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storage

Page 18 of 27 · 646 questions tagged storage.

646 questions · sorted by votes · page 18 of 27

14 votes5 answers9.1k views
Does racemisation dominate for retatrutide held at 30 °C?

Details up front: racemisation · retatrutide · 30 °C. I suspect the usual explanation for this is wrong, or at least incomplete. I am aware this may have a boring…

peptide-stability
peptide-stability

The chemistry of peptide degradation: deamidation, oxidation, hydrolysis, aggregation and fibrillation, and how temperature, pH, ionic strength,…

832 questions
storage
storage

Storage conditions and their evidence base: minus twenty degrees for powder, refrigerated for solution, protection from light, and what the…

646 questions
hplc
hplc

Reverse-phase high-performance liquid chromatography, the workhorse purity method. Column chemistry, mobile-phase choice, gradient slope,…

466 questions
asked by net_peptide 16k · 19 months ago
14 votes5 answers8.8k views
Why does dimerisation accelerate at 2–8 °C rather than proceeding linearly?

Setup, so nobody has to ask: dimerisation · 2–8 °C. The empirical answer seems settled. The explanation does not. If the honest answer is that nobody knows, I would…

peptide-stability
peptide-stability

The chemistry of peptide degradation: deamidation, oxidation, hydrolysis, aggregation and fibrillation, and how temperature, pH, ionic strength,…

832 questions
storage
storage

Storage conditions and their evidence base: minus twenty degrees for powder, refrigerated for solution, protection from light, and what the…

646 questions
hplc
hplc

Reverse-phase high-performance liquid chromatography, the workhorse purity method. Column chemistry, mobile-phase choice, gradient slope,…

466 questions
asked by u100_marks 38k · 2 months ago
14 votes5 answers6.3k views
Why does aggregation accelerate at 37 °C rather than proceeding linearly?

What I am working with: aggregation · 37 °C. I keep seeing this stated as a fact with no explanation attached, and unexplained facts make me suspicious. My background…

peptide-stability
peptide-stability

The chemistry of peptide degradation: deamidation, oxidation, hydrolysis, aggregation and fibrillation, and how temperature, pH, ionic strength,…

832 questions
storage
storage

Storage conditions and their evidence base: minus twenty degrees for powder, refrigerated for solution, protection from light, and what the…

646 questions
hplc
hplc

Reverse-phase high-performance liquid chromatography, the workhorse purity method. Column chemistry, mobile-phase choice, gradient slope,…

466 questions
asked by swab_and_wait 15k · 11 months ago
14 votes 5 answers6k views
Does orforglipron adsorb measurably to the vial wall at 5 mg/mL?

Stated plainly: orforglipron · 5 mg/mL. I have worked this out and I would like someone to find the error, because I suspect there is one. My working so far, for the…

peptide-stability
peptide-stability

The chemistry of peptide degradation: deamidation, oxidation, hydrolysis, aggregation and fibrillation, and how temperature, pH, ionic strength,…

832 questions
content-assay
content-assay

Quantified content: how many milligrams of peptide are actually in the vial, measured against a calibrated reference standard. A separate test…

438 questions
storage
storage

Storage conditions and their evidence base: minus twenty degrees for powder, refrigerated for solution, protection from light, and what the…

646 questions
asked by ten_mg_vial 16k · 10 months ago
14 votes0 answers4.5k views
Is a laboratory refrigerator good enough for storing reconstituted dulaglutide?

Numbers first: a laboratory refrigerator · dulaglutide. I would rather over-plan the first cycle and simplify later. I am prepared to do the work if someone can tell…

storage
storage

Storage conditions and their evidence base: minus twenty degrees for powder, refrigerated for solution, protection from light, and what the…

646 questions
cold-chain
cold-chain

Keeping material within a temperature window from manufacture to use: phase-change packs versus dry ice, thermal mass, transit-lane temperature…

524 questions
harm-reduction
harm-reduction

Reducing avoidable risk where a decision has already been made: independent verification before use, sterility practice, dose arithmetic checked…

445 questions
asked by n_takahashi 36k · 2 months ago
14 votes 5 answers4.2k views
Does fibrillation dominate for semaglutide held at 37 °C?

For reference: fibrillation · semaglutide · 37 °C. I understand the observation; what I do not understand is the mechanism behind it. I have read the two review…

peptide-stability
peptide-stability

The chemistry of peptide degradation: deamidation, oxidation, hydrolysis, aggregation and fibrillation, and how temperature, pH, ionic strength,…

832 questions
storage
storage

Storage conditions and their evidence base: minus twenty degrees for powder, refrigerated for solution, protection from light, and what the…

646 questions
hplc
hplc

Reverse-phase high-performance liquid chromatography, the workhorse purity method. Column chemistry, mobile-phase choice, gradient slope,…

466 questions
asked by ben_akintola 14k · 2 months ago
14 votes0 answers3.1k views
Is room temperature an acceptable storage condition for lyophilised liraglutide?

