Page 23 of 35 · 832 questions tagged peptide-stability.
The material is still sealed, so I have not committed to anything yet. I understand the observation; what I do not understand is the mechanism behind it. I have read…
Concretely: semaglutide · 8 mg/mL. I have done this once and I suspect I got away with it rather than got it right. For context: I keep records of every batch, every…
The specifics, since they change the answer: deamidation · ecnoglutide · 37 °C. I would like the mechanism, because I want to be able to reason about the cases nobody…
The specifics, since they change the answer: deamidation · semaglutide · 30 °C. I understand the observation; what I do not understand is the mechanism behind it. I…
Details up front: hydrolysis · dulaglutide · 30 °C. I suspect the usual explanation for this is wrong, or at least incomplete. I am aware this may have a boring…
Details up front: racemisation · retatrutide · VendorInvestigate. I can find plenty of assertions about this and almost no reasoning, which is usually a sign that…
Details up front: cagrilintide · 4 °C. I would like to understand the steps well enough to explain them to someone else. I have access to a refrigerator with a logger…
Details up front: hydrolysis · retatrutide · 40 °C. I can predict the outcome but I cannot explain it, which means I will get the next case wrong. I would like to…
For reference: deamidation · 30 °C. I would like the mechanism, because I want to be able to reason about the cases nobody has written about. I have tried to reason…
The case in front of me: oxidation · oral semaglutide · Janoshik. I have done this once and I suspect I got away with it rather than got it right. For context: I keep…
Details up front: racemisation · retatrutide · 30 °C. I suspect the usual explanation for this is wrong, or at least incomplete. I am aware this may have a boring…
Concretely: aspartimide formation · tirzepatide · 25 °C. This is one of those things that everyone repeats and nobody derives. This matters practically, not just…
Setup, so nobody has to ask: dimerisation · 2–8 °C. The empirical answer seems settled. The explanation does not. If the honest answer is that nobody knows, I would…
What I am working with: aggregation · 37 °C. I keep seeing this stated as a fact with no explanation attached, and unexplained facts make me suspicious. My background…
Stated plainly: orforglipron · 5 mg/mL. I have worked this out and I would like someone to find the error, because I suspect there is one. My working so far, for the…
Stated plainly: dimerisation · cagrilintide · minus 80 °C. I keep seeing this stated as a fact with no explanation attached, and unexplained facts make me suspicious.…
For reference: fibrillation · semaglutide · 37 °C. I understand the observation; what I do not understand is the mechanism behind it. I have read the two review…
The case in front of me: room temperature · liraglutide. I want to know whether there is evidence behind this or only repetition. I have checked the obvious…
For reference: tirzepatide · minus 80 °C · fourteen days. I am at the decision point and I would rather think it through than improvise. I would rather spend money on…
Conditions: 4 °C · oral semaglutide. I want to know whether there is evidence behind this or only repetition. I have checked the obvious registries and monographs…
Setup, so nobody has to ask: 25 °C · mazdutide. This has the shape of a fact but I cannot find its origin. What I found instead were three secondary sources all…
What I am working with: dulaglutide · minus 80 °C. Everything I have found on this is either a forum aside or a product page, neither of which I trust. I am…
Conditions: semaglutide · minus 20 °C. I have done this once and I suspect I got away with it rather than got it right. For context: I keep records of every batch,…
The case in front of me: aspartimide formation · liraglutide · minus 20 °C. This is one of those things that everyone repeats and nobody derives. This matters…