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coa

Page 14 of 32 · 749 questions tagged coa.

749 questions · sorted by votes · page 14 of 32

21 votes5 answers17k views
Why is a residual-solvent figure almost never on a research certificate?

I have the report as a PDF with the chromatogram on page two, so I can quote specifics. I would like the mechanism, because I want to be able to reason about the…

residual-solvent
residual-solvent

Solvents left behind by synthesis and purification - acetonitrile, TFA, DMF, DCM - their ICH limits, how they are measured by headspace GC, and…

14 questions
coa
coa

Certificates of analysis: what fields a useful one carries, how to tell a real analytical report from a marketing document, batch and lot…

749 questions
purity
purity

Purity as chromatographic area per cent - the fraction of detected material that is your target peak. It says nothing about how much material is…

788 questions
asked by fill_volume 13k · 2.2 years ago
21 votes0 answers15k views
How do I reconcile 98.8% from PeptideMeter with 97.6% from the supplier?

The specifics, since they change the answer: 98.8% · PeptideMeter · 97.6%. Something has gone wrong and I would like to know how badly before I decide what to do.…

purity
purity

Purity as chromatographic area per cent - the fraction of detected material that is your target peak. It says nothing about how much material is…

788 questions
batch-testing
batch-testing

Testing at the batch or lot level: sampling plans, how many vials from a lot need testing to say anything about the lot, and the difference…

865 questions
coa
coa

Certificates of analysis: what fields a useful one carries, how to tell a real analytical report from a marketing document, batch and lot…

749 questions
asked by Dr_Priya_Raghunathan 94k · 2.2 years ago
21 votes5 answers12k views
How do I reconcile 97.9% from Medutest with 98.8% from the supplier?

Stated plainly: 97.9% · Medutest · 98.8%. I noticed this today and I have not touched anything since, in case the state is diagnostic. I have not discarded anything…

purity
purity

Purity as chromatographic area per cent - the fraction of detected material that is your target peak. It says nothing about how much material is…

788 questions
batch-testing
batch-testing

Testing at the batch or lot level: sampling plans, how many vials from a lot need testing to say anything about the lot, and the difference…

865 questions
coa
coa

Certificates of analysis: what fields a useful one carries, how to tell a real analytical report from a marketing document, batch and lot…

749 questions
asked by tess_amankwah 48k · 5 months ago
21 votes 4 answers12k views
Has anyone independently verified a KP orforglipron batch COA?

What I have: KP · orforglipron. I am asking for verification rather than opinion, ideally with something I can read myself. It is possible the evidence exists and I…

vendor-vetting
vendor-vetting

Evaluating a supplier on evidence rather than reputation: testing history across batches, whether certificates are batch-specific, how failures…

436 questions
coa
coa

Certificates of analysis: what fields a useful one carries, how to tell a real analytical report from a marketing document, batch and lot…

749 questions
batch-testing
batch-testing

Testing at the batch or lot level: sampling plans, how many vials from a lot need testing to say anything about the lot, and the difference…

865 questions
asked by mateo_iglesias 16k · 3 months ago
21 votes 4 answers11k views
What does a 98.8% purity with a list of related substances attached let me conclude?

For reference: 98.8% · list of related substances. I have the document in front of me and I can read the numbers. What I cannot do is interpret them. I am reasonably…

purity
purity

Purity as chromatographic area per cent - the fraction of detected material that is your target peak. It says nothing about how much material is…

788 questions
coa
coa

Certificates of analysis: what fields a useful one carries, how to tell a real analytical report from a marketing document, batch and lot…

749 questions
hplc
hplc

Reverse-phase high-performance liquid chromatography, the workhorse purity method. Column chemistry, mobile-phase choice, gradient slope,…

466 questions
asked by ben_akintola 14k · 15 months ago
21 votes0 answers9.3k views
How do I read a cagrilintide chromatogram from Janoshik beyond the headline number?

What I have: cagrilintide · Janoshik. I can parse the result. I am less sure what it licenses me to conclude. I have deliberately not looked at anyone else’s…

hplc
hplc

Reverse-phase high-performance liquid chromatography, the workhorse purity method. Column chemistry, mobile-phase choice, gradient slope,…

466 questions
purity
purity

Purity as chromatographic area per cent - the fraction of detected material that is your target peak. It says nothing about how much material is…

788 questions
coa
coa

Certificates of analysis: what fields a useful one carries, how to tell a real analytical report from a marketing document, batch and lot…

749 questions
asked by zeynep_arslan 20k · 2.2 years ago
21 votes4 answers8.9k views
What does a batch certificate on an ERP report change about how I read it?

