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storage

Page 12 of 27 · 646 questions tagged storage.

646 questions · sorted by votes · page 12 of 27

21 votes 4 answers21k views
Is there any published stability data for orforglipron at 4 °C?

Setup, so nobody has to ask: orforglipron · 4 °C. This is asserted often enough that I assumed it was established, and then I went looking for the source. I have…

peptide-stability
peptide-stability

The chemistry of peptide degradation: deamidation, oxidation, hydrolysis, aggregation and fibrillation, and how temperature, pH, ionic strength,…

832 questions
storage
storage

Storage conditions and their evidence base: minus twenty degrees for powder, refrigerated for solution, protection from light, and what the…

646 questions
clinical-trials
clinical-trials

Reading the primary literature properly: estimands, intention-to-treat versus per-protocol, confidence intervals, absolute versus relative…

913 questions
asked by leah_ferrers 15k · 16 months ago
21 votes 5 answers20k views
What happens to mazdutide after six weeks at 4 °C in solution?

Details up front: mazdutide · six weeks · 4 °C. I can predict the outcome but I cannot explain it, which means I will get the next case wrong. I would like to know…

peptide-stability
peptide-stability

The chemistry of peptide degradation: deamidation, oxidation, hydrolysis, aggregation and fibrillation, and how temperature, pH, ionic strength,…

832 questions
storage
storage

Storage conditions and their evidence base: minus twenty degrees for powder, refrigerated for solution, protection from light, and what the…

646 questions
shelf-life
shelf-life

How long a preparation remains within specification: labelled expiry for a sealed lyophilised vial, beyond-use dating after reconstitution, and…

301 questions
asked by Dr_Fatima_Belkacem 52k · 22 months ago
21 votes 5 answers16k views
How long does oral semaglutide stay within specification at room temperature once reconstituted?

The particulars: oral semaglutide · room temperature. I want a method I can write down and repeat, not a rule of thumb. I would rather over-engineer this than…

peptide-stability
peptide-stability

The chemistry of peptide degradation: deamidation, oxidation, hydrolysis, aggregation and fibrillation, and how temperature, pH, ionic strength,…

832 questions
storage
storage

Storage conditions and their evidence base: minus twenty degrees for powder, refrigerated for solution, protection from light, and what the…

646 questions
shelf-life
shelf-life

How long a preparation remains within specification: labelled expiry for a sealed lyophilised vial, beyond-use dating after reconstitution, and…

301 questions
asked by pierce_count 15k · 16 months ago
21 votes2 answers15k views
What happens to dulaglutide after eight weeks at 25 °C in solution?

What I am working with: dulaglutide · eight weeks · 25 °C. I keep seeing this stated as a fact with no explanation attached, and unexplained facts make me suspicious.…

peptide-stability
peptide-stability

The chemistry of peptide degradation: deamidation, oxidation, hydrolysis, aggregation and fibrillation, and how temperature, pH, ionic strength,…

832 questions
storage
storage

Storage conditions and their evidence base: minus twenty degrees for powder, refrigerated for solution, protection from light, and what the…

646 questions
shelf-life
shelf-life

How long a preparation remains within specification: labelled expiry for a sealed lyophilised vial, beyond-use dating after reconstitution, and…

301 questions
asked by lucia_marchetti 18k · 16 months ago
21 votes2 answers11k views
Is 37 °C an acceptable storage condition for lyophilised a GLP-1 receptor agonist?

What I am working with: 37 °C · a GLP-1 receptor agonist. This is asserted often enough that I assumed it was established, and then I went looking for the source. I…

storage
storage

Storage conditions and their evidence base: minus twenty degrees for powder, refrigerated for solution, protection from light, and what the…

646 questions
peptide-stability
peptide-stability

The chemistry of peptide degradation: deamidation, oxidation, hydrolysis, aggregation and fibrillation, and how temperature, pH, ionic strength,…

832 questions
shelf-life
shelf-life

How long a preparation remains within specification: labelled expiry for a sealed lyophilised vial, beyond-use dating after reconstitution, and…

301 questions
asked by sample_id 17k · 5 months ago
21 votes 5 answers9.2k views
Does a phase-change pack hold an ecnoglutide shipment for seven days in transit?

Conditions: ecnoglutide · seven days. I want the working, not the result — I need to be able to redo it with different numbers. I care about the precision as well as…

cold-chain
cold-chain

Keeping material within a temperature window from manufacture to use: phase-change packs versus dry ice, thermal mass, transit-lane temperature…

524 questions
international-shipping
international-shipping

Cross-border movement of research material: transit lanes and their thermal profiles, tracked versus untracked, declaration accuracy, and what…

427 questions
storage
storage

Storage conditions and their evidence base: minus twenty degrees for powder, refrigerated for solution, protection from light, and what the…

646 questions
asked by unit_math 13k · 8 months ago
21 votes5 answers7.8k views
Is there any published stability data for retatrutide at minus 80 °C?

