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dosing-math

Page 24 of 34 · 811 questions tagged dosing-math.

811 questions · sorted by votes · page 24 of 34

13 votes 5 answers8.3k views
What is the dead-space loss per draw with a 29G needle at 2.5 mg/mL?

For reference: a 29G needle · 2.5 mg/mL. I would like the arithmetic checked rather than the conclusion asserted. I have deliberately not used an online calculator…

dead-space
dead-space

The volume trapped in the syringe hub and needle after the plunger bottoms out. It is small in absolute terms and large as a fraction of a small…

110 questions
insulin-syringe
insulin-syringe

U-100 and U-40 insulin syringes as measuring instruments. A U-100 syringe is graduated in insulin units where 100 units equals 1 mL, so one unit…

268 questions
dosing-math
dosing-math

The arithmetic itself: milligrams to millilitres to insulin units, concentration after reconstitution, dose per draw, and vial-days per vial. Show…

811 questions
asked by Dr_Otto_Lindqvist 38k · 8 months ago
13 votes4 answers7.9k views
How do I work out vial-days from a concentration and a weekly dose?

I keep a written log of every draw with date, volume and syringe type. This should be a straightforward calculation and I keep getting two different answers. The…

dosing-math
dosing-math

The arithmetic itself: milligrams to millilitres to insulin units, concentration after reconstitution, dose per draw, and vial-days per vial. Show…

811 questions
cost-analysis
cost-analysis

Cost arithmetic done honestly: cost per milligram after dead-space loss, list versus net price, comparing a multi-dose vial to a fixed-dose pen,…

261 questions
diluent-volume
diluent-volume

Choosing how much diluent to add, which is really a question about what you want your measurement resolution to be. Larger volumes buy you…

308 questions
asked by area_percent 13k · 2 months ago
13 votes 5 answers6.9k views
If I reconstitute a 15 mg vial with 5 mL of phosphate-buffered diluent, what concentration do I end up with?

For reference: 15 mg · 5 mL · phosphate-buffered diluent. I would like the arithmetic checked rather than the conclusion asserted. I have deliberately not used an…

reconstitution
reconstitution

Taking a lyophilised vial to a solution of known concentration: choice of diluent, volume selection, how to add liquid without shearing the cake,…

330 questions
diluent-volume
diluent-volume

Choosing how much diluent to add, which is really a question about what you want your measurement resolution to be. Larger volumes buy you…

308 questions
dosing-math
dosing-math

The arithmetic itself: milligrams to millilitres to insulin units, concentration after reconstitution, dose per draw, and vial-days per vial. Show…

811 questions
asked by colm_dunphy 16k · 2 months ago
13 votes 5 answers6.8k views
What does SURMOUNT-2 report at the 50 mg dose level?

What I am working with: SURMOUNT-2 · 50 mg. I have read the primary source rather than the summary, which has left me with more questions. I understand the headline.…

clinical-trials
clinical-trials

Reading the primary literature properly: estimands, intention-to-treat versus per-protocol, confidence intervals, absolute versus relative…

913 questions
dosing-math
dosing-math

The arithmetic itself: milligrams to millilitres to insulin units, concentration after reconstitution, dose per draw, and vial-days per vial. Show…

811 questions
titration
titration

Stepwise dose increases over weeks, why the label schedules exist at all, and what tolerability-driven deviation from a schedule looks like in…

444 questions
asked by oona_kekkonen 16k · 2 months ago
13 votes2 answers6.8k views
Is 8 mg in 5 mL of sterile water for injection a sensible presentation for semaglutide?

Numbers first: 8 mg · 5 mL · sterile water for injection · semaglutide. This is a planning question. I know what my options are; I do not know how to weigh them. What…

diluent-volume
diluent-volume

Choosing how much diluent to add, which is really a question about what you want your measurement resolution to be. Larger volumes buy you…

308 questions
reconstitution
reconstitution

Taking a lyophilised vial to a solution of known concentration: choice of diluent, volume selection, how to add liquid without shearing the cake,…

330 questions
dosing-math
dosing-math

The arithmetic itself: milligrams to millilitres to insulin units, concentration after reconstitution, dose per draw, and vial-days per vial. Show…

811 questions
asked by bea_castellanos 47k · 3 months ago
13 votes 2 answers6.3k views
What is the dead-space loss per draw with a 29G needle at 6.67 mg/mL?

