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storage

Page 6 of 27 · 646 questions tagged storage.

646 questions · sorted by votes · page 6 of 27

30 votes 5 answers30k views
Does mazdutide adsorb measurably to the vial wall at 1 mg/mL?

Numbers first: mazdutide · 1 mg/mL. This should be a straightforward calculation and I keep getting two different answers. The numbers are arbitrary; the method is…

peptide-stability
peptide-stability

The chemistry of peptide degradation: deamidation, oxidation, hydrolysis, aggregation and fibrillation, and how temperature, pH, ionic strength,…

832 questions
content-assay
content-assay

Quantified content: how many milligrams of peptide are actually in the vial, measured against a calibrated reference standard. A separate test…

438 questions
storage
storage

Storage conditions and their evidence base: minus twenty degrees for powder, refrigerated for solution, protection from light, and what the…

646 questions
asked by Dr_Wren_Halliday 40k · 2.3 years ago
30 votes5 answers28k views
Does racemisation dominate for retatrutide held at 4 °C?

Details up front: racemisation · retatrutide · 4 °C. I suspect the usual explanation for this is wrong, or at least incomplete. I am aware this may have a boring…

peptide-stability
peptide-stability

The chemistry of peptide degradation: deamidation, oxidation, hydrolysis, aggregation and fibrillation, and how temperature, pH, ionic strength,…

832 questions
storage
storage

Storage conditions and their evidence base: minus twenty degrees for powder, refrigerated for solution, protection from light, and what the…

646 questions
hplc
hplc

Reverse-phase high-performance liquid chromatography, the workhorse purity method. Column chemistry, mobile-phase choice, gradient slope,…

466 questions
asked by RP_C18 85k · 15 months ago
30 votes 5 answers28k views
What is the thermal exposure on a Wuxi to Ireland lane in summer?

Details up front: Wuxi · Ireland. This is presented as though it settles something, and I am not convinced it does. I have two documents that appear to disagree,…

cold-chain
cold-chain

Keeping material within a temperature window from manufacture to use: phase-change packs versus dry ice, thermal mass, transit-lane temperature…

524 questions
international-shipping
international-shipping

Cross-border movement of research material: transit lanes and their thermal profiles, tracked versus untracked, declaration accuracy, and what…

427 questions
storage
storage

Storage conditions and their evidence base: minus twenty degrees for powder, refrigerated for solution, protection from light, and what the…

646 questions
asked by Dr_Priya_Raghunathan 94k · 10 months ago
30 votes5 answers27k views
Is 30 °C an acceptable storage condition for lyophilised retatrutide?

What I have: 30 °C · retatrutide. I am asking for verification rather than opinion, ideally with something I can read myself. It is possible the evidence exists and I…

storage
storage

Storage conditions and their evidence base: minus twenty degrees for powder, refrigerated for solution, protection from light, and what the…

646 questions
peptide-stability
peptide-stability

The chemistry of peptide degradation: deamidation, oxidation, hydrolysis, aggregation and fibrillation, and how temperature, pH, ionic strength,…

832 questions
shelf-life
shelf-life

How long a preparation remains within specification: labelled expiry for a sealed lyophilised vial, beyond-use dating after reconstitution, and…

301 questions
asked by aine_mulcahy 35k · 2.1 years ago
30 votes5 answers22k views
Does light exposure matter for a peptide in an amber vial?

I have continuous temperature data for the period in question, which is unusual and I would like to use it. I suspect the usual explanation for this is wrong, or at…

storage
storage

Storage conditions and their evidence base: minus twenty degrees for powder, refrigerated for solution, protection from light, and what the…

646 questions
peptide-stability
peptide-stability

The chemistry of peptide degradation: deamidation, oxidation, hydrolysis, aggregation and fibrillation, and how temperature, pH, ionic strength,…

832 questions
shelf-life
shelf-life

How long a preparation remains within specification: labelled expiry for a sealed lyophilised vial, beyond-use dating after reconstitution, and…

301 questions
asked by hana_petrikova 19k · 2.2 years ago
30 votes 5 answers18k views
How long does orforglipron stay within specification at room temperature once reconstituted?

Setup, so nobody has to ask: orforglipron · room temperature. This is a procedural question rather than a theoretical one, and I would like the procedure rather than…

peptide-stability
peptide-stability

The chemistry of peptide degradation: deamidation, oxidation, hydrolysis, aggregation and fibrillation, and how temperature, pH, ionic strength,…

832 questions
storage
storage

Storage conditions and their evidence base: minus twenty degrees for powder, refrigerated for solution, protection from light, and what the…

646 questions
shelf-life
shelf-life

How long a preparation remains within specification: labelled expiry for a sealed lyophilised vial, beyond-use dating after reconstitution, and…

301 questions
asked by ines_delacruz 16k · 11 months ago
30 votes5 answers18k views
Why does oxidation accelerate at 4 °C rather than proceeding linearly?

