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tirzepatide

Page 7 of 7 · 162 questions tagged tirzepatide.

162 questions · sorted by votes · page 7 of 7

7 votes 5 answers11k views
Is GIP agonism or antagonism the metabolically useful direction?

The receptor pharmacology I can follow; the in vivo translation is where I lose the thread. I would like the axes of comparison first and the recommendation second. I…

gip-receptor
gip-receptor

GIP receptor pharmacology, and the still-unsettled question of whether agonism or antagonism at GIPR is the metabolically useful direction.…

83 questions
tirzepatide
tirzepatide

A dual GIP and GLP-1 receptor agonist. Questions here cover the SURPASS and SURMOUNT programmes, the practical differences from a pure GLP-1…

162 questions
glp1-mechanism
glp1-mechanism

Receptor-level pharmacology: GLP-1R as a class B GPCR, cAMP and PKA signalling, biased agonism, internalisation and resensitisation, and the…

175 questions
retatrutide
retatrutide

An investigational GLP-1, GIP and glucagon receptor tri-agonist, studied in the TRIUMPH programme. Not approved anywhere. Use this tag for…

14 questions
asked by marcus_thorbjorn 16k · 6 months ago
6 votes 5 answers19k views
How comparable are tirzepatide and cagrilintide on the evidence available?

For reference: tirzepatide · cagrilintide. The comparison I want does not seem to exist anywhere in a form I can evaluate. I have read the arguments for each and they…

clinical-trials
clinical-trials

Reading the primary literature properly: estimands, intention-to-treat versus per-protocol, confidence intervals, absolute versus relative…

913 questions
semaglutide
semaglutide

A GLP-1 receptor agonist with a fatty-acid-acylated backbone and a roughly one-week half-life, marketed for type 2 diabetes and for weight…

360 questions
tirzepatide
tirzepatide

A dual GIP and GLP-1 receptor agonist. Questions here cover the SURPASS and SURMOUNT programmes, the practical differences from a pure GLP-1…

162 questions
asked by rosa_mendieta 13k · 20 months ago
6 votes 3 answers16k views
How comparable are tirzepatide and liraglutide on the evidence available?

For reference: tirzepatide · liraglutide. I am trying to choose between two options that are usually discussed as though only one exists. I am not optimising for…

clinical-trials
clinical-trials

Reading the primary literature properly: estimands, intention-to-treat versus per-protocol, confidence intervals, absolute versus relative…

913 questions
semaglutide
semaglutide

A GLP-1 receptor agonist with a fatty-acid-acylated backbone and a roughly one-week half-life, marketed for type 2 diabetes and for weight…

360 questions
tirzepatide
tirzepatide

A dual GIP and GLP-1 receptor agonist. Questions here cover the SURPASS and SURMOUNT programmes, the practical differences from a pure GLP-1…

162 questions
asked by two_two_micron 15k · 17 months ago
6 votes5 answers15k views
Is SURMOUNT-2 a fair comparison of ecnoglutide against its comparator arm?

The specifics, since they change the answer: SURMOUNT-2 · ecnoglutide. Somebody stated this to me confidently and I would like to check it before repeating it. I…

clinical-trials
clinical-trials

Reading the primary literature properly: estimands, intention-to-treat versus per-protocol, confidence intervals, absolute versus relative…

913 questions
semaglutide
semaglutide

A GLP-1 receptor agonist with a fatty-acid-acylated backbone and a roughly one-week half-life, marketed for type 2 diabetes and for weight…

360 questions
tirzepatide
tirzepatide

A dual GIP and GLP-1 receptor agonist. Questions here cover the SURPASS and SURMOUNT programmes, the practical differences from a pure GLP-1…

162 questions
thyroid
thyroid

Thyroid questions: the rodent C-cell findings behind the labelled warning, human calcitonin data, TSH drift during weight loss, and the…

14 questions
asked by m_haraldsen 38k · 2.1 years ago
6 votes 5 answers11k views
Is PIONEER-1 a fair comparison of survodutide against its comparator arm?