The specifics, since they change the answer: a 29G needle · 6.67 mg/mL. I would rather understand the derivation than memorise the outcome. Two people I asked gave…

dead-space
dead-space

The volume trapped in the syringe hub and needle after the plunger bottoms out. It is small in absolute terms and large as a fraction of a small…

110 questions
insulin-syringe
insulin-syringe

U-100 and U-40 insulin syringes as measuring instruments. A U-100 syringe is graduated in insulin units where 100 units equals 1 mL, so one unit…

268 questions
dosing-math
dosing-math

The arithmetic itself: milligrams to millilitres to insulin units, concentration after reconstitution, dose per draw, and vial-days per vial. Show…

811 questions
asked by zeynep_arslan 20k · 4 months ago
13 votes0 answers6k views
How does oral semaglutide at 60 mg weekly compare on cost per milligram across routes?

The specifics, since they change the answer: oral semaglutide · 60 mg. I would like the arithmetic checked rather than the conclusion asserted. I have deliberately…

cost-analysis
cost-analysis

Cost arithmetic done honestly: cost per milligram after dead-space loss, list versus net price, comparing a multi-dose vial to a fixed-dose pen,…

261 questions
vendor-comparison
vendor-comparison

Side-by-side comparison of suppliers on measurable axes - independently confirmed purity and content, lead time, cold-chain handling,…

351 questions
dosing-math
dosing-math

The arithmetic itself: milligrams to millilitres to insulin units, concentration after reconstitution, dose per draw, and vial-days per vial. Show…

811 questions
asked by threadlock7 14k · 7 months ago
13 votes0 answers5.3k views
How does cagrilintide at 40 mg weekly compare on cost per milligram across routes?

Numbers first: cagrilintide · 40 mg. This should be a straightforward calculation and I keep getting two different answers. The numbers are arbitrary; the method is…

cost-analysis
cost-analysis

Cost arithmetic done honestly: cost per milligram after dead-space loss, list versus net price, comparing a multi-dose vial to a fixed-dose pen,…

261 questions
vendor-comparison
vendor-comparison

Side-by-side comparison of suppliers on measurable axes - independently confirmed purity and content, lead time, cold-chain handling,…

351 questions
dosing-math
dosing-math

The arithmetic itself: milligrams to millilitres to insulin units, concentration after reconstitution, dose per draw, and vial-days per vial. Show…

811 questions
asked by unit_math 13k · 6 months ago
13 votes5 answers5k views
Can I reconstitute retatrutide at 5 mg/mL and still measure a small dose accurately?

What I am working with: retatrutide · 5 mg/mL. I would like to set this up properly once, rather than adjust it repeatedly. My budget is real but not tight, and my…

diluent-volume
diluent-volume

Choosing how much diluent to add, which is really a question about what you want your measurement resolution to be. Larger volumes buy you…

308 questions
insulin-syringe
insulin-syringe

U-100 and U-40 insulin syringes as measuring instruments. A U-100 syringe is graduated in insulin units where 100 units equals 1 mL, so one unit…

268 questions
dosing-math
dosing-math

The arithmetic itself: milligrams to millilitres to insulin units, concentration after reconstitution, dose per draw, and vial-days per vial. Show…

811 questions
asked by petra_hovland 42k · 3 months ago
13 votes 4 answers4.9k views
Can I reconstitute mazdutide at 6.67 mg/mL and still measure a small dose accurately?

Details up front: mazdutide · 6.67 mg/mL. I would rather over-plan the first cycle and simplify later. I am prepared to do the work if someone can tell me which work…

diluent-volume
diluent-volume

Choosing how much diluent to add, which is really a question about what you want your measurement resolution to be. Larger volumes buy you…

308 questions
insulin-syringe
insulin-syringe

U-100 and U-40 insulin syringes as measuring instruments. A U-100 syringe is graduated in insulin units where 100 units equals 1 mL, so one unit…

268 questions
dosing-math
dosing-math

The arithmetic itself: milligrams to millilitres to insulin units, concentration after reconstitution, dose per draw, and vial-days per vial. Show…

811 questions
asked by RP_C18 85k · 8 months ago
13 votes0 answers3.9k views
Does splitting a 30 mg weekly dose of dulaglutide across two administrations change anything?

