Page 17 of 35 · 832 questions tagged peptide-stability.
The specifics, since they change the answer: tirzepatide · 37 °C. Somebody stated this to me confidently and I would like to check it before repeating it. I would…
What I have: cagrilintide · room temperature. I can find plenty of assertions about this and almost no reasoning, which is usually a sign that nobody has checked.…
Numbers first: a GLP-1 receptor agonist · 2.5 mg/mL · eight weeks. I would rather be corrected now than propagate something wrong. I am specifically not interested in…
The case in front of me: oxidation · minus 80 °C. This is one of those things that everyone repeats and nobody derives. This matters practically, not just…
Details up front: cagrilintide · room temperature. I am asking for verification rather than opinion, ideally with something I can read myself. It is possible the…
For reference: tirzepatide · 1 mg/mL. I want a method I can write down and repeat, not a rule of thumb. I would rather over-engineer this than discover a problem…
What I have: racemisation · 37 °C. I suspect the usual explanation for this is wrong, or at least incomplete. I am aware this may have a boring answer. I would still…
Stated plainly: retatrutide · 2–8 °C. This is a procedural question rather than a theoretical one, and I would like the procedure rather than the theory. What I have…
Numbers first: hydrolysis · retatrutide · minus 80 °C. I can predict the outcome but I cannot explain it, which means I will get the next case wrong. I would like to…
I ran a small experiment I should probably have run before ordering anything. I put a cheap USB temperature logger in a parcel and shipped it on a route I had used…
I have two vials of nominally the same compound from different suppliers. One cake is a dense white puck that sits proud in the vial; the other is a thin, almost…
Two connected things I cannot get a straight answer on. First, chemistry. I keep reading that benzyl alcohol "can destabilise proteins" and I have seen it cited as a…
The specifics, since they change the answer: deamidation · ecnoglutide · 30 °C. I understand the observation; what I do not understand is the mechanism behind it. I…
The particulars: oral semaglutide · 6.67 mg/mL. I would like the arithmetic checked rather than the conclusion asserted. I have deliberately not used an online…
For reference: fibrillation · semaglutide · 40 °C. I would like the mechanism, because I want to be able to reason about the cases nobody has written about. I have…
Concretely: survodutide · 5 mg/mL · ten weeks. The claim is plausible, which is exactly why I want to check it. I am able to read a paper if someone points me at one.…
Stated plainly: retatrutide · 2 mg/mL · sixteen weeks. This is asserted often enough that I assumed it was established, and then I went looking for the source. I have…
Stated plainly: dulaglutide · 8 mg/mL. Everything I have found on this is either a forum aside or a product page, neither of which I trust. I am comfortable with the…
Numbers first: a GLP-1 receptor agonist · 1 mg/mL. I can do the algebra. I am not confident about the conversion factors. If there is a standard way to lay this out,…
Stated plainly: dulaglutide · 4 °C. This is asserted often enough that I assumed it was established, and then I went looking for the source. I have searched the…
The case in front of me: survodutide · 30 °C. I want to know whether there is evidence behind this or only repetition. I have checked the obvious registries and…
Numbers first: mazdutide · six weeks · minus 80 °C. I can predict the outcome but I cannot explain it, which means I will get the next case wrong. I would like to…
Details up front: a GLP-1 receptor agonist · 6.67 mg/mL. I would like to understand the steps well enough to explain them to someone else. I have access to a…
For reference: fibrillation · semaglutide · Medutest. I want a method I can write down and repeat, not a rule of thumb. I would rather over-engineer this than…