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dosing-math

Page 10 of 34 · 811 questions tagged dosing-math.

811 questions · sorted by votes · page 10 of 34

26 votes 5 answers25k views
Why do two papers on SOUL report different headline figures?

I have the full paper rather than the abstract, and the supplementary appendix. I can predict the outcome but I cannot explain it, which means I will get the next…

clinical-trials
clinical-trials

Reading the primary literature properly: estimands, intention-to-treat versus per-protocol, confidence intervals, absolute versus relative…

913 questions
dosing-math
dosing-math

The arithmetic itself: milligrams to millilitres to insulin units, concentration after reconstitution, dose per draw, and vial-days per vial. Show…

811 questions
semaglutide
semaglutide

A GLP-1 receptor agonist with a fatty-acid-acylated backbone and a roughly one-week half-life, marketed for type 2 diabetes and for weight…

360 questions
asked by m_haraldsen 38k · 9 months ago
26 votes 5 answers22k views
How many units on a U-40 insulin syringe is a 4 mg dose at 10 mg/mL?

Setup, so nobody has to ask: a U-40 insulin syringe · 4 mg · 10 mg/mL. The units are where I keep going wrong, so please be explicit about them. I have sanity-checked…

dosing-math
dosing-math

The arithmetic itself: milligrams to millilitres to insulin units, concentration after reconstitution, dose per draw, and vial-days per vial. Show…

811 questions
insulin-syringe
insulin-syringe

U-100 and U-40 insulin syringes as measuring instruments. A U-100 syringe is graduated in insulin units where 100 units equals 1 mL, so one unit…

268 questions
reconstitution
reconstitution

Taking a lyophilised vial to a solution of known concentration: choice of diluent, volume selection, how to add liquid without shearing the cake,…

330 questions
asked by gel_pack_warm 13k · 8 months ago
26 votes 2 answers21k views
How do I get 10 units out of a vial reconstituted to 10 mg/mL without guessing?

What I have: 10 units · 10 mg/mL. I would like to understand the steps well enough to explain them to someone else. I have access to a refrigerator with a logger and…

insulin-syringe
insulin-syringe

U-100 and U-40 insulin syringes as measuring instruments. A U-100 syringe is graduated in insulin units where 100 units equals 1 mL, so one unit…

268 questions
dosing-math
dosing-math

The arithmetic itself: milligrams to millilitres to insulin units, concentration after reconstitution, dose per draw, and vial-days per vial. Show…

811 questions
diluent-volume
diluent-volume

Choosing how much diluent to add, which is really a question about what you want your measurement resolution to be. Larger volumes buy you…

308 questions
asked by anja_hellstrom 13k · 17 months ago
26 votes0 answers18k views
How many units on a U-100 insulin syringe is a 5 mg dose at 2 mg/mL?

The particulars: a U-100 insulin syringe · 5 mg · 2 mg/mL. I would like the arithmetic checked rather than the conclusion asserted. I have deliberately not used an…

dosing-math
dosing-math

The arithmetic itself: milligrams to millilitres to insulin units, concentration after reconstitution, dose per draw, and vial-days per vial. Show…

811 questions
insulin-syringe
insulin-syringe

U-100 and U-40 insulin syringes as measuring instruments. A U-100 syringe is graduated in insulin units where 100 units equals 1 mL, so one unit…

268 questions
reconstitution
reconstitution

Taking a lyophilised vial to a solution of known concentration: choice of diluent, volume selection, how to add liquid without shearing the cake,…

330 questions
asked by mira_sundqvist 19k · 23 months ago
26 votes 5 answers18k views
What is the arithmetic to convert 10 mg in 2 mL into units on a U-100 scale?

