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gi-side-effects

Page 7 of 18 · 416 questions tagged gi-side-effects.

416 questions · sorted by votes · page 7 of 18

25 votes 4 answers15k views
What does PIONEER-4 tell me about headache at the 2 mg dose?

The specifics, since they change the answer: PIONEER-4 · headache · 2 mg. I have the document in front of me and I can read the numbers. What I cannot do is interpret…

clinical-trials
clinical-trials

Reading the primary literature properly: estimands, intention-to-treat versus per-protocol, confidence intervals, absolute versus relative…

913 questions
gi-side-effects
gi-side-effects

The gastrointestinal cluster as a whole - nausea, vomiting, diarrhoea, constipation, reflux, early satiety - with trial incidence rates, dropout…

416 questions
titration
titration

Stepwise dose increases over weeks, why the label schedules exist at all, and what tolerability-driven deviation from a schedule looks like in…

444 questions
asked by ravenna_pace 13k · 7 months ago
25 votes 5 answers13k views
Does constipation at week four of dulaglutide usually resolve without a dose change?

The case in front of me: constipation · four · dulaglutide. I am trying to do this correctly the first time rather than learn it by getting it wrong. I have already…

gi-side-effects
gi-side-effects

The gastrointestinal cluster as a whole - nausea, vomiting, diarrhoea, constipation, reflux, early satiety - with trial incidence rates, dropout…

416 questions
titration
titration

Stepwise dose increases over weeks, why the label schedules exist at all, and what tolerability-driven deviation from a schedule looks like in…

444 questions
nausea
nausea

The dominant tolerability signal in every trial of the class: incidence, timing relative to a dose step, duration, and the distinction between…

346 questions
injection-site-reaction
injection-site-reaction

Local reactions: erythema, induration, pruritus and nodules. Their relationship to injection depth, diluent composition, benzyl alcohol…

14 questions
asked by tri_gly_ala 48k · 4 months ago
25 votes0 answers9.5k views
What does STEP 4 tell me about fatigue at the 5 mg dose?

Conditions: STEP 4 · fatigue · 5 mg. The figures are clear enough; the question is what they mean and what they do not. I can supply the numbers if the specifics…

clinical-trials
clinical-trials

Reading the primary literature properly: estimands, intention-to-treat versus per-protocol, confidence intervals, absolute versus relative…

913 questions
gi-side-effects
gi-side-effects

The gastrointestinal cluster as a whole - nausea, vomiting, diarrhoea, constipation, reflux, early satiety - with trial incidence rates, dropout…

416 questions
titration
titration

Stepwise dose increases over weeks, why the label schedules exist at all, and what tolerability-driven deviation from a schedule looks like in…

444 questions
injection-site-reaction
injection-site-reaction

Local reactions: erythema, induration, pruritus and nodules. Their relationship to injection depth, diluent composition, benzyl alcohol…

14 questions
pcos
pcos

Polycystic ovary syndrome: insulin resistance as the shared mechanism, ovulatory and menstrual outcomes reported on treatment, androgen changes,…

14 questions
asked by cake_collapsed 13k · 13 months ago
25 votes 5 answers5.7k views
When does injection-site erythema stop being a tolerability issue and become a clinical one?

I have kept every message, invoice and document, which I gather is the useful habit. This is a planning question. I know what my options are; I do not know how to…

harm-reduction
harm-reduction

Reducing avoidable risk where a decision has already been made: independent verification before use, sterility practice, dose arithmetic checked…

445 questions
gi-side-effects
gi-side-effects

The gastrointestinal cluster as a whole - nausea, vomiting, diarrhoea, constipation, reflux, early satiety - with trial incidence rates, dropout…

416 questions
pancreatitis
pancreatitis

Acute pancreatitis as a labelled risk: background incidence, the signal in pooled trial and pharmacovigilance data, lipase interpretation, and the…

14 questions
constipation
constipation

Slowed transit as a consequence of delayed gastric emptying and reduced intake: incidence figures, fibre and hydration evidence, and why it often…

14 questions
asked by Dr_Priya_Raghunathan 94k · 4 months ago
24 votes5 answers50k views
What did PIONEER-4 do with participants who could not tolerate a step?