Stated plainly: retatrutide · minus 80 °C. This is asserted often enough that I assumed it was established, and then I went looking for the source. I have searched…

peptide-stability
peptide-stability

The chemistry of peptide degradation: deamidation, oxidation, hydrolysis, aggregation and fibrillation, and how temperature, pH, ionic strength,…

832 questions
storage
storage

Storage conditions and their evidence base: minus twenty degrees for powder, refrigerated for solution, protection from light, and what the…

646 questions
clinical-trials
clinical-trials

Reading the primary literature properly: estimands, intention-to-treat versus per-protocol, confidence intervals, absolute versus relative…

913 questions
asked by pascal_thibault 13k · 2 months ago
21 votes0 answers6k views
Does retatrutide adsorb measurably to the vial wall at 3.33 mg/mL?

Setup, so nobody has to ask: retatrutide · 3.33 mg/mL. I have worked this out and I would like someone to find the error, because I suspect there is one. My working…

peptide-stability
peptide-stability

The chemistry of peptide degradation: deamidation, oxidation, hydrolysis, aggregation and fibrillation, and how temperature, pH, ionic strength,…

832 questions
content-assay
content-assay

Quantified content: how many milligrams of peptide are actually in the vial, measured against a calibrated reference standard. A separate test…

438 questions
storage
storage

Storage conditions and their evidence base: minus twenty degrees for powder, refrigerated for solution, protection from light, and what the…

646 questions
asked by grainne_ahearn 13k · 3 months ago
21 votes 5 answers5.6k views
Does racemisation dominate for dulaglutide held at minus 20 °C?

Details up front: racemisation · dulaglutide · minus 20 °C. I suspect the usual explanation for this is wrong, or at least incomplete. I am aware this may have a…

peptide-stability
peptide-stability

The chemistry of peptide degradation: deamidation, oxidation, hydrolysis, aggregation and fibrillation, and how temperature, pH, ionic strength,…

832 questions
storage
storage

Storage conditions and their evidence base: minus twenty degrees for powder, refrigerated for solution, protection from light, and what the…

646 questions
hplc
hplc

Reverse-phase high-performance liquid chromatography, the workhorse purity method. Column chemistry, mobile-phase choice, gradient slope,…

466 questions
asked by imani_dube 19k · 3 months ago
21 votes 5 answers5.4k views
How many freeze-thaw cycles will survodutide at 8 mg/mL tolerate?

Conditions: survodutide · 8 mg/mL. I am trying to do this correctly the first time rather than learn it by getting it wrong. I have already made one mistake here that…

freeze-thaw
freeze-thaw

What repeated freezing does to a peptide in solution: ice-crystal shear at the growing front, freeze-concentration of solutes, pH shifts as buffer…

55 questions
peptide-stability
peptide-stability

The chemistry of peptide degradation: deamidation, oxidation, hydrolysis, aggregation and fibrillation, and how temperature, pH, ionic strength,…

832 questions
storage
storage

Storage conditions and their evidence base: minus twenty degrees for powder, refrigerated for solution, protection from light, and what the…

646 questions
asked by yuki_morishita 19k · 8 days ago
21 votes5 answers5.1k views
Does a desiccant sachet in the box do anything useful?

This is a recurring problem with one particular shipping lane rather than a one-off. I want to know whether this is a real physical effect or an artefact of how it is…

storage
storage

Storage conditions and their evidence base: minus twenty degrees for powder, refrigerated for solution, protection from light, and what the…

646 questions
water-content
water-content

Residual moisture in a lyophilised solid, measured by Karl Fischer titration or loss on drying. It drives both the mass balance on a content assay…

39 questions
lyophilisation
lyophilisation

Freeze-drying: primary and secondary drying, collapse temperature, the role of bulking agents and cryoprotectants such as mannitol and trehalose,…

17 questions
asked by leah_ferrers 15k · 5 months ago
21 votes0 answers4.4k views
Is a wine cooler good enough for storing reconstituted orforglipron?

Numbers first: a wine cooler · orforglipron. I would rather over-plan the first cycle and simplify later. I am prepared to do the work if someone can tell me which…

storage
storage

Storage conditions and their evidence base: minus twenty degrees for powder, refrigerated for solution, protection from light, and what the…

646 questions
cold-chain
cold-chain

Keeping material within a temperature window from manufacture to use: phase-change packs versus dry ice, thermal mass, transit-lane temperature…

524 questions
harm-reduction
harm-reduction

Reducing avoidable risk where a decision has already been made: independent verification before use, sterility practice, dose arithmetic checked…

445 questions
asked by Dr_Wren_Halliday 40k · 10 months ago
21 votes0 answers3.9k views
What happens to mazdutide after six weeks at 25 °C in solution?