Conditions: 10 mg · 2 mL. I want the working, not the result — I need to be able to redo it with different numbers. I care about the precision as well as the value —…

dosing-math
dosing-math

The arithmetic itself: milligrams to millilitres to insulin units, concentration after reconstitution, dose per draw, and vial-days per vial. Show…

811 questions
insulin-syringe
insulin-syringe

U-100 and U-40 insulin syringes as measuring instruments. A U-100 syringe is graduated in insulin units where 100 units equals 1 mL, so one unit…

268 questions
reconstitution
reconstitution

Taking a lyophilised vial to a solution of known concentration: choice of diluent, volume selection, how to add liquid without shearing the cake,…

330 questions
asked by coring_risk 17k · 9 months ago
26 votes5 answers17k views
What is the arithmetic to convert 30 mg in 1 mL into units on a U-100 scale?

Details up front: 30 mg · 1 mL. This should be a straightforward calculation and I keep getting two different answers. The numbers are arbitrary; the method is what I…

dosing-math
dosing-math

The arithmetic itself: milligrams to millilitres to insulin units, concentration after reconstitution, dose per draw, and vial-days per vial. Show…

811 questions
insulin-syringe
insulin-syringe

U-100 and U-40 insulin syringes as measuring instruments. A U-100 syringe is graduated in insulin units where 100 units equals 1 mL, so one unit…

268 questions
reconstitution
reconstitution

Taking a lyophilised vial to a solution of known concentration: choice of diluent, volume selection, how to add liquid without shearing the cake,…

330 questions
asked by swab_stopper 16k · 7 months ago
26 votes 5 answers15k views
Is 5 mg/mL a sensible working concentration for survodutide, or should I go lower?

The particulars: 5 mg/mL · survodutide. The comparison I want does not seem to exist anywhere in a form I can evaluate. I have read the arguments for each and they do…

diluent-volume
diluent-volume

Choosing how much diluent to add, which is really a question about what you want your measurement resolution to be. Larger volumes buy you…

308 questions
reconstitution
reconstitution

Taking a lyophilised vial to a solution of known concentration: choice of diluent, volume selection, how to add liquid without shearing the cake,…

330 questions
dosing-math
dosing-math

The arithmetic itself: milligrams to millilitres to insulin units, concentration after reconstitution, dose per draw, and vial-days per vial. Show…

811 questions
asked by bac_or_bust 37k · 20 months ago
26 votes 4 answers12k views
Can I reconstitute liraglutide at 6.67 mg/mL and still measure a small dose accurately?

The particulars: liraglutide · 6.67 mg/mL. I would like to define my thresholds before I have a result, for obvious reasons. I want a plan with explicit stopping…

diluent-volume
diluent-volume

Choosing how much diluent to add, which is really a question about what you want your measurement resolution to be. Larger volumes buy you…

308 questions
insulin-syringe
insulin-syringe

U-100 and U-40 insulin syringes as measuring instruments. A U-100 syringe is graduated in insulin units where 100 units equals 1 mL, so one unit…

268 questions
dosing-math
dosing-math

The arithmetic itself: milligrams to millilitres to insulin units, concentration after reconstitution, dose per draw, and vial-days per vial. Show…

811 questions
asked by sian_llewellyn 85k · 6 months ago
26 votes0 answers9.2k views
How does semaglutide at 30 mg weekly compare on cost per milligram across routes?

Conditions: semaglutide · 30 mg. I want the working, not the result — I need to be able to redo it with different numbers. I care about the precision as well as the…

cost-analysis
cost-analysis

Cost arithmetic done honestly: cost per milligram after dead-space loss, list versus net price, comparing a multi-dose vial to a fixed-dose pen,…

261 questions
vendor-comparison
vendor-comparison

Side-by-side comparison of suppliers on measurable axes - independently confirmed purity and content, lead time, cold-chain handling,…

351 questions
dosing-math
dosing-math

The arithmetic itself: milligrams to millilitres to insulin units, concentration after reconstitution, dose per draw, and vial-days per vial. Show…

811 questions
asked by eighty_six_hours 16k · 9 months ago
26 votes 3 answers9.1k views
Why does STEP 1 report -14.9% when other papers quote about -17% for the same 2.4 mg dose?

