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titration

Page 13 of 19 · 444 questions tagged titration.

444 questions · sorted by votes · page 13 of 19

14 votes 5 answers38k views
What does REDEFINE-1 tell me about nausea at the 30 mg dose?

For reference: REDEFINE-1 · nausea · 30 mg. I have the document in front of me and I can read the numbers. What I cannot do is interpret them. I am reasonably…

clinical-trials
clinical-trials

Reading the primary literature properly: estimands, intention-to-treat versus per-protocol, confidence intervals, absolute versus relative…

913 questions
gi-side-effects
gi-side-effects

The gastrointestinal cluster as a whole - nausea, vomiting, diarrhoea, constipation, reflux, early satiety - with trial incidence rates, dropout…

416 questions
titration
titration

Stepwise dose increases over weeks, why the label schedules exist at all, and what tolerability-driven deviation from a schedule looks like in…

444 questions
asked by samir_bennani 13k · 23 months ago
14 votes 4 answers13k views
Does holding at 40 mg for four weeks before escalating reduce nausea?

The case in front of me: 40 mg · four weeks · nausea. This is one of those things that everyone repeats and nobody derives. This matters practically, not just…

titration
titration

Stepwise dose increases over weeks, why the label schedules exist at all, and what tolerability-driven deviation from a schedule looks like in…

444 questions
nausea
nausea

The dominant tolerability signal in every trial of the class: incidence, timing relative to a dose step, duration, and the distinction between…

346 questions
dose-escalation
dose-escalation

The decision to move up a step: what evidence supports a four-week interval, what happens when you compress it, and how trial protocols handled…

88 questions
asked by gunnar_isaksen 16k · 15 months ago
14 votes 2 answers11k views
What does PIONEER-1 tell me about headache at the 2 mg dose?

For reference: PIONEER-1 · headache · 2 mg. I have the document in front of me and I can read the numbers. What I cannot do is interpret them. I am reasonably…

clinical-trials
clinical-trials

Reading the primary literature properly: estimands, intention-to-treat versus per-protocol, confidence intervals, absolute versus relative…

913 questions
gi-side-effects
gi-side-effects

The gastrointestinal cluster as a whole - nausea, vomiting, diarrhoea, constipation, reflux, early satiety - with trial incidence rates, dropout…

416 questions
titration
titration

Stepwise dose increases over weeks, why the label schedules exist at all, and what tolerability-driven deviation from a schedule looks like in…

444 questions
asked by leonid_marchuk 15k · 2.0 years ago
14 votes4 answers11k views
What does STEP 2 tell me about hair thinning at the 8 mg dose?

For reference: STEP 2 · hair thinning · 8 mg. I have the document in front of me and I can read the numbers. What I cannot do is interpret them. I am reasonably…

clinical-trials
clinical-trials

Reading the primary literature properly: estimands, intention-to-treat versus per-protocol, confidence intervals, absolute versus relative…

913 questions
gi-side-effects
gi-side-effects

The gastrointestinal cluster as a whole - nausea, vomiting, diarrhoea, constipation, reflux, early satiety - with trial incidence rates, dropout…

416 questions
titration
titration

Stepwise dose increases over weeks, why the label schedules exist at all, and what tolerability-driven deviation from a schedule looks like in…

444 questions
asked by t_oyelaran 41k · 14 months ago
14 votes5 answers9.7k views
Is headache on liraglutide dose-dependent or dose-rate dependent?

The case in front of me: headache · liraglutide. I want to know whether this is a real physical effect or an artefact of how it is measured. What prompted the…

nausea
nausea

The dominant tolerability signal in every trial of the class: incidence, timing relative to a dose step, duration, and the distinction between…

346 questions
titration
titration

Stepwise dose increases over weeks, why the label schedules exist at all, and what tolerability-driven deviation from a schedule looks like in…

444 questions
gi-side-effects
gi-side-effects

The gastrointestinal cluster as a whole - nausea, vomiting, diarrhoea, constipation, reflux, early satiety - with trial incidence rates, dropout…

416 questions
gallbladder
gallbladder

Cholelithiasis and cholecystitis risk during rapid weight loss and on treatment: how much is attributable to the rate of loss versus to the drug,…

14 questions
asked by lucia_marchetti 18k · 7 months ago
14 votes 3 answers8.6k views
What did STEP 2 do with participants who could not tolerate a step?

I have been on a stable schedule for eleven weeks, so this is not a first-week question. I have the document in front of me and I can read the numbers. What I cannot…

titration
titration

Stepwise dose increases over weeks, why the label schedules exist at all, and what tolerability-driven deviation from a schedule looks like in…

444 questions
clinical-trials
clinical-trials

Reading the primary literature properly: estimands, intention-to-treat versus per-protocol, confidence intervals, absolute versus relative…

913 questions
gi-side-effects
gi-side-effects

The gastrointestinal cluster as a whole - nausea, vomiting, diarrhoea, constipation, reflux, early satiety - with trial incidence rates, dropout…

416 questions
asked by seven_day_half 16k · 9 months ago
14 votes0 answers6.2k views
Is fatigue on semaglutide dose-dependent or dose-rate dependent?

