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gip-receptor

Page 3 of 4 · 83 questions tagged gip-receptor.

83 questions · sorted by votes · page 3 of 4

16 votes5 answers24k views
What does the mechanism of ecnoglutide predict that STEP 8 did not test?

Concretely: ecnoglutide · STEP 8. I want to know whether this is a real physical effect or an artefact of how it is measured. What prompted the question is an…

glp1-mechanism
glp1-mechanism

Receptor-level pharmacology: GLP-1R as a class B GPCR, cAMP and PKA signalling, biased agonism, internalisation and resensitisation, and the…

175 questions
clinical-trials
clinical-trials

Reading the primary literature properly: estimands, intention-to-treat versus per-protocol, confidence intervals, absolute versus relative…

913 questions
gip-receptor
gip-receptor

GIP receptor pharmacology, and the still-unsettled question of whether agonism or antagonism at GIPR is the metabolically useful direction.…

83 questions
asked by swirl_dont_shake 19k · 16 months ago
16 votes5 answers22k views
What does the mechanism of liraglutide predict that REDEFINE-1 did not test?

The specifics, since they change the answer: liraglutide · REDEFINE-1. I understand the observation; what I do not understand is the mechanism behind it. I have read…

glp1-mechanism
glp1-mechanism

Receptor-level pharmacology: GLP-1R as a class B GPCR, cAMP and PKA signalling, biased agonism, internalisation and resensitisation, and the…

175 questions
clinical-trials
clinical-trials

Reading the primary literature properly: estimands, intention-to-treat versus per-protocol, confidence intervals, absolute versus relative…

913 questions
gip-receptor
gip-receptor

GIP receptor pharmacology, and the still-unsettled question of whether agonism or antagonism at GIPR is the metabolically useful direction.…

83 questions
asked by leah_ferrers 15k · 19 months ago
16 votes 5 answers9.9k views
What does the mechanism of dulaglutide predict that ESSENCE did not test?

What I am working with: dulaglutide · ESSENCE. The empirical answer seems settled. The explanation does not. If the honest answer is that nobody knows, I would rather…

glp1-mechanism
glp1-mechanism

Receptor-level pharmacology: GLP-1R as a class B GPCR, cAMP and PKA signalling, biased agonism, internalisation and resensitisation, and the…

175 questions
clinical-trials
clinical-trials

Reading the primary literature properly: estimands, intention-to-treat versus per-protocol, confidence intervals, absolute versus relative…

913 questions
gip-receptor
gip-receptor

GIP receptor pharmacology, and the still-unsettled question of whether agonism or antagonism at GIPR is the metabolically useful direction.…

83 questions
orforglipron
orforglipron

A non-peptide, orally bioavailable small-molecule GLP-1 receptor agonist studied in the ATTAIN programme. It is not a peptide, which changes…

14 questions
asked by micron22 36k · 4 months ago
15 votes 5 answers11k views
What does the mechanism of cagrilintide predict that PIONEER-4 did not test?

Numbers first: cagrilintide · PIONEER-4. I suspect the usual explanation for this is wrong, or at least incomplete. I am aware this may have a boring answer. I would…

glp1-mechanism
glp1-mechanism

Receptor-level pharmacology: GLP-1R as a class B GPCR, cAMP and PKA signalling, biased agonism, internalisation and resensitisation, and the…

175 questions
clinical-trials
clinical-trials

Reading the primary literature properly: estimands, intention-to-treat versus per-protocol, confidence intervals, absolute versus relative…

913 questions
gip-receptor
gip-receptor

GIP receptor pharmacology, and the still-unsettled question of whether agonism or antagonism at GIPR is the metabolically useful direction.…

83 questions
asked by halvard_ness 42k · 4 months ago
14 votes 5 answers26k views
What does the mechanism of orforglipron predict that REDEFINE-1 did not test?

Stated plainly: orforglipron · REDEFINE-1. The empirical answer seems settled. The explanation does not. If the honest answer is that nobody knows, I would rather…

glp1-mechanism
glp1-mechanism

Receptor-level pharmacology: GLP-1R as a class B GPCR, cAMP and PKA signalling, biased agonism, internalisation and resensitisation, and the…

175 questions
clinical-trials
clinical-trials

Reading the primary literature properly: estimands, intention-to-treat versus per-protocol, confidence intervals, absolute versus relative…

913 questions
gip-receptor
gip-receptor

GIP receptor pharmacology, and the still-unsettled question of whether agonism or antagonism at GIPR is the metabolically useful direction.…

83 questions
asked by haze_check 17k · 16 months ago
14 votes 5 answers5.3k views
What does the mechanism of cagrilintide predict that SURMOUNT-4 did not test?