I have been trying to build a spreadsheet of published weight-loss results so I can compare programmes properly, and I keep tripping over the same thing. The primary…

semaglutide
semaglutide

A GLP-1 receptor agonist with a fatty-acid-acylated backbone and a roughly one-week half-life, marketed for type 2 diabetes and for weight…

360 questions
clinical-trials
clinical-trials

Reading the primary literature properly: estimands, intention-to-treat versus per-protocol, confidence intervals, absolute versus relative…

913 questions
dosing-math
dosing-math

The arithmetic itself: milligrams to millilitres to insulin units, concentration after reconstitution, dose per draw, and vial-days per vial. Show…

811 questions
asked by marta_okonkwo 87k · 2.1 years ago
26 votes 5 answers8.9k views
What is the arithmetic to convert 5 mg in 0.5 mL into units on a U-100 scale?

Setup, so nobody has to ask: 5 mg · 0.5 mL. The units are where I keep going wrong, so please be explicit about them. I have sanity-checked the order of magnitude and…

dosing-math
dosing-math

The arithmetic itself: milligrams to millilitres to insulin units, concentration after reconstitution, dose per draw, and vial-days per vial. Show…

811 questions
insulin-syringe
insulin-syringe

U-100 and U-40 insulin syringes as measuring instruments. A U-100 syringe is graduated in insulin units where 100 units equals 1 mL, so one unit…

268 questions
reconstitution
reconstitution

Taking a lyophilised vial to a solution of known concentration: choice of diluent, volume selection, how to add liquid without shearing the cake,…

330 questions
asked by mala_venkatesh 21k · 7 months ago
26 votes0 answers4.3k views
Is 3.33 mg/mL a sensible working concentration for survodutide, or should I go lower?

For reference: 3.33 mg/mL · survodutide. The comparison I want does not seem to exist anywhere in a form I can evaluate. I have read the arguments for each and they…

diluent-volume
diluent-volume

Choosing how much diluent to add, which is really a question about what you want your measurement resolution to be. Larger volumes buy you…

308 questions
reconstitution
reconstitution

Taking a lyophilised vial to a solution of known concentration: choice of diluent, volume selection, how to add liquid without shearing the cake,…

330 questions
dosing-math
dosing-math

The arithmetic itself: milligrams to millilitres to insulin units, concentration after reconstitution, dose per draw, and vial-days per vial. Show…

811 questions
asked by second_lot 11k · 6 months ago
25 votes4 answers46k views
How many vial-days does a 60 mg vial give at 2 mg/mL on a weekly schedule?

Setup, so nobody has to ask: 60 mg · 2 mg/mL. The units are where I keep going wrong, so please be explicit about them. I have sanity-checked the order of magnitude…

dosing-math
dosing-math

The arithmetic itself: milligrams to millilitres to insulin units, concentration after reconstitution, dose per draw, and vial-days per vial. Show…

811 questions
cost-analysis
cost-analysis

Cost arithmetic done honestly: cost per milligram after dead-space loss, list versus net price, comparing a multi-dose vial to a fixed-dose pen,…

261 questions
diluent-volume
diluent-volume

Choosing how much diluent to add, which is really a question about what you want your measurement resolution to be. Larger volumes buy you…

308 questions
asked by bufferline42 49k · 22 months ago
25 votes 5 answers42k views
If I reconstitute a 2.5 mg vial with 5 mL of 0.9% sodium chloride, what concentration do I end up with?

Conditions: 2.5 mg · 5 mL · 0.9% sodium chloride. I want the working, not the result — I need to be able to redo it with different numbers. I care about the precision…

reconstitution
reconstitution

Taking a lyophilised vial to a solution of known concentration: choice of diluent, volume selection, how to add liquid without shearing the cake,…

330 questions
diluent-volume
diluent-volume

Choosing how much diluent to add, which is really a question about what you want your measurement resolution to be. Larger volumes buy you…

308 questions
dosing-math
dosing-math

The arithmetic itself: milligrams to millilitres to insulin units, concentration after reconstitution, dose per draw, and vial-days per vial. Show…

811 questions
asked by threadlock7 14k · 2.0 years ago
25 votes 5 answers40k views
What does STEP 1 report at the 50 mg dose level?

