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dose-escalation

Page 4 of 4 · 88 questions tagged dose-escalation.

88 questions · sorted by votes · page 4 of 4

9 votes 4 answers3.7k views
Does holding at 40 mg for four weeks before escalating reduce early satiety?

Conditions: 40 mg · four weeks · early satiety. This is one of those things that everyone repeats and nobody derives. This matters practically, not just academically,…

titration
titration

Stepwise dose increases over weeks, why the label schedules exist at all, and what tolerability-driven deviation from a schedule looks like in…

444 questions
nausea
nausea

The dominant tolerability signal in every trial of the class: incidence, timing relative to a dose step, duration, and the distinction between…

346 questions
dose-escalation
dose-escalation

The decision to move up a step: what evidence supports a four-week interval, what happens when you compress it, and how trial protocols handled…

88 questions
asked by tadhg_o_riordan 14k · 4 months ago
8 votes5 answers13k views
Does holding at 20 mg for two weeks before escalating reduce early satiety?

Setup, so nobody has to ask: 20 mg · two weeks · early satiety. I keep seeing this stated as a fact with no explanation attached, and unexplained facts make me…

titration
titration

Stepwise dose increases over weeks, why the label schedules exist at all, and what tolerability-driven deviation from a schedule looks like in…

444 questions
nausea
nausea

The dominant tolerability signal in every trial of the class: incidence, timing relative to a dose step, duration, and the distinction between…

346 questions
dose-escalation
dose-escalation

The decision to move up a step: what evidence supports a four-week interval, what happens when you compress it, and how trial protocols handled…

88 questions
asked by bufferline42 49k · 18 months ago
8 votes5 answers9k views
Does holding at 15 mg for ten weeks before escalating reduce vomiting?

The particulars: 15 mg · ten weeks · vomiting. I understand the observation; what I do not understand is the mechanism behind it. I have read the two review articles…

titration
titration

Stepwise dose increases over weeks, why the label schedules exist at all, and what tolerability-driven deviation from a schedule looks like in…

444 questions
nausea
nausea

The dominant tolerability signal in every trial of the class: incidence, timing relative to a dose step, duration, and the distinction between…

346 questions
dose-escalation
dose-escalation

The decision to move up a step: what evidence supports a four-week interval, what happens when you compress it, and how trial protocols handled…

88 questions
asked by Dr_Idris_Coulibaly 40k · 6 months ago
8 votes5 answers5.5k views
Does holding at 2 mg for sixteen weeks before escalating reduce dizziness?

Numbers first: 2 mg · sixteen weeks · dizziness. I can predict the outcome but I cannot explain it, which means I will get the next case wrong. I would like to know…

titration
titration

Stepwise dose increases over weeks, why the label schedules exist at all, and what tolerability-driven deviation from a schedule looks like in…

444 questions
nausea
nausea

The dominant tolerability signal in every trial of the class: incidence, timing relative to a dose step, duration, and the distinction between…

346 questions
dose-escalation
dose-escalation

The decision to move up a step: what evidence supports a four-week interval, what happens when you compress it, and how trial protocols handled…

88 questions
asked by samir_bennani 13k · 3 months ago
8 votes 5 answers4.8k views
Does holding at 60 mg for two weeks before escalating reduce nausea?

Setup, so nobody has to ask: 60 mg · two weeks · nausea. I keep seeing this stated as a fact with no explanation attached, and unexplained facts make me suspicious.…

titration
titration

Stepwise dose increases over weeks, why the label schedules exist at all, and what tolerability-driven deviation from a schedule looks like in…

444 questions
nausea
nausea

The dominant tolerability signal in every trial of the class: incidence, timing relative to a dose step, duration, and the distinction between…

346 questions
dose-escalation
dose-escalation

The decision to move up a step: what evidence supports a four-week interval, what happens when you compress it, and how trial protocols handled…

88 questions
asked by marcus_thorbjorn 16k · 4 months ago
7 votes0 answers3.4k views
Does holding at 20 mg for eight weeks before escalating reduce early satiety?