I am asking about the protocol logic rather than about my own case specifically. I want to understand what this actually establishes, as opposed to what it is being…

titration
titration

Stepwise dose increases over weeks, why the label schedules exist at all, and what tolerability-driven deviation from a schedule looks like in…

444 questions
clinical-trials
clinical-trials

Reading the primary literature properly: estimands, intention-to-treat versus per-protocol, confidence intervals, absolute versus relative…

913 questions
gi-side-effects
gi-side-effects

The gastrointestinal cluster as a whole - nausea, vomiting, diarrhoea, constipation, reflux, early satiety - with trial incidence rates, dropout…

416 questions
asked by one_ml_bac 12k · 23 months ago
24 votes 5 answers43k views
What does SELECT tell me about early satiety at the 4 mg dose?

Details up front: SELECT · early satiety · 4 mg. This is presented as though it settles something, and I am not convinced it does. I have two documents that appear to…

clinical-trials
clinical-trials

Reading the primary literature properly: estimands, intention-to-treat versus per-protocol, confidence intervals, absolute versus relative…

913 questions
gi-side-effects
gi-side-effects

The gastrointestinal cluster as a whole - nausea, vomiting, diarrhoea, constipation, reflux, early satiety - with trial incidence rates, dropout…

416 questions
titration
titration

Stepwise dose increases over weeks, why the label schedules exist at all, and what tolerability-driven deviation from a schedule looks like in…

444 questions
asked by cap_the_luer 15k · 23 months ago
24 votes 5 answers38k views
Does dizziness at week seven of a GLP-1 receptor agonist usually resolve without a dose change?

For reference: dizziness · seven · a GLP-1 receptor agonist. I have read the obvious sources and they disagree with each other, so I would rather ask people who have…

gi-side-effects
gi-side-effects

The gastrointestinal cluster as a whole - nausea, vomiting, diarrhoea, constipation, reflux, early satiety - with trial incidence rates, dropout…

416 questions
titration
titration

Stepwise dose increases over weeks, why the label schedules exist at all, and what tolerability-driven deviation from a schedule looks like in…

444 questions
nausea
nausea

The dominant tolerability signal in every trial of the class: incidence, timing relative to a dose step, duration, and the distinction between…

346 questions
asked by meniscus_film 34k · 2.3 years ago
24 votes5 answers35k views
What did the placebo arm of SURMOUNT-4 report for fatigue?

The case in front of me: SURMOUNT-4 · fatigue. I would like to know the limits of what can be inferred from this. What I am trying to avoid is over-reading a single…

clinical-trials
clinical-trials

Reading the primary literature properly: estimands, intention-to-treat versus per-protocol, confidence intervals, absolute versus relative…

913 questions
gi-side-effects
gi-side-effects

The gastrointestinal cluster as a whole - nausea, vomiting, diarrhoea, constipation, reflux, early satiety - with trial incidence rates, dropout…

416 questions
nausea
nausea

The dominant tolerability signal in every trial of the class: incidence, timing relative to a dose step, duration, and the distinction between…

346 questions
asked by rosa_mendieta 13k · 15 months ago
24 votes 5 answers32k views
What is the reported incidence of early satiety on a GLP-1 receptor agonist in TRIUMPH-1?

Stated plainly: early satiety · a GLP-1 receptor agonist · TRIUMPH-1. I would like help reading this properly rather than being told what conclusion to reach. I have…

gi-side-effects
gi-side-effects

The gastrointestinal cluster as a whole - nausea, vomiting, diarrhoea, constipation, reflux, early satiety - with trial incidence rates, dropout…

416 questions
clinical-trials
clinical-trials

Reading the primary literature properly: estimands, intention-to-treat versus per-protocol, confidence intervals, absolute versus relative…

913 questions
nausea
nausea

The dominant tolerability signal in every trial of the class: incidence, timing relative to a dose step, duration, and the distinction between…

346 questions
asked by eighty_six_hours 16k · 18 months ago
24 votes 5 answers29k views
What is the reported incidence of reflux on retatrutide in SURMOUNT-3?