The specifics, since they change the answer: PIONEER-1 · survodutide. I would like to know whether this claim survives contact with evidence. If the answer is "nobody…

clinical-trials
clinical-trials

Reading the primary literature properly: estimands, intention-to-treat versus per-protocol, confidence intervals, absolute versus relative…

913 questions
semaglutide
semaglutide

A GLP-1 receptor agonist with a fatty-acid-acylated backbone and a roughly one-week half-life, marketed for type 2 diabetes and for weight…

360 questions
tirzepatide
tirzepatide

A dual GIP and GLP-1 receptor agonist. Questions here cover the SURPASS and SURMOUNT programmes, the practical differences from a pure GLP-1…

162 questions
asked by mass_shift_18 14k · 21 months ago
6 votes5 answers6.8k views
Is ESSENCE a fair comparison of oral semaglutide against its comparator arm?

The case in front of me: ESSENCE · oral semaglutide. The claim is plausible, which is exactly why I want to check it. I am able to read a paper if someone points me…

clinical-trials
clinical-trials

Reading the primary literature properly: estimands, intention-to-treat versus per-protocol, confidence intervals, absolute versus relative…

913 questions
semaglutide
semaglutide

A GLP-1 receptor agonist with a fatty-acid-acylated backbone and a roughly one-week half-life, marketed for type 2 diabetes and for weight…

360 questions
tirzepatide
tirzepatide

A dual GIP and GLP-1 receptor agonist. Questions here cover the SURPASS and SURMOUNT programmes, the practical differences from a pure GLP-1…

162 questions
liraglutide
liraglutide

A once-daily GLP-1 receptor agonist and the compound that established the class. Still relevant for its shorter half-life, its paediatric and…

14 questions
asked by plate_count_9k 95k · 9 months ago
5 votes 5 answers24k views
How comparable are ecnoglutide and tirzepatide on the evidence available?

The case in front of me: ecnoglutide · tirzepatide. I would like the axes of comparison first and the recommendation second. I have tried the first option and it…

clinical-trials
clinical-trials

Reading the primary literature properly: estimands, intention-to-treat versus per-protocol, confidence intervals, absolute versus relative…

913 questions
semaglutide
semaglutide

A GLP-1 receptor agonist with a fatty-acid-acylated backbone and a roughly one-week half-life, marketed for type 2 diabetes and for weight…

360 questions
tirzepatide
tirzepatide

A dual GIP and GLP-1 receptor agonist. Questions here cover the SURPASS and SURMOUNT programmes, the practical differences from a pure GLP-1…

162 questions
renal-outcomes
renal-outcomes

Kidney endpoints: the FLOW composite, eGFR slope as an endpoint, albuminuria regression, and why an early eGFR dip is expected rather than alarming.

14 questions
asked by fib4_reader 35k · 2.0 years ago
5 votes 5 answers20k views
Is REDEFINE-1 a fair comparison of cagrilintide against its comparator arm?

Setup, so nobody has to ask: REDEFINE-1 · cagrilintide. This is asserted often enough that I assumed it was established, and then I went looking for the source. I…

clinical-trials
clinical-trials

Reading the primary literature properly: estimands, intention-to-treat versus per-protocol, confidence intervals, absolute versus relative…

913 questions
semaglutide
semaglutide

A GLP-1 receptor agonist with a fatty-acid-acylated backbone and a roughly one-week half-life, marketed for type 2 diabetes and for weight…

360 questions
tirzepatide
tirzepatide

A dual GIP and GLP-1 receptor agonist. Questions here cover the SURPASS and SURMOUNT programmes, the practical differences from a pure GLP-1…

162 questions
asked by Dr_Lena_Ostrowska 42k · 20 months ago
4 votes 5 answers22k views
Is SURMOUNT-OSA a fair comparison of ecnoglutide against its comparator arm?