What I am working with: 20 mg · eight weeks · early satiety. The empirical answer seems settled. The explanation does not. If the honest answer is that nobody knows,…

titration
titration

Stepwise dose increases over weeks, why the label schedules exist at all, and what tolerability-driven deviation from a schedule looks like in…

444 questions
nausea
nausea

The dominant tolerability signal in every trial of the class: incidence, timing relative to a dose step, duration, and the distinction between…

346 questions
dose-escalation
dose-escalation

The decision to move up a step: what evidence supports a four-week interval, what happens when you compress it, and how trial protocols handled…

88 questions
asked by fresh_bac 13k · 15 months ago
7 votes0 answers2.9k views
Is the maximum studied dose the same as the maximum useful dose?

My records go back to the first dose with dates, so I can reconstruct the timeline exactly. I suspect the honest answer is that it depends, in which case I would like…

maintenance-dose
maintenance-dose

Staying put: the lowest dose that holds a result, the difference between the maximum studied dose and the maximum useful dose, and what the…

44 questions
clinical-trials
clinical-trials

Reading the primary literature properly: estimands, intention-to-treat versus per-protocol, confidence intervals, absolute versus relative…

913 questions
dose-escalation
dose-escalation

The decision to move up a step: what evidence supports a four-week interval, what happens when you compress it, and how trial protocols handled…

88 questions
asked by eighty_six_hours 16k · 16 months ago
6 votes 5 answers15k views
Does holding at 50 mg for ten weeks before escalating reduce injection-site erythema?

For reference: 50 mg · ten weeks · injection-site erythema. I understand the observation; what I do not understand is the mechanism behind it. I have read the two…

titration
titration

Stepwise dose increases over weeks, why the label schedules exist at all, and what tolerability-driven deviation from a schedule looks like in…

444 questions
nausea
nausea

The dominant tolerability signal in every trial of the class: incidence, timing relative to a dose step, duration, and the distinction between…

346 questions
dose-escalation
dose-escalation

The decision to move up a step: what evidence supports a four-week interval, what happens when you compress it, and how trial protocols handled…

88 questions
asked by pieter_maas 22k · 19 months ago
6 votes5 answers8.1k views
Does holding at 4 mg for three weeks before escalating reduce reflux?

The particulars: 4 mg · three weeks · reflux. I would like the mechanism, because I want to be able to reason about the cases nobody has written about. I have tried…

titration
titration

Stepwise dose increases over weeks, why the label schedules exist at all, and what tolerability-driven deviation from a schedule looks like in…

444 questions
nausea
nausea

The dominant tolerability signal in every trial of the class: incidence, timing relative to a dose step, duration, and the distinction between…

346 questions
dose-escalation
dose-escalation

The decision to move up a step: what evidence supports a four-week interval, what happens when you compress it, and how trial protocols handled…

88 questions
asked by two_two_micron 15k · 5 months ago
5 votes5 answers25k views
Does holding at 2.5 mg for twelve weeks before escalating reduce constipation?

Concretely: 2.5 mg · twelve weeks · constipation. I want to know whether this is a real physical effect or an artefact of how it is measured. What prompted the…

titration
titration

Stepwise dose increases over weeks, why the label schedules exist at all, and what tolerability-driven deviation from a schedule looks like in…

444 questions
nausea
nausea

The dominant tolerability signal in every trial of the class: incidence, timing relative to a dose step, duration, and the distinction between…

346 questions
dose-escalation
dose-escalation

The decision to move up a step: what evidence supports a four-week interval, what happens when you compress it, and how trial protocols handled…

88 questions
asked by thabo_maseko 20k · 2.1 years ago
5 votes 5 answers9.4k views
Does holding at 2.5 mg for four weeks before escalating reduce early satiety?

Conditions: 2.5 mg · four weeks · early satiety. This is one of those things that everyone repeats and nobody derives. This matters practically, not just…

titration
titration

Stepwise dose increases over weeks, why the label schedules exist at all, and what tolerability-driven deviation from a schedule looks like in…

444 questions
nausea
nausea

The dominant tolerability signal in every trial of the class: incidence, timing relative to a dose step, duration, and the distinction between…

346 questions
dose-escalation
dose-escalation

The decision to move up a step: what evidence supports a four-week interval, what happens when you compress it, and how trial protocols handled…

88 questions
asked by assay_blank 39k · 2.2 years ago
4 votes 2 answers12k views
Does a plateau mean I need a dose step, or that I need to wait?

