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storage

Page 19 of 27 · 646 questions tagged storage.

646 questions · sorted by votes · page 19 of 27

13 votes5 answers6k views
Is 37 °C an acceptable storage condition for lyophilised orforglipron?

What I have: 37 °C · orforglipron. I am asking for verification rather than opinion, ideally with something I can read myself. It is possible the evidence exists and…

storage
storage

Storage conditions and their evidence base: minus twenty degrees for powder, refrigerated for solution, protection from light, and what the…

646 questions
peptide-stability
peptide-stability

The chemistry of peptide degradation: deamidation, oxidation, hydrolysis, aggregation and fibrillation, and how temperature, pH, ionic strength,…

832 questions
shelf-life
shelf-life

How long a preparation remains within specification: labelled expiry for a sealed lyophilised vial, beyond-use dating after reconstitution, and…

301 questions
asked by thermal_mass 16k · 11 days ago
13 votes3 answers5.7k views
What happens to oral semaglutide after ten weeks at minus 20 °C in solution?

For reference: oral semaglutide · ten weeks · minus 20 °C. I would like the mechanism, because I want to be able to reason about the cases nobody has written about. I…

peptide-stability
peptide-stability

The chemistry of peptide degradation: deamidation, oxidation, hydrolysis, aggregation and fibrillation, and how temperature, pH, ionic strength,…

832 questions
storage
storage

Storage conditions and their evidence base: minus twenty degrees for powder, refrigerated for solution, protection from light, and what the…

646 questions
shelf-life
shelf-life

How long a preparation remains within specification: labelled expiry for a sealed lyophilised vial, beyond-use dating after reconstitution, and…

301 questions
asked by bounty_hunter_q 18k · 1 months ago
13 votes 5 answers5.2k views
Is a wine cooler good enough for storing reconstituted oral semaglutide?

Conditions: a wine cooler · oral semaglutide. The failure mode I am trying to avoid is making this decision emotionally. I have twelve months in view and I would like…

storage
storage

Storage conditions and their evidence base: minus twenty degrees for powder, refrigerated for solution, protection from light, and what the…

646 questions
cold-chain
cold-chain

Keeping material within a temperature window from manufacture to use: phase-change packs versus dry ice, thermal mass, transit-lane temperature…

524 questions
harm-reduction
harm-reduction

Reducing avoidable risk where a decision has already been made: independent verification before use, sterility practice, dose arithmetic checked…

445 questions
asked by pieter_maas 22k · 3 months ago
13 votes0 answers3.6k views
What is the thermal exposure on a Suzhou to the United States lane in summer?

Stated plainly: Suzhou · the United States. I have read the primary source rather than the summary, which has left me with more questions. I understand the headline.…

cold-chain
cold-chain

Keeping material within a temperature window from manufacture to use: phase-change packs versus dry ice, thermal mass, transit-lane temperature…

524 questions
international-shipping
international-shipping

Cross-border movement of research material: transit lanes and their thermal profiles, tracked versus untracked, declaration accuracy, and what…

427 questions
storage
storage

Storage conditions and their evidence base: minus twenty degrees for powder, refrigerated for solution, protection from light, and what the…

646 questions
asked by samir_bennani 13k · 13 months ago
13 votes 2 answers2.2k views
Does hydrolysis dominate for orforglipron held at 4 °C?

Details up front: hydrolysis · orforglipron · 4 °C. I can predict the outcome but I cannot explain it, which means I will get the next case wrong. I would like to…

peptide-stability
peptide-stability

The chemistry of peptide degradation: deamidation, oxidation, hydrolysis, aggregation and fibrillation, and how temperature, pH, ionic strength,…

832 questions
storage
storage

Storage conditions and their evidence base: minus twenty degrees for powder, refrigerated for solution, protection from light, and what the…

646 questions
hplc
hplc

Reverse-phase high-performance liquid chromatography, the workhorse purity method. Column chemistry, mobile-phase choice, gradient slope,…

466 questions
asked by hana_petrikova 19k · 4 months ago
13 votes0 answers2.1k views
Does a phase-change pack hold a GLP-1 receptor agonist shipment for five days in transit?

What I have: a GLP-1 receptor agonist · five days. This should be a straightforward calculation and I keep getting two different answers. The numbers are arbitrary;…

cold-chain
cold-chain

Keeping material within a temperature window from manufacture to use: phase-change packs versus dry ice, thermal mass, transit-lane temperature…

524 questions
international-shipping
international-shipping

Cross-border movement of research material: transit lanes and their thermal profiles, tracked versus untracked, declaration accuracy, and what…

427 questions
storage
storage

Storage conditions and their evidence base: minus twenty degrees for powder, refrigerated for solution, protection from light, and what the…

646 questions
asked by cake_collapsed 13k · 5 months ago
12 votes 4 answers34k views
What happens to tirzepatide after three weeks at 30 °C in solution?

