Newest first. 5.2k questions across 107 tags.
Concretely: seven · 1,100 kcal. I want to decide this in advance so that I am not deciding it under pressure later. Assume I will follow the plan I write down, so I…
The case in front of me: VendorInvestigate · MKM. The figures are clear enough; the question is what they mean and what they do not. I can supply the numbers if the…
Concretely: SURMOUNT-1 · vomiting. The figures are clear enough; the question is what they mean and what they do not. I can supply the numbers if the specifics change…
The case in front of me: semaglutide · 2 mg. I want the working, not the result — I need to be able to redo it with different numbers. I care about the precision as…
The case in front of me: constipation · four · orforglipron. I am trying to do this correctly the first time rather than learn it by getting it wrong. I have already…
Concretely: Suzhou · Australia. The figures are clear enough; the question is what they mean and what they do not. I can supply the numbers if the specifics change…
Conditions: 96.4% · method section. The figures are clear enough; the question is what they mean and what they do not. I can supply the numbers if the specifics…
Conditions: semaglutide · SURPASS-3. This is one of those things that everyone repeats and nobody derives. This matters practically, not just academically, because it…
The particulars: SUSTAIN-6 · nausea. I have the document in front of me and I can read the numbers. What I cannot do is interpret them. I am reasonably comfortable…
The particulars: tirzepatide · retatrutide. I am trying to choose between two options that are usually discussed as though only one exists. I am not optimising for…
The particulars: STEP 4 · 5 mg. I have the document in front of me and I can read the numbers. What I cannot do is interpret them. I am reasonably comfortable with…
Eleven months, 18 kg down. My creatinine has fallen from 1.05 to 0.96 mg/dL and the reported eGFR has gone from 85 to 95. I would like to believe my kidneys have…
For reference: QYB · Hunan Aslsen Technology. I am trying to choose between two options that are usually discussed as though only one exists. I am not optimising for…
For reference: 99.4% · PeptideMeter · 98.2% · Janoshik. I am trying to choose between two options that are usually discussed as though only one exists. I am not…
The particulars: tirzepatide · chromatogram. I have the document in front of me and I can read the numbers. What I cannot do is interpret them. I am reasonably…
The deconvolved mass spectrum on a tirzepatide report shows the expected 4813.5 peak plus three satellites I do not understand: one at 4795.5, one at 4814.5 that…
What I am working with: 4 mg/mL · mazdutide. I suspect the honest answer is that it depends, in which case I would like to know on what. Assume I can obtain either…
Stated plainly: 97.9% · Medutest · 96.4% · PeptideMeter. I suspect the honest answer is that it depends, in which case I would like to know on what. Assume I can…
The receptor pharmacology I can follow; the in vivo translation is where I lose the thread. The empirical answer seems settled. The explanation does not. If the…
I am comparing three suppliers on documentation rather than on price. I have read the primary source rather than the summary, which has left me with more questions. I…
I noticed that the placebo arms in this literature do not behave consistently. STEP 1 placebo loses 2.4%. STEP 3 placebo loses 5.7%. SURMOUNT-3 placebo gains 2.5%.…
What I am working with: FLOW · reflux. I have read the primary source rather than the summary, which has left me with more questions. I understand the headline. I do…
Stated plainly: dulaglutide · 30 °C · forty-two days. I am trying to build something sustainable rather than something thorough that I will abandon. I have already…
Setup, so nobody has to ask: FGP · Hangzhou · New Zealand. I am trying to build something sustainable rather than something thorough that I will abandon. I have…