The reduction in intrusive, appetitive thinking about food that most people on the class describe. Its likely basis in central GLP-1R signalling, why it is not the same thing as nausea-driven aversion, and what its return may signal.
Started tirzepatide in February. Nothing unusual until early June, when the shedding started, and it is now substantial: handfuls in the shower, hair on the pillow,…
The phrase "food noise" is used constantly and I have never seen it defined precisely. My own experience of it was extremely specific and I would like to know what it…
I started semaglutide for weight and something I did not expect happened: I stopped drinking, more or less by accident. I was on four or five drinks most evenings for…
Eight weeks in on tirzepatide and I cannot work out which of two things is happening, and I think it matters. Version A: my appetite drive is genuinely reduced, food…
Months two through six were the quietest my head has been about food since childhood. Around month seven it started coming back, and now at month nine it is maybe 40%…
Details up front: vomiting · 1,000 kcal. I have a result I cannot explain, and I would rather diagnose it than guess. I have checked the obvious explanations and…
Stated plainly: dulaglutide · two weeks. I am trying to build something sustainable rather than something thorough that I will abandon. I have already decided the…
The specifics, since they change the answer: liraglutide · REDEFINE-1. I have the document in front of me and I can read the numbers. What I cannot do is interpret…
Scale weight, waist circumference and a repetition maximum, all logged weekly. I want to know whether this is a real physical effect or an artefact of how it is…
The case in front of me: survodutide · PIONEER-4. I would like to know the limits of what can be inferred from this. What I am trying to avoid is over-reading a…
No other medication changes, no dietary changes, nothing else obviously confounding. I want to know whether this is a real physical effect or an artefact of how it is…
I would like to know what to measure as much as what to do. I am trying to do this correctly the first time rather than learn it by getting it wrong. I have already…
Details up front: vomiting · 800 kcal. I have a result I cannot explain, and I would rather diagnose it than guess. I have checked the obvious explanations and…
This matters because it predicts what a related molecule should do. I keep seeing this stated as a fact with no explanation attached, and unexplained facts make me…
Analytical standards and reagents with traceable certificates. Every quantitative result you read inherits the accuracy of the standard behind it.
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