dermot_kiely
Reading the primary literature slowly and out of order.
14kreputation
31answers
5accepted
27questions
0·1·7badges g·s·b
54tags
39How do I compute the +4 charge state m/z for a peptide of 4207.2 Da?5 answers, accepted · 65k views · mass-spec, dosing-math, purity37Does fibrillation dominate for semaglutide held at 4 °C?5 answers · 64k views · peptide-stability, storage, hplc27How much protein in grams do I need at 74 kg on 900 kcal a day?3 answers, accepted · 29k views · protein-intake, nutrition, lean-mass26Does deamidation dominate for semaglutide held at room temperature?5 answers, accepted · 14k views · peptide-stability, storage, hplc26What counter-ion should I expect on a QYB semaglutide lot?5 answers · 44k views · acetate-content, purity, content-assay26Why did two TFC lots of oral semaglutide differ on content assay?5 answers, accepted · 25k views · batch-testing, content-assay, vendor-vetting24What does the mechanism of tirzepatide predict that STEP 4 did not test?5 answers, accepted · 22k views · glp1-mechanism, clinical-trials, gip-receptor21Does reflux at week five of a GLP-1 receptor agonist usually resolve without a dose change?0 answers · 15k views · gi-side-effects, titration, nausea21Is 60 mg in 0.5 mL of bacteriostatic water a sensible presentation for oral semaglutide?5 answers, accepted · 10k views · diluent-volume, reconstitution, dosing-math19What does an HPLC purity test add for dulaglutide that a purity figure does not?5 answers, accepted · 11k views · content-assay, purity, coa19What does "identity confirmed" mean without a quantified content figure?5 answers, accepted · 21k views · coa, content-assay, mass-spec18Is a 27G needle the right choice for drawing tirzepatide at 10 mg/mL?5 answers · 19k views · needle-gauge, injection-technique, dead-space17My survodutide vial sat at 25 °C for twenty-one days — is testing worth it before use?5 answers · 9.5k views · cold-chain, peptide-stability, batch-testing17Would you accept 98.2% on dulaglutide from SSA without a content assay?5 answers, accepted · 29k views · purity, content-assay, vendor-vetting15How many units on a 1 mL luer-lock syringe is a 40 mg dose at 3.33 mg/mL?2 answers, accepted · 5.1k views · dosing-math, insulin-syringe, reconstitution15What is the dead-space loss per draw with a 30G needle at 5 mg/mL?5 answers, accepted · 26k views · dead-space, insulin-syringe, dosing-math13How do I compare KP and QSC on lead time to Japan?0 answers · 3.1k views · vendor-comparison, international-shipping, cold-chain13How much of the gross mass of a 50 mg survodutide vial is actually peptide?1 answer, accepted · 3.6k views · content-assay, water-content, acetate-content13What should I ask a supplier before ordering that they cannot fake?5 answers · 13k views · vendor-vetting, coa, batch-testing12Would you accept 97.9% on dulaglutide from GL Biochem without a content assay?5 answers, accepted · 34k views · purity, content-assay, vendor-vetting10How do I interpret a creatinine trend across three draws?4 answers · 11k views · bloodwork, a1c, lipids9How do VendorInvestigate and PeptideMeter compare on the same mazdutide batch?2 answers · 8.9k views · janoshik, medutest, batch-testing9Is a mini-fridge good enough for storing reconstituted semaglutide?1 answer, accepted · 2.8k views · storage, cold-chain, harm-reduction9Is TRIUMPH-3 a fair comparison of ecnoglutide against its comparator arm?0 answers · 6.1k views · clinical-trials, semaglutide, tirzepatide8Does semaglutide adsorb measurably to the vial wall at 8 mg/mL?5 answers, accepted · 7.8k views · peptide-stability, content-assay, storage8If a GLP-1 receptor agonist dose is missed by twenty-one days, does the ladder reset?5 answers, accepted · 17k views · missed-dose, titration, dosing-math5How would I detect racemisation in a dulaglutide vial without sending it to VendorInvestigate?5 answers, accepted · 7.4k views · vial-inspection, peptide-stability, harm-reduction