Endocrine changes accompanying substantial weight loss: sex hormone binding globulin, testosterone, oestradiol, cortisol and the reproductive axis, including PCOS-specific findings.
Diagnosed with PCOS at 24, now 31, BMI 34. I have been told for years that losing weight will improve my symptoms, and separately that insulin resistance is the…
Hypothyroid on 125 µg levothyroxine for six years, stable TSH around 1.4 mIU/L that whole time. Since starting tirzepatide nine months ago and losing 21 kg, my TSH…
Baseline, before starting treatment: total testosterone 2.6 nmol/L, SHBG 22 nmol/L. After eight months and 16 kg of weight loss: total testosterone 1.9 nmol/L, SHBG…
For reference: triglycerides · LDL-C · cagrilintide. The comparison I want does not seem to exist anywhere in a form I can evaluate. I have read the arguments for…
I have three data points across nine months, which I hope is enough to see a trend. I can parse the result. I am less sure what it licenses me to conclude. I have…
Setup, so nobody has to ask: constipation · mazdutide · SURMOUNT-2. I have read the primary source rather than the summary, which has left me with more questions. I…
What I am working with: retatrutide · tirzepatide. I suspect the honest answer is that it depends, in which case I would like to know on what. Assume I can obtain…
The particulars: fatigue · ecnoglutide · PIONEER-4. I want to understand what this actually establishes, as opposed to what it is being used to imply. My concern is…
The case in front of me: magnesium · twelve weeks · dulaglutide. I have two candidate explanations and no way to distinguish them. The same procedure has worked…
The case in front of me: STEP 1 · oral semaglutide. I want to know whether there is evidence behind this or only repetition. I have checked the obvious registries and…
What I have: ApoB · dulaglutide. I would rather over-plan the first cycle and simplify later. I am prepared to do the work if someone can tell me which work matters.…
Stated plainly: dulaglutide · mazdutide. Both of these get recommended confidently by different people, which suggests neither is obviously right. My constraints are…
Setup, so nobody has to ask: creatinine · cystatin C · semaglutide. I suspect the honest answer is that it depends, in which case I would like to know on what. Assume…
Numbers first: fatigue · dulaglutide · SURMOUNT-OSA. This is presented as though it settles something, and I am not convinced it does. I have two documents that…
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