The case in front of me: room temperature · liraglutide. I want to know whether there is evidence behind this or only repetition. I have checked the obvious…

storage
storage

Storage conditions and their evidence base: minus twenty degrees for powder, refrigerated for solution, protection from light, and what the…

646 questions
peptide-stability
peptide-stability

The chemistry of peptide degradation: deamidation, oxidation, hydrolysis, aggregation and fibrillation, and how temperature, pH, ionic strength,…

832 questions
shelf-life
shelf-life

How long a preparation remains within specification: labelled expiry for a sealed lyophilised vial, beyond-use dating after reconstitution, and…

301 questions
asked by noor_alhassan 15k · 2 months ago
13 votes 5 answers39k views
Is 4 °C an acceptable storage condition for lyophilised oral semaglutide?

Conditions: 4 °C · oral semaglutide. I want to know whether there is evidence behind this or only repetition. I have checked the obvious registries and monographs…

storage
storage

Storage conditions and their evidence base: minus twenty degrees for powder, refrigerated for solution, protection from light, and what the…

646 questions
peptide-stability
peptide-stability

The chemistry of peptide degradation: deamidation, oxidation, hydrolysis, aggregation and fibrillation, and how temperature, pH, ionic strength,…

832 questions
shelf-life
shelf-life

How long a preparation remains within specification: labelled expiry for a sealed lyophilised vial, beyond-use dating after reconstitution, and…

301 questions
asked by siobhan_deasy 16k · 2.2 years ago
13 votes5 answers34k views
Is 25 °C an acceptable storage condition for lyophilised mazdutide?

Setup, so nobody has to ask: 25 °C · mazdutide. This has the shape of a fact but I cannot find its origin. What I found instead were three secondary sources all…

storage
storage

Storage conditions and their evidence base: minus twenty degrees for powder, refrigerated for solution, protection from light, and what the…

646 questions
peptide-stability
peptide-stability

The chemistry of peptide degradation: deamidation, oxidation, hydrolysis, aggregation and fibrillation, and how temperature, pH, ionic strength,…

832 questions
shelf-life
shelf-life

How long a preparation remains within specification: labelled expiry for a sealed lyophilised vial, beyond-use dating after reconstitution, and…

301 questions
asked by two_two_micron 15k · 2.3 years ago
13 votes 5 answers31k views
How long does dulaglutide stay within specification at minus 80 °C once reconstituted?

What I am working with: dulaglutide · minus 80 °C. Everything I have found on this is either a forum aside or a product page, neither of which I trust. I am…

peptide-stability
peptide-stability

The chemistry of peptide degradation: deamidation, oxidation, hydrolysis, aggregation and fibrillation, and how temperature, pH, ionic strength,…

832 questions
storage
storage

Storage conditions and their evidence base: minus twenty degrees for powder, refrigerated for solution, protection from light, and what the…

646 questions
shelf-life
shelf-life

How long a preparation remains within specification: labelled expiry for a sealed lyophilised vial, beyond-use dating after reconstitution, and…

301 questions
asked by harriet_lonsdale 14k · 22 months ago
13 votes 5 answers29k views
How long does semaglutide stay within specification at minus 20 °C once reconstituted?

Conditions: semaglutide · minus 20 °C. I have done this once and I suspect I got away with it rather than got it right. For context: I keep records of every batch,…

peptide-stability
peptide-stability

The chemistry of peptide degradation: deamidation, oxidation, hydrolysis, aggregation and fibrillation, and how temperature, pH, ionic strength,…

832 questions
storage
storage

Storage conditions and their evidence base: minus twenty degrees for powder, refrigerated for solution, protection from light, and what the…

646 questions
shelf-life
shelf-life

How long a preparation remains within specification: labelled expiry for a sealed lyophilised vial, beyond-use dating after reconstitution, and…

301 questions
asked by stopper_core 50k · 2.2 years ago
13 votes 5 answers21k views
What is the thermal exposure on a Chengdu to Norway lane in summer?

The case in front of me: Chengdu · Norway. I would like to know the limits of what can be inferred from this. What I am trying to avoid is over-reading a single…

cold-chain
cold-chain

Keeping material within a temperature window from manufacture to use: phase-change packs versus dry ice, thermal mass, transit-lane temperature…

524 questions
international-shipping
international-shipping

Cross-border movement of research material: transit lanes and their thermal profiles, tracked versus untracked, declaration accuracy, and what…

427 questions
storage
storage

Storage conditions and their evidence base: minus twenty degrees for powder, refrigerated for solution, protection from light, and what the…

646 questions
asked by Dr_Ilse_Vandenberg 78k · 14 months ago
13 votes 5 answers19k views
How long does survodutide stay within specification at room temperature once reconstituted?