For reference: fatigue · semaglutide. I would like the mechanism, because I want to be able to reason about the cases nobody has written about. I have tried to reason…

nausea
nausea

The dominant tolerability signal in every trial of the class: incidence, timing relative to a dose step, duration, and the distinction between…

346 questions
titration
titration

Stepwise dose increases over weeks, why the label schedules exist at all, and what tolerability-driven deviation from a schedule looks like in…

444 questions
gi-side-effects
gi-side-effects

The gastrointestinal cluster as a whole - nausea, vomiting, diarrhoea, constipation, reflux, early satiety - with trial incidence rates, dropout…

416 questions
asked by sian_llewellyn 85k · 14 months ago
14 votes 2 answers5.7k views
How many weeks to steady state for cagrilintide on a weekly schedule?

I would like to know how much of this is established and how much is a reasonable story. This should be a straightforward calculation and I keep getting two different…

glp1-mechanism
glp1-mechanism

Receptor-level pharmacology: GLP-1R as a class B GPCR, cAMP and PKA signalling, biased agonism, internalisation and resensitisation, and the…

175 questions
titration
titration

Stepwise dose increases over weeks, why the label schedules exist at all, and what tolerability-driven deviation from a schedule looks like in…

444 questions
dosing-math
dosing-math

The arithmetic itself: milligrams to millilitres to insulin units, concentration after reconstitution, dose per draw, and vial-days per vial. Show…

811 questions
asked by pascal_thibault 13k · 4 months ago
14 votes 3 answers2.8k views
Does holding at 30 mg for six weeks before escalating reduce reflux?

Numbers first: 30 mg · six weeks · reflux. I suspect the usual explanation for this is wrong, or at least incomplete. I am aware this may have a boring answer. I…

titration
titration

Stepwise dose increases over weeks, why the label schedules exist at all, and what tolerability-driven deviation from a schedule looks like in…

444 questions
nausea
nausea

The dominant tolerability signal in every trial of the class: incidence, timing relative to a dose step, duration, and the distinction between…

346 questions
dose-escalation
dose-escalation

The decision to move up a step: what evidence supports a four-week interval, what happens when you compress it, and how trial protocols handled…

88 questions
asked by dead_volume 49k · 3 months ago
13 votes 5 answers36k views
What does TRIUMPH-3 report at the 4 mg dose level?

Stated plainly: TRIUMPH-3 · 4 mg. I would like help reading this properly rather than being told what conclusion to reach. I have the full report including the method…

clinical-trials
clinical-trials

Reading the primary literature properly: estimands, intention-to-treat versus per-protocol, confidence intervals, absolute versus relative…

913 questions
dosing-math
dosing-math

The arithmetic itself: milligrams to millilitres to insulin units, concentration after reconstitution, dose per draw, and vial-days per vial. Show…

811 questions
titration
titration

Stepwise dose increases over weeks, why the label schedules exist at all, and what tolerability-driven deviation from a schedule looks like in…

444 questions
asked by hana_petrikova 19k · 2.2 years ago
13 votes5 answers24k views
What does STEP 5 tell me about vomiting at the 40 mg dose?

Stated plainly: STEP 5 · vomiting · 40 mg. I would like help reading this properly rather than being told what conclusion to reach. I have the full report including…

clinical-trials
clinical-trials

Reading the primary literature properly: estimands, intention-to-treat versus per-protocol, confidence intervals, absolute versus relative…

913 questions
gi-side-effects
gi-side-effects

The gastrointestinal cluster as a whole - nausea, vomiting, diarrhoea, constipation, reflux, early satiety - with trial incidence rates, dropout…

416 questions
titration
titration

Stepwise dose increases over weeks, why the label schedules exist at all, and what tolerability-driven deviation from a schedule looks like in…

444 questions
asked by plate_count_9k 95k · 2.0 years ago
13 votes 5 answers18k views
Is hair thinning on a GLP-1 receptor agonist dose-dependent or dose-rate dependent?

Setup, so nobody has to ask: hair thinning · a GLP-1 receptor agonist. I keep seeing this stated as a fact with no explanation attached, and unexplained facts make me…

nausea
nausea

The dominant tolerability signal in every trial of the class: incidence, timing relative to a dose step, duration, and the distinction between…

346 questions
titration
titration

Stepwise dose increases over weeks, why the label schedules exist at all, and what tolerability-driven deviation from a schedule looks like in…

444 questions
gi-side-effects
gi-side-effects

The gastrointestinal cluster as a whole - nausea, vomiting, diarrhoea, constipation, reflux, early satiety - with trial incidence rates, dropout…

416 questions
asked by anouk_desmet 18k · 19 months ago
13 votes 4 answers11k views
What did SURMOUNT-2 do with participants who could not tolerate a step?