The specifics, since they change the answer: SURMOUNT-OSA · ecnoglutide. Somebody stated this to me confidently and I would like to check it before repeating it. I…

clinical-trials
clinical-trials

Reading the primary literature properly: estimands, intention-to-treat versus per-protocol, confidence intervals, absolute versus relative…

913 questions
semaglutide
semaglutide

A GLP-1 receptor agonist with a fatty-acid-acylated backbone and a roughly one-week half-life, marketed for type 2 diabetes and for weight…

360 questions
tirzepatide
tirzepatide

A dual GIP and GLP-1 receptor agonist. Questions here cover the SURPASS and SURMOUNT programmes, the practical differences from a pure GLP-1…

162 questions
asked by tenth_of_a_unit 40k · 21 months ago
4 votes0 answers6.4k views
How comparable are liraglutide and survodutide on the evidence available?

For reference: liraglutide · survodutide. I am trying to choose between two options that are usually discussed as though only one exists. I am not optimising for…

clinical-trials
clinical-trials

Reading the primary literature properly: estimands, intention-to-treat versus per-protocol, confidence intervals, absolute versus relative…

913 questions
semaglutide
semaglutide

A GLP-1 receptor agonist with a fatty-acid-acylated backbone and a roughly one-week half-life, marketed for type 2 diabetes and for weight…

360 questions
tirzepatide
tirzepatide

A dual GIP and GLP-1 receptor agonist. Questions here cover the SURPASS and SURMOUNT programmes, the practical differences from a pure GLP-1…

162 questions
asked by priya_menon 11k · 23 months ago
4 votes4 answers6.1k views
Is STEP 8 a fair comparison of oral semaglutide against its comparator arm?

Concretely: STEP 8 · oral semaglutide. The claim is plausible, which is exactly why I want to check it. I am able to read a paper if someone points me at one. Has…

clinical-trials
clinical-trials

Reading the primary literature properly: estimands, intention-to-treat versus per-protocol, confidence intervals, absolute versus relative…

913 questions
semaglutide
semaglutide

A GLP-1 receptor agonist with a fatty-acid-acylated backbone and a roughly one-week half-life, marketed for type 2 diabetes and for weight…

360 questions
tirzepatide
tirzepatide

A dual GIP and GLP-1 receptor agonist. Questions here cover the SURPASS and SURMOUNT programmes, the practical differences from a pure GLP-1…

162 questions
asked by lucia_marchetti 18k · 14 months ago
4 votes3 answers4.6k views
Is SUSTAIN-6 a fair comparison of dulaglutide against its comparator arm?

Numbers first: SUSTAIN-6 · dulaglutide. I am asking for verification rather than opinion, ideally with something I can read myself. It is possible the evidence exists…

clinical-trials
clinical-trials

Reading the primary literature properly: estimands, intention-to-treat versus per-protocol, confidence intervals, absolute versus relative…

913 questions
semaglutide
semaglutide

A GLP-1 receptor agonist with a fatty-acid-acylated backbone and a roughly one-week half-life, marketed for type 2 diabetes and for weight…

360 questions
tirzepatide
tirzepatide

A dual GIP and GLP-1 receptor agonist. Questions here cover the SURPASS and SURMOUNT programmes, the practical differences from a pure GLP-1…

162 questions
asked by Dr_Ravi_Selvarajah 42k · 6 months ago
4 votes0 answers2.5k views
How comparable are orforglipron and semaglutide on the evidence available?

What I am working with: orforglipron · semaglutide. Both of these get recommended confidently by different people, which suggests neither is obviously right. My…

clinical-trials
clinical-trials

Reading the primary literature properly: estimands, intention-to-treat versus per-protocol, confidence intervals, absolute versus relative…

913 questions
semaglutide
semaglutide

A GLP-1 receptor agonist with a fatty-acid-acylated backbone and a roughly one-week half-life, marketed for type 2 diabetes and for weight…

360 questions
tirzepatide
tirzepatide

A dual GIP and GLP-1 receptor agonist. Questions here cover the SURPASS and SURMOUNT programmes, the practical differences from a pure GLP-1…

162 questions
asked by leah_ferrers 15k · 9 months ago
3 votes 5 answers5.8k views
Is PIONEER-4 a fair comparison of oral semaglutide against its comparator arm?

