Page 6 of 39 · 913 questions tagged clinical-trials.
I keep seeing SELECT summarised as "semaglutide cuts heart attacks and strokes by 20%". I understand that 20% comes from the hazard ratio of 0.80, and I understand…
Details up front: mazdutide · minus 20 °C. I would rather be corrected now than propagate something wrong. I am specifically not interested in a testimonial; I am…
What I have: FLOW · dulaglutide. I can parse the result. I am less sure what it licenses me to conclude. I have deliberately not looked at anyone else’s…
For reference: oral semaglutide · liraglutide. The comparison I want does not seem to exist anywhere in a form I can evaluate. I have read the arguments for each and…
What I have: SURMOUNT-2 · hair thinning. I can parse the result. I am less sure what it licenses me to conclude. I have deliberately not looked at anyone else’s…
Details up front: ATTAIN-1 · early satiety · 50 mg. I can parse the result. I am less sure what it licenses me to conclude. I have deliberately not looked at anyone…
The case in front of me: early satiety · tirzepatide · SURMOUNT-4. I would like to know the limits of what can be inferred from this. What I am trying to avoid is…
Details up front: ESSENCE · constipation · 15 mg. This is presented as though it settles something, and I am not convinced it does. I have two documents that appear…
The particulars: tirzepatide · SOUL. I would like the mechanism, because I want to be able to reason about the cases nobody has written about. I have tried to reason…
What I have: 30 mg · retatrutide. I would rather over-plan the first cycle and simplify later. I am prepared to do the work if someone can tell me which work matters.…
I am reading the trial table rather than the press release, which is why the numbers differ. I can predict the outcome but I cannot explain it, which means I will get…
Numbers first: SURMOUNT-2 · nausea · 15 mg. I can parse the result. I am less sure what it licenses me to conclude. I have deliberately not looked at anyone else’s…
Stated plainly: retatrutide · cagrilintide. I suspect the honest answer is that it depends, in which case I would like to know on what. Assume I can obtain either…
For reference: REDEFINE-1 · semaglutide. I want to understand what this actually establishes, as opposed to what it is being used to imply. My concern is that I am…
For reference: STEP 2 · nausea. I want to understand what this actually establishes, as opposed to what it is being used to imply. My concern is that I am being…
Numbers first: STEP 8 · 10 mg. This is presented as though it settles something, and I am not convinced it does. I have two documents that appear to disagree, which…
Details up front: SURMOUNT-3 · dulaglutide. This is presented as though it settles something, and I am not convinced it does. I have two documents that appear to…
The case in front of me: TRIUMPH-3 · tirzepatide. I would like to know the limits of what can be inferred from this. What I am trying to avoid is over-reading a…
Concretely: PIONEER-4 · tirzepatide. I would like to know the limits of what can be inferred from this. What I am trying to avoid is over-reading a single result,…
Setup, so nobody has to ask: SUSTAIN-6 · reflux · 10 mg. I have read the primary source rather than the summary, which has left me with more questions. I understand…
Conditions: semaglutide · SURPASS-3. This is one of those things that everyone repeats and nobody derives. This matters practically, not just academically, because it…
Stated plainly: SURMOUNT-2 · reflux. I have read the primary source rather than the summary, which has left me with more questions. I understand the headline. I do…
Concretely: ESSENCE · 2 mg. I would like to know the limits of what can be inferred from this. What I am trying to avoid is over-reading a single result, which I have…
What I have: SURMOUNT-1 · headache · 50 mg. I can parse the result. I am less sure what it licenses me to conclude. I have deliberately not looked at anyone else’s…