What I have: batch certificate · ERP. This is presented as though it settles something, and I am not convinced it does. I have two documents that appear to disagree,…

coa
coa

Certificates of analysis: what fields a useful one carries, how to tell a real analytical report from a marketing document, batch and lot…

749 questions
batch-testing
batch-testing

Testing at the batch or lot level: sampling plans, how many vials from a lot need testing to say anything about the lot, and the difference…

865 questions
vendor-vetting
vendor-vetting

Evaluating a supplier on evidence rather than reputation: testing history across batches, whether certificates are batch-specific, how failures…

436 questions
asked by cold_lane 14k · 5 months ago
21 votes 4 answers6.9k views
What makes something a "certified reference material", and why is my content result only as good as the standard?

Every explanation of quantitative HPLC I have read says the result is traceable to the reference standard, and then moves on as though that settles it. I want to open…

reference-standard
reference-standard

Certified reference materials and in-house standards: traceability, the certificate of the standard itself, system suitability, and why every…

179 questions
content-assay
content-assay

Quantified content: how many milligrams of peptide are actually in the vial, measured against a calibrated reference standard. A separate test…

438 questions
coa
coa

Certificates of analysis: what fields a useful one carries, how to tell a real analytical report from a marketing document, batch and lot…

749 questions
batch-testing
batch-testing

Testing at the batch or lot level: sampling plans, how many vials from a lot need testing to say anything about the lot, and the difference…

865 questions
purity
purity

Purity as chromatographic area per cent - the fraction of detected material that is your target peak. It says nothing about how much material is…

788 questions
asked by lukas_sedlacek 17k · 16 months ago
21 votes 3 answers5.2k views
Can peptide mapping detect a D-amino acid or a scrambled sequence that co-elutes with the main peak?

The recurring point in this tag is that stereoisomers and sequence isomers are invisible to mass spectrometry. I accept that for intact mass. What I want to know is…

peptide-mapping
peptide-mapping

Enzymatic digestion followed by LC-MS/MS to confirm sequence rather than just mass. The method that catches a scrambled sequence or a D-amino-acid…

83 questions
purity
purity

Purity as chromatographic area per cent - the fraction of detected material that is your target peak. It says nothing about how much material is…

788 questions
lc-ms
lc-ms

Liquid chromatography coupled to mass spectrometry: separation and identification in one run, and the method of choice when you need to know not…

14 questions
coa
coa

Certificates of analysis: what fields a useful one carries, how to tell a real analytical report from a marketing document, batch and lot…

749 questions
reference-standard
reference-standard

Certified reference materials and in-house standards: traceability, the certificate of the standard itself, system suitability, and why every…

179 questions
asked by Dr_Jonas_Halvorsen 41k · 6 months ago
20 votes5 answers39k views
How does BCH compare to Shanghai Sigma-Audley on documentation quality?

What I am working with: BCH · Shanghai Sigma-Audley. Both of these get recommended confidently by different people, which suggests neither is obviously right. My…

vendor-comparison
vendor-comparison

Side-by-side comparison of suppliers on measurable axes - independently confirmed purity and content, lead time, cold-chain handling,…

351 questions
coa
coa

Certificates of analysis: what fields a useful one carries, how to tell a real analytical report from a marketing document, batch and lot…

749 questions
vendor-vetting
vendor-vetting

Evaluating a supplier on evidence rather than reputation: testing history across batches, whether certificates are batch-specific, how failures…

436 questions
asked by fiadh_cronin 14k · 2.3 years ago
20 votes5 answers38k views
How do I reconcile 98.2% from Medutest with 99.1% from the supplier?

Setup, so nobody has to ask: 98.2% · Medutest · 99.1%. This is not behaving the way I expected and I want to understand the discrepancy before I act on it. I have…

purity
purity

Purity as chromatographic area per cent - the fraction of detected material that is your target peak. It says nothing about how much material is…

788 questions
batch-testing
batch-testing

Testing at the batch or lot level: sampling plans, how many vials from a lot need testing to say anything about the lot, and the difference…

865 questions
coa
coa

Certificates of analysis: what fields a useful one carries, how to tell a real analytical report from a marketing document, batch and lot…

749 questions
asked by cal_hennessy 14k · 2.2 years ago
20 votes 4 answers31k views
How do I trace a CPC lot number back to a synthesis date?

