks · 40 °C. I suspect the usual explanation for this is wrong, or at least incomplete. I am aware this may have a…

peptide-stability
peptide-stability

The chemistry of peptide degradation: deamidation, oxidation, hydrolysis, aggregation and fibrillation, and how temperature, pH, ionic strength,…

832 questions
storage
storage

Storage conditions and their evidence base: minus twenty degrees for powder, refrigerated for solution, protection from light, and what the…

646 questions
shelf-life
shelf-life

How long a preparation remains within specification: labelled expiry for a sealed lyophilised vial, beyond-use dating after reconstitution, and…

301 questions
asked by kirsi_lahtinen 45k · 6 months ago
17 votes 5 answers9.9k views
Is a wine cooler good enough for storing reconstituted tirzepatide?

Concretely: a wine cooler · tirzepatide. I want to decide this in advance so that I am not deciding it under pressure later. Assume I will follow the plan I write…

storage
storage

Storage conditions and their evidence base: minus twenty degrees for powder, refrigerated for solution, protection from light, and what the…

646 questions
cold-chain
cold-chain

Keeping material within a temperature window from manufacture to use: phase-change packs versus dry ice, thermal mass, transit-lane temperature…

524 questions
harm-reduction
harm-reduction

Reducing avoidable risk where a decision has already been made: independent verification before use, sterility practice, dose arithmetic checked…

445 questions
asked by mira_sundqvist 19k · 5 months ago
17 votes5 answers9k views
How long does ecnoglutide stay within specification at 30 °C once reconstituted?

Conditions: ecnoglutide · 30 °C. I have done this once and I suspect I got away with it rather than got it right. For context: I keep records of every batch, every…

peptide-stability
peptide-stability

The chemistry of peptide degradation: deamidation, oxidation, hydrolysis, aggregation and fibrillation, and how temperature, pH, ionic strength,…

832 questions
storage
storage

Storage conditions and their evidence base: minus twenty degrees for powder, refrigerated for solution, protection from light, and what the…

646 questions
shelf-life
shelf-life

How long a preparation remains within specification: labelled expiry for a sealed lyophilised vial, beyond-use dating after reconstitution, and…

301 questions
asked by pierce_count 15k · 7 months ago
17 votes 5 answers7.1k views
How many freeze-thaw cycles will tirzepatide at 2.5 mg/mL tolerate?

The particulars: tirzepatide · 2.5 mg/mL. I have read the obvious sources and they disagree with each other, so I would rather ask people who have actually done this.…

freeze-thaw
freeze-thaw

What repeated freezing does to a peptide in solution: ice-crystal shear at the growing front, freeze-concentration of solutes, pH shifts as buffer…

55 questions
peptide-stability
peptide-stability

The chemistry of peptide degradation: deamidation, oxidation, hydrolysis, aggregation and fibrillation, and how temperature, pH, ionic strength,…

832 questions
storage
storage

Storage conditions and their evidence base: minus twenty degrees for powder, refrigerated for solution, protection from light, and what the…

646 questions
asked by rota_site 55k · 6 months ago
17 votes5 answers7k views
How long does tirzepatide stay within specification at room temperature once reconstituted?

The particulars: tirzepatide · room temperature. I want a method I can write down and repeat, not a rule of thumb. I would rather over-engineer this than discover a…

peptide-stability
peptide-stability

The chemistry of peptide degradation: deamidation, oxidation, hydrolysis, aggregation and fibrillation, and how temperature, pH, ionic strength,…

832 questions
storage
storage

Storage conditions and their evidence base: minus twenty degrees for powder, refrigerated for solution, protection from light, and what the…

646 questions
shelf-life
shelf-life

How long a preparation remains within specification: labelled expiry for a sealed lyophilised vial, beyond-use dating after reconstitution, and…

301 questions
asked by elke_brunner 14k · 4 months ago
17 votes0 answers6.3k views
What happens to tirzepatide after three weeks at room temperature in solution?

