Questions with no answer at all. Not questions with no accepted answer — those are elsewhere.
The case in front of me: 97.6% · VendorInvestigate · 96.8% · PeptideMeter. These are treated as interchangeable and I do not think they are. If both are acceptable I…
The specifics, since they change the answer: an 18G drawing needle · semaglutide · 20 mg/mL. I am trying to choose between two options that are usually discussed as…
For reference: SELECT · survodutide. I want to understand what this actually establishes, as opposed to what it is being used to imply. My concern is that I am being…
The particulars: PeptideMeter · CPC. I want to understand what this actually establishes, as opposed to what it is being used to imply. My concern is that I am being…
The specifics, since they change the answer: fibrillation · semaglutide · 25 °C. I would like the mechanism, because I want to be able to reason about the cases…
Numbers first: 99.1% · a C8 column · tirzepatide. This is presented as though it settles something, and I am not convinced it does. I have two documents that appear…
What I have: ESSENCE · hair thinning · 4 mg. This is presented as though it settles something, and I am not convinced it does. I have two documents that appear to…
Stated plainly: 62 kg · 1,400 kcal. The units are where I keep going wrong, so please be explicit about them. I have sanity-checked the order of magnitude and it…
Numbers first: hydrolysis · retatrutide · minus 80 °C. I can predict the outcome but I cannot explain it, which means I will get the next case wrong. I would like to…
I would like to know how much of this is established and how much is a reasonable story. I would rather understand the derivation than memorise the outcome. Two…
I have three data points across nine months, which I hope is enough to see a trend. I want to understand what this actually establishes, as opposed to what it is…
What I am working with: 5 mg · cagrilintide. I keep seeing this stated as a fact with no explanation attached, and unexplained facts make me suspicious. My background…
What I have: 2 mg · dulaglutide. I suspect the usual explanation for this is wrong, or at least incomplete. I am aware this may have a boring answer. I would still…
What I have: an HPLC purity test · orforglipron. I have used one of these for a while and I am considering switching, which requires a reason. What I care about is…
Numbers first: 2 mg · orforglipron. I would rather over-plan the first cycle and simplify later. I am prepared to do the work if someone can tell me which work…
Numbers first: reflux · three · tirzepatide. I would like to understand the steps well enough to explain them to someone else. I have access to a refrigerator with a…
Conditions: semaglutide · 8 mg/mL · three weeks. I want to know whether there is evidence behind this or only repetition. I have checked the obvious registries and…
Conditions: ecnoglutide · 30 mg. I want the working, not the result — I need to be able to redo it with different numbers. I care about the precision as well as the…
Setup, so nobody has to ask: a 27G needle · mazdutide · 4 mg/mL. Both of these get recommended confidently by different people, which suggests neither is obviously…
Numbers first: eGFR · HbA1c · oral semaglutide. I want to know what the trade-off actually is rather than which option is fashionable. I would rather have a…
Setup, so nobody has to ask: dulaglutide · eight weeks · 4 °C. I keep seeing this stated as a fact with no explanation attached, and unexplained facts make me…
The case in front of me: VendorInvestigate · Shanghai Wibson Biotechnology. The figures are clear enough; the question is what they mean and what they do not. I can…
The specifics, since they change the answer: 98.8% · PeptideMeter · 97.6%. Something has gone wrong and I would like to know how badly before I decide what to do.…
What I have: cagrilintide · Janoshik. I can parse the result. I am less sure what it licenses me to conclude. I have deliberately not looked at anyone else’s…