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maintenance-dose

Page 2 of 2 · 44 questions tagged maintenance-dose.

44 questions · sorted by votes · page 2 of 2

20 votes 5 answers4k views
Is 2 mg weekly a defensible maintenance dose for dulaglutide?

Details up front: 2 mg · dulaglutide. This is a planning question. I know what my options are; I do not know how to weigh them. What I want is the minimum viable…

maintenance-dose
maintenance-dose

Staying put: the lowest dose that holds a result, the difference between the maximum studied dose and the maximum useful dose, and what the…

44 questions
clinical-trials
clinical-trials

Reading the primary literature properly: estimands, intention-to-treat versus per-protocol, confidence intervals, absolute versus relative…

913 questions
dosing-math
dosing-math

The arithmetic itself: milligrams to millilitres to insulin units, concentration after reconstitution, dose per draw, and vial-days per vial. Show…

811 questions
asked by petra_hovland 42k · 2 months ago
19 votes5 answers5.5k views
Is 40 mg weekly a defensible maintenance dose for liraglutide?

Concretely: 40 mg · liraglutide. The failure mode I am trying to avoid is making this decision emotionally. I have twelve months in view and I would like the plan to…

maintenance-dose
maintenance-dose

Staying put: the lowest dose that holds a result, the difference between the maximum studied dose and the maximum useful dose, and what the…

44 questions
clinical-trials
clinical-trials

Reading the primary literature properly: estimands, intention-to-treat versus per-protocol, confidence intervals, absolute versus relative…

913 questions
dosing-math
dosing-math

The arithmetic itself: milligrams to millilitres to insulin units, concentration after reconstitution, dose per draw, and vial-days per vial. Show…

811 questions
asked by Dr_Tomas_Kral 37k · 8 months ago
16 votes 5 answers12k views
Is 15 mg weekly a defensible maintenance dose for survodutide?

For reference: 15 mg · survodutide. I would like to define my thresholds before I have a result, for obvious reasons. I want a plan with explicit stopping rules, not…

maintenance-dose
maintenance-dose

Staying put: the lowest dose that holds a result, the difference between the maximum studied dose and the maximum useful dose, and what the…

44 questions
clinical-trials
clinical-trials

Reading the primary literature properly: estimands, intention-to-treat versus per-protocol, confidence intervals, absolute versus relative…

913 questions
dosing-math
dosing-math

The arithmetic itself: milligrams to millilitres to insulin units, concentration after reconstitution, dose per draw, and vial-days per vial. Show…

811 questions
asked by cake_intact 18k · 5 months ago
16 votes 3 answers3.6k views
Is 5 mg weekly a defensible maintenance dose for a GLP-1 receptor agonist?

Stated plainly: 5 mg · a GLP-1 receptor agonist. I am trying to build something sustainable rather than something thorough that I will abandon. I have already decided…

maintenance-dose
maintenance-dose

Staying put: the lowest dose that holds a result, the difference between the maximum studied dose and the maximum useful dose, and what the…

44 questions
clinical-trials
clinical-trials

Reading the primary literature properly: estimands, intention-to-treat versus per-protocol, confidence intervals, absolute versus relative…

913 questions
dosing-math
dosing-math

The arithmetic itself: milligrams to millilitres to insulin units, concentration after reconstitution, dose per draw, and vial-days per vial. Show…

811 questions
asked by k_szabo 45k · 34 days ago
15 votes 1 answer8.6k views
Is 8 mg weekly a defensible maintenance dose for retatrutide?

Numbers first: 8 mg · retatrutide. This is a planning question. I know what my options are; I do not know how to weigh them. What I want is the minimum viable…

maintenance-dose
maintenance-dose

Staying put: the lowest dose that holds a result, the difference between the maximum studied dose and the maximum useful dose, and what the…

44 questions
clinical-trials
clinical-trials

Reading the primary literature properly: estimands, intention-to-treat versus per-protocol, confidence intervals, absolute versus relative…

913 questions
dosing-math
dosing-math

The arithmetic itself: milligrams to millilitres to insulin units, concentration after reconstitution, dose per draw, and vial-days per vial. Show…

811 questions
asked by lipid_panel_q 44k · 7 months ago
13 votes5 answers21k views
Is 10 mg weekly a defensible maintenance dose for oral semaglutide?

