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dosing-math

Page 29 of 34 · 811 questions tagged dosing-math.

811 questions · sorted by votes · page 29 of 34

8 votes 4 answers7.2k views
Is 15 mg in 3 mL of phosphate-buffered diluent a sensible presentation for orforglipron?

For reference: 15 mg · 3 mL · phosphate-buffered diluent · orforglipron. I would like to define my thresholds before I have a result, for obvious reasons. I want a…

diluent-volume
diluent-volume

Choosing how much diluent to add, which is really a question about what you want your measurement resolution to be. Larger volumes buy you…

308 questions
reconstitution
reconstitution

Taking a lyophilised vial to a solution of known concentration: choice of diluent, volume selection, how to add liquid without shearing the cake,…

330 questions
dosing-math
dosing-math

The arithmetic itself: milligrams to millilitres to insulin units, concentration after reconstitution, dose per draw, and vial-days per vial. Show…

811 questions
asked by nils_karlberg 13k · 8 months ago
8 votes5 answers6.5k views
Is there a pharmacokinetic case for moving liraglutide injection day by forty-two days?

The specifics, since they change the answer: liraglutide · forty-two days. I would like the mechanism, because I want to be able to reason about the cases nobody has…

missed-dose
missed-dose

What the label instructions for a missed weekly dose are, why they differ between agents, and what the pharmacokinetics say about drift in an…

41 questions
glp1-mechanism
glp1-mechanism

Receptor-level pharmacology: GLP-1R as a class B GPCR, cAMP and PKA signalling, biased agonism, internalisation and resensitisation, and the…

175 questions
dosing-math
dosing-math

The arithmetic itself: milligrams to millilitres to insulin units, concentration after reconstitution, dose per draw, and vial-days per vial. Show…

811 questions
asked by orla_ferriter 47k · 1 months ago
8 votes0 answers5.5k views
What is the arithmetic to convert 5 mg in 3 mL into units on a U-100 scale?

What I am working with: 5 mg · 3 mL. I have worked this out and I would like someone to find the error, because I suspect there is one. My working so far, for the…

dosing-math
dosing-math

The arithmetic itself: milligrams to millilitres to insulin units, concentration after reconstitution, dose per draw, and vial-days per vial. Show…

811 questions
insulin-syringe
insulin-syringe

U-100 and U-40 insulin syringes as measuring instruments. A U-100 syringe is graduated in insulin units where 100 units equals 1 mL, so one unit…

268 questions
reconstitution
reconstitution

Taking a lyophilised vial to a solution of known concentration: choice of diluent, volume selection, how to add liquid without shearing the cake,…

330 questions
asked by rune_thoresen 14k · 23 months ago
8 votes 4 answers5.5k views
Is 8 mg weekly a defensible maintenance dose for dulaglutide?

Numbers first: 8 mg · dulaglutide. This is a planning question. I know what my options are; I do not know how to weigh them. What I want is the minimum viable…

maintenance-dose
maintenance-dose

Staying put: the lowest dose that holds a result, the difference between the maximum studied dose and the maximum useful dose, and what the…

44 questions
clinical-trials
clinical-trials

Reading the primary literature properly: estimands, intention-to-treat versus per-protocol, confidence intervals, absolute versus relative…

913 questions
dosing-math
dosing-math

The arithmetic itself: milligrams to millilitres to insulin units, concentration after reconstitution, dose per draw, and vial-days per vial. Show…

811 questions
asked by Dr_Lena_Ostrowska 42k · 5 months ago
8 votes 4 answers5.3k views
How do I compute the +2 charge state m/z for a peptide of 3751.0 Da?

Numbers first: +2 · 3751.0 Da. This should be a straightforward calculation and I keep getting two different answers. The numbers are arbitrary; the method is what I…

mass-spec
mass-spec

Mass spectrometry for identity confirmation: electrospray ionisation, multiple charge states, monoisotopic versus average mass, deconvolution, and…

38 questions
dosing-math
dosing-math

The arithmetic itself: milligrams to millilitres to insulin units, concentration after reconstitution, dose per draw, and vial-days per vial. Show…

811 questions
purity
purity

Purity as chromatographic area per cent - the fraction of detected material that is your target peak. It says nothing about how much material is…

788 questions
asked by two_point_four 14k · 3 months ago
8 votes2 answers3.5k views
What does STEP 2 report at the 2 mg dose level?