Concretely: oxidation · 4 °C. This is one of those things that everyone repeats and nobody derives. This matters practically, not just academically, because it…

peptide-stability
peptide-stability

The chemistry of peptide degradation: deamidation, oxidation, hydrolysis, aggregation and fibrillation, and how temperature, pH, ionic strength,…

832 questions
storage
storage

Storage conditions and their evidence base: minus twenty degrees for powder, refrigerated for solution, protection from light, and what the…

646 questions
hplc
hplc

Reverse-phase high-performance liquid chromatography, the workhorse purity method. Column chemistry, mobile-phase choice, gradient slope,…

466 questions
asked by pascal_thibault 13k · 18 months ago
30 votes 5 answers17k views
Why does fibrillation accelerate at 37 °C rather than proceeding linearly?

For reference: fibrillation · 37 °C. I understand the observation; what I do not understand is the mechanism behind it. I have read the two review articles that come…

peptide-stability
peptide-stability

The chemistry of peptide degradation: deamidation, oxidation, hydrolysis, aggregation and fibrillation, and how temperature, pH, ionic strength,…

832 questions
storage
storage

Storage conditions and their evidence base: minus twenty degrees for powder, refrigerated for solution, protection from light, and what the…

646 questions
hplc
hplc

Reverse-phase high-performance liquid chromatography, the workhorse purity method. Column chemistry, mobile-phase choice, gradient slope,…

466 questions
asked by lukas_sedlacek 17k · 21 months ago
30 votes 5 answers16k views
What happens to oral semaglutide after three weeks at minus 20 °C in solution?

The specifics, since they change the answer: oral semaglutide · three weeks · minus 20 °C. I understand the observation; what I do not understand is the mechanism…

peptide-stability
peptide-stability

The chemistry of peptide degradation: deamidation, oxidation, hydrolysis, aggregation and fibrillation, and how temperature, pH, ionic strength,…

832 questions
storage
storage

Storage conditions and their evidence base: minus twenty degrees for powder, refrigerated for solution, protection from light, and what the…

646 questions
shelf-life
shelf-life

How long a preparation remains within specification: labelled expiry for a sealed lyophilised vial, beyond-use dating after reconstitution, and…

301 questions
asked by meniscus_film 34k · 10 months ago
29 votes 5 answers57k views
What is the thermal exposure on a Chengdu to Canada lane in summer?

Stated plainly: Chengdu · Canada. I have read the primary source rather than the summary, which has left me with more questions. I understand the headline. I do not…

cold-chain
cold-chain

Keeping material within a temperature window from manufacture to use: phase-change packs versus dry ice, thermal mass, transit-lane temperature…

524 questions
international-shipping
international-shipping

Cross-border movement of research material: transit lanes and their thermal profiles, tracked versus untracked, declaration accuracy, and what…

427 questions
storage
storage

Storage conditions and their evidence base: minus twenty degrees for powder, refrigerated for solution, protection from light, and what the…

646 questions
asked by retest_please 13k · 23 months ago
29 votes 5 answers54k views
Is 40 °C an acceptable storage condition for lyophilised a GLP-1 receptor agonist?

Stated plainly: 40 °C · a GLP-1 receptor agonist. This has the shape of a fact but I cannot find its origin. What I found instead were three secondary sources all…

storage
storage

Storage conditions and their evidence base: minus twenty degrees for powder, refrigerated for solution, protection from light, and what the…

646 questions
peptide-stability
peptide-stability

The chemistry of peptide degradation: deamidation, oxidation, hydrolysis, aggregation and fibrillation, and how temperature, pH, ionic strength,…

832 questions
shelf-life
shelf-life

How long a preparation remains within specification: labelled expiry for a sealed lyophilised vial, beyond-use dating after reconstitution, and…

301 questions
asked by net_peptide 16k · 2.2 years ago
29 votes 5 answers52k views
Why does oxidation accelerate at 30 °C rather than proceeding linearly?

The case in front of me: oxidation · 30 °C. This is one of those things that everyone repeats and nobody derives. This matters practically, not just academically,…

peptide-stability
peptide-stability

The chemistry of peptide degradation: deamidation, oxidation, hydrolysis, aggregation and fibrillation, and how temperature, pH, ionic strength,…

832 questions
storage
storage

Storage conditions and their evidence base: minus twenty degrees for powder, refrigerated for solution, protection from light, and what the…

646 questions
hplc
hplc

Reverse-phase high-performance liquid chromatography, the workhorse purity method. Column chemistry, mobile-phase choice, gradient slope,…

466 questions
asked by day_seven_trough 11k · 2.2 years ago
29 votes 5 answers47k views
How long does semaglutide stay within specification at 4 °C once reconstituted?