Setup, so nobody has to ask: STEP 1 · 50 mg. I have read the primary source rather than the summary, which has left me with more questions. I understand the headline.…

clinical-trials
clinical-trials

Reading the primary literature properly: estimands, intention-to-treat versus per-protocol, confidence intervals, absolute versus relative…

913 questions
dosing-math
dosing-math

The arithmetic itself: milligrams to millilitres to insulin units, concentration after reconstitution, dose per draw, and vial-days per vial. Show…

811 questions
titration
titration

Stepwise dose increases over weeks, why the label schedules exist at all, and what tolerability-driven deviation from a schedule looks like in…

444 questions
asked by lucia_marchetti 18k · 17 months ago
25 votes 5 answers34k views
How do I convert the SURPASS-3 hazard ratio into an absolute risk reduction?

I have the full paper rather than the abstract, and the supplementary appendix. I can do the algebra. I am not confident about the conversion factors. If there is a…

cardiovascular
cardiovascular

Cardiovascular outcomes: the SELECT major-adverse-event result, SOUL, SUSTAIN 6 and REWIND, how to convert a hazard ratio into an absolute risk…

111 questions
clinical-trials
clinical-trials

Reading the primary literature properly: estimands, intention-to-treat versus per-protocol, confidence intervals, absolute versus relative…

913 questions
dosing-math
dosing-math

The arithmetic itself: milligrams to millilitres to insulin units, concentration after reconstitution, dose per draw, and vial-days per vial. Show…

811 questions
asked by nils_karlberg 13k · 15 months ago
25 votes 5 answers29k views
Is 2 mg/mL a sensible working concentration for semaglutide, or should I go lower?

The particulars: 2 mg/mL · semaglutide. I am trying to choose between two options that are usually discussed as though only one exists. I am not optimising for price,…

diluent-volume
diluent-volume

Choosing how much diluent to add, which is really a question about what you want your measurement resolution to be. Larger volumes buy you…

308 questions
reconstitution
reconstitution

Taking a lyophilised vial to a solution of known concentration: choice of diluent, volume selection, how to add liquid without shearing the cake,…

330 questions
dosing-math
dosing-math

The arithmetic itself: milligrams to millilitres to insulin units, concentration after reconstitution, dose per draw, and vial-days per vial. Show…

811 questions
asked by tess_amankwah 48k · 15 months ago
25 votes 3 answers26k views
What is the arithmetic to convert 60 mg in 5 mL into units on a U-100 scale?

What I am working with: 60 mg · 5 mL. I have worked this out and I would like someone to find the error, because I suspect there is one. My working so far, for the…

dosing-math
dosing-math

The arithmetic itself: milligrams to millilitres to insulin units, concentration after reconstitution, dose per draw, and vial-days per vial. Show…

811 questions
insulin-syringe
insulin-syringe

U-100 and U-40 insulin syringes as measuring instruments. A U-100 syringe is graduated in insulin units where 100 units equals 1 mL, so one unit…

268 questions
reconstitution
reconstitution

Taking a lyophilised vial to a solution of known concentration: choice of diluent, volume selection, how to add liquid without shearing the cake,…

330 questions
asked by low_dead_space 42k · 23 months ago
25 votes 5 answers24k views
What is the real cost per milligram after dead-space loss?

I am comparing three suppliers on documentation rather than on price. I want the working, not the result — I need to be able to redo it with different numbers. I care…

cost-analysis
cost-analysis

Cost arithmetic done honestly: cost per milligram after dead-space loss, list versus net price, comparing a multi-dose vial to a fixed-dose pen,…

261 questions
dead-space
dead-space

The volume trapped in the syringe hub and needle after the plunger bottoms out. It is small in absolute terms and large as a fraction of a small…

110 questions
dosing-math
dosing-math

The arithmetic itself: milligrams to millilitres to insulin units, concentration after reconstitution, dose per draw, and vial-days per vial. Show…

811 questions
asked by ruaidhri_o_shea 51k · 12 months ago
25 votes5 answers21k views
What is the arithmetic to convert 10 mg in 1 mL into units on a U-100 scale?