The method section is present, which is unusual enough that I want to make use of it. I am trying to do this correctly the first time rather than learn it by getting…

batch-testing
batch-testing

Testing at the batch or lot level: sampling plans, how many vials from a lot need testing to say anything about the lot, and the difference…

865 questions
coa
coa

Certificates of analysis: what fields a useful one carries, how to tell a real analytical report from a marketing document, batch and lot…

749 questions
vendor-vetting
vendor-vetting

Evaluating a supplier on evidence rather than reputation: testing history across batches, whether certificates are batch-specific, how failures…

436 questions
asked by priya_menon 11k · 23 months ago
20 votes 5 answers30k views
What does 99.4% purity on a C4 column actually tell me about an orforglipron vial?

Conditions: 99.4% · a C4 column · orforglipron. I would like to know the limits of what can be inferred from this. What I am trying to avoid is over-reading a single…

hplc
hplc

Reverse-phase high-performance liquid chromatography, the workhorse purity method. Column chemistry, mobile-phase choice, gradient slope,…

466 questions
purity
purity

Purity as chromatographic area per cent - the fraction of detected material that is your target peak. It says nothing about how much material is…

788 questions
coa
coa

Certificates of analysis: what fields a useful one carries, how to tell a real analytical report from a marketing document, batch and lot…

749 questions
asked by harriet_lonsdale 14k · 19 months ago
20 votes 5 answers28k views
What accept/reject threshold would you set for ecnoglutide before seeing the result?

The method section is present, which is unusual enough that I want to make use of it. I want to decide this in advance so that I am not deciding it under pressure…

batch-testing
batch-testing

Testing at the batch or lot level: sampling plans, how many vials from a lot need testing to say anything about the lot, and the difference…

865 questions
harm-reduction
harm-reduction

Reducing avoidable risk where a decision has already been made: independent verification before use, sterility practice, dose arithmetic checked…

445 questions
coa
coa

Certificates of analysis: what fields a useful one carries, how to tell a real analytical report from a marketing document, batch and lot…

749 questions
asked by anders_vestby 17k · 19 months ago
20 votes5 answers26k views
How does SGN compare to Bachem Holding (Suzhou) on documentation quality?

What I have: SGN · Bachem Holding (Suzhou). I have used one of these for a while and I am considering switching, which requires a reason. What I care about is…

vendor-comparison
vendor-comparison

Side-by-side comparison of suppliers on measurable axes - independently confirmed purity and content, lead time, cold-chain handling,…

351 questions
coa
coa

Certificates of analysis: what fields a useful one carries, how to tell a real analytical report from a marketing document, batch and lot…

749 questions
vendor-vetting
vendor-vetting

Evaluating a supplier on evidence rather than reputation: testing history across batches, whether certificates are batch-specific, how failures…

436 questions
asked by swab_stopper 16k · 13 months ago
20 votes 5 answers24k views
What does a 95.2% purity with a batch certificate attached let me conclude?

What I am working with: 95.2% · batch certificate. I have read the primary source rather than the summary, which has left me with more questions. I understand the…

purity
purity

Purity as chromatographic area per cent - the fraction of detected material that is your target peak. It says nothing about how much material is…

788 questions
coa
coa

Certificates of analysis: what fields a useful one carries, how to tell a real analytical report from a marketing document, batch and lot…

749 questions
hplc
hplc

Reverse-phase high-performance liquid chromatography, the workhorse purity method. Column chemistry, mobile-phase choice, gradient slope,…

466 questions
asked by leonid_marchuk 15k · 20 months ago
20 votes5 answers24k views
How do I trace an HJ lot number back to a synthesis date?

The method section is present, which is unusual enough that I want to make use of it. I have done this once and I suspect I got away with it rather than got it right.…

batch-testing
batch-testing

Testing at the batch or lot level: sampling plans, how many vials from a lot need testing to say anything about the lot, and the difference…

865 questions
coa
coa

Certificates of analysis: what fields a useful one carries, how to tell a real analytical report from a marketing document, batch and lot…

749 questions
vendor-vetting
vendor-vetting

Evaluating a supplier on evidence rather than reputation: testing history across batches, whether certificates are batch-specific, how failures…

436 questions
asked by greta_holzmann 15k · 21 months ago
20 votes0 answers22k views
Why does my content assay disagree with the label by more than purity would allow?

The method section is present, which is unusual enough that I want to make use of it. I noticed this today and I have not touched anything since, in case the state is…

content-assay
content-assay

Quantified content: how many milligrams of peptide are actually in the vial, measured against a calibrated reference standard. A separate test…

438 questions
purity
purity

Purity as chromatographic area per cent - the fraction of detected material that is your target peak. It says nothing about how much material is…

788 questions
coa
coa

Certificates of analysis: what fields a useful one carries, how to tell a real analytical report from a marketing document, batch and lot…

749 questions
asked by pieter_maas 22k · 2.2 years ago
20 votes 5 answers20k views
What is traceability, in practical terms, for a reference material?

