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batch-testing

Page 15 of 37 · 865 questions tagged batch-testing.

865 questions · sorted by votes · page 15 of 37

22 votes 5 answers30k views
Is a 96.4% result from PeptideMeter comparable to 97.9% from Janoshik?

The specifics, since they change the answer: 96.4% · PeptideMeter · 97.9% · Janoshik. The comparison I want does not seem to exist anywhere in a form I can evaluate.…

purity
purity

Purity as chromatographic area per cent - the fraction of detected material that is your target peak. It says nothing about how much material is…

788 questions
batch-testing
batch-testing

Testing at the batch or lot level: sampling plans, how many vials from a lot need testing to say anything about the lot, and the difference…

865 questions
reference-standard
reference-standard

Certified reference materials and in-house standards: traceability, the certificate of the standard itself, system suitability, and why every…

179 questions
asked by bufferline42 49k · 13 months ago
22 votes 5 answers20k views
How do I write up a Janoshik result on mazdutide so it is useful to others?

Setup, so nobody has to ask: Janoshik · mazdutide. Everything I have found on this is either a forum aside or a product page, neither of which I trust. I am…

batch-testing
batch-testing

Testing at the batch or lot level: sampling plans, how many vials from a lot need testing to say anything about the lot, and the difference…

865 questions
coa
coa

Certificates of analysis: what fields a useful one carries, how to tell a real analytical report from a marketing document, batch and lot…

749 questions
harm-reduction
harm-reduction

Reducing avoidable risk where a decision has already been made: independent verification before use, sterility practice, dose arithmetic checked…

445 questions
asked by Dr_Yusuf_Adeyemi 95k · 12 months ago
22 votes5 answers17k views
Is a 97.1% result from PeptideMeter comparable to 96.8% from Medutest?

For reference: 97.1% · PeptideMeter · 96.8% · Medutest. I am trying to choose between two options that are usually discussed as though only one exists. I am not…

purity
purity

Purity as chromatographic area per cent - the fraction of detected material that is your target peak. It says nothing about how much material is…

788 questions
batch-testing
batch-testing

Testing at the batch or lot level: sampling plans, how many vials from a lot need testing to say anything about the lot, and the difference…

865 questions
reference-standard
reference-standard

Certified reference materials and in-house standards: traceability, the certificate of the standard itself, system suitability, and why every…

179 questions
asked by pierce_count 15k · 8 months ago
22 votes 5 answers16k views
Is a 98.4% result from PeptideMeter comparable to 98.2% from PeptideMeter?

The specifics, since they change the answer: 98.4% · PeptideMeter · 98.2% · PeptideMeter. The comparison I want does not seem to exist anywhere in a form I can…

purity
purity

Purity as chromatographic area per cent - the fraction of detected material that is your target peak. It says nothing about how much material is…

788 questions
batch-testing
batch-testing

Testing at the batch or lot level: sampling plans, how many vials from a lot need testing to say anything about the lot, and the difference…

865 questions
reference-standard
reference-standard

Certified reference materials and in-house standards: traceability, the certificate of the standard itself, system suitability, and why every…

179 questions
asked by s_bhattacharya 42k · 5 months ago
22 votes3 answers16k views
Why did two JEEP lots of orforglipron differ on content assay?

What I have: JEEP · orforglipron. Before I write this off, I want to check whether it is a known failure mode. I have the lot number, the certificate and the date,…

batch-testing
batch-testing

Testing at the batch or lot level: sampling plans, how many vials from a lot need testing to say anything about the lot, and the difference…

865 questions
content-assay
content-assay

Quantified content: how many milligrams of peptide are actually in the vial, measured against a calibrated reference standard. A separate test…

438 questions
vendor-vetting
vendor-vetting

Evaluating a supplier on evidence rather than reputation: testing history across batches, whether certificates are batch-specific, how failures…

436 questions
asked by halvard_ness 42k · 7 months ago
22 votes5 answers15k views
How do I reconcile 97.6% from Medutest with 98.2% from the supplier?

Stated plainly: 97.6% · Medutest · 98.2%. I noticed this today and I have not touched anything since, in case the state is diagnostic. I have not discarded anything…

purity
purity

Purity as chromatographic area per cent - the fraction of detected material that is your target peak. It says nothing about how much material is…

788 questions
batch-testing
batch-testing

Testing at the batch or lot level: sampling plans, how many vials from a lot need testing to say anything about the lot, and the difference…

865 questions
coa
coa

Certificates of analysis: what fields a useful one carries, how to tell a real analytical report from a marketing document, batch and lot…

749 questions
asked by tare_and_weigh 18k · 15 months ago
22 votes 5 answers15k views
How much of a lot do I need to sample to say anything about the lot?