Concretely: 10 mg · 1 mL. I want the working, not the result — I need to be able to redo it with different numbers. I care about the precision as well as the value —…

dosing-math
dosing-math

The arithmetic itself: milligrams to millilitres to insulin units, concentration after reconstitution, dose per draw, and vial-days per vial. Show…

811 questions
insulin-syringe
insulin-syringe

U-100 and U-40 insulin syringes as measuring instruments. A U-100 syringe is graduated in insulin units where 100 units equals 1 mL, so one unit…

268 questions
reconstitution
reconstitution

Taking a lyophilised vial to a solution of known concentration: choice of diluent, volume selection, how to add liquid without shearing the cake,…

330 questions
asked by Dr_Ravi_Selvarajah 42k · 8 months ago
25 votes1 answer19k views
How do I compute the +4 charge state m/z for a peptide of 4731.3 Da?

For reference: +4 · 4731.3 Da. I would rather understand the derivation than memorise the outcome. Two people I asked gave two answers that differ by a factor of ten,…

mass-spec
mass-spec

Mass spectrometry for identity confirmation: electrospray ionisation, multiple charge states, monoisotopic versus average mass, deconvolution, and…

38 questions
dosing-math
dosing-math

The arithmetic itself: milligrams to millilitres to insulin units, concentration after reconstitution, dose per draw, and vial-days per vial. Show…

811 questions
purity
purity

Purity as chromatographic area per cent - the fraction of detected material that is your target peak. It says nothing about how much material is…

788 questions
asked by gradient_slope 41k · 13 months ago
25 votes 5 answers19k views
What is the arithmetic to convert 15 mg in 1 mL into units on a U-100 scale?

For reference: 15 mg · 1 mL. I would rather understand the derivation than memorise the outcome. Two people I asked gave two answers that differ by a factor of ten,…

dosing-math
dosing-math

The arithmetic itself: milligrams to millilitres to insulin units, concentration after reconstitution, dose per draw, and vial-days per vial. Show…

811 questions
insulin-syringe
insulin-syringe

U-100 and U-40 insulin syringes as measuring instruments. A U-100 syringe is graduated in insulin units where 100 units equals 1 mL, so one unit…

268 questions
reconstitution
reconstitution

Taking a lyophilised vial to a solution of known concentration: choice of diluent, volume selection, how to add liquid without shearing the cake,…

330 questions
asked by fill_volume 13k · 9 months ago
25 votes 5 answers17k views
What is the arithmetic to convert 15 mg in 3 mL into units on a U-100 scale?

The particulars: 15 mg · 3 mL. I would like the arithmetic checked rather than the conclusion asserted. I have deliberately not used an online calculator because I…

dosing-math
dosing-math

The arithmetic itself: milligrams to millilitres to insulin units, concentration after reconstitution, dose per draw, and vial-days per vial. Show…

811 questions
insulin-syringe
insulin-syringe

U-100 and U-40 insulin syringes as measuring instruments. A U-100 syringe is graduated in insulin units where 100 units equals 1 mL, so one unit…

268 questions
reconstitution
reconstitution

Taking a lyophilised vial to a solution of known concentration: choice of diluent, volume selection, how to add liquid without shearing the cake,…

330 questions
asked by mateo_iglesias 16k · 13 months ago
25 votes 5 answers16k views
How do I get 15 units out of a vial reconstituted to 6.67 mg/mL without guessing?

The specifics, since they change the answer: 15 units · 6.67 mg/mL. I want a method I can write down and repeat, not a rule of thumb. I would rather over-engineer…

insulin-syringe
insulin-syringe

U-100 and U-40 insulin syringes as measuring instruments. A U-100 syringe is graduated in insulin units where 100 units equals 1 mL, so one unit…

268 questions
dosing-math
dosing-math

The arithmetic itself: milligrams to millilitres to insulin units, concentration after reconstitution, dose per draw, and vial-days per vial. Show…

811 questions
diluent-volume
diluent-volume

Choosing how much diluent to add, which is really a question about what you want your measurement resolution to be. Larger volumes buy you…

308 questions
asked by sample_id 17k · 7 months ago