Details up front: mazdutide · six weeks · 25 °C. I can predict the outcome but I cannot explain it, which means I will get the next case wrong. I would like to know…

peptide-stability
peptide-stability

The chemistry of peptide degradation: deamidation, oxidation, hydrolysis, aggregation and fibrillation, and how temperature, pH, ionic strength,…

832 questions
storage
storage

Storage conditions and their evidence base: minus twenty degrees for powder, refrigerated for solution, protection from light, and what the…

646 questions
shelf-life
shelf-life

How long a preparation remains within specification: labelled expiry for a sealed lyophilised vial, beyond-use dating after reconstitution, and…

301 questions
asked by Dr_Ravi_Selvarajah 42k · 43 days ago
21 votes 5 answers3.8k views
Is a wine cooler good enough for storing reconstituted ecnoglutide?

The particulars: a wine cooler · ecnoglutide. I am at the decision point and I would rather think it through than improvise. I would rather spend money on measurement…

storage
storage

Storage conditions and their evidence base: minus twenty degrees for powder, refrigerated for solution, protection from light, and what the…

646 questions
cold-chain
cold-chain

Keeping material within a temperature window from manufacture to use: phase-change packs versus dry ice, thermal mass, transit-lane temperature…

524 questions
harm-reduction
harm-reduction

Reducing avoidable risk where a decision has already been made: independent verification before use, sterility practice, dose arithmetic checked…

445 questions
asked by bea_forsberg 14k · 41 days ago
20 votes 5 answers45k views
What is the thermal exposure on a Guangzhou to Australia lane in summer?

Conditions: Guangzhou · Australia. I would like to know the limits of what can be inferred from this. What I am trying to avoid is over-reading a single result, which…

cold-chain
cold-chain

Keeping material within a temperature window from manufacture to use: phase-change packs versus dry ice, thermal mass, transit-lane temperature…

524 questions
international-shipping
international-shipping

Cross-border movement of research material: transit lanes and their thermal profiles, tracked versus untracked, declaration accuracy, and what…

427 questions
storage
storage

Storage conditions and their evidence base: minus twenty degrees for powder, refrigerated for solution, protection from light, and what the…

646 questions
asked by ravi_pillai 16k · 2.0 years ago
20 votes 5 answers37k views
What happens to retatrutide after two weeks at 4 °C in solution?

Setup, so nobody has to ask: retatrutide · two weeks · 4 °C. The empirical answer seems settled. The explanation does not. If the honest answer is that nobody knows,…

peptide-stability
peptide-stability

The chemistry of peptide degradation: deamidation, oxidation, hydrolysis, aggregation and fibrillation, and how temperature, pH, ionic strength,…

832 questions
storage
storage

Storage conditions and their evidence base: minus twenty degrees for powder, refrigerated for solution, protection from light, and what the…

646 questions
shelf-life
shelf-life

How long a preparation remains within specification: labelled expiry for a sealed lyophilised vial, beyond-use dating after reconstitution, and…

301 questions
asked by eighty_six_hours 16k · 22 months ago
20 votes5 answers36k views
How long does ecnoglutide stay within specification at 37 °C once reconstituted?

The case in front of me: ecnoglutide · 37 °C. I am trying to do this correctly the first time rather than learn it by getting it wrong. I have already made one…

peptide-stability
peptide-stability

The chemistry of peptide degradation: deamidation, oxidation, hydrolysis, aggregation and fibrillation, and how temperature, pH, ionic strength,…

832 questions
storage
storage

Storage conditions and their evidence base: minus twenty degrees for powder, refrigerated for solution, protection from light, and what the…

646 questions
shelf-life
shelf-life

How long a preparation remains within specification: labelled expiry for a sealed lyophilised vial, beyond-use dating after reconstitution, and…

301 questions
asked by mg_per_ml 12k · 19 months ago
20 votes 5 answers35k views
Why does oxidation accelerate at 2–8 °C rather than proceeding linearly?

Concretely: oxidation · 2–8 °C. This is one of those things that everyone repeats and nobody derives. This matters practically, not just academically, because it…

peptide-stability
peptide-stability

The chemistry of peptide degradation: deamidation, oxidation, hydrolysis, aggregation and fibrillation, and how temperature, pH, ionic strength,…

832 questions
storage
storage

Storage conditions and their evidence base: minus twenty degrees for powder, refrigerated for solution, protection from light, and what the…

646 questions
hplc
hplc

Reverse-phase high-performance liquid chromatography, the workhorse purity method. Column chemistry, mobile-phase choice, gradient slope,…

466 questions
asked by s_bhattacharya 42k · 2.3 years ago
20 votes 5 answers32k views
What happens to liraglutide after three weeks at 25 °C in solution?