My records go back to the first dose with dates, so I can reconstruct the timeline exactly. I have read the primary source rather than the summary, which has left me…

titration
titration

Stepwise dose increases over weeks, why the label schedules exist at all, and what tolerability-driven deviation from a schedule looks like in…

444 questions
clinical-trials
clinical-trials

Reading the primary literature properly: estimands, intention-to-treat versus per-protocol, confidence intervals, absolute versus relative…

913 questions
gi-side-effects
gi-side-effects

The gastrointestinal cluster as a whole - nausea, vomiting, diarrhoea, constipation, reflux, early satiety - with trial incidence rates, dropout…

416 questions
asked by bac_or_bust 37k · 13 months ago
13 votes5 answers9.7k views
Does reflux at week seven of mazdutide usually resolve without a dose change?

For reference: reflux · seven · mazdutide. I have read the obvious sources and they disagree with each other, so I would rather ask people who have actually done…

gi-side-effects
gi-side-effects

The gastrointestinal cluster as a whole - nausea, vomiting, diarrhoea, constipation, reflux, early satiety - with trial incidence rates, dropout…

416 questions
titration
titration

Stepwise dose increases over weeks, why the label schedules exist at all, and what tolerability-driven deviation from a schedule looks like in…

444 questions
nausea
nausea

The dominant tolerability signal in every trial of the class: incidence, timing relative to a dose step, duration, and the distinction between…

346 questions
asked by stopper_core 50k · 11 months ago
13 votes5 answers8.5k views
What does PIONEER-4 tell me about nausea at the 50 mg dose?

Numbers first: PIONEER-4 · nausea · 50 mg. I can parse the result. I am less sure what it licenses me to conclude. I have deliberately not looked at anyone else’s…

clinical-trials
clinical-trials

Reading the primary literature properly: estimands, intention-to-treat versus per-protocol, confidence intervals, absolute versus relative…

913 questions
gi-side-effects
gi-side-effects

The gastrointestinal cluster as a whole - nausea, vomiting, diarrhoea, constipation, reflux, early satiety - with trial incidence rates, dropout…

416 questions
titration
titration

Stepwise dose increases over weeks, why the label schedules exist at all, and what tolerability-driven deviation from a schedule looks like in…

444 questions
asked by meniscus_film 34k · 15 months ago
13 votes 5 answers6.8k views
What does SURMOUNT-2 report at the 50 mg dose level?

What I am working with: SURMOUNT-2 · 50 mg. I have read the primary source rather than the summary, which has left me with more questions. I understand the headline.…

clinical-trials
clinical-trials

Reading the primary literature properly: estimands, intention-to-treat versus per-protocol, confidence intervals, absolute versus relative…

913 questions
dosing-math
dosing-math

The arithmetic itself: milligrams to millilitres to insulin units, concentration after reconstitution, dose per draw, and vial-days per vial. Show…

811 questions
titration
titration

Stepwise dose increases over weeks, why the label schedules exist at all, and what tolerability-driven deviation from a schedule looks like in…

444 questions
asked by oona_kekkonen 16k · 2 months ago
13 votes 5 answers5.7k views
What did SURMOUNT-4 do with participants who could not tolerate a step?

This came up because two published schedules for the same agent differ. I would like help reading this properly rather than being told what conclusion to reach. I…

titration
titration

Stepwise dose increases over weeks, why the label schedules exist at all, and what tolerability-driven deviation from a schedule looks like in…

444 questions
clinical-trials
clinical-trials

Reading the primary literature properly: estimands, intention-to-treat versus per-protocol, confidence intervals, absolute versus relative…

913 questions
gi-side-effects
gi-side-effects

The gastrointestinal cluster as a whole - nausea, vomiting, diarrhoea, constipation, reflux, early satiety - with trial incidence rates, dropout…

416 questions
asked by rune_thoresen 14k · 5 months ago
13 votes5 answers3.1k views
Does holding at 2.5 mg for four weeks before escalating reduce nausea?

The case in front of me: 2.5 mg · four weeks · nausea. This is one of those things that everyone repeats and nobody derives. This matters practically, not just…

titration
titration

Stepwise dose increases over weeks, why the label schedules exist at all, and what tolerability-driven deviation from a schedule looks like in…

444 questions
nausea
nausea

The dominant tolerability signal in every trial of the class: incidence, timing relative to a dose step, duration, and the distinction between…

346 questions
dose-escalation
dose-escalation

The decision to move up a step: what evidence supports a four-week interval, what happens when you compress it, and how trial protocols handled…

88 questions
asked by Dr_Hanne_Solberg 40k · 2 months ago
13 votes 2 answers2.7k views
Does injection-site erythema at week nine of a GLP-1 receptor agonist usually resolve without a dose change?