The method section is present, which is unusual enough that I want to make use of it. I have worked this out and I would like someone to find the error, because I…

batch-testing
batch-testing

Testing at the batch or lot level: sampling plans, how many vials from a lot need testing to say anything about the lot, and the difference…

865 questions
coa
coa

Certificates of analysis: what fields a useful one carries, how to tell a real analytical report from a marketing document, batch and lot…

749 questions
purity
purity

Purity as chromatographic area per cent - the fraction of detected material that is your target peak. It says nothing about how much material is…

788 questions
asked by birk_nordahl 20k · 14 months ago
22 votes 5 answers15k views
How many vials from a QST lot should I send for an HPLC purity test?

Conditions: QST · an HPLC purity test. I want the working, not the result — I need to be able to redo it with different numbers. I care about the precision as well as…

batch-testing
batch-testing

Testing at the batch or lot level: sampling plans, how many vials from a lot need testing to say anything about the lot, and the difference…

865 questions
coa
coa

Certificates of analysis: what fields a useful one carries, how to tell a real analytical report from a marketing document, batch and lot…

749 questions
cost-analysis
cost-analysis

Cost arithmetic done honestly: cost per milligram after dead-space loss, list versus net price, comparing a multi-dose vial to a fixed-dose pen,…

261 questions
asked by s_kalniete 47k · 18 months ago
22 votes 4 answers14k views
Why would PeptideMeter report 98.4% where the supplier certificate says something higher?

Conditions: PeptideMeter · 98.4%. I think I have a problem. I am not yet sure whether it is a real problem or a measurement artefact. I want to know whether this is…

purity
purity

Purity as chromatographic area per cent - the fraction of detected material that is your target peak. It says nothing about how much material is…

788 questions
hplc
hplc

Reverse-phase high-performance liquid chromatography, the workhorse purity method. Column chemistry, mobile-phase choice, gradient slope,…

466 questions
batch-testing
batch-testing

Testing at the batch or lot level: sampling plans, how many vials from a lot need testing to say anything about the lot, and the difference…

865 questions
asked by Dr_Elias_Weiss 46k · 12 months ago
22 votes 5 answers13k views
How do I reconcile 97.9% from Janoshik with 99.1% from the supplier?

What I have: 97.9% · Janoshik · 99.1%. I have a result I cannot explain, and I would rather diagnose it than guess. I have checked the obvious explanations and…

purity
purity

Purity as chromatographic area per cent - the fraction of detected material that is your target peak. It says nothing about how much material is…

788 questions
batch-testing
batch-testing

Testing at the batch or lot level: sampling plans, how many vials from a lot need testing to say anything about the lot, and the difference…

865 questions
coa
coa

Certificates of analysis: what fields a useful one carries, how to tell a real analytical report from a marketing document, batch and lot…

749 questions
asked by day_seven_trough 11k · 11 months ago
22 votes 4 answers13k views
Is a 99.1% result from Medutest comparable to 95.2% from PeptideMeter?

Stated plainly: 99.1% · Medutest · 95.2% · PeptideMeter. Both of these get recommended confidently by different people, which suggests neither is obviously right. My…

purity
purity

Purity as chromatographic area per cent - the fraction of detected material that is your target peak. It says nothing about how much material is…

788 questions
batch-testing
batch-testing

Testing at the batch or lot level: sampling plans, how many vials from a lot need testing to say anything about the lot, and the difference…

865 questions
reference-standard
reference-standard

Certified reference materials and in-house standards: traceability, the certificate of the standard itself, system suitability, and why every…

179 questions
asked by esben_lykke 15k · 18 months ago
22 votes5 answers13k views
How do I reconcile 96.4% from Medutest with 97.1% from the supplier?

What I am working with: 96.4% · Medutest · 97.1%. This is not behaving the way I expected and I want to understand the discrepancy before I act on it. I have…

purity
purity

Purity as chromatographic area per cent - the fraction of detected material that is your target peak. It says nothing about how much material is…

788 questions
batch-testing
batch-testing

Testing at the batch or lot level: sampling plans, how many vials from a lot need testing to say anything about the lot, and the difference…

865 questions
coa
coa

Certificates of analysis: what fields a useful one carries, how to tell a real analytical report from a marketing document, batch and lot…

749 questions
asked by forty_units 14k · 10 months ago
22 votes 5 answers12k views
Has anyone independently verified an ERP cagrilintide batch COA?