The case in front of me: STEP 2 · 2 mg. The figures are clear enough; the question is what they mean and what they do not. I can supply the numbers if the specifics…

clinical-trials
clinical-trials

Reading the primary literature properly: estimands, intention-to-treat versus per-protocol, confidence intervals, absolute versus relative…

913 questions
dosing-math
dosing-math

The arithmetic itself: milligrams to millilitres to insulin units, concentration after reconstitution, dose per draw, and vial-days per vial. Show…

811 questions
titration
titration

Stepwise dose increases over weeks, why the label schedules exist at all, and what tolerability-driven deviation from a schedule looks like in…

444 questions
asked by Dr_Bram_Verhoeven 85k · 4 months ago
8 votes4 answers3k views
What is the arithmetic to convert 40 mg in 1 mL into units on a U-100 scale?

Conditions: 40 mg · 1 mL. Please show the division. I want to check my own against yours. I would like the general form as well as the specific number, so I can apply…

dosing-math
dosing-math

The arithmetic itself: milligrams to millilitres to insulin units, concentration after reconstitution, dose per draw, and vial-days per vial. Show…

811 questions
insulin-syringe
insulin-syringe

U-100 and U-40 insulin syringes as measuring instruments. A U-100 syringe is graduated in insulin units where 100 units equals 1 mL, so one unit…

268 questions
reconstitution
reconstitution

Taking a lyophilised vial to a solution of known concentration: choice of diluent, volume selection, how to add liquid without shearing the cake,…

330 questions
asked by rosa_mendieta 13k · 20 days ago
8 votes 5 answers2.7k views
What is the arithmetic to convert 2 mg in 5 mL into units on a U-100 scale?

Details up front: 2 mg · 5 mL. I can do the algebra. I am not confident about the conversion factors. If there is a standard way to lay this out, I would rather learn…

dosing-math
dosing-math

The arithmetic itself: milligrams to millilitres to insulin units, concentration after reconstitution, dose per draw, and vial-days per vial. Show…

811 questions
insulin-syringe
insulin-syringe

U-100 and U-40 insulin syringes as measuring instruments. A U-100 syringe is graduated in insulin units where 100 units equals 1 mL, so one unit…

268 questions
reconstitution
reconstitution

Taking a lyophilised vial to a solution of known concentration: choice of diluent, volume selection, how to add liquid without shearing the cake,…

330 questions
asked by vial_five 15k · 31 days ago
8 votes0 answers2.6k views
Does splitting a 5 mg weekly dose of mazdutide across two administrations change anything?

Stated plainly: 5 mg · mazdutide. The empirical answer seems settled. The explanation does not. If the honest answer is that nobody knows, I would rather hear that…

split-dosing
split-dosing

Dividing a weekly dose across more than one administration. Questions here concern the pharmacokinetic rationale, whether the peak-to-trough ratio…

39 questions
dosing-math
dosing-math

The arithmetic itself: milligrams to millilitres to insulin units, concentration after reconstitution, dose per draw, and vial-days per vial. Show…

811 questions
glp1-mechanism
glp1-mechanism

Receptor-level pharmacology: GLP-1R as a class B GPCR, cAMP and PKA signalling, biased agonism, internalisation and resensitisation, and the…

175 questions
asked by tare_and_weigh 18k · 5 months ago
7 votes 5 answers14k views
If I reconstitute a 50 mg vial with 2 mL of phosphate-buffered diluent, what concentration do I end up with?