The trend is what I care about; individual weeks are obviously noise. This is a planning question. I know what my options are; I do not know how to weigh them. What I…

plateau
plateau

A stall in progress: distinguishing adaptive thermogenesis from measurement error from adherence drift, how long to observe before changing…

35 questions
dose-escalation
dose-escalation

The decision to move up a step: what evidence supports a four-week interval, what happens when you compress it, and how trial protocols handled…

88 questions
maintenance-dose
maintenance-dose

Staying put: the lowest dose that holds a result, the difference between the maximum studied dose and the maximum useful dose, and what the…

44 questions
asked by cap_the_luer 15k · 20 months ago
4 votes 4 answers5.2k views
Does holding at 40 mg for twelve weeks before escalating reduce nausea?

Conditions: 40 mg · twelve weeks · nausea. I want to know whether this is a real physical effect or an artefact of how it is measured. What prompted the question is…

titration
titration

Stepwise dose increases over weeks, why the label schedules exist at all, and what tolerability-driven deviation from a schedule looks like in…

444 questions
nausea
nausea

The dominant tolerability signal in every trial of the class: incidence, timing relative to a dose step, duration, and the distinction between…

346 questions
dose-escalation
dose-escalation

The decision to move up a step: what evidence supports a four-week interval, what happens when you compress it, and how trial protocols handled…

88 questions
asked by halvard_ness 42k · 14 months ago
3 votes 5 answers1.6k views
Does holding at 4 mg for ten weeks before escalating reduce fatigue?

The particulars: 4 mg · ten weeks · fatigue. I understand the observation; what I do not understand is the mechanism behind it. I have read the two review articles…

titration
titration

Stepwise dose increases over weeks, why the label schedules exist at all, and what tolerability-driven deviation from a schedule looks like in…

444 questions
nausea
nausea

The dominant tolerability signal in every trial of the class: incidence, timing relative to a dose step, duration, and the distinction between…

346 questions
dose-escalation
dose-escalation

The decision to move up a step: what evidence supports a four-week interval, what happens when you compress it, and how trial protocols handled…

88 questions
asked by thermal_mass 16k · 17 days ago
2 votes0 answers896 views
Does holding at 5 mg for eight weeks before escalating reduce nausea?

What I am working with: 5 mg · eight weeks · nausea. The empirical answer seems settled. The explanation does not. If the honest answer is that nobody knows, I would…

titration
titration

Stepwise dose increases over weeks, why the label schedules exist at all, and what tolerability-driven deviation from a schedule looks like in…

444 questions
nausea
nausea

The dominant tolerability signal in every trial of the class: incidence, timing relative to a dose step, duration, and the distinction between…

346 questions
dose-escalation
dose-escalation

The decision to move up a step: what evidence supports a four-week interval, what happens when you compress it, and how trial protocols handled…

88 questions
asked by sample_id 17k · 12 months ago
1 vote5 answers3.9k views
How predictive is a Phase 2 dose-response for a Phase 3 result?

The clinician who ordered the panel was not concerned; I would still like to understand it. This is one of those things that everyone repeats and nobody derives. This…

clinical-trials
clinical-trials

Reading the primary literature properly: estimands, intention-to-treat versus per-protocol, confidence intervals, absolute versus relative…

913 questions
retatrutide
retatrutide

An investigational GLP-1, GIP and glucagon receptor tri-agonist, studied in the TRIUMPH programme. Not approved anywhere. Use this tag for…

14 questions
dose-escalation
dose-escalation

The decision to move up a step: what evidence supports a four-week interval, what happens when you compress it, and how trial protocols handled…

88 questions
mazdutide
mazdutide

A GLP-1 and glucagon receptor dual agonist developed primarily in China, with a distinct dose range and a fast-moving publication record.…

14 questions
asked by rosa_mendieta 13k · 4 months ago