Details up front: reflux · retatrutide · SURMOUNT-3. This is presented as though it settles something, and I am not convinced it does. I have two documents that…

gi-side-effects
gi-side-effects

The gastrointestinal cluster as a whole - nausea, vomiting, diarrhoea, constipation, reflux, early satiety - with trial incidence rates, dropout…

416 questions
clinical-trials
clinical-trials

Reading the primary literature properly: estimands, intention-to-treat versus per-protocol, confidence intervals, absolute versus relative…

913 questions
nausea
nausea

The dominant tolerability signal in every trial of the class: incidence, timing relative to a dose step, duration, and the distinction between…

346 questions
renal-outcomes
renal-outcomes

Kidney endpoints: the FLOW composite, eGFR slope as an endpoint, albuminuria regression, and why an early eGFR dip is expected rather than alarming.

14 questions
asked by two_two_micron 15k · 17 months ago
24 votes 5 answers26k views
What did the placebo arm of SOUL report for early satiety?

The specifics, since they change the answer: SOUL · early satiety. I want to understand what this actually establishes, as opposed to what it is being used to imply.…

clinical-trials
clinical-trials

Reading the primary literature properly: estimands, intention-to-treat versus per-protocol, confidence intervals, absolute versus relative…

913 questions
gi-side-effects
gi-side-effects

The gastrointestinal cluster as a whole - nausea, vomiting, diarrhoea, constipation, reflux, early satiety - with trial incidence rates, dropout…

416 questions
nausea
nausea

The dominant tolerability signal in every trial of the class: incidence, timing relative to a dose step, duration, and the distinction between…

346 questions
asked by micron22 36k · 2.0 years ago
24 votes0 answers23k views
Does vomiting at week three of tirzepatide usually resolve without a dose change?

What I have: vomiting · three · tirzepatide. I would like to understand the steps well enough to explain them to someone else. I have access to a refrigerator with a…

gi-side-effects
gi-side-effects

The gastrointestinal cluster as a whole - nausea, vomiting, diarrhoea, constipation, reflux, early satiety - with trial incidence rates, dropout…

416 questions
titration
titration

Stepwise dose increases over weeks, why the label schedules exist at all, and what tolerability-driven deviation from a schedule looks like in…

444 questions
nausea
nausea

The dominant tolerability signal in every trial of the class: incidence, timing relative to a dose step, duration, and the distinction between…

346 questions
asked by coring_risk 17k · 2.2 years ago
24 votes0 answers22k views
What did the placebo arm of SURMOUNT-1 report for nausea?

What I have: SURMOUNT-1 · nausea. This is presented as though it settles something, and I am not convinced it does. I have two documents that appear to disagree,…

clinical-trials
clinical-trials

Reading the primary literature properly: estimands, intention-to-treat versus per-protocol, confidence intervals, absolute versus relative…

913 questions
gi-side-effects
gi-side-effects

The gastrointestinal cluster as a whole - nausea, vomiting, diarrhoea, constipation, reflux, early satiety - with trial incidence rates, dropout…

416 questions
nausea
nausea

The dominant tolerability signal in every trial of the class: incidence, timing relative to a dose step, duration, and the distinction between…

346 questions
thyroid
thyroid

Thyroid questions: the rodent C-cell findings behind the labelled warning, human calcitonin data, TSH drift during weight loss, and the…

14 questions
asked by lane_transit 42k · 2.1 years ago
24 votes0 answers22k views
What does REDEFINE-1 tell me about early satiety at the 50 mg dose?

Numbers first: REDEFINE-1 · early satiety · 50 mg. This is presented as though it settles something, and I am not convinced it does. I have two documents that appear…

clinical-trials
clinical-trials

Reading the primary literature properly: estimands, intention-to-treat versus per-protocol, confidence intervals, absolute versus relative…

913 questions
gi-side-effects
gi-side-effects

The gastrointestinal cluster as a whole - nausea, vomiting, diarrhoea, constipation, reflux, early satiety - with trial incidence rates, dropout…

416 questions
titration
titration

Stepwise dose increases over weeks, why the label schedules exist at all, and what tolerability-driven deviation from a schedule looks like in…

444 questions
asked by ayo_fadipe 19k · 20 months ago
24 votes 3 answers20k views
What did the registration protocols actually do with participants who could not tolerate a titration step?