The particulars: 50 mg · 2 mL · phosphate-buffered diluent. I would rather understand the derivation than memorise the outcome. Two people I asked gave two answers…

reconstitution
reconstitution

Taking a lyophilised vial to a solution of known concentration: choice of diluent, volume selection, how to add liquid without shearing the cake,…

330 questions
diluent-volume
diluent-volume

Choosing how much diluent to add, which is really a question about what you want your measurement resolution to be. Larger volumes buy you…

308 questions
dosing-math
dosing-math

The arithmetic itself: milligrams to millilitres to insulin units, concentration after reconstitution, dose per draw, and vial-days per vial. Show…

811 questions
asked by tandem_gradient 85k · 10 months ago
7 votes5 answers12k views
What does STEP 5 report at the 15 mg dose level?

Stated plainly: STEP 5 · 15 mg. I would like help reading this properly rather than being told what conclusion to reach. I have the full report including the method…

clinical-trials
clinical-trials

Reading the primary literature properly: estimands, intention-to-treat versus per-protocol, confidence intervals, absolute versus relative…

913 questions
dosing-math
dosing-math

The arithmetic itself: milligrams to millilitres to insulin units, concentration after reconstitution, dose per draw, and vial-days per vial. Show…

811 questions
titration
titration

Stepwise dose increases over weeks, why the label schedules exist at all, and what tolerability-driven deviation from a schedule looks like in…

444 questions
asked by eoin_mcgarry 16k · 16 months ago
7 votes 2 answers10k views
Is 10 mg in 1 mL of 0.9% sodium chloride a sensible presentation for cagrilintide?

The case in front of me: 10 mg · 1 mL · 0.9% sodium chloride · cagrilintide. I want to decide this in advance so that I am not deciding it under pressure later.…

diluent-volume
diluent-volume

Choosing how much diluent to add, which is really a question about what you want your measurement resolution to be. Larger volumes buy you…

308 questions
reconstitution
reconstitution

Taking a lyophilised vial to a solution of known concentration: choice of diluent, volume selection, how to add liquid without shearing the cake,…

330 questions
dosing-math
dosing-math

The arithmetic itself: milligrams to millilitres to insulin units, concentration after reconstitution, dose per draw, and vial-days per vial. Show…

811 questions
asked by juan_esquivel 14k · 16 months ago
7 votes3 answers10k views
Can I reconstitute cagrilintide at 6.67 mg/mL and still measure a small dose accurately?

Numbers first: cagrilintide · 6.67 mg/mL. This is a planning question. I know what my options are; I do not know how to weigh them. What I want is the minimum viable…

diluent-volume
diluent-volume

Choosing how much diluent to add, which is really a question about what you want your measurement resolution to be. Larger volumes buy you…

308 questions
insulin-syringe
insulin-syringe

U-100 and U-40 insulin syringes as measuring instruments. A U-100 syringe is graduated in insulin units where 100 units equals 1 mL, so one unit…

268 questions
dosing-math
dosing-math

The arithmetic itself: milligrams to millilitres to insulin units, concentration after reconstitution, dose per draw, and vial-days per vial. Show…

811 questions
asked by rune_thoresen 14k · 9 months ago
7 votes 4 answers9.9k views
Is 2 mg/mL a sensible working concentration for orforglipron, or should I go lower?

Numbers first: 2 mg/mL · orforglipron. I want to know what the trade-off actually is rather than which option is fashionable. I would rather have a defensible reason…

diluent-volume
diluent-volume

Choosing how much diluent to add, which is really a question about what you want your measurement resolution to be. Larger volumes buy you…

308 questions
reconstitution
reconstitution

Taking a lyophilised vial to a solution of known concentration: choice of diluent, volume selection, how to add liquid without shearing the cake,…

330 questions
dosing-math
dosing-math

The arithmetic itself: milligrams to millilitres to insulin units, concentration after reconstitution, dose per draw, and vial-days per vial. Show…

811 questions
asked by nils_karlberg 13k · 9 months ago
7 votes 5 answers8.8k views
How many units on a 1 mL luer-lock syringe is a 2.5 mg dose at 2 mg/mL?

