Page 5 of 39 · 913 questions tagged clinical-trials.
What I am working with: retatrutide · retatrutide. I suspect the honest answer is that it depends, in which case I would like to know on what. Assume I can obtain…
Concretely: SOUL · tirzepatide. The figures are clear enough; the question is what they mean and what they do not. I can supply the numbers if the specifics change…
Details up front: a GLP-1 receptor agonist · SURMOUNT-4. I can predict the outcome but I cannot explain it, which means I will get the next case wrong. I would like…
What I am working with: SURMOUNT-5 · cagrilintide. I have read the primary source rather than the summary, which has left me with more questions. I understand the…
Numbers first: cagrilintide · FLOW. I suspect the usual explanation for this is wrong, or at least incomplete. I am aware this may have a boring answer. I would still…
What I have: a GLP-1 receptor agonist · 2–8 °C. I would rather be corrected now than propagate something wrong. I am specifically not interested in a testimonial; I…
Setup, so nobody has to ask: SUSTAIN-6 · vomiting. I have read the primary source rather than the summary, which has left me with more questions. I understand the…
The US labelling for several drugs in this class carries a boxed warning about thyroid C-cell tumours, and it is stated fairly starkly — tumours in both rats and…
The specifics, since they change the answer: 4 mg · survodutide. I am at the decision point and I would rather think it through than improvise. I would rather spend…
I have reached a weight I am happy with on tirzepatide 12.5 mg and I do not want to keep losing. Cost is a factor and so is the fact that I would rather take less of…
Stated plainly: orforglipron · mazdutide. I suspect the honest answer is that it depends, in which case I would like to know on what. Assume I can obtain either…
1.6 g/kg is quoted as though it were a physical constant. I would like to know what study it came from, what population, and whether the conditions of that study…
My eGFR is 92 and has been for years, which I had taken to mean my kidneys were not a topic. A urine albumin:creatinine ratio was added to a recent panel and came…
What I am working with: orforglipron · SURMOUNT-OSA. The empirical answer seems settled. The explanation does not. If the honest answer is that nobody knows, I would…
What I am working with: orforglipron · 40 °C. This has the shape of a fact but I cannot find its origin. What I found instead were three secondary sources all citing…
Stated plainly: dulaglutide · STEP 1. I keep seeing this stated as a fact with no explanation attached, and unexplained facts make me suspicious. My background is…
Setup, so nobody has to ask: ATTAIN-1 · cagrilintide. This has the shape of a fact but I cannot find its origin. What I found instead were three secondary sources all…
For reference: liraglutide · STEP 3. I understand the observation; what I do not understand is the mechanism behind it. I have read the two review articles that come…
My laboratory results are from the same laboratory each time, drawn fasting, which I gather matters. Please show the division. I want to check my own against yours. I…
What I have: SURPASS-3 · dulaglutide. I can parse the result. I am less sure what it licenses me to conclude. I have deliberately not looked at anyone else’s…
My laboratory results are from the same laboratory each time, drawn fasting, which I gather matters. I want to know whether this is a real physical effect or an…
The specifics, since they change the answer: SUSTAIN-6 · ecnoglutide. I want to understand what this actually establishes, as opposed to what it is being used to…
This is a question about interpretation, not about whether to act — I will take action questions elsewhere. I keep seeing this stated as a fact with no explanation…
My laboratory results are from the same laboratory each time, drawn fasting, which I gather matters. I want the working, not the result — I need to be able to redo it…