Concretely: survodutide · room temperature. I am trying to do this correctly the first time rather than learn it by getting it wrong. I have already made one mistake…

peptide-stability
peptide-stability

The chemistry of peptide degradation: deamidation, oxidation, hydrolysis, aggregation and fibrillation, and how temperature, pH, ionic strength,…

832 questions
storage
storage

Storage conditions and their evidence base: minus twenty degrees for powder, refrigerated for solution, protection from light, and what the…

646 questions
shelf-life
shelf-life

How long a preparation remains within specification: labelled expiry for a sealed lyophilised vial, beyond-use dating after reconstitution, and…

301 questions
asked by lukas_sedlacek 17k · 2.2 years ago
13 votes0 answers17k views
Does retatrutide adsorb measurably to the vial wall at 2 mg/mL?

What I am working with: retatrutide · 2 mg/mL. The units are where I keep going wrong, so please be explicit about them. I have sanity-checked the order of magnitude…

peptide-stability
peptide-stability

The chemistry of peptide degradation: deamidation, oxidation, hydrolysis, aggregation and fibrillation, and how temperature, pH, ionic strength,…

832 questions
content-assay
content-assay

Quantified content: how many milligrams of peptide are actually in the vial, measured against a calibrated reference standard. A separate test…

438 questions
storage
storage

Storage conditions and their evidence base: minus twenty degrees for powder, refrigerated for solution, protection from light, and what the…

646 questions
asked by Dr_Ingrid_Baumgartner 39k · 2.2 years ago
13 votes 5 answers13k views
What is the thermal exposure on a Wuhan to Japan lane in summer?

The case in front of me: Wuhan · Japan. The figures are clear enough; the question is what they mean and what they do not. I can supply the numbers if the specifics…

cold-chain
cold-chain

Keeping material within a temperature window from manufacture to use: phase-change packs versus dry ice, thermal mass, transit-lane temperature…

524 questions
international-shipping
international-shipping

Cross-border movement of research material: transit lanes and their thermal profiles, tracked versus untracked, declaration accuracy, and what…

427 questions
storage
storage

Storage conditions and their evidence base: minus twenty degrees for powder, refrigerated for solution, protection from light, and what the…

646 questions
asked by micron22 36k · 23 months ago
13 votes5 answers13k views
Does survodutide adsorb measurably to the vial wall at 2 mg/mL?

Concretely: survodutide · 2 mg/mL. Please show the division. I want to check my own against yours. I would like the general form as well as the specific number, so I…

peptide-stability
peptide-stability

The chemistry of peptide degradation: deamidation, oxidation, hydrolysis, aggregation and fibrillation, and how temperature, pH, ionic strength,…

832 questions
content-assay
content-assay

Quantified content: how many milligrams of peptide are actually in the vial, measured against a calibrated reference standard. A separate test…

438 questions
storage
storage

Storage conditions and their evidence base: minus twenty degrees for powder, refrigerated for solution, protection from light, and what the…

646 questions
asked by anouk_desmet 18k · 8 months ago
13 votes 5 answers12k views
Does dimerisation dominate for cagrilintide held at 25 °C?

Stated plainly: dimerisation · cagrilintide · 25 °C. The empirical answer seems settled. The explanation does not. If the honest answer is that nobody knows, I would…

peptide-stability
peptide-stability

The chemistry of peptide degradation: deamidation, oxidation, hydrolysis, aggregation and fibrillation, and how temperature, pH, ionic strength,…

832 questions
storage
storage

Storage conditions and their evidence base: minus twenty degrees for powder, refrigerated for solution, protection from light, and what the…

646 questions
hplc
hplc

Reverse-phase high-performance liquid chromatography, the workhorse purity method. Column chemistry, mobile-phase choice, gradient slope,…

466 questions
asked by thermal_mass 16k · 8 months ago
13 votes5 answers12k views
Does a phase-change pack hold a survodutide shipment for seven days in transit?

Conditions: survodutide · seven days. I want the working, not the result — I need to be able to redo it with different numbers. I care about the precision as well as…

cold-chain
cold-chain

Keeping material within a temperature window from manufacture to use: phase-change packs versus dry ice, thermal mass, transit-lane temperature…

524 questions
international-shipping
international-shipping

Cross-border movement of research material: transit lanes and their thermal profiles, tracked versus untracked, declaration accuracy, and what…

427 questions
storage
storage

Storage conditions and their evidence base: minus twenty degrees for powder, refrigerated for solution, protection from light, and what the…

646 questions
asked by dana_wexler 15k · 2.1 years ago
13 votes0 answers12k views
Does dimerisation dominate for a GLP-1 receptor agonist held at 25 °C?

