Clinically meaningful loss of muscle mass and function, particularly in older adults on treatment. Distinguishing a proportional reduction from a functional deficit, and the strength and gait-speed measures that matter.
The case in front of me: twelve · 1,400 kcal. I want to decide this in advance so that I am not deciding it under pressure later. Assume I will follow the plan I…
The specifics, since they change the answer: 81 kg · 1,200 kcal. I would rather understand the derivation than memorise the outcome. Two people I asked gave two…
I am trying to calibrate how likely it is that GI side effects end up being the reason someone stops, as opposed to being an unpleasant thing they get through. The…
I would like to sanity-check the electrolyte question with numbers rather than by adding a supplement and seeing what happens. My hypothesis is that the reason people…
Scale weight, waist circumference and a repetition maximum, all logged weekly. I suspect the honest answer is that it depends, in which case I would like to know on…
Stated plainly: headache · 900 kcal. I noticed this today and I have not touched anything since, in case the state is diagnostic. I have not discarded anything yet,…
What I have: cagrilintide · SURMOUNT-2. This is presented as though it settles something, and I am not convinced it does. I have two documents that appear to…
What I have: mazdutide · SURMOUNT-1. I can parse the result. I am less sure what it licenses me to conclude. I have deliberately not looked at anyone else’s…
What I am working with: dulaglutide · PIONEER-1. I would like help reading this properly rather than being told what conclusion to reach. I have the full report…
Details up front: cagrilintide · ATTAIN-1. I can parse the result. I am less sure what it licenses me to conclude. I have deliberately not looked at anyone else’s…
The case in front of me: ecnoglutide · SURMOUNT-5. I would like to know the limits of what can be inferred from this. What I am trying to avoid is over-reading a…
Intake is tracked, imperfectly, and I am aware of the direction of the error. I think I have a problem. I am not yet sure whether it is a real problem or a…
Concretely: semaglutide · SURMOUNT-2. The figures are clear enough; the question is what they mean and what they do not. I can supply the numbers if the specifics…
Setup, so nobody has to ask: 95 kg · 1,400 kcal. The units are where I keep going wrong, so please be explicit about them. I have sanity-checked the order of…
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