What I have: 30 mg · dulaglutide. I suspect the usual explanation for this is wrong, or at least incomplete. I am aware this may have a boring answer. I would still…

split-dosing
split-dosing

Dividing a weekly dose across more than one administration. Questions here concern the pharmacokinetic rationale, whether the peak-to-trough ratio…

39 questions
dosing-math
dosing-math

The arithmetic itself: milligrams to millilitres to insulin units, concentration after reconstitution, dose per draw, and vial-days per vial. Show…

811 questions
glp1-mechanism
glp1-mechanism

Receptor-level pharmacology: GLP-1R as a class B GPCR, cAMP and PKA signalling, biased agonism, internalisation and resensitisation, and the…

175 questions
asked by net_peptide 16k · 4 months ago
12 votes 5 answers27k views
What is the dead-space loss per draw with a 27G needle at 3.33 mg/mL?

Concretely: a 27G needle · 3.33 mg/mL. Please show the division. I want to check my own against yours. I would like the general form as well as the specific number,…

dead-space
dead-space

The volume trapped in the syringe hub and needle after the plunger bottoms out. It is small in absolute terms and large as a fraction of a small…

110 questions
insulin-syringe
insulin-syringe

U-100 and U-40 insulin syringes as measuring instruments. A U-100 syringe is graduated in insulin units where 100 units equals 1 mL, so one unit…

268 questions
dosing-math
dosing-math

The arithmetic itself: milligrams to millilitres to insulin units, concentration after reconstitution, dose per draw, and vial-days per vial. Show…

811 questions
asked by bridget_nyathi 16k · 18 months ago
12 votes 5 answers27k views
How do I get 25 units out of a vial reconstituted to 10 mg/mL without guessing?

The specifics, since they change the answer: 25 units · 10 mg/mL. I want a method I can write down and repeat, not a rule of thumb. I would rather over-engineer this…

insulin-syringe
insulin-syringe

U-100 and U-40 insulin syringes as measuring instruments. A U-100 syringe is graduated in insulin units where 100 units equals 1 mL, so one unit…

268 questions
dosing-math
dosing-math

The arithmetic itself: milligrams to millilitres to insulin units, concentration after reconstitution, dose per draw, and vial-days per vial. Show…

811 questions
diluent-volume
diluent-volume

Choosing how much diluent to add, which is really a question about what you want your measurement resolution to be. Larger volumes buy you…

308 questions
asked by ten_mg_vial 16k · 19 months ago
12 votes 5 answers27k views
How does mazdutide at 40 mg weekly compare on cost per milligram across routes?

What I have: mazdutide · 40 mg. This should be a straightforward calculation and I keep getting two different answers. The numbers are arbitrary; the method is what I…

cost-analysis
cost-analysis

Cost arithmetic done honestly: cost per milligram after dead-space loss, list versus net price, comparing a multi-dose vial to a fixed-dose pen,…

261 questions
vendor-comparison
vendor-comparison

Side-by-side comparison of suppliers on measurable axes - independently confirmed purity and content, lead time, cold-chain handling,…

351 questions
dosing-math
dosing-math

The arithmetic itself: milligrams to millilitres to insulin units, concentration after reconstitution, dose per draw, and vial-days per vial. Show…

811 questions
asked by ben_akintola 14k · 21 months ago
12 votes5 answers23k views
If I reconstitute a 10 mg vial with 5 mL of 0.9% sodium chloride, what concentration do I end up with?