Conditions: 10 mg · oral semaglutide. The failure mode I am trying to avoid is making this decision emotionally. I have twelve months in view and I would like the…

maintenance-dose
maintenance-dose

Staying put: the lowest dose that holds a result, the difference between the maximum studied dose and the maximum useful dose, and what the…

44 questions
clinical-trials
clinical-trials

Reading the primary literature properly: estimands, intention-to-treat versus per-protocol, confidence intervals, absolute versus relative…

913 questions
dosing-math
dosing-math

The arithmetic itself: milligrams to millilitres to insulin units, concentration after reconstitution, dose per draw, and vial-days per vial. Show…

811 questions
asked by rosa_mendieta 13k · 18 months ago
12 votes 5 answers31k views
Is tapering better supported than stopping abruptly?

I have three DEXA scans on the same scanner at twelve-week intervals, fasted, same time of day. I would like to know whether this claim survives contact with…

discontinuation
discontinuation

Stopping treatment: tapering versus abrupt cessation, what the trial withdrawal arms measured, clinically driven stops, and the practical planning…

21 questions
maintenance-dose
maintenance-dose

Staying put: the lowest dose that holds a result, the difference between the maximum studied dose and the maximum useful dose, and what the…

44 questions
weight-regain
weight-regain

Regain after stopping or reducing: the trajectory reported in the withdrawal extensions, how much is fluid, and what the maintenance arms tell us…

14 questions
asked by mira_sundqvist 19k · 2.1 years ago
9 votes0 answers5.7k views
Is 2 mg weekly a defensible maintenance dose for orforglipron?

Numbers first: 2 mg · orforglipron. I would rather over-plan the first cycle and simplify later. I am prepared to do the work if someone can tell me which work…

maintenance-dose
maintenance-dose

Staying put: the lowest dose that holds a result, the difference between the maximum studied dose and the maximum useful dose, and what the…

44 questions
clinical-trials
clinical-trials

Reading the primary literature properly: estimands, intention-to-treat versus per-protocol, confidence intervals, absolute versus relative…

913 questions
dosing-math
dosing-math

The arithmetic itself: milligrams to millilitres to insulin units, concentration after reconstitution, dose per draw, and vial-days per vial. Show…

811 questions
asked by tyndall_haze 48k · 2.1 years ago
8 votes 5 answers9k views
Is 5 mg weekly a defensible maintenance dose for mazdutide?

Setup, so nobody has to ask: 5 mg · mazdutide. I am trying to build something sustainable rather than something thorough that I will abandon. I have already decided…

maintenance-dose
maintenance-dose

Staying put: the lowest dose that holds a result, the difference between the maximum studied dose and the maximum useful dose, and what the…

44 questions
clinical-trials
clinical-trials

Reading the primary literature properly: estimands, intention-to-treat versus per-protocol, confidence intervals, absolute versus relative…

913 questions
dosing-math
dosing-math

The arithmetic itself: milligrams to millilitres to insulin units, concentration after reconstitution, dose per draw, and vial-days per vial. Show…

811 questions
asked by ellis_thorne 17k · 20 months ago
8 votes 4 answers5.5k views
Is 8 mg weekly a defensible maintenance dose for dulaglutide?

Numbers first: 8 mg · dulaglutide. This is a planning question. I know what my options are; I do not know how to weigh them. What I want is the minimum viable…

maintenance-dose
maintenance-dose

Staying put: the lowest dose that holds a result, the difference between the maximum studied dose and the maximum useful dose, and what the…

44 questions
clinical-trials
clinical-trials

Reading the primary literature properly: estimands, intention-to-treat versus per-protocol, confidence intervals, absolute versus relative…

913 questions
dosing-math
dosing-math

The arithmetic itself: milligrams to millilitres to insulin units, concentration after reconstitution, dose per draw, and vial-days per vial. Show…

811 questions
asked by Dr_Lena_Ostrowska 42k · 5 months ago
7 votes0 answers2.9k views
Is the maximum studied dose the same as the maximum useful dose?