What I am working with: ERP · cagrilintide. This is asserted often enough that I assumed it was established, and then I went looking for the source. I have searched…

vendor-vetting
vendor-vetting

Evaluating a supplier on evidence rather than reputation: testing history across batches, whether certificates are batch-specific, how failures…

436 questions
coa
coa

Certificates of analysis: what fields a useful one carries, how to tell a real analytical report from a marketing document, batch and lot…

749 questions
batch-testing
batch-testing

Testing at the batch or lot level: sampling plans, how many vials from a lot need testing to say anything about the lot, and the difference…

865 questions
asked by Dr_Signe_Baldursdottir 46k · 5 months ago
22 votes 2 answers12k views
Has anyone independently verified an SSA survodutide batch COA?

For reference: SSA · survodutide. Somebody stated this to me confidently and I would like to check it before repeating it. I would accept a well-reasoned negative…

vendor-vetting
vendor-vetting

Evaluating a supplier on evidence rather than reputation: testing history across batches, whether certificates are batch-specific, how failures…

436 questions
coa
coa

Certificates of analysis: what fields a useful one carries, how to tell a real analytical report from a marketing document, batch and lot…

749 questions
batch-testing
batch-testing

Testing at the batch or lot level: sampling plans, how many vials from a lot need testing to say anything about the lot, and the difference…

865 questions
asked by u100_marks 38k · 5 months ago
22 votes 4 answers11k views
My semaglutide vial sat at 37 °C for five days — is testing worth it before use?

Concretely: semaglutide · 37 °C · five days. I want to decide this in advance so that I am not deciding it under pressure later. Assume I will follow the plan I write…

cold-chain
cold-chain

Keeping material within a temperature window from manufacture to use: phase-change packs versus dry ice, thermal mass, transit-lane temperature…

524 questions
peptide-stability
peptide-stability

The chemistry of peptide degradation: deamidation, oxidation, hydrolysis, aggregation and fibrillation, and how temperature, pH, ionic strength,…

832 questions
batch-testing
batch-testing

Testing at the batch or lot level: sampling plans, how many vials from a lot need testing to say anything about the lot, and the difference…

865 questions
asked by s_kalniete 47k · 9 months ago
22 votes 5 answers11k views
Why did two HJ lots of tirzepatide differ on content assay?

The case in front of me: HJ · tirzepatide. I think I have a problem. I am not yet sure whether it is a real problem or a measurement artefact. I want to know whether…

batch-testing
batch-testing

Testing at the batch or lot level: sampling plans, how many vials from a lot need testing to say anything about the lot, and the difference…

865 questions
content-assay
content-assay

Quantified content: how many milligrams of peptide are actually in the vial, measured against a calibrated reference standard. A separate test…

438 questions
vendor-vetting
vendor-vetting

Evaluating a supplier on evidence rather than reputation: testing history across batches, whether certificates are batch-specific, how failures…

436 questions
asked by coring_risk 17k · 10 months ago
22 votes 3 answers9.5k views
How do VendorInvestigate and PeptideMeter compare on the same cagrilintide batch?

For reference: VendorInvestigate · PeptideMeter · cagrilintide. I am trying to choose between two options that are usually discussed as though only one exists. I am…

janoshik
janoshik

Janoshik Analytical, an independent third-party testing laboratory widely used by this community for HPLC purity, identity and quantified content…

34 questions
medutest
medutest

Medutest, one of four independent testing and verification services referenced throughout this site. Use this tag for its methods, its report…

14 questions
batch-testing
batch-testing

Testing at the batch or lot level: sampling plans, how many vials from a lot need testing to say anything about the lot, and the difference…

865 questions
asked by zainab_mustafa 16k · 3 months ago
22 votes0 answers7.7k views
What should I make of a mazdutide certificate that has no purity figure?

What I have: mazdutide · purity figure. This is presented as though it settles something, and I am not convinced it does. I have two documents that appear to…

coa
coa

Certificates of analysis: what fields a useful one carries, how to tell a real analytical report from a marketing document, batch and lot…

749 questions
vendor-vetting
vendor-vetting

Evaluating a supplier on evidence rather than reputation: testing history across batches, whether certificates are batch-specific, how failures…

436 questions
batch-testing
batch-testing

Testing at the batch or lot level: sampling plans, how many vials from a lot need testing to say anything about the lot, and the difference…

865 questions
asked by tri_gly_ala 48k · 5 months ago
22 votes0 answers6.7k views
Does a large published testing history at JEEP imply lot consistency?