The method section is present, which is unusual enough that I want to make use of it. I keep seeing this stated as a fact with no explanation attached, and…

reference-standard
reference-standard

Certified reference materials and in-house standards: traceability, the certificate of the standard itself, system suitability, and why every…

179 questions
coa
coa

Certificates of analysis: what fields a useful one carries, how to tell a real analytical report from a marketing document, batch and lot…

749 questions
content-assay
content-assay

Quantified content: how many milligrams of peptide are actually in the vial, measured against a calibrated reference standard. A separate test…

438 questions
asked by ahmed_zerouali 19k · 23 months ago
20 votes 3 answers19k views
Is a batch certificate from QSC sufficient basis to skip independent testing?

Numbers first: batch certificate · QSC. I would rather over-plan the first cycle and simplify later. I am prepared to do the work if someone can tell me which work…

coa
coa

Certificates of analysis: what fields a useful one carries, how to tell a real analytical report from a marketing document, batch and lot…

749 questions
batch-testing
batch-testing

Testing at the batch or lot level: sampling plans, how many vials from a lot need testing to say anything about the lot, and the difference…

865 questions
harm-reduction
harm-reduction

Reducing avoidable risk where a decision has already been made: independent verification before use, sterility practice, dose arithmetic checked…

445 questions
asked by deamidation_watch 43k · 17 months ago
20 votes 5 answers19k views
Has anyone independently verified a QST liraglutide batch COA?

Conditions: QST · liraglutide. I want to know whether there is evidence behind this or only repetition. I have checked the obvious registries and monographs without…

vendor-vetting
vendor-vetting

Evaluating a supplier on evidence rather than reputation: testing history across batches, whether certificates are batch-specific, how failures…

436 questions
coa
coa

Certificates of analysis: what fields a useful one carries, how to tell a real analytical report from a marketing document, batch and lot…

749 questions
batch-testing
batch-testing

Testing at the batch or lot level: sampling plans, how many vials from a lot need testing to say anything about the lot, and the difference…

865 questions
asked by ekaterina_volk 16k · 15 months ago
20 votes 5 answers17k views
Would you re-test retatrutide after eight weeks at 4 °C, or accept the original certificate?

Setup, so nobody has to ask: retatrutide · eight weeks · 4 °C. I would like to set this up properly once, rather than adjust it repeatedly. My budget is real but not…

batch-testing
batch-testing

Testing at the batch or lot level: sampling plans, how many vials from a lot need testing to say anything about the lot, and the difference…

865 questions
peptide-stability
peptide-stability

The chemistry of peptide degradation: deamidation, oxidation, hydrolysis, aggregation and fibrillation, and how temperature, pH, ionic strength,…

832 questions
coa
coa

Certificates of analysis: what fields a useful one carries, how to tell a real analytical report from a marketing document, batch and lot…

749 questions
asked by fiadh_cronin 14k · 2.1 years ago
20 votes 5 answers17k views
Does SSA issue lot-specific documentation, or a batch certificate?

I have the report as a PDF with the chromatogram on page two, so I can quote specifics. I have the document in front of me and I can read the numbers. What I cannot…

batch-testing
batch-testing

Testing at the batch or lot level: sampling plans, how many vials from a lot need testing to say anything about the lot, and the difference…

865 questions
coa
coa

Certificates of analysis: what fields a useful one carries, how to tell a real analytical report from a marketing document, batch and lot…

749 questions
vendor-vetting
vendor-vetting

Evaluating a supplier on evidence rather than reputation: testing history across batches, whether certificates are batch-specific, how failures…

436 questions
asked by orla_sheridan 14k · 13 months ago
20 votes 5 answers17k views
What does a 99.4% purity with a date of analysis attached let me conclude?

Concretely: 99.4% · date of analysis. I would like to know the limits of what can be inferred from this. What I am trying to avoid is over-reading a single result,…

purity
purity

Purity as chromatographic area per cent - the fraction of detected material that is your target peak. It says nothing about how much material is…

788 questions
coa
coa

Certificates of analysis: what fields a useful one carries, how to tell a real analytical report from a marketing document, batch and lot…

749 questions
hplc
hplc

Reverse-phase high-performance liquid chromatography, the workhorse purity method. Column chemistry, mobile-phase choice, gradient slope,…

466 questions
asked by rhian_prydderch 44k · 15 months ago