My records go back to the first dose with dates, so I can reconstruct the timeline exactly. I suspect the honest answer is that it depends, in which case I would like…

maintenance-dose
maintenance-dose

Staying put: the lowest dose that holds a result, the difference between the maximum studied dose and the maximum useful dose, and what the…

44 questions
clinical-trials
clinical-trials

Reading the primary literature properly: estimands, intention-to-treat versus per-protocol, confidence intervals, absolute versus relative…

913 questions
dose-escalation
dose-escalation

The decision to move up a step: what evidence supports a four-week interval, what happens when you compress it, and how trial protocols handled…

88 questions
asked by eighty_six_hours 16k · 16 months ago
7 votes 2 answers1.2k views
Is 10 mg weekly a defensible maintenance dose for liraglutide?

Concretely: 10 mg · liraglutide. The failure mode I am trying to avoid is making this decision emotionally. I have twelve months in view and I would like the plan to…

maintenance-dose
maintenance-dose

Staying put: the lowest dose that holds a result, the difference between the maximum studied dose and the maximum useful dose, and what the…

44 questions
clinical-trials
clinical-trials

Reading the primary literature properly: estimands, intention-to-treat versus per-protocol, confidence intervals, absolute versus relative…

913 questions
dosing-math
dosing-math

The arithmetic itself: milligrams to millilitres to insulin units, concentration after reconstitution, dose per draw, and vial-days per vial. Show…

811 questions
asked by colm_dunphy 16k · 28 days ago
6 votes5 answers8.6k views
Is 2 mg weekly a defensible maintenance dose for retatrutide?

Numbers first: 2 mg · retatrutide. I would rather over-plan the first cycle and simplify later. I am prepared to do the work if someone can tell me which work…

maintenance-dose
maintenance-dose

Staying put: the lowest dose that holds a result, the difference between the maximum studied dose and the maximum useful dose, and what the…

44 questions
clinical-trials
clinical-trials

Reading the primary literature properly: estimands, intention-to-treat versus per-protocol, confidence intervals, absolute versus relative…

913 questions
dosing-math
dosing-math

The arithmetic itself: milligrams to millilitres to insulin units, concentration after reconstitution, dose per draw, and vial-days per vial. Show…

811 questions
asked by greta_holzmann 15k · 6 months ago
4 votes5 answers19k views
What is the lowest maintenance dose with published maintenance data behind it?

I have been on a stable schedule for eleven weeks, so this is not a first-week question. I am asking for verification rather than opinion, ideally with something I…

maintenance-dose
maintenance-dose

Staying put: the lowest dose that holds a result, the difference between the maximum studied dose and the maximum useful dose, and what the…

44 questions
clinical-trials
clinical-trials

Reading the primary literature properly: estimands, intention-to-treat versus per-protocol, confidence intervals, absolute versus relative…

913 questions
weight-regain
weight-regain

Regain after stopping or reducing: the trajectory reported in the withdrawal extensions, how much is fluid, and what the maintenance arms tell us…

14 questions
asked by claudia_ferrante 46k · 2.3 years ago
4 votes 2 answers12k views
Does a plateau mean I need a dose step, or that I need to wait?

The trend is what I care about; individual weeks are obviously noise. This is a planning question. I know what my options are; I do not know how to weigh them. What I…

plateau
plateau

A stall in progress: distinguishing adaptive thermogenesis from measurement error from adherence drift, how long to observe before changing…

35 questions
dose-escalation
dose-escalation

The decision to move up a step: what evidence supports a four-week interval, what happens when you compress it, and how trial protocols handled…

88 questions
maintenance-dose
maintenance-dose

Staying put: the lowest dose that holds a result, the difference between the maximum studied dose and the maximum useful dose, and what the…

44 questions
asked by cap_the_luer 15k · 20 months ago
3 votes 5 answers2k views
Is 20 mg weekly a defensible maintenance dose for cagrilintide?