Every summary of these trials reports the result as though everyone in the active arm reached the assigned dose. "Semaglutide 2.4 mg produced 14.9 % weight loss." But…

titration
titration

Stepwise dose increases over weeks, why the label schedules exist at all, and what tolerability-driven deviation from a schedule looks like in…

444 questions
dose-escalation
dose-escalation

The decision to move up a step: what evidence supports a four-week interval, what happens when you compress it, and how trial protocols handled…

88 questions
clinical-trials
clinical-trials

Reading the primary literature properly: estimands, intention-to-treat versus per-protocol, confidence intervals, absolute versus relative…

913 questions
gi-side-effects
gi-side-effects

The gastrointestinal cluster as a whole - nausea, vomiting, diarrhoea, constipation, reflux, early satiety - with trial incidence rates, dropout…

416 questions
asked by cap_the_luer 15k · 18 months ago
24 votes0 answers17k views
What is the reported incidence of nausea on oral semaglutide in PIONEER-1?

The case in front of me: nausea · oral semaglutide · PIONEER-1. I would like to know the limits of what can be inferred from this. What I am trying to avoid is…

gi-side-effects
gi-side-effects

The gastrointestinal cluster as a whole - nausea, vomiting, diarrhoea, constipation, reflux, early satiety - with trial incidence rates, dropout…

416 questions
clinical-trials
clinical-trials

Reading the primary literature properly: estimands, intention-to-treat versus per-protocol, confidence intervals, absolute versus relative…

913 questions
nausea
nausea

The dominant tolerability signal in every trial of the class: incidence, timing relative to a dose step, duration, and the distinction between…

346 questions
asked by linnea_wahlberg 14k · 13 months ago
24 votes 2 answers17k views
What does SURMOUNT-OSA tell me about nausea at the 2 mg dose?

The specifics, since they change the answer: SURMOUNT-OSA · nausea · 2 mg. I have the document in front of me and I can read the numbers. What I cannot do is…

clinical-trials
clinical-trials

Reading the primary literature properly: estimands, intention-to-treat versus per-protocol, confidence intervals, absolute versus relative…

913 questions
gi-side-effects
gi-side-effects

The gastrointestinal cluster as a whole - nausea, vomiting, diarrhoea, constipation, reflux, early satiety - with trial incidence rates, dropout…

416 questions
titration
titration

Stepwise dose increases over weeks, why the label schedules exist at all, and what tolerability-driven deviation from a schedule looks like in…

444 questions
asked by zainab_mustafa 16k · 2.3 years ago
24 votes 3 answers15k views
Does nausea at week four of retatrutide usually resolve without a dose change?

The case in front of me: nausea · four · retatrutide. I have done this once and I suspect I got away with it rather than got it right. For context: I keep records of…

gi-side-effects
gi-side-effects

The gastrointestinal cluster as a whole - nausea, vomiting, diarrhoea, constipation, reflux, early satiety - with trial incidence rates, dropout…

416 questions
titration
titration

Stepwise dose increases over weeks, why the label schedules exist at all, and what tolerability-driven deviation from a schedule looks like in…

444 questions
nausea
nausea

The dominant tolerability signal in every trial of the class: incidence, timing relative to a dose step, duration, and the distinction between…

346 questions
asked by tamsin_wray 13k · 8 months ago
24 votes5 answers12k views
What did PIONEER-1 do with participants who could not tolerate a step?

My records go back to the first dose with dates, so I can reconstruct the timeline exactly. The figures are clear enough; the question is what they mean and what they…

titration
titration

Stepwise dose increases over weeks, why the label schedules exist at all, and what tolerability-driven deviation from a schedule looks like in…

444 questions
clinical-trials
clinical-trials

Reading the primary literature properly: estimands, intention-to-treat versus per-protocol, confidence intervals, absolute versus relative…

913 questions
gi-side-effects
gi-side-effects

The gastrointestinal cluster as a whole - nausea, vomiting, diarrhoea, constipation, reflux, early satiety - with trial incidence rates, dropout…

416 questions
asked by forty_units 14k · 8 months ago
24 votes 3 answers9.8k views
Does headache at week ten of retatrutide usually resolve without a dose change?