Concretely: 10 mg · 5 mL · 0.9% sodium chloride. I want the working, not the result — I need to be able to redo it with different numbers. I care about the precision…

reconstitution
reconstitution

Taking a lyophilised vial to a solution of known concentration: choice of diluent, volume selection, how to add liquid without shearing the cake,…

330 questions
diluent-volume
diluent-volume

Choosing how much diluent to add, which is really a question about what you want your measurement resolution to be. Larger volumes buy you…

308 questions
dosing-math
dosing-math

The arithmetic itself: milligrams to millilitres to insulin units, concentration after reconstitution, dose per draw, and vial-days per vial. Show…

811 questions
asked by dead_volume 49k · 16 months ago
12 votes 5 answers22k views
How many units on a U-100 insulin syringe is a 2.5 mg dose at 2 mg/mL?

Numbers first: a U-100 insulin syringe · 2.5 mg · 2 mg/mL. This should be a straightforward calculation and I keep getting two different answers. The numbers are…

dosing-math
dosing-math

The arithmetic itself: milligrams to millilitres to insulin units, concentration after reconstitution, dose per draw, and vial-days per vial. Show…

811 questions
insulin-syringe
insulin-syringe

U-100 and U-40 insulin syringes as measuring instruments. A U-100 syringe is graduated in insulin units where 100 units equals 1 mL, so one unit…

268 questions
reconstitution
reconstitution

Taking a lyophilised vial to a solution of known concentration: choice of diluent, volume selection, how to add liquid without shearing the cake,…

330 questions
asked by fib4_reader 35k · 2.3 years ago
12 votes5 answers21k views
Is there a pharmacokinetic case for moving cagrilintide injection day by five days?

Details up front: cagrilintide · five days. I can predict the outcome but I cannot explain it, which means I will get the next case wrong. I would like to know how…

missed-dose
missed-dose

What the label instructions for a missed weekly dose are, why they differ between agents, and what the pharmacokinetics say about drift in an…

41 questions
glp1-mechanism
glp1-mechanism

Receptor-level pharmacology: GLP-1R as a class B GPCR, cAMP and PKA signalling, biased agonism, internalisation and resensitisation, and the…

175 questions
dosing-math
dosing-math

The arithmetic itself: milligrams to millilitres to insulin units, concentration after reconstitution, dose per draw, and vial-days per vial. Show…

811 questions
asked by Dr_Ingrid_Baumgartner 39k · 2.2 years ago
12 votes 5 answers20k views
What is the dead-space loss per draw with a 18G drawing needle at 6.67 mg/mL?

The specifics, since they change the answer: an 18G drawing needle · 6.67 mg/mL. I would like the arithmetic checked rather than the conclusion asserted. I have…

dead-space
dead-space

The volume trapped in the syringe hub and needle after the plunger bottoms out. It is small in absolute terms and large as a fraction of a small…

110 questions
insulin-syringe
insulin-syringe

U-100 and U-40 insulin syringes as measuring instruments. A U-100 syringe is graduated in insulin units where 100 units equals 1 mL, so one unit…

268 questions
dosing-math
dosing-math

The arithmetic itself: milligrams to millilitres to insulin units, concentration after reconstitution, dose per draw, and vial-days per vial. Show…

811 questions
asked by nkem_obiora 46k · 2.2 years ago
12 votes5 answers17k views
Why do two papers on SURMOUNT-2 report different headline figures?

I have the full paper rather than the abstract, and the supplementary appendix. I understand the observation; what I do not understand is the mechanism behind it. I…

clinical-trials
clinical-trials

Reading the primary literature properly: estimands, intention-to-treat versus per-protocol, confidence intervals, absolute versus relative…

913 questions
dosing-math
dosing-math

The arithmetic itself: milligrams to millilitres to insulin units, concentration after reconstitution, dose per draw, and vial-days per vial. Show…

811 questions
semaglutide
semaglutide

A GLP-1 receptor agonist with a fatty-acid-acylated backbone and a roughly one-week half-life, marketed for type 2 diabetes and for weight…

360 questions
asked by ilaria_bertone 43k · 22 months ago
12 votes 5 answers14k views
How many vial-days does a 20 mg vial give at 3.33 mg/mL on a weekly schedule?