The case in front of me: semaglutide · 4 °C. I have done this once and I suspect I got away with it rather than got it right. For context: I keep records of every…

peptide-stability
peptide-stability

The chemistry of peptide degradation: deamidation, oxidation, hydrolysis, aggregation and fibrillation, and how temperature, pH, ionic strength,…

832 questions
storage
storage

Storage conditions and their evidence base: minus twenty degrees for powder, refrigerated for solution, protection from light, and what the…

646 questions
shelf-life
shelf-life

How long a preparation remains within specification: labelled expiry for a sealed lyophilised vial, beyond-use dating after reconstitution, and…

301 questions
asked by tare_weight 47k · 2.1 years ago
29 votes 5 answers40k views
Does a phase-change pack hold a retatrutide shipment for fourteen days in transit?

What I am working with: retatrutide · fourteen days. I have worked this out and I would like someone to find the error, because I suspect there is one. My working so…

cold-chain
cold-chain

Keeping material within a temperature window from manufacture to use: phase-change packs versus dry ice, thermal mass, transit-lane temperature…

524 questions
international-shipping
international-shipping

Cross-border movement of research material: transit lanes and their thermal profiles, tracked versus untracked, declaration accuracy, and what…

427 questions
storage
storage

Storage conditions and their evidence base: minus twenty degrees for powder, refrigerated for solution, protection from light, and what the…

646 questions
asked by charge_state_3 39k · 15 months ago
29 votes 3 answers36k views
Is there any published stability data for oral semaglutide at minus 80 °C?

The particulars: oral semaglutide · minus 80 °C. I would like to know whether this claim survives contact with evidence. If the answer is "nobody has tested that", I…

peptide-stability
peptide-stability

The chemistry of peptide degradation: deamidation, oxidation, hydrolysis, aggregation and fibrillation, and how temperature, pH, ionic strength,…

832 questions
storage
storage

Storage conditions and their evidence base: minus twenty degrees for powder, refrigerated for solution, protection from light, and what the…

646 questions
clinical-trials
clinical-trials

Reading the primary literature properly: estimands, intention-to-treat versus per-protocol, confidence intervals, absolute versus relative…

913 questions
asked by bac_or_bust 37k · 15 months ago
29 votes 3 answers33k views
Is freezing a reconstituted peptide solution ever acceptable, and what exactly does an ice crystal do to it?

Every label on an approved incretin product says do not freeze, and discard if frozen. I would like to know what that instruction is protecting against, because if I…

freeze-thaw
freeze-thaw

What repeated freezing does to a peptide in solution: ice-crystal shear at the growing front, freeze-concentration of solutes, pH shifts as buffer…

55 questions
peptide-stability
peptide-stability

The chemistry of peptide degradation: deamidation, oxidation, hydrolysis, aggregation and fibrillation, and how temperature, pH, ionic strength,…

832 questions
reconstitution
reconstitution

Taking a lyophilised vial to a solution of known concentration: choice of diluent, volume selection, how to add liquid without shearing the cake,…

330 questions
storage
storage

Storage conditions and their evidence base: minus twenty degrees for powder, refrigerated for solution, protection from light, and what the…

646 questions
asked by rosa_mendieta 13k · 21 months ago
29 votes 5 answers30k views
How many freeze-thaw cycles will orforglipron at 20 mg/mL tolerate?

Setup, so nobody has to ask: orforglipron · 20 mg/mL. This is a procedural question rather than a theoretical one, and I would like the procedure rather than the…

freeze-thaw
freeze-thaw

What repeated freezing does to a peptide in solution: ice-crystal shear at the growing front, freeze-concentration of solutes, pH shifts as buffer…

55 questions
peptide-stability
peptide-stability

The chemistry of peptide degradation: deamidation, oxidation, hydrolysis, aggregation and fibrillation, and how temperature, pH, ionic strength,…

832 questions
storage
storage

Storage conditions and their evidence base: minus twenty degrees for powder, refrigerated for solution, protection from light, and what the…

646 questions
asked by ahmed_zerouali 19k · 20 months ago
29 votes 5 answers29k views
Does a phase-change pack hold an ecnoglutide shipment for twenty-eight days in transit?

Conditions: ecnoglutide · twenty-eight days. Please show the division. I want to check my own against yours. I would like the general form as well as the specific…

cold-chain
cold-chain

Keeping material within a temperature window from manufacture to use: phase-change packs versus dry ice, thermal mass, transit-lane temperature…

524 questions
international-shipping
international-shipping

Cross-border movement of research material: transit lanes and their thermal profiles, tracked versus untracked, declaration accuracy, and what…

427 questions
storage
storage

Storage conditions and their evidence base: minus twenty degrees for powder, refrigerated for solution, protection from light, and what the…

646 questions
asked by dana_wexler 15k · 14 months ago
29 votes 5 answers27k views
Why does racemisation accelerate at 4 °C rather than proceeding linearly?