Conditions: headache · ten · retatrutide. I am trying to do this correctly the first time rather than learn it by getting it wrong. I have already made one mistake…

gi-side-effects
gi-side-effects

The gastrointestinal cluster as a whole - nausea, vomiting, diarrhoea, constipation, reflux, early satiety - with trial incidence rates, dropout…

416 questions
titration
titration

Stepwise dose increases over weeks, why the label schedules exist at all, and what tolerability-driven deviation from a schedule looks like in…

444 questions
nausea
nausea

The dominant tolerability signal in every trial of the class: incidence, timing relative to a dose step, duration, and the distinction between…

346 questions
asked by s_kalniete 47k · 4 months ago
24 votes 5 answers8.2k views
What is the reported incidence of fatigue on ecnoglutide in SURPASS-2?

The particulars: fatigue · ecnoglutide · SURPASS-2. I have the document in front of me and I can read the numbers. What I cannot do is interpret them. I am reasonably…

gi-side-effects
gi-side-effects

The gastrointestinal cluster as a whole - nausea, vomiting, diarrhoea, constipation, reflux, early satiety - with trial incidence rates, dropout…

416 questions
clinical-trials
clinical-trials

Reading the primary literature properly: estimands, intention-to-treat versus per-protocol, confidence intervals, absolute versus relative…

913 questions
nausea
nausea

The dominant tolerability signal in every trial of the class: incidence, timing relative to a dose step, duration, and the distinction between…

346 questions
asked by net_peptide 16k · 3 months ago
24 votes 2 answers6.5k views
Does hair thinning at week eight of survodutide usually resolve without a dose change?

Stated plainly: hair thinning · eight · survodutide. This is a procedural question rather than a theoretical one, and I would like the procedure rather than the…

gi-side-effects
gi-side-effects

The gastrointestinal cluster as a whole - nausea, vomiting, diarrhoea, constipation, reflux, early satiety - with trial incidence rates, dropout…

416 questions
titration
titration

Stepwise dose increases over weeks, why the label schedules exist at all, and what tolerability-driven deviation from a schedule looks like in…

444 questions
nausea
nausea

The dominant tolerability signal in every trial of the class: incidence, timing relative to a dose step, duration, and the distinction between…

346 questions
asked by eoin_mcgarry 16k · 10 months ago
24 votes5 answers6.3k views
Is early satiety on tirzepatide dose-dependent or dose-rate dependent?

Concretely: early satiety · tirzepatide. I want to know whether this is a real physical effect or an artefact of how it is measured. What prompted the question is an…

nausea
nausea

The dominant tolerability signal in every trial of the class: incidence, timing relative to a dose step, duration, and the distinction between…

346 questions
titration
titration

Stepwise dose increases over weeks, why the label schedules exist at all, and what tolerability-driven deviation from a schedule looks like in…

444 questions
gi-side-effects
gi-side-effects

The gastrointestinal cluster as a whole - nausea, vomiting, diarrhoea, constipation, reflux, early satiety - with trial incidence rates, dropout…

416 questions
constipation
constipation

Slowed transit as a consequence of delayed gastric emptying and reduced intake: incidence figures, fibre and hydration evidence, and why it often…

14 questions
asked by k_szabo 45k · 6 months ago
23 votes 5 answers51k views
What is the reported incidence of early satiety on cagrilintide in SOUL?

What I am working with: early satiety · cagrilintide · SOUL. I have read the primary source rather than the summary, which has left me with more questions. I…

gi-side-effects
gi-side-effects

The gastrointestinal cluster as a whole - nausea, vomiting, diarrhoea, constipation, reflux, early satiety - with trial incidence rates, dropout…

416 questions
clinical-trials
clinical-trials

Reading the primary literature properly: estimands, intention-to-treat versus per-protocol, confidence intervals, absolute versus relative…

913 questions
nausea
nausea

The dominant tolerability signal in every trial of the class: incidence, timing relative to a dose step, duration, and the distinction between…

346 questions
asked by Dr_Idris_Coulibaly 40k · 2.1 years ago