What I have: cagrilintide · SURMOUNT-4. I can predict the outcome but I cannot explain it, which means I will get the next case wrong. I would like to know how…

glp1-mechanism
glp1-mechanism

Receptor-level pharmacology: GLP-1R as a class B GPCR, cAMP and PKA signalling, biased agonism, internalisation and resensitisation, and the…

175 questions
clinical-trials
clinical-trials

Reading the primary literature properly: estimands, intention-to-treat versus per-protocol, confidence intervals, absolute versus relative…

913 questions
gip-receptor
gip-receptor

GIP receptor pharmacology, and the still-unsettled question of whether agonism or antagonism at GIPR is the metabolically useful direction.…

83 questions
asked by Dr_Rosalind_Achebe 90k · 27 days ago
13 votes 4 answers8k views
What does the mechanism of oral semaglutide predict that STEP 2 did not test?

For reference: oral semaglutide · STEP 2. I would like the mechanism, because I want to be able to reason about the cases nobody has written about. I have tried to…

glp1-mechanism
glp1-mechanism

Receptor-level pharmacology: GLP-1R as a class B GPCR, cAMP and PKA signalling, biased agonism, internalisation and resensitisation, and the…

175 questions
clinical-trials
clinical-trials

Reading the primary literature properly: estimands, intention-to-treat versus per-protocol, confidence intervals, absolute versus relative…

913 questions
gip-receptor
gip-receptor

GIP receptor pharmacology, and the still-unsettled question of whether agonism or antagonism at GIPR is the metabolically useful direction.…

83 questions
asked by retest_please 13k · 7 months ago
13 votes5 answers5.8k views
What does the mechanism of semaglutide predict that SELECT did not test?

Conditions: semaglutide · SELECT. I want to know whether this is a real physical effect or an artefact of how it is measured. What prompted the question is an…

glp1-mechanism
glp1-mechanism

Receptor-level pharmacology: GLP-1R as a class B GPCR, cAMP and PKA signalling, biased agonism, internalisation and resensitisation, and the…

175 questions
clinical-trials
clinical-trials

Reading the primary literature properly: estimands, intention-to-treat versus per-protocol, confidence intervals, absolute versus relative…

913 questions
gip-receptor
gip-receptor

GIP receptor pharmacology, and the still-unsettled question of whether agonism or antagonism at GIPR is the metabolically useful direction.…

83 questions
asked by gunnar_isaksen 16k · 28 days ago
12 votes0 answers9.9k views
What does the mechanism of a GLP-1 receptor agonist predict that PIONEER-1 did not test?

Numbers first: a GLP-1 receptor agonist · PIONEER-1. I suspect the usual explanation for this is wrong, or at least incomplete. I am aware this may have a boring…

glp1-mechanism
glp1-mechanism

Receptor-level pharmacology: GLP-1R as a class B GPCR, cAMP and PKA signalling, biased agonism, internalisation and resensitisation, and the…

175 questions
clinical-trials
clinical-trials

Reading the primary literature properly: estimands, intention-to-treat versus per-protocol, confidence intervals, absolute versus relative…

913 questions
gip-receptor
gip-receptor

GIP receptor pharmacology, and the still-unsettled question of whether agonism or antagonism at GIPR is the metabolically useful direction.…

83 questions
asked by s_bhattacharya 42k · 2.1 years ago
12 votes 4 answers4.8k views
What does the mechanism of semaglutide predict that PIONEER-1 did not test?

Conditions: semaglutide · PIONEER-1. I want to know whether this is a real physical effect or an artefact of how it is measured. What prompted the question is an…

glp1-mechanism
glp1-mechanism

Receptor-level pharmacology: GLP-1R as a class B GPCR, cAMP and PKA signalling, biased agonism, internalisation and resensitisation, and the…

175 questions
clinical-trials
clinical-trials

Reading the primary literature properly: estimands, intention-to-treat versus per-protocol, confidence intervals, absolute versus relative…

913 questions
gip-receptor
gip-receptor

GIP receptor pharmacology, and the still-unsettled question of whether agonism or antagonism at GIPR is the metabolically useful direction.…

83 questions
asked by haze_check 17k · 44 days ago
11 votes 5 answers20k views
What does the mechanism of orforglipron predict that PIONEER-1 did not test?