The specifics, since they change the answer: tirzepatide · three weeks · room temperature. I understand the observation; what I do not understand is the mechanism…

peptide-stability
peptide-stability

The chemistry of peptide degradation: deamidation, oxidation, hydrolysis, aggregation and fibrillation, and how temperature, pH, ionic strength,…

832 questions
storage
storage

Storage conditions and their evidence base: minus twenty degrees for powder, refrigerated for solution, protection from light, and what the…

646 questions
shelf-life
shelf-life

How long a preparation remains within specification: labelled expiry for a sealed lyophilised vial, beyond-use dating after reconstitution, and…

301 questions
asked by deamidation_watch 43k · 4 months ago
17 votes0 answers5.5k views
How do I log storage temperature cheaply and defensibly?

Transit was eleven days with two scanning gaps, so the thermal history is partly inferred. I have read the obvious sources and they disagree with each other, so I…

storage
storage

Storage conditions and their evidence base: minus twenty degrees for powder, refrigerated for solution, protection from light, and what the…

646 questions
cold-chain
cold-chain

Keeping material within a temperature window from manufacture to use: phase-change packs versus dry ice, thermal mass, transit-lane temperature…

524 questions
harm-reduction
harm-reduction

Reducing avoidable risk where a decision has already been made: independent verification before use, sterility practice, dose arithmetic checked…

445 questions
asked by samir_bennani 13k · 9 months ago
17 votes5 answers5.4k views
Does mazdutide adsorb measurably to the vial wall at 2.5 mg/mL?

Details up front: mazdutide · 2.5 mg/mL. This should be a straightforward calculation and I keep getting two different answers. The numbers are arbitrary; the method…

peptide-stability
peptide-stability

The chemistry of peptide degradation: deamidation, oxidation, hydrolysis, aggregation and fibrillation, and how temperature, pH, ionic strength,…

832 questions
content-assay
content-assay

Quantified content: how many milligrams of peptide are actually in the vial, measured against a calibrated reference standard. A separate test…

438 questions
storage
storage

Storage conditions and their evidence base: minus twenty degrees for powder, refrigerated for solution, protection from light, and what the…

646 questions
asked by jana_horakova 15k · 8 months ago
17 votes 5 answers5.3k views
Is 30 °C an acceptable storage condition for lyophilised tirzepatide?

The case in front of me: 30 °C · tirzepatide. I want to know whether there is evidence behind this or only repetition. I have checked the obvious registries and…

storage
storage

Storage conditions and their evidence base: minus twenty degrees for powder, refrigerated for solution, protection from light, and what the…

646 questions
peptide-stability
peptide-stability

The chemistry of peptide degradation: deamidation, oxidation, hydrolysis, aggregation and fibrillation, and how temperature, pH, ionic strength,…

832 questions
shelf-life
shelf-life

How long a preparation remains within specification: labelled expiry for a sealed lyophilised vial, beyond-use dating after reconstitution, and…

301 questions
asked by ruaidhri_o_shea 51k · 3 months ago
17 votes 5 answers4.2k views
Is there any published stability data for cagrilintide at 4 °C?

Numbers first: cagrilintide · 4 °C. I am asking for verification rather than opinion, ideally with something I can read myself. It is possible the evidence exists and…

peptide-stability
peptide-stability

The chemistry of peptide degradation: deamidation, oxidation, hydrolysis, aggregation and fibrillation, and how temperature, pH, ionic strength,…

832 questions
storage
storage

Storage conditions and their evidence base: minus twenty degrees for powder, refrigerated for solution, protection from light, and what the…

646 questions
clinical-trials
clinical-trials

Reading the primary literature properly: estimands, intention-to-treat versus per-protocol, confidence intervals, absolute versus relative…

913 questions
asked by Dr_Wren_Halliday 40k · 27 days ago
16 votes 5 answers24k views
Is 40 °C an acceptable storage condition for lyophilised survodutide?

The particulars: 40 °C · survodutide. I would like to know whether this claim survives contact with evidence. If the answer is "nobody has tested that", I would like…

storage
storage

Storage conditions and their evidence base: minus twenty degrees for powder, refrigerated for solution, protection from light, and what the…

646 questions
peptide-stability
peptide-stability

The chemistry of peptide degradation: deamidation, oxidation, hydrolysis, aggregation and fibrillation, and how temperature, pH, ionic strength,…

832 questions
shelf-life
shelf-life

How long a preparation remains within specification: labelled expiry for a sealed lyophilised vial, beyond-use dating after reconstitution, and…

301 questions
asked by w_okoye 40k · 13 months ago