Numbers first: a 1 mL luer-lock syringe · 2.5 mg · 2 mg/mL. I can do the algebra. I am not confident about the conversion factors. If there is a standard way to lay…

dosing-math
dosing-math

The arithmetic itself: milligrams to millilitres to insulin units, concentration after reconstitution, dose per draw, and vial-days per vial. Show…

811 questions
insulin-syringe
insulin-syringe

U-100 and U-40 insulin syringes as measuring instruments. A U-100 syringe is graduated in insulin units where 100 units equals 1 mL, so one unit…

268 questions
reconstitution
reconstitution

Taking a lyophilised vial to a solution of known concentration: choice of diluent, volume selection, how to add liquid without shearing the cake,…

330 questions
asked by b_delacroix 48k · 4 months ago
7 votes4 answers8.4k views
If I reconstitute a 2.5 mg vial with 2.5 mL of 0.9% sodium chloride, what concentration do I end up with?

The case in front of me: 2.5 mg · 2.5 mL · 0.9% sodium chloride. Please show the division. I want to check my own against yours. I would like the general form as well…

reconstitution
reconstitution

Taking a lyophilised vial to a solution of known concentration: choice of diluent, volume selection, how to add liquid without shearing the cake,…

330 questions
diluent-volume
diluent-volume

Choosing how much diluent to add, which is really a question about what you want your measurement resolution to be. Larger volumes buy you…

308 questions
dosing-math
dosing-math

The arithmetic itself: milligrams to millilitres to insulin units, concentration after reconstitution, dose per draw, and vial-days per vial. Show…

811 questions
asked by bufferline42 49k · 5 months ago
7 votes 3 answers6.2k views
How do I get 20 units out of a vial reconstituted to 5 mg/mL without guessing?

The case in front of me: 20 units · 5 mg/mL. I am trying to do this correctly the first time rather than learn it by getting it wrong. I have already made one mistake…

insulin-syringe
insulin-syringe

U-100 and U-40 insulin syringes as measuring instruments. A U-100 syringe is graduated in insulin units where 100 units equals 1 mL, so one unit…

268 questions
dosing-math
dosing-math

The arithmetic itself: milligrams to millilitres to insulin units, concentration after reconstitution, dose per draw, and vial-days per vial. Show…

811 questions
diluent-volume
diluent-volume

Choosing how much diluent to add, which is really a question about what you want your measurement resolution to be. Larger volumes buy you…

308 questions
asked by rae_oyelowo 21k · 6 months ago
7 votes 3 answers5.1k views
What does STEP 4 report at the 4 mg dose level?

Setup, so nobody has to ask: STEP 4 · 4 mg. I would like help reading this properly rather than being told what conclusion to reach. I have the full report including…

clinical-trials
clinical-trials

Reading the primary literature properly: estimands, intention-to-treat versus per-protocol, confidence intervals, absolute versus relative…

913 questions
dosing-math
dosing-math

The arithmetic itself: milligrams to millilitres to insulin units, concentration after reconstitution, dose per draw, and vial-days per vial. Show…

811 questions
titration
titration

Stepwise dose increases over weeks, why the label schedules exist at all, and what tolerability-driven deviation from a schedule looks like in…

444 questions
asked by grainne_ahearn 13k · 18 months ago
7 votes0 answers4.3k views
If I reconstitute a 30 mg vial with 1 mL of sterile water for injection, what concentration do I end up with?

What I have: 30 mg · 1 mL · sterile water for injection. This should be a straightforward calculation and I keep getting two different answers. The numbers are…

reconstitution
reconstitution

Taking a lyophilised vial to a solution of known concentration: choice of diluent, volume selection, how to add liquid without shearing the cake,…

330 questions
diluent-volume
diluent-volume

Choosing how much diluent to add, which is really a question about what you want your measurement resolution to be. Larger volumes buy you…

308 questions
dosing-math
dosing-math

The arithmetic itself: milligrams to millilitres to insulin units, concentration after reconstitution, dose per draw, and vial-days per vial. Show…

811 questions
asked by retest_please 13k · 9 months ago
7 votes5 answers4.2k views
What is the arithmetic to convert 20 mg in 0.5 mL into units on a U-100 scale?