What I am working with: orforglipron · PIONEER-1. I keep seeing this stated as a fact with no explanation attached, and unexplained facts make me suspicious. My…

glp1-mechanism
glp1-mechanism

Receptor-level pharmacology: GLP-1R as a class B GPCR, cAMP and PKA signalling, biased agonism, internalisation and resensitisation, and the…

175 questions
clinical-trials
clinical-trials

Reading the primary literature properly: estimands, intention-to-treat versus per-protocol, confidence intervals, absolute versus relative…

913 questions
gip-receptor
gip-receptor

GIP receptor pharmacology, and the still-unsettled question of whether agonism or antagonism at GIPR is the metabolically useful direction.…

83 questions
asked by Dr_Wren_Halliday 40k · 23 months ago
11 votes5 answers8.2k views
What does the mechanism of dulaglutide predict that FLOW did not test?

Stated plainly: dulaglutide · FLOW. The empirical answer seems settled. The explanation does not. If the honest answer is that nobody knows, I would rather hear that…

glp1-mechanism
glp1-mechanism

Receptor-level pharmacology: GLP-1R as a class B GPCR, cAMP and PKA signalling, biased agonism, internalisation and resensitisation, and the…

175 questions
clinical-trials
clinical-trials

Reading the primary literature properly: estimands, intention-to-treat versus per-protocol, confidence intervals, absolute versus relative…

913 questions
gip-receptor
gip-receptor

GIP receptor pharmacology, and the still-unsettled question of whether agonism or antagonism at GIPR is the metabolically useful direction.…

83 questions
asked by Dr_Sara_Kuusela 46k · 15 months ago
9 votes 4 answers22k views
What does the mechanism of a GLP-1 receptor agonist predict that TRIUMPH-1 did not test?

Numbers first: a GLP-1 receptor agonist · TRIUMPH-1. I suspect the usual explanation for this is wrong, or at least incomplete. I am aware this may have a boring…

glp1-mechanism
glp1-mechanism

Receptor-level pharmacology: GLP-1R as a class B GPCR, cAMP and PKA signalling, biased agonism, internalisation and resensitisation, and the…

175 questions
clinical-trials
clinical-trials

Reading the primary literature properly: estimands, intention-to-treat versus per-protocol, confidence intervals, absolute versus relative…

913 questions
gip-receptor
gip-receptor

GIP receptor pharmacology, and the still-unsettled question of whether agonism or antagonism at GIPR is the metabolically useful direction.…

83 questions
asked by pieter_maas 22k · 22 months ago
8 votes 5 answers17k views
What does the mechanism of semaglutide predict that STEP 5 did not test?

Conditions: semaglutide · STEP 5. This is one of those things that everyone repeats and nobody derives. This matters practically, not just academically, because it…

glp1-mechanism
glp1-mechanism

Receptor-level pharmacology: GLP-1R as a class B GPCR, cAMP and PKA signalling, biased agonism, internalisation and resensitisation, and the…

175 questions
clinical-trials
clinical-trials

Reading the primary literature properly: estimands, intention-to-treat versus per-protocol, confidence intervals, absolute versus relative…

913 questions
gip-receptor
gip-receptor

GIP receptor pharmacology, and the still-unsettled question of whether agonism or antagonism at GIPR is the metabolically useful direction.…

83 questions
asked by olu_babatunde 14k · 23 months ago
8 votes 5 answers2.5k views
What does the mechanism of retatrutide predict that PIONEER-1 did not test?

Stated plainly: retatrutide · PIONEER-1. The empirical answer seems settled. The explanation does not. If the honest answer is that nobody knows, I would rather hear…

glp1-mechanism
glp1-mechanism

Receptor-level pharmacology: GLP-1R as a class B GPCR, cAMP and PKA signalling, biased agonism, internalisation and resensitisation, and the…

175 questions
clinical-trials
clinical-trials

Reading the primary literature properly: estimands, intention-to-treat versus per-protocol, confidence intervals, absolute versus relative…

913 questions
gip-receptor
gip-receptor

GIP receptor pharmacology, and the still-unsettled question of whether agonism or antagonism at GIPR is the metabolically useful direction.…

83 questions
asked by area_percent 13k · 3 months ago
8 votes0 answers2.4k views
What does the mechanism of mazdutide predict that SUSTAIN-6 did not test?

