Loss of contractile tissue during energy deficit: what fraction of total loss is lean mass, why the commonly quoted figures are measurement artefacts as often as findings, and what mitigates it.
For reference: liraglutide · SURPASS-3. I want to understand what this actually establishes, as opposed to what it is being used to imply. My concern is that I am…
Numbers first: mazdutide · STEP 2. This is presented as though it settles something, and I am not convinced it does. I have two documents that appear to disagree,…
Setup, so nobody has to ask: retatrutide · PIONEER-1. I have read the primary source rather than the summary, which has left me with more questions. I understand the…
The trend is what I care about; individual weeks are obviously noise. I want to understand what this actually establishes, as opposed to what it is being used to…
Stated plainly: retatrutide · STEP 4. I have read the primary source rather than the summary, which has left me with more questions. I understand the headline. I do…
The particulars: oral semaglutide · STEP 2. I have the document in front of me and I can read the numbers. What I cannot do is interpret them. I am reasonably…
I want the floor, not the optimum. I am losing about 0.9 kg a week on tirzepatide and I have limited capacity to train: realistically two sessions a week, 40 minutes…
Intake is tracked, imperfectly, and I am aware of the direction of the error. I suspect the honest answer is that it depends, in which case I would like to know on…
The case in front of me: survodutide · SURMOUNT-4. I would like to know the limits of what can be inferred from this. What I am trying to avoid is over-reading a…
The particulars: liraglutide · TRIUMPH-1. I want to understand what this actually establishes, as opposed to what it is being used to imply. My concern is that I am…
The case in front of me: survodutide · SUSTAIN-6. I would like to know the limits of what can be inferred from this. What I am trying to avoid is over-reading a…
Concretely: ecnoglutide · SURPASS-3. The figures are clear enough; the question is what they mean and what they do not. I can supply the numbers if the specifics…
I would like to know what to measure as much as what to do. Both of these get recommended confidently by different people, which suggests neither is obviously right.…
The case in front of me: ecnoglutide · SOUL. The figures are clear enough; the question is what they mean and what they do not. I can supply the numbers if the…
The specifics, since they change the answer: oral semaglutide · ESSENCE. I want to understand what this actually establishes, as opposed to what it is being used to…
The trend is what I care about; individual weeks are obviously noise. I have used one of these for a while and I am considering switching, which requires a reason.…
I have measured myself three ways inside eight days and got three different stories, and I would like to understand which one to believe before I change anything…
What I have: cagrilintide · STEP 5. I can parse the result. I am less sure what it licenses me to conclude. I have deliberately not looked at anyone else’s…
Stated plainly: dulaglutide · STEP 1. I have read the primary source rather than the summary, which has left me with more questions. I understand the headline. I do…
For reference: tirzepatide · SUSTAIN-6. I have the document in front of me and I can read the numbers. What I cannot do is interpret them. I am reasonably comfortable…
What I have: a GLP-1 receptor agonist · STEP 5. This is presented as though it settles something, and I am not convinced it does. I have two documents that appear to…
Eleven months, 18 kg down. My creatinine has fallen from 1.05 to 0.96 mg/dL and the reported eGFR has gone from 85 to 95. I would like to believe my kidneys have…
The case in front of me: semaglutide · SURPASS-3. The figures are clear enough; the question is what they mean and what they do not. I can supply the numbers if the…
What I have: cagrilintide · REDEFINE-1. I can parse the result. I am less sure what it licenses me to conclude. I have deliberately not looked at anyone else’s…
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