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Is early satiety on a GLP-1 receptor agonist dose-dependent or dose-rate dependent?

Asked 25 Jul 2025Modified 12 months agoViewed 23k times
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Setup, so nobody has to ask: early satiety · a GLP-1 receptor agonist.

The empirical answer seems settled. The explanation does not.

If the honest answer is that nobody knows, I would rather hear that than a plausible story.

What is the causal chain, and where does it stop being established?

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The gastrointestinal cluster as a whole - nausea, vomiting, diarrhoea, constipation, reflux, early satiety - with trial incidence rates, dropout…

416 questions
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askedivo_paunovic15k1825 Jul 2025
7Two of us worked through this independently and arrived here, so it is at least reproducible. – Dr_Ravi_Selvarajah 4 days ago
6Worth adding that the method section is where the answer usually is. – ivo_paunovic 8 months ago
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