Numbers first: mazdutide · SUSTAIN-6. I can predict the outcome but I cannot explain it, which means I will get the next case wrong. I would like to know how…

glp1-mechanism
glp1-mechanism

Receptor-level pharmacology: GLP-1R as a class B GPCR, cAMP and PKA signalling, biased agonism, internalisation and resensitisation, and the…

175 questions
clinical-trials
clinical-trials

Reading the primary literature properly: estimands, intention-to-treat versus per-protocol, confidence intervals, absolute versus relative…

913 questions
gip-receptor
gip-receptor

GIP receptor pharmacology, and the still-unsettled question of whether agonism or antagonism at GIPR is the metabolically useful direction.…

83 questions
asked by tare_and_weigh 18k · 5 months ago
7 votes 5 answers17k views
What does the mechanism of dulaglutide predict that TRIUMPH-3 did not test?

Stated plainly: dulaglutide · TRIUMPH-3. I keep seeing this stated as a fact with no explanation attached, and unexplained facts make me suspicious. My background is…

glp1-mechanism
glp1-mechanism

Receptor-level pharmacology: GLP-1R as a class B GPCR, cAMP and PKA signalling, biased agonism, internalisation and resensitisation, and the…

175 questions
clinical-trials
clinical-trials

Reading the primary literature properly: estimands, intention-to-treat versus per-protocol, confidence intervals, absolute versus relative…

913 questions
gip-receptor
gip-receptor

GIP receptor pharmacology, and the still-unsettled question of whether agonism or antagonism at GIPR is the metabolically useful direction.…

83 questions
asked by vial_five 15k · 17 months ago
7 votes 5 answers11k views
Is GIP agonism or antagonism the metabolically useful direction?

The receptor pharmacology I can follow; the in vivo translation is where I lose the thread. I would like the axes of comparison first and the recommendation second. I…

gip-receptor
gip-receptor

GIP receptor pharmacology, and the still-unsettled question of whether agonism or antagonism at GIPR is the metabolically useful direction.…

83 questions
tirzepatide
tirzepatide

A dual GIP and GLP-1 receptor agonist. Questions here cover the SURPASS and SURMOUNT programmes, the practical differences from a pure GLP-1…

162 questions
glp1-mechanism
glp1-mechanism

Receptor-level pharmacology: GLP-1R as a class B GPCR, cAMP and PKA signalling, biased agonism, internalisation and resensitisation, and the…

175 questions
retatrutide
retatrutide

An investigational GLP-1, GIP and glucagon receptor tri-agonist, studied in the TRIUMPH programme. Not approved anywhere. Use this tag for…

14 questions
asked by marcus_thorbjorn 16k · 6 months ago
7 votes 2 answers2.4k views
What does the mechanism of ecnoglutide predict that SOUL did not test?

Conditions: ecnoglutide · SOUL. This is one of those things that everyone repeats and nobody derives. This matters practically, not just academically, because it…

glp1-mechanism
glp1-mechanism

Receptor-level pharmacology: GLP-1R as a class B GPCR, cAMP and PKA signalling, biased agonism, internalisation and resensitisation, and the…

175 questions
clinical-trials
clinical-trials

Reading the primary literature properly: estimands, intention-to-treat versus per-protocol, confidence intervals, absolute versus relative…

913 questions
gip-receptor
gip-receptor

GIP receptor pharmacology, and the still-unsettled question of whether agonism or antagonism at GIPR is the metabolically useful direction.…

83 questions
asked by hana_petrikova 19k · 5 months ago
6 votes0 answers7.5k views
What does the mechanism of liraglutide predict that PIONEER-4 did not test?