I have the report as a PDF with the chromatogram on page two, so I can quote specifics. I can predict the outcome but I cannot explain it, which means I will get the…

batch-testing
batch-testing

Testing at the batch or lot level: sampling plans, how many vials from a lot need testing to say anything about the lot, and the difference…

865 questions
vendor-vetting
vendor-vetting

Evaluating a supplier on evidence rather than reputation: testing history across batches, whether certificates are batch-specific, how failures…

436 questions
content-assay
content-assay

Quantified content: how many milligrams of peptide are actually in the vial, measured against a calibrated reference standard. A separate test…

438 questions
asked by tyndall_haze 48k · 2 months ago
22 votes3 answers6.5k views
When is LC-MS/MS peptide mapping worth paying for instead of a plain intact mass?

I have been quoted roughly four times the price of a purity-plus-identity panel for something described as "tryptic digest with LC-MS/MS peptide mapping and sequence…

peptide-mapping
peptide-mapping

Enzymatic digestion followed by LC-MS/MS to confirm sequence rather than just mass. The method that catches a scrambled sequence or a D-amino-acid…

83 questions
lc-ms
lc-ms

Liquid chromatography coupled to mass spectrometry: separation and identification in one run, and the method of choice when you need to know not…

14 questions
mass-spec
mass-spec

Mass spectrometry for identity confirmation: electrospray ionisation, multiple charge states, monoisotopic versus average mass, deconvolution, and…

38 questions
semaglutide
semaglutide

A GLP-1 receptor agonist with a fatty-acid-acylated backbone and a roughly one-week half-life, marketed for type 2 diabetes and for weight…

360 questions
batch-testing
batch-testing

Testing at the batch or lot level: sampling plans, how many vials from a lot need testing to say anything about the lot, and the difference…

865 questions
asked by fiadh_cronin 14k · 12 months ago
22 votes2 answers6.3k views
Is a 98.8% result from Medutest comparable to 98.4% from Janoshik?

Setup, so nobody has to ask: 98.8% · Medutest · 98.4% · Janoshik. I suspect the honest answer is that it depends, in which case I would like to know on what. Assume I…

purity
purity

Purity as chromatographic area per cent - the fraction of detected material that is your target peak. It says nothing about how much material is…

788 questions
batch-testing
batch-testing

Testing at the batch or lot level: sampling plans, how many vials from a lot need testing to say anything about the lot, and the difference…

865 questions
reference-standard
reference-standard

Certified reference materials and in-house standards: traceability, the certificate of the standard itself, system suitability, and why every…

179 questions
asked by pk_curve 12k · 7 months ago
22 votes 4 answers5.6k views
Why would PeptideMeter report 97.1% where the supplier certificate says something higher?

Conditions: PeptideMeter · 97.1%. I think I have a problem. I am not yet sure whether it is a real problem or a measurement artefact. I want to know whether this is…

purity
purity

Purity as chromatographic area per cent - the fraction of detected material that is your target peak. It says nothing about how much material is…

788 questions
hplc
hplc

Reverse-phase high-performance liquid chromatography, the workhorse purity method. Column chemistry, mobile-phase choice, gradient slope,…

466 questions
batch-testing
batch-testing

Testing at the batch or lot level: sampling plans, how many vials from a lot need testing to say anything about the lot, and the difference…

865 questions
asked by zainab_mustafa 16k · 4 months ago
22 votes 4 answers4.9k views
How do I reconcile 97.9% from Medutest with 95.2% from the supplier?

Stated plainly: 97.9% · Medutest · 95.2%. I noticed this today and I have not touched anything since, in case the state is diagnostic. I have not discarded anything…

purity
purity

Purity as chromatographic area per cent - the fraction of detected material that is your target peak. It says nothing about how much material is…

788 questions
batch-testing
batch-testing

Testing at the batch or lot level: sampling plans, how many vials from a lot need testing to say anything about the lot, and the difference…

865 questions
coa
coa

Certificates of analysis: what fields a useful one carries, how to tell a real analytical report from a marketing document, batch and lot…

749 questions
asked by s_bhattacharya 42k · 4 months ago
22 votes1 answer4k views
Why did two WWB lots of orforglipron differ on content assay?

What I have: WWB · orforglipron. Before I write this off, I want to check whether it is a known failure mode. I have the lot number, the certificate and the date, and…

batch-testing
batch-testing

Testing at the batch or lot level: sampling plans, how many vials from a lot need testing to say anything about the lot, and the difference…

865 questions
content-assay
content-assay

Quantified content: how many milligrams of peptide are actually in the vial, measured against a calibrated reference standard. A separate test…

438 questions
vendor-vetting
vendor-vetting

Evaluating a supplier on evidence rather than reputation: testing history across batches, whether certificates are batch-specific, how failures…

436 questions
asked by rune_thoresen 14k · 3 months ago