Details up front: racemisation · 4 °C. I suspect the usual explanation for this is wrong, or at least incomplete. I am aware this may have a boring answer. I would…

peptide-stability
peptide-stability

The chemistry of peptide degradation: deamidation, oxidation, hydrolysis, aggregation and fibrillation, and how temperature, pH, ionic strength,…

832 questions
storage
storage

Storage conditions and their evidence base: minus twenty degrees for powder, refrigerated for solution, protection from light, and what the…

646 questions
hplc
hplc

Reverse-phase high-performance liquid chromatography, the workhorse purity method. Column chemistry, mobile-phase choice, gradient slope,…

466 questions
asked by threadlock7 14k · 11 months ago
29 votes 5 answers22k views
Does racemisation dominate for orforglipron held at 2–8 °C?

What I have: racemisation · orforglipron · 2–8 °C. I suspect the usual explanation for this is wrong, or at least incomplete. I am aware this may have a boring…

peptide-stability
peptide-stability

The chemistry of peptide degradation: deamidation, oxidation, hydrolysis, aggregation and fibrillation, and how temperature, pH, ionic strength,…

832 questions
storage
storage

Storage conditions and their evidence base: minus twenty degrees for powder, refrigerated for solution, protection from light, and what the…

646 questions
hplc
hplc

Reverse-phase high-performance liquid chromatography, the workhorse purity method. Column chemistry, mobile-phase choice, gradient slope,…

466 questions
asked by Dr_Jonas_Halvorsen 41k · 18 months ago
29 votes 5 answers17k views
Is there any published stability data for survodutide at 2–8 °C?

Concretely: survodutide · 2–8 °C. The claim is plausible, which is exactly why I want to check it. I am able to read a paper if someone points me at one. Has anyone…

peptide-stability
peptide-stability

The chemistry of peptide degradation: deamidation, oxidation, hydrolysis, aggregation and fibrillation, and how temperature, pH, ionic strength,…

832 questions
storage
storage

Storage conditions and their evidence base: minus twenty degrees for powder, refrigerated for solution, protection from light, and what the…

646 questions
clinical-trials
clinical-trials

Reading the primary literature properly: estimands, intention-to-treat versus per-protocol, confidence intervals, absolute versus relative…

913 questions
asked by Dr_Otto_Lindqvist 38k · 11 months ago
29 votes 5 answers15k views
Does a domestic warehouse leg genuinely shorten cold-chain exposure?

The vial was lyophilised at the time, which I understand may matter a great deal. I want to know whether there is evidence behind this or only repetition. I have…

cold-chain
cold-chain

Keeping material within a temperature window from manufacture to use: phase-change packs versus dry ice, thermal mass, transit-lane temperature…

524 questions
international-shipping
international-shipping

Cross-border movement of research material: transit lanes and their thermal profiles, tracked versus untracked, declaration accuracy, and what…

427 questions
storage
storage

Storage conditions and their evidence base: minus twenty degrees for powder, refrigerated for solution, protection from light, and what the…

646 questions
asked by halvard_ness 42k · 10 months ago
29 votes 5 answers14k views
How long does cagrilintide stay within specification at 25 °C once reconstituted?

What I have: cagrilintide · 25 °C. I would like to understand the steps well enough to explain them to someone else. I have access to a refrigerator with a logger and…

peptide-stability
peptide-stability

The chemistry of peptide degradation: deamidation, oxidation, hydrolysis, aggregation and fibrillation, and how temperature, pH, ionic strength,…

832 questions
storage
storage

Storage conditions and their evidence base: minus twenty degrees for powder, refrigerated for solution, protection from light, and what the…

646 questions
shelf-life
shelf-life

How long a preparation remains within specification: labelled expiry for a sealed lyophilised vial, beyond-use dating after reconstitution, and…

301 questions
asked by carys_meredith 17k · 9 months ago
28 votes4 answers40k views
What is the thermal exposure on a Zhuhai to Ireland lane in summer?

Details up front: Zhuhai · Ireland. This is presented as though it settles something, and I am not convinced it does. I have two documents that appear to disagree,…

cold-chain
cold-chain

Keeping material within a temperature window from manufacture to use: phase-change packs versus dry ice, thermal mass, transit-lane temperature…

524 questions
international-shipping
international-shipping

Cross-border movement of research material: transit lanes and their thermal profiles, tracked versus untracked, declaration accuracy, and what…

427 questions
storage
storage

Storage conditions and their evidence base: minus twenty degrees for powder, refrigerated for solution, protection from light, and what the…

646 questions
asked by marta_okonkwo 87k · 2.2 years ago