The particulars: liraglutide · PIONEER-4. I understand the observation; what I do not understand is the mechanism behind it. I have read the two review articles that…

glp1-mechanism
glp1-mechanism

Receptor-level pharmacology: GLP-1R as a class B GPCR, cAMP and PKA signalling, biased agonism, internalisation and resensitisation, and the…

175 questions
clinical-trials
clinical-trials

Reading the primary literature properly: estimands, intention-to-treat versus per-protocol, confidence intervals, absolute versus relative…

913 questions
gip-receptor
gip-receptor

GIP receptor pharmacology, and the still-unsettled question of whether agonism or antagonism at GIPR is the metabolically useful direction.…

83 questions
asked by tandem_gradient 85k · 19 months ago
6 votes 3 answers5.5k views
What does the mechanism of survodutide predict that REDEFINE-1 did not test?

The case in front of me: survodutide · REDEFINE-1. This is one of those things that everyone repeats and nobody derives. This matters practically, not just…

glp1-mechanism
glp1-mechanism

Receptor-level pharmacology: GLP-1R as a class B GPCR, cAMP and PKA signalling, biased agonism, internalisation and resensitisation, and the…

175 questions
clinical-trials
clinical-trials

Reading the primary literature properly: estimands, intention-to-treat versus per-protocol, confidence intervals, absolute versus relative…

913 questions
gip-receptor
gip-receptor

GIP receptor pharmacology, and the still-unsettled question of whether agonism or antagonism at GIPR is the metabolically useful direction.…

83 questions
asked by ivo_paunovic 15k · 3 months ago
6 votes0 answers2.2k views
What does the mechanism of tirzepatide predict that ESSENCE did not test?

The particulars: tirzepatide · ESSENCE. I understand the observation; what I do not understand is the mechanism behind it. I have read the two review articles that…

glp1-mechanism
glp1-mechanism

Receptor-level pharmacology: GLP-1R as a class B GPCR, cAMP and PKA signalling, biased agonism, internalisation and resensitisation, and the…

175 questions
clinical-trials
clinical-trials

Reading the primary literature properly: estimands, intention-to-treat versus per-protocol, confidence intervals, absolute versus relative…

913 questions
gip-receptor
gip-receptor

GIP receptor pharmacology, and the still-unsettled question of whether agonism or antagonism at GIPR is the metabolically useful direction.…

83 questions
retatrutide
retatrutide

An investigational GLP-1, GIP and glucagon receptor tri-agonist, studied in the TRIUMPH programme. Not approved anywhere. Use this tag for…

14 questions
glucagon-receptor
glucagon-receptor

Glucagon receptor agonism as a deliberate component of dual and tri-agonists: what it adds in energy expenditure and hepatic fat mobilisation, and…

14 questions
asked by ravenna_pace 13k · 4 months ago
5 votes 5 answers12k views
What does the mechanism of survodutide predict that ATTAIN-1 did not test?

Conditions: survodutide · ATTAIN-1. I want to know whether this is a real physical effect or an artefact of how it is measured. What prompted the question is an…

glp1-mechanism
glp1-mechanism

Receptor-level pharmacology: GLP-1R as a class B GPCR, cAMP and PKA signalling, biased agonism, internalisation and resensitisation, and the…

175 questions
clinical-trials
clinical-trials

Reading the primary literature properly: estimands, intention-to-treat versus per-protocol, confidence intervals, absolute versus relative…

913 questions
gip-receptor
gip-receptor

GIP receptor pharmacology, and the still-unsettled question of whether agonism or antagonism at GIPR is the metabolically useful direction.…

83 questions
orforglipron
orforglipron

A non-peptide, orally bioavailable small-molecule GLP-1 receptor agonist studied in the ATTAIN programme. It is not a peptide, which changes…

14 questions
asked by oona_kekkonen 16k · 2.1 years ago
5 votes3 answers6.6k views
What does the mechanism of ecnoglutide predict that STEP 2 did not test?

The case in front of me: ecnoglutide · STEP 2. This is one of those things that everyone repeats and nobody derives. This matters practically, not just academically,…

glp1-mechanism
glp1-mechanism

Receptor-level pharmacology: GLP-1R as a class B GPCR, cAMP and PKA signalling, biased agonism, internalisation and resensitisation, and the…

175 questions
clinical-trials
clinical-trials

Reading the primary literature properly: estimands, intention-to-treat versus per-protocol, confidence intervals, absolute versus relative…

913 questions
gip-receptor
gip-receptor

GIP receptor pharmacology, and the still-unsettled question of whether agonism or antagonism at GIPR is the metabolically useful direction.…

83 questions
asked by yuki_morishita 19k · 7 months ago