The case in front of me: PIONEER-4 · oral semaglutide. The claim is plausible, which is exactly why I want to check it. I am able to read a paper if someone points me…

clinical-trials
clinical-trials

Reading the primary literature properly: estimands, intention-to-treat versus per-protocol, confidence intervals, absolute versus relative…

913 questions
semaglutide
semaglutide

A GLP-1 receptor agonist with a fatty-acid-acylated backbone and a roughly one-week half-life, marketed for type 2 diabetes and for weight…

360 questions
tirzepatide
tirzepatide

A dual GIP and GLP-1 receptor agonist. Questions here cover the SURPASS and SURMOUNT programmes, the practical differences from a pure GLP-1…

162 questions
asked by seven_day_half 16k · 6 months ago
3 votes0 answers560 views
Is SURMOUNT-1 a fair comparison of liraglutide against its comparator arm?

Concretely: SURMOUNT-1 · liraglutide. The claim is plausible, which is exactly why I want to check it. I am able to read a paper if someone points me at one. Can…

clinical-trials
clinical-trials

Reading the primary literature properly: estimands, intention-to-treat versus per-protocol, confidence intervals, absolute versus relative…

913 questions
semaglutide
semaglutide

A GLP-1 receptor agonist with a fatty-acid-acylated backbone and a roughly one-week half-life, marketed for type 2 diabetes and for weight…

360 questions
tirzepatide
tirzepatide

A dual GIP and GLP-1 receptor agonist. Questions here cover the SURPASS and SURMOUNT programmes, the practical differences from a pure GLP-1…

162 questions
asked by fiadh_cronin 14k · 12 days ago
2 votes 5 answers4.1k views
Is REDEFINE-1 a fair comparison of oral semaglutide against its comparator arm?

Conditions: REDEFINE-1 · oral semaglutide. I want to know whether there is evidence behind this or only repetition. I have checked the obvious registries and…

clinical-trials
clinical-trials

Reading the primary literature properly: estimands, intention-to-treat versus per-protocol, confidence intervals, absolute versus relative…

913 questions
semaglutide
semaglutide

A GLP-1 receptor agonist with a fatty-acid-acylated backbone and a roughly one-week half-life, marketed for type 2 diabetes and for weight…

360 questions
tirzepatide
tirzepatide

A dual GIP and GLP-1 receptor agonist. Questions here cover the SURPASS and SURMOUNT programmes, the practical differences from a pure GLP-1…

162 questions
asked by bridget_nyathi 16k · 14 months ago
1 vote 5 answers6.8k views
Is PIONEER-4 a fair comparison of liraglutide against its comparator arm?

Concretely: PIONEER-4 · liraglutide. The claim is plausible, which is exactly why I want to check it. I am able to read a paper if someone points me at one. Has…

clinical-trials
clinical-trials

Reading the primary literature properly: estimands, intention-to-treat versus per-protocol, confidence intervals, absolute versus relative…

913 questions
semaglutide
semaglutide

A GLP-1 receptor agonist with a fatty-acid-acylated backbone and a roughly one-week half-life, marketed for type 2 diabetes and for weight…

360 questions
tirzepatide
tirzepatide

A dual GIP and GLP-1 receptor agonist. Questions here cover the SURPASS and SURMOUNT programmes, the practical differences from a pure GLP-1…

162 questions
asked by esben_lykke 15k · 6 months ago
1 vote0 answers308 views
How comparable are retatrutide and mazdutide on the evidence available?

Setup, so nobody has to ask: retatrutide · mazdutide. Both of these get recommended confidently by different people, which suggests neither is obviously right. My…

clinical-trials
clinical-trials

Reading the primary literature properly: estimands, intention-to-treat versus per-protocol, confidence intervals, absolute versus relative…

913 questions
semaglutide
semaglutide

A GLP-1 receptor agonist with a fatty-acid-acylated backbone and a roughly one-week half-life, marketed for type 2 diabetes and for weight…

360 questions
tirzepatide
tirzepatide

A dual GIP and GLP-1 receptor agonist. Questions here cover the SURPASS and SURMOUNT programmes, the practical differences from a pure GLP-1…

162 questions
asked by nadia_kowalczyk 14k · 6 days ago