Stated plainly: 20 mg · 3.33 mg/mL. The units are where I keep going wrong, so please be explicit about them. I have sanity-checked the order of magnitude and it…

dosing-math
dosing-math

The arithmetic itself: milligrams to millilitres to insulin units, concentration after reconstitution, dose per draw, and vial-days per vial. Show…

811 questions
cost-analysis
cost-analysis

Cost arithmetic done honestly: cost per milligram after dead-space loss, list versus net price, comparing a multi-dose vial to a fixed-dose pen,…

261 questions
diluent-volume
diluent-volume

Choosing how much diluent to add, which is really a question about what you want your measurement resolution to be. Larger volumes buy you…

308 questions
asked by mira_sundqvist 19k · 6 months ago
12 votes 5 answers12k views
Can I reconstitute ecnoglutide at 2 mg/mL and still measure a small dose accurately?

Concretely: ecnoglutide · 2 mg/mL. The failure mode I am trying to avoid is making this decision emotionally. I have twelve months in view and I would like the plan…

diluent-volume
diluent-volume

Choosing how much diluent to add, which is really a question about what you want your measurement resolution to be. Larger volumes buy you…

308 questions
insulin-syringe
insulin-syringe

U-100 and U-40 insulin syringes as measuring instruments. A U-100 syringe is graduated in insulin units where 100 units equals 1 mL, so one unit…

268 questions
dosing-math
dosing-math

The arithmetic itself: milligrams to millilitres to insulin units, concentration after reconstitution, dose per draw, and vial-days per vial. Show…

811 questions
asked by tri_gly_ala 48k · 16 months ago
12 votes 5 answers9.9k views
Is 10 mg in 0.5 mL of 0.9% sodium chloride a sensible presentation for a GLP-1 receptor agonist?

The case in front of me: 10 mg · 0.5 mL · 0.9% sodium chloride · a GLP-1 receptor agonist. I want to decide this in advance so that I am not deciding it under…

diluent-volume
diluent-volume

Choosing how much diluent to add, which is really a question about what you want your measurement resolution to be. Larger volumes buy you…

308 questions
reconstitution
reconstitution

Taking a lyophilised vial to a solution of known concentration: choice of diluent, volume selection, how to add liquid without shearing the cake,…

330 questions
dosing-math
dosing-math

The arithmetic itself: milligrams to millilitres to insulin units, concentration after reconstitution, dose per draw, and vial-days per vial. Show…

811 questions
asked by rania_haddad 17k · 4 months ago
12 votes1 answer8.7k views
If I reconstitute a 30 mg vial with 2 mL of sterile water for injection, what concentration do I end up with?

What I have: 30 mg · 2 mL · sterile water for injection. I can do the algebra. I am not confident about the conversion factors. If there is a standard way to lay this…

reconstitution
reconstitution

Taking a lyophilised vial to a solution of known concentration: choice of diluent, volume selection, how to add liquid without shearing the cake,…

330 questions
diluent-volume
diluent-volume

Choosing how much diluent to add, which is really a question about what you want your measurement resolution to be. Larger volumes buy you…

308 questions
dosing-math
dosing-math

The arithmetic itself: milligrams to millilitres to insulin units, concentration after reconstitution, dose per draw, and vial-days per vial. Show…

811 questions
asked by ben_akintola 14k · 8 months ago
12 votes 5 answers8.4k views
How many units on a 0.3 mL insulin syringe is a 20 mg dose at 20 mg/mL?

The specifics, since they change the answer: a 0.3 mL insulin syringe · 20 mg · 20 mg/mL. I would like the arithmetic checked rather than the conclusion asserted. I…

dosing-math
dosing-math

The arithmetic itself: milligrams to millilitres to insulin units, concentration after reconstitution, dose per draw, and vial-days per vial. Show…

811 questions
insulin-syringe
insulin-syringe

U-100 and U-40 insulin syringes as measuring instruments. A U-100 syringe is graduated in insulin units where 100 units equals 1 mL, so one unit…

268 questions
reconstitution
reconstitution

Taking a lyophilised vial to a solution of known concentration: choice of diluent, volume selection, how to add liquid without shearing the cake,…

330 questions
asked by ten_mg_vial 16k · 5 months ago