Stated plainly: dimerisation · a GLP-1 receptor agonist · 25 °C. The empirical answer seems settled. The explanation does not. If the honest answer is that nobody…

peptide-stability
peptide-stability

The chemistry of peptide degradation: deamidation, oxidation, hydrolysis, aggregation and fibrillation, and how temperature, pH, ionic strength,…

832 questions
storage
storage

Storage conditions and their evidence base: minus twenty degrees for powder, refrigerated for solution, protection from light, and what the…

646 questions
hplc
hplc

Reverse-phase high-performance liquid chromatography, the workhorse purity method. Column chemistry, mobile-phase choice, gradient slope,…

466 questions
asked by n_takahashi 36k · 2.0 years ago
13 votes 5 answers12k views
Does aggregation dominate for cagrilintide held at 37 °C?

Setup, so nobody has to ask: aggregation · cagrilintide · 37 °C. I keep seeing this stated as a fact with no explanation attached, and unexplained facts make me…

peptide-stability
peptide-stability

The chemistry of peptide degradation: deamidation, oxidation, hydrolysis, aggregation and fibrillation, and how temperature, pH, ionic strength,…

832 questions
storage
storage

Storage conditions and their evidence base: minus twenty degrees for powder, refrigerated for solution, protection from light, and what the…

646 questions
hplc
hplc

Reverse-phase high-performance liquid chromatography, the workhorse purity method. Column chemistry, mobile-phase choice, gradient slope,…

466 questions
asked by lukas_sedlacek 17k · 21 months ago
13 votes 5 answers10k views
What is the thermal exposure on a Guangzhou to Germany lane in summer?

Concretely: Guangzhou · Germany. The figures are clear enough; the question is what they mean and what they do not. I can supply the numbers if the specifics change…

cold-chain
cold-chain

Keeping material within a temperature window from manufacture to use: phase-change packs versus dry ice, thermal mass, transit-lane temperature…

524 questions
international-shipping
international-shipping

Cross-border movement of research material: transit lanes and their thermal profiles, tracked versus untracked, declaration accuracy, and what…

427 questions
storage
storage

Storage conditions and their evidence base: minus twenty degrees for powder, refrigerated for solution, protection from light, and what the…

646 questions
asked by vial_five 15k · 12 months ago
13 votes 5 answers9.5k views
How long does oral semaglutide stay within specification at 2–8 °C once reconstituted?

For reference: oral semaglutide · 2–8 °C. I have read the obvious sources and they disagree with each other, so I would rather ask people who have actually done this.…

peptide-stability
peptide-stability

The chemistry of peptide degradation: deamidation, oxidation, hydrolysis, aggregation and fibrillation, and how temperature, pH, ionic strength,…

832 questions
storage
storage

Storage conditions and their evidence base: minus twenty degrees for powder, refrigerated for solution, protection from light, and what the…

646 questions
shelf-life
shelf-life

How long a preparation remains within specification: labelled expiry for a sealed lyophilised vial, beyond-use dating after reconstitution, and…

301 questions
asked by harriet_lonsdale 14k · 7 months ago
13 votes 5 answers7.7k views
What happens to semaglutide after four weeks at room temperature in solution?

Concretely: semaglutide · four weeks · room temperature. I want to know whether this is a real physical effect or an artefact of how it is measured. What prompted the…

peptide-stability
peptide-stability

The chemistry of peptide degradation: deamidation, oxidation, hydrolysis, aggregation and fibrillation, and how temperature, pH, ionic strength,…

832 questions
storage
storage

Storage conditions and their evidence base: minus twenty degrees for powder, refrigerated for solution, protection from light, and what the…

646 questions
shelf-life
shelf-life

How long a preparation remains within specification: labelled expiry for a sealed lyophilised vial, beyond-use dating after reconstitution, and…

301 questions
asked by assay_blank 39k · 14 months ago
13 votes0 answers6.2k views
What happens to dulaglutide after eight weeks at 4 °C in solution?

Setup, so nobody has to ask: dulaglutide · eight weeks · 4 °C. I keep seeing this stated as a fact with no explanation attached, and unexplained facts make me…

peptide-stability
peptide-stability

The chemistry of peptide degradation: deamidation, oxidation, hydrolysis, aggregation and fibrillation, and how temperature, pH, ionic strength,…

832 questions
storage
storage

Storage conditions and their evidence base: minus twenty degrees for powder, refrigerated for solution, protection from light, and what the…

646 questions
shelf-life
shelf-life

How long a preparation remains within specification: labelled expiry for a sealed lyophilised vial, beyond-use dating after reconstitution, and…

301 questions
asked by ravenna_pace 13k · 2.2 years ago