Stated plainly: 20 mg · cagrilintide. I would like to set this up properly once, rather than adjust it repeatedly. My budget is real but not tight, and my tolerance…

maintenance-dose
maintenance-dose

Staying put: the lowest dose that holds a result, the difference between the maximum studied dose and the maximum useful dose, and what the…

44 questions
clinical-trials
clinical-trials

Reading the primary literature properly: estimands, intention-to-treat versus per-protocol, confidence intervals, absolute versus relative…

913 questions
dosing-math
dosing-math

The arithmetic itself: milligrams to millilitres to insulin units, concentration after reconstitution, dose per draw, and vial-days per vial. Show…

811 questions
asked by unit_math 13k · 3 months ago
2 votes 5 answers7.3k views
Is 30 mg weekly a defensible maintenance dose for dulaglutide?

Numbers first: 30 mg · dulaglutide. I would rather over-plan the first cycle and simplify later. I am prepared to do the work if someone can tell me which work…

maintenance-dose
maintenance-dose

Staying put: the lowest dose that holds a result, the difference between the maximum studied dose and the maximum useful dose, and what the…

44 questions
clinical-trials
clinical-trials

Reading the primary literature properly: estimands, intention-to-treat versus per-protocol, confidence intervals, absolute versus relative…

913 questions
dosing-math
dosing-math

The arithmetic itself: milligrams to millilitres to insulin units, concentration after reconstitution, dose per draw, and vial-days per vial. Show…

811 questions
asked by rukhsana_iqbal 14k · 6 months ago
1 vote 5 answers6.5k views
Is 60 mg weekly a defensible maintenance dose for cagrilintide?

Stated plainly: 60 mg · cagrilintide. I would like to set this up properly once, rather than adjust it repeatedly. My budget is real but not tight, and my tolerance…

maintenance-dose
maintenance-dose

Staying put: the lowest dose that holds a result, the difference between the maximum studied dose and the maximum useful dose, and what the…

44 questions
clinical-trials
clinical-trials

Reading the primary literature properly: estimands, intention-to-treat versus per-protocol, confidence intervals, absolute versus relative…

913 questions
dosing-math
dosing-math

The arithmetic itself: milligrams to millilitres to insulin units, concentration after reconstitution, dose per draw, and vial-days per vial. Show…

811 questions
asked by felix_araya 17k · 4 months ago
1 vote5 answers5.6k views
Is 40 mg weekly a defensible maintenance dose for oral semaglutide?

Concretely: 40 mg · oral semaglutide. I want to decide this in advance so that I am not deciding it under pressure later. Assume I will follow the plan I write down,…

maintenance-dose
maintenance-dose

Staying put: the lowest dose that holds a result, the difference between the maximum studied dose and the maximum useful dose, and what the…

44 questions
clinical-trials
clinical-trials

Reading the primary literature properly: estimands, intention-to-treat versus per-protocol, confidence intervals, absolute versus relative…

913 questions
dosing-math
dosing-math

The arithmetic itself: milligrams to millilitres to insulin units, concentration after reconstitution, dose per draw, and vial-days per vial. Show…

811 questions
asked by seamus_brady 17k · 8 months ago
1 vote 5 answers2.1k views
Is 2.5 mg weekly a defensible maintenance dose for oral semaglutide?

Conditions: 2.5 mg · oral semaglutide. The failure mode I am trying to avoid is making this decision emotionally. I have twelve months in view and I would like the…

maintenance-dose
maintenance-dose

Staying put: the lowest dose that holds a result, the difference between the maximum studied dose and the maximum useful dose, and what the…

44 questions
clinical-trials
clinical-trials

Reading the primary literature properly: estimands, intention-to-treat versus per-protocol, confidence intervals, absolute versus relative…

913 questions
dosing-math
dosing-math

The arithmetic itself: milligrams to millilitres to insulin units, concentration after reconstitution, dose per draw, and vial-days per vial. Show…

811 questions
asked by Dr_Ilse_Vandenberg 78k · 4 months ago