What I am working with: 20 mg · 0.5 mL. I have worked this out and I would like someone to find the error, because I suspect there is one. My working so far, for the…

dosing-math
dosing-math

The arithmetic itself: milligrams to millilitres to insulin units, concentration after reconstitution, dose per draw, and vial-days per vial. Show…

811 questions
insulin-syringe
insulin-syringe

U-100 and U-40 insulin syringes as measuring instruments. A U-100 syringe is graduated in insulin units where 100 units equals 1 mL, so one unit…

268 questions
reconstitution
reconstitution

Taking a lyophilised vial to a solution of known concentration: choice of diluent, volume selection, how to add liquid without shearing the cake,…

330 questions
asked by swab_and_wait 15k · 2 months ago
7 votes0 answers3.2k views
Why do two papers on FLOW report different headline figures?

I have the full paper rather than the abstract, and the supplementary appendix. I would like the mechanism, because I want to be able to reason about the cases nobody…

clinical-trials
clinical-trials

Reading the primary literature properly: estimands, intention-to-treat versus per-protocol, confidence intervals, absolute versus relative…

913 questions
dosing-math
dosing-math

The arithmetic itself: milligrams to millilitres to insulin units, concentration after reconstitution, dose per draw, and vial-days per vial. Show…

811 questions
semaglutide
semaglutide

A GLP-1 receptor agonist with a fatty-acid-acylated backbone and a roughly one-week half-life, marketed for type 2 diabetes and for weight…

360 questions
asked by v_ramaswamy 40k · 3 months ago
7 votes 4 answers2.3k views
What does ATTAIN-1 report at the 4 mg dose level?

Stated plainly: ATTAIN-1 · 4 mg. I have read the primary source rather than the summary, which has left me with more questions. I understand the headline. I do not…

clinical-trials
clinical-trials

Reading the primary literature properly: estimands, intention-to-treat versus per-protocol, confidence intervals, absolute versus relative…

913 questions
dosing-math
dosing-math

The arithmetic itself: milligrams to millilitres to insulin units, concentration after reconstitution, dose per draw, and vial-days per vial. Show…

811 questions
titration
titration

Stepwise dose increases over weeks, why the label schedules exist at all, and what tolerability-driven deviation from a schedule looks like in…

444 questions
asked by anders_vestby 17k · 2 months ago
7 votes 2 answers1.2k views
Is 10 mg weekly a defensible maintenance dose for liraglutide?

Concretely: 10 mg · liraglutide. The failure mode I am trying to avoid is making this decision emotionally. I have twelve months in view and I would like the plan to…

maintenance-dose
maintenance-dose

Staying put: the lowest dose that holds a result, the difference between the maximum studied dose and the maximum useful dose, and what the…

44 questions
clinical-trials
clinical-trials

Reading the primary literature properly: estimands, intention-to-treat versus per-protocol, confidence intervals, absolute versus relative…

913 questions
dosing-math
dosing-math

The arithmetic itself: milligrams to millilitres to insulin units, concentration after reconstitution, dose per draw, and vial-days per vial. Show…

811 questions
asked by colm_dunphy 16k · 28 days ago
6 votes5 answers23k views
What is the dead-space loss per draw with a 29G needle at 10 mg/mL?

For reference: a 29G needle · 10 mg/mL. I would like the arithmetic checked rather than the conclusion asserted. I have deliberately not used an online calculator…

dead-space
dead-space

The volume trapped in the syringe hub and needle after the plunger bottoms out. It is small in absolute terms and large as a fraction of a small…

110 questions
insulin-syringe
insulin-syringe

U-100 and U-40 insulin syringes as measuring instruments. A U-100 syringe is graduated in insulin units where 100 units equals 1 mL, so one unit…

268 questions
dosing-math
dosing-math

The arithmetic itself: milligrams to millilitres to insulin units, concentration after reconstitution, dose per draw, and vial-days per vial. Show…

811 questions
asked by Dr_Elias_Weiss 46k · 23 months ago