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storage

Page 22 of 27 · 646 questions tagged storage.

646 questions · sorted by votes · page 22 of 27

9 votes2 answers13k views
Is there any published stability data for a GLP-1 receptor agonist at room temperature?

What I have: a GLP-1 receptor agonist · room temperature. I would rather be corrected now than propagate something wrong. I am specifically not interested in a…

peptide-stability
peptide-stability

The chemistry of peptide degradation: deamidation, oxidation, hydrolysis, aggregation and fibrillation, and how temperature, pH, ionic strength,…

832 questions
storage
storage

Storage conditions and their evidence base: minus twenty degrees for powder, refrigerated for solution, protection from light, and what the…

646 questions
clinical-trials
clinical-trials

Reading the primary literature properly: estimands, intention-to-treat versus per-protocol, confidence intervals, absolute versus relative…

913 questions
asked by swab_and_wait 15k · 22 months ago
9 votes 5 answers11k views
What happens to ecnoglutide after four weeks at 2–8 °C in solution?

The case in front of me: ecnoglutide · four weeks · 2–8 °C. I want to know whether this is a real physical effect or an artefact of how it is measured. What prompted…

peptide-stability
peptide-stability

The chemistry of peptide degradation: deamidation, oxidation, hydrolysis, aggregation and fibrillation, and how temperature, pH, ionic strength,…

832 questions
storage
storage

Storage conditions and their evidence base: minus twenty degrees for powder, refrigerated for solution, protection from light, and what the…

646 questions
shelf-life
shelf-life

How long a preparation remains within specification: labelled expiry for a sealed lyophilised vial, beyond-use dating after reconstitution, and…

301 questions
asked by rosa_mendieta 13k · 13 months ago
9 votes5 answers11k views
What is the thermal exposure on a Zhuhai to the United Kingdom lane in summer?

Details up front: Zhuhai · the United Kingdom. I can parse the result. I am less sure what it licenses me to conclude. I have deliberately not looked at anyone else’s…

cold-chain
cold-chain

Keeping material within a temperature window from manufacture to use: phase-change packs versus dry ice, thermal mass, transit-lane temperature…

524 questions
international-shipping
international-shipping

Cross-border movement of research material: transit lanes and their thermal profiles, tracked versus untracked, declaration accuracy, and what…

427 questions
storage
storage

Storage conditions and their evidence base: minus twenty degrees for powder, refrigerated for solution, protection from light, and what the…

646 questions
asked by two_two_micron 15k · 9 months ago
9 votes4 answers9.6k views
Does aspartimide formation dominate for liraglutide held at 25 °C?

The case in front of me: aspartimide formation · liraglutide · 25 °C. I want to know whether this is a real physical effect or an artefact of how it is measured. What…

peptide-stability
peptide-stability

The chemistry of peptide degradation: deamidation, oxidation, hydrolysis, aggregation and fibrillation, and how temperature, pH, ionic strength,…

832 questions
storage
storage

Storage conditions and their evidence base: minus twenty degrees for powder, refrigerated for solution, protection from light, and what the…

646 questions
hplc
hplc

Reverse-phase high-performance liquid chromatography, the workhorse purity method. Column chemistry, mobile-phase choice, gradient slope,…

466 questions
asked by a_lindgren 46k · 7 months ago
9 votes0 answers7.7k views
What is the thermal exposure on a Suzhou to Norway lane in summer?

Concretely: Suzhou · Norway. I would like to know the limits of what can be inferred from this. What I am trying to avoid is over-reading a single result, which I…

cold-chain
cold-chain

Keeping material within a temperature window from manufacture to use: phase-change packs versus dry ice, thermal mass, transit-lane temperature…

524 questions
international-shipping
international-shipping

Cross-border movement of research material: transit lanes and their thermal profiles, tracked versus untracked, declaration accuracy, and what…

427 questions
storage
storage

Storage conditions and their evidence base: minus twenty degrees for powder, refrigerated for solution, protection from light, and what the…

646 questions
asked by nynke_dekker 18k · 13 months ago
9 votes 1 answer6.1k views
Is room temperature an acceptable storage condition for lyophilised dulaglutide?

Numbers first: room temperature · dulaglutide. I am asking for verification rather than opinion, ideally with something I can read myself. It is possible the evidence…

storage
storage

Storage conditions and their evidence base: minus twenty degrees for powder, refrigerated for solution, protection from light, and what the…

646 questions
peptide-stability
peptide-stability

The chemistry of peptide degradation: deamidation, oxidation, hydrolysis, aggregation and fibrillation, and how temperature, pH, ionic strength,…

832 questions
shelf-life
shelf-life

How long a preparation remains within specification: labelled expiry for a sealed lyophilised vial, beyond-use dating after reconstitution, and…

301 questions
asked by yuki