The particulars: liraglutide · three weeks · 25 °C. I understand the observation; what I do not understand is the mechanism behind it. I have read the two review…

peptide-stability
peptide-stability

The chemistry of peptide degradation: deamidation, oxidation, hydrolysis, aggregation and fibrillation, and how temperature, pH, ionic strength,…

832 questions
storage
storage

Storage conditions and their evidence base: minus twenty degrees for powder, refrigerated for solution, protection from light, and what the…

646 questions
shelf-life
shelf-life

How long a preparation remains within specification: labelled expiry for a sealed lyophilised vial, beyond-use dating after reconstitution, and…

301 questions
asked by cal_hennessy 14k · 18 months ago
20 votes 5 answers29k views
How long does dulaglutide stay within specification at minus 20 °C once reconstituted?

Stated plainly: dulaglutide · minus 20 °C. Everything I have found on this is either a forum aside or a product page, neither of which I trust. I am comfortable with…

peptide-stability
peptide-stability

The chemistry of peptide degradation: deamidation, oxidation, hydrolysis, aggregation and fibrillation, and how temperature, pH, ionic strength,…

832 questions
storage
storage

Storage conditions and their evidence base: minus twenty degrees for powder, refrigerated for solution, protection from light, and what the…

646 questions
shelf-life
shelf-life

How long a preparation remains within specification: labelled expiry for a sealed lyophilised vial, beyond-use dating after reconstitution, and…

301 questions
asked by thabo_maseko 20k · 19 months ago
20 votes 5 answers29k views
Is room temperature an acceptable storage condition for lyophilised cagrilintide?

Setup, so nobody has to ask: room temperature · cagrilintide. This is asserted often enough that I assumed it was established, and then I went looking for the source.…

storage
storage

Storage conditions and their evidence base: minus twenty degrees for powder, refrigerated for solution, protection from light, and what the…

646 questions
peptide-stability
peptide-stability

The chemistry of peptide degradation: deamidation, oxidation, hydrolysis, aggregation and fibrillation, and how temperature, pH, ionic strength,…

832 questions
shelf-life
shelf-life

How long a preparation remains within specification: labelled expiry for a sealed lyophilised vial, beyond-use dating after reconstitution, and…

301 questions
asked by leah_ferrers 15k · 2.1 years ago
20 votes 5 answers25k views
Is there any published stability data for semaglutide at 2–8 °C?

The case in front of me: semaglutide · 2–8 °C. The claim is plausible, which is exactly why I want to check it. I am able to read a paper if someone points me at one.…

peptide-stability
peptide-stability

The chemistry of peptide degradation: deamidation, oxidation, hydrolysis, aggregation and fibrillation, and how temperature, pH, ionic strength,…

832 questions
storage
storage

Storage conditions and their evidence base: minus twenty degrees for powder, refrigerated for solution, protection from light, and what the…

646 questions
clinical-trials
clinical-trials

Reading the primary literature properly: estimands, intention-to-treat versus per-protocol, confidence intervals, absolute versus relative…

913 questions
asked by tobias_reint 19k · 2.0 years ago
20 votes 5 answers22k views
Does oxidation dominate for liraglutide held at 25 °C?

Concretely: oxidation · liraglutide · 25 °C. This is one of those things that everyone repeats and nobody derives. This matters practically, not just academically,…

peptide-stability
peptide-stability

The chemistry of peptide degradation: deamidation, oxidation, hydrolysis, aggregation and fibrillation, and how temperature, pH, ionic strength,…

832 questions
storage
storage

Storage conditions and their evidence base: minus twenty degrees for powder, refrigerated for solution, protection from light, and what the…

646 questions
hplc
hplc

Reverse-phase high-performance liquid chromatography, the workhorse purity method. Column chemistry, mobile-phase choice, gradient slope,…

466 questions
asked by sasha_ferreira 15k · 21 months ago
20 votes 5 answers22k views
How many freeze-thaw cycles will oral semaglutide at 1 mg/mL tolerate?

The specifics, since they change the answer: oral semaglutide · 1 mg/mL. I want a method I can write down and repeat, not a rule of thumb. I would rather…

freeze-thaw
freeze-thaw

What repeated freezing does to a peptide in solution: ice-crystal shear at the growing front, freeze-concentration of solutes, pH shifts as buffer…

55 questions
peptide-stability
peptide-stability

The chemistry of peptide degradation: deamidation, oxidation, hydrolysis, aggregation and fibrillation, and how temperature, pH, ionic strength,…

832 questions
storage
storage

Storage conditions and their evidence base: minus twenty degrees for powder, refrigerated for solution, protection from light, and what the…

646 questions
asked by tare_weight 47k · 17 months ago