For reference: injection-site erythema · nine · a GLP-1 receptor agonist. I have read the obvious sources and they disagree with each other, so I would rather ask…

gi-side-effects
gi-side-effects

The gastrointestinal cluster as a whole - nausea, vomiting, diarrhoea, constipation, reflux, early satiety - with trial incidence rates, dropout…

416 questions
titration
titration

Stepwise dose increases over weeks, why the label schedules exist at all, and what tolerability-driven deviation from a schedule looks like in…

444 questions
nausea
nausea

The dominant tolerability signal in every trial of the class: incidence, timing relative to a dose step, duration, and the distinction between…

346 questions
asked by fibre_or_fragment 12k · 9 days ago
12 votes 5 answers28k views
Does holding at 15 mg for three weeks before escalating reduce fatigue?

The particulars: 15 mg · three weeks · fatigue. I would like the mechanism, because I want to be able to reason about the cases nobody has written about. I have tried…

titration
titration

Stepwise dose increases over weeks, why the label schedules exist at all, and what tolerability-driven deviation from a schedule looks like in…

444 questions
nausea
nausea

The dominant tolerability signal in every trial of the class: incidence, timing relative to a dose step, duration, and the distinction between…

346 questions
dose-escalation
dose-escalation

The decision to move up a step: what evidence supports a four-week interval, what happens when you compress it, and how trial protocols handled…

88 questions
asked by otto_brenner 19k · 21 months ago
12 votes 5 answers24k views
What did STEP 1 do with participants who could not tolerate a step?

I have been on a stable schedule for eleven weeks, so this is not a first-week question. This is presented as though it settles something, and I am not convinced it…

titration
titration

Stepwise dose increases over weeks, why the label schedules exist at all, and what tolerability-driven deviation from a schedule looks like in…

444 questions
clinical-trials
clinical-trials

Reading the primary literature properly: estimands, intention-to-treat versus per-protocol, confidence intervals, absolute versus relative…

913 questions
gi-side-effects
gi-side-effects

The gastrointestinal cluster as a whole - nausea, vomiting, diarrhoea, constipation, reflux, early satiety - with trial incidence rates, dropout…

416 questions
asked by swab_stopper 16k · 20 months ago
12 votes5 answers20k views
Does reflux at week twelve of tirzepatide usually resolve without a dose change?

What I have: reflux · twelve · tirzepatide. I would like to understand the steps well enough to explain them to someone else. I have access to a refrigerator with a…

gi-side-effects
gi-side-effects

The gastrointestinal cluster as a whole - nausea, vomiting, diarrhoea, constipation, reflux, early satiety - with trial incidence rates, dropout…

416 questions
titration
titration

Stepwise dose increases over weeks, why the label schedules exist at all, and what tolerability-driven deviation from a schedule looks like in…

444 questions
nausea
nausea

The dominant tolerability signal in every trial of the class: incidence, timing relative to a dose step, duration, and the distinction between…

346 questions
asked by gel_pack_warm 13k · 20 months ago
12 votes5 answers16k views
What does STEP 4 tell me about injection-site erythema at the 2.5 mg dose?

Stated plainly: STEP 4 · injection-site erythema · 2.5 mg. I would like help reading this properly rather than being told what conclusion to reach. I have the full…

clinical-trials
clinical-trials

Reading the primary literature properly: estimands, intention-to-treat versus per-protocol, confidence intervals, absolute versus relative…

913 questions
gi-side-effects
gi-side-effects

The gastrointestinal cluster as a whole - nausea, vomiting, diarrhoea, constipation, reflux, early satiety - with trial incidence rates, dropout…

416 questions
titration
titration

Stepwise dose increases over weeks, why the label schedules exist at all, and what tolerability-driven deviation from a schedule looks like in…

444 questions
asked by kelvin_lam 11k · 10 months ago
12 votes0 answers14k views
What did STEP 5 do with participants who could not tolerate a step?

I have been on a stable schedule for eleven weeks, so this is not a first-week question. This is presented as though it settles something, and I am not convinced it…

titration
titration

Stepwise dose increases over weeks, why the label schedules exist at all, and what tolerability-driven deviation from a schedule looks like in…

444 questions
clinical-trials
clinical-trials

Reading the primary literature properly: estimands, intention-to-treat versus per-protocol, confidence intervals, absolute versus relative…

913 questions
gi-side-effects
gi-side-effects

The gastrointestinal cluster as a whole - nausea, vomiting, diarrhoea, constipation, reflux, early satiety - with trial incidence rates, dropout…

416 questions
asked by second_lot 11k · 2.0 years ago