The specifics, since they change the answer: tirzepatide · three weeks · 30 °C. I understand the observation; what I do not understand is the mechanism behind it. I…

peptide-stability
peptide-stability

The chemistry of peptide degradation: deamidation, oxidation, hydrolysis, aggregation and fibrillation, and how temperature, pH, ionic strength,…

832 questions
storage
storage

Storage conditions and their evidence base: minus twenty degrees for powder, refrigerated for solution, protection from light, and what the…

646 questions
shelf-life
shelf-life

How long a preparation remains within specification: labelled expiry for a sealed lyophilised vial, beyond-use dating after reconstitution, and…

301 questions
asked by carys_meredith 17k · 2.3 years ago
12 votes 5 answers27k views
How many freeze-thaw cycles will a GLP-1 receptor agonist at 1 mg/mL tolerate?

What I have: a GLP-1 receptor agonist · 1 mg/mL. I can find plenty of assertions about this and almost no reasoning, which is usually a sign that nobody has checked.…

freeze-thaw
freeze-thaw

What repeated freezing does to a peptide in solution: ice-crystal shear at the growing front, freeze-concentration of solutes, pH shifts as buffer…

55 questions
peptide-stability
peptide-stability

The chemistry of peptide degradation: deamidation, oxidation, hydrolysis, aggregation and fibrillation, and how temperature, pH, ionic strength,…

832 questions
storage
storage

Storage conditions and their evidence base: minus twenty degrees for powder, refrigerated for solution, protection from light, and what the…

646 questions
asked by per_haugen 18k · 23 months ago
12 votes4 answers27k views
Does deamidation dominate for survodutide held at minus 80 °C?

The particulars: deamidation · survodutide · minus 80 °C. I would like the mechanism, because I want to be able to reason about the cases nobody has written about. I…

peptide-stability
peptide-stability

The chemistry of peptide degradation: deamidation, oxidation, hydrolysis, aggregation and fibrillation, and how temperature, pH, ionic strength,…

832 questions
storage
storage

Storage conditions and their evidence base: minus twenty degrees for powder, refrigerated for solution, protection from light, and what the…

646 questions
hplc
hplc

Reverse-phase high-performance liquid chromatography, the workhorse purity method. Column chemistry, mobile-phase choice, gradient slope,…

466 questions
asked by tyndall_haze 48k · 23 months ago
12 votes 4 answers25k views
How many freeze-thaw cycles will liraglutide at 1 mg/mL tolerate?

The specifics, since they change the answer: liraglutide · 1 mg/mL. I have read the obvious sources and they disagree with each other, so I would rather ask people…

freeze-thaw
freeze-thaw

What repeated freezing does to a peptide in solution: ice-crystal shear at the growing front, freeze-concentration of solutes, pH shifts as buffer…

55 questions
peptide-stability
peptide-stability

The chemistry of peptide degradation: deamidation, oxidation, hydrolysis, aggregation and fibrillation, and how temperature, pH, ionic strength,…

832 questions
storage
storage

Storage conditions and their evidence base: minus twenty degrees for powder, refrigerated for solution, protection from light, and what the…

646 questions
asked by thermal_mass 16k · 2.0 years ago
12 votes5 answers24k views
Is a domestic freezer good enough for storing reconstituted a GLP-1 receptor agonist?

Setup, so nobody has to ask: a domestic freezer · a GLP-1 receptor agonist. I am trying to build something sustainable rather than something thorough that I will…

storage
storage

Storage conditions and their evidence base: minus twenty degrees for powder, refrigerated for solution, protection from light, and what the…

646 questions
cold-chain
cold-chain

Keeping material within a temperature window from manufacture to use: phase-change packs versus dry ice, thermal mass, transit-lane temperature…

524 questions
harm-reduction
harm-reduction

Reducing avoidable risk where a decision has already been made: independent verification before use, sterility practice, dose arithmetic checked…

445 questions
asked by a_lindgren 46k · 17 months ago
12 votes 5 answers23k views
Does oral semaglutide adsorb measurably to the vial wall at 2.5 mg/mL?

For reference: oral semaglutide · 2.5 mg/mL. I would like the arithmetic checked rather than the conclusion asserted. I have deliberately not used an online…

peptide-stability
peptide-stability

The chemistry of peptide degradation: deamidation, oxidation, hydrolysis, aggregation and fibrillation, and how temperature, pH, ionic strength,…

832 questions
content-assay
content-assay

Quantified content: how many milligrams of peptide are actually in the vial, measured against a calibrated reference standard. A separate test…

438 questions
storage
storage

Storage conditions and their evidence base: minus twenty degrees for powder, refrigerated for solution, protection from light, and what the…

646 questions
asked by claudia_ferrante 46k · 2.3 years ago
12 votes5 answers21k views
Is 40 °C an acceptable storage condition for lyophilised semaglutide?

The particulars: 40 °C · semaglutide. I would like to know whether this claim survives contact with evidence. If the answer is "nobody has tested that", I would like…

storage
storage

Storage conditions and their evidence base: minus twenty degrees for powder, refrigerated for solution, protection from light, and what the…

646 questions
peptide-stability
peptide-stability

The chemistry of peptide degradation: deamidation, oxidation, hydrolysis, aggregation and fibrillation, and how temperature, pH, ionic strength,…

832 questions
shelf-life
shelf-life

How long a preparation remains within specification: labelled expiry for a sealed lyophilised vial, beyond-use dating after reconstitution, and…

301 questions
asked by seamus_brady 17k · 2.1 years ago
12 votes 5 answers17k views
Is 2–8 °C an acceptable storage condition for lyophilised a GLP-1 receptor agonist?

Stated plainly: 2–8 °C · a GLP-1 receptor agonist. This is asserted often enough that I assumed it was established, and then I went looking for the source. I have…

storage
storage

Storage conditions and their evidence base: minus twenty degrees for powder, refrigerated for solution, protection from light, and what the…

646 questions
peptide-stability
peptide-stability

The chemistry of peptide degradation: deamidation, oxidation, hydrolysis, aggregation and fibrillation, and how temperature, pH, ionic strength,…

832 questions
shelf-life
shelf-life

How long a preparation remains within specification: labelled expiry for a sealed lyophilised vial, beyond-use dating after reconstitution, and…

301 questions
asked by Dr_Colm_Fitzhenry 85k · 16 months ago
12 votes 5 answers14k views
Why does aggregation accelerate at 25 °C rather than proceeding linearly?

Setup, so nobody has to ask: aggregation · 25 °C. I keep seeing this stated as a fact with no explanation attached, and unexplained facts make me suspicious. My…

peptide-stability
peptide-stability

The chemistry of peptide degradation: deamidation, oxidation, hydrolysis, aggregation and fibrillation, and how temperature, pH, ionic strength,…

832 questions
storage
storage

Storage conditions and their evidence base: minus twenty degrees for powder, refrigerated for solution, protection from light, and what the…

646 questions
hplc
hplc

Reverse-phase high-performance liquid chromatography, the workhorse purity method. Column chemistry, mobile-phase choice, gradient slope,…

466 questions
asked by dead_volume 49k · 15 months ago
12 votes5 answers11k views
How many freeze-thaw cycles will mazdutide at 6.67 mg/mL tolerate?

Numbers first: mazdutide · 6.67 mg/mL. I can find plenty of assertions about this and almost no reasoning, which is usually a sign that nobody has checked. Assume no…

freeze-thaw
freeze-thaw

What repeated freezing does to a peptide in solution: ice-crystal shear at the growing front, freeze-concentration of solutes, pH shifts as buffer…

55 questions
peptide-stability
peptide-stability

The chemistry of peptide degradation: deamidation, oxidation, hydrolysis, aggregation and fibrillation, and how temperature, pH, ionic strength,…

832 questions
storage
storage

Storage conditions and their evidence base: minus twenty degrees for powder, refrigerated for solution, protection from light, and what the…

646 questions
asked by anja_hellstrom 13k · 4 months ago
12 votes 1 answer8.2k views
Is a laboratory refrigerator good enough for storing reconstituted orforglipron?

What I have: a laboratory refrigerator · orforglipron. This is a planning question. I know what my options are; I do not know how to weigh them. What I want is the…

storage
storage

Storage conditions and their evidence base: minus twenty degrees for powder, refrigerated for solution, protection from light, and what the…

646 questions
cold-chain
cold-chain

Keeping material within a temperature window from manufacture to use: phase-change packs versus dry ice, thermal mass, transit-lane temperature…

524 questions
harm-reduction
harm-reduction

Reducing avoidable risk where a decision has already been made: independent verification before use, sterility practice, dose arithmetic checked…

445 questions
asked by Dr_Nadia_Farsi 90k · 7 months ago
12 votes0 answers7.3k views
Is a mini-fridge good enough for storing reconstituted orforglipron?

What I have: a mini-fridge · orforglipron. This is a planning question. I know what my options are; I do not know how to weigh them. What I want is the minimum viable…

storage
storage

Storage conditions and their evidence base: minus twenty degrees for powder, refrigerated for solution, protection from light, and what the…

646 questions
cold-chain
cold-chain

Keeping material within a temperature window from manufacture to use: phase-change packs versus dry ice, thermal mass, transit-lane temperature…

524 questions
harm-reduction
harm-reduction

Reducing avoidable risk where a decision has already been made: independent verification before use, sterility practice, dose arithmetic checked…

445 questions
asked by assay_blank 39k · 22 months ago
12 votes 5 answers6.8k views
How do I plan for a semaglutide supply interruption without stockpiling badly?

This is a recurring problem with one particular shipping lane rather than a one-off. I want to decide this in advance so that I am not deciding it under pressure…

storage
storage

Storage conditions and their evidence base: minus twenty degrees for powder, refrigerated for solution, protection from light, and what the…

646 questions
discontinuation
discontinuation

Stopping treatment: tapering versus abrupt cessation, what the trial withdrawal arms measured, clinically driven stops, and the practical planning…

21 questions
cost-analysis
cost-analysis

Cost arithmetic done honestly: cost per milligram after dead-space loss, list versus net price, comparing a multi-dose vial to a fixed-dose pen,…

261 questions
asked by Dr_Sara_Kuusela 46k · 40 days ago
12 votes 2 answers6k views
How long does ecnoglutide stay within specification at 25 °C once reconstituted?

The case in front of me: ecnoglutide · 25 °C. I have done this once and I suspect I got away with it rather than got it right. For context: I keep records of every…

peptide-stability
peptide-stability

The chemistry of peptide degradation: deamidation, oxidation, hydrolysis, aggregation and fibrillation, and how temperature, pH, ionic strength,…

832 questions
storage
storage

Storage conditions and their evidence base: minus twenty degrees for powder, refrigerated for solution, protection from light, and what the…

646 questions
shelf-life
shelf-life

How long a preparation remains within specification: labelled expiry for a sealed lyophilised vial, beyond-use dating after reconstitution, and…

301 questions
asked by syringe_ninety 15k · 11 months ago
12 votes0 answers4.2k views
Does a phase-change pack hold a cagrilintide shipment for five days in transit?

Numbers first: cagrilintide · five days. This should be a straightforward calculation and I keep getting two different answers. The numbers are arbitrary; the method…

cold-chain
cold-chain

Keeping material within a temperature window from manufacture to use: phase-change packs versus dry ice, thermal mass, transit-lane temperature…

524 questions
international-shipping
international-shipping

Cross-border movement of research material: transit lanes and their thermal profiles, tracked versus untracked, declaration accuracy, and what…

427 questions
storage
storage

Storage conditions and their evidence base: minus twenty degrees for powder, refrigerated for solution, protection from light, and what the…

646 questions
asked by mateo_iglesias 16k · 19 months ago
12 votes 4 answers4.2k views
Why does deamidation accelerate at 40 °C rather than proceeding linearly?

The specifics, since they change the answer: deamidation · 40 °C. I would like the mechanism, because I want to be able to reason about the cases nobody has written…

peptide-stability
peptide-stability

The chemistry of peptide degradation: deamidation, oxidation, hydrolysis, aggregation and fibrillation, and how temperature, pH, ionic strength,…

832 questions
storage
storage

Storage conditions and their evidence base: minus twenty degrees for powder, refrigerated for solution, protection from light, and what the…

646 questions
hplc
hplc

Reverse-phase high-performance liquid chromatography, the workhorse purity method. Column chemistry, mobile-phase choice, gradient slope,…

466 questions
asked by Dr_Nadia_Farsi 90k · 2 months ago
12 votes0 answers3.4k views
Can I re-freeze a lyophilised vial that reached room temperature in transit?

This is a recurring problem with one particular shipping lane rather than a one-off. Everything I have found on this is either a forum aside or a product page,…

freeze-thaw
freeze-thaw

What repeated freezing does to a peptide in solution: ice-crystal shear at the growing front, freeze-concentration of solutes, pH shifts as buffer…

55 questions
storage
storage

Storage conditions and their evidence base: minus twenty degrees for powder, refrigerated for solution, protection from light, and what the…

646 questions
cold-chain
cold-chain

Keeping material within a temperature window from manufacture to use: phase-change packs versus dry ice, thermal mass, transit-lane temperature…

524 questions
asked by lucia_marchetti 18k · 11 months ago
12 votes 4 answers2.5k views
What is the thermal exposure on a Shanghai to Norway lane in summer?

The case in front of me: Shanghai · Norway. I would like to know the limits of what can be inferred from this. What I am trying to avoid is over-reading a single…

cold-chain
cold-chain

Keeping material within a temperature window from manufacture to use: phase-change packs versus dry ice, thermal mass, transit-lane temperature…

524 questions
international-shipping
international-shipping

Cross-border movement of research material: transit lanes and their thermal profiles, tracked versus untracked, declaration accuracy, and what…

427 questions
storage
storage

Storage conditions and their evidence base: minus twenty degrees for powder, refrigerated for solution, protection from light, and what the…

646 questions
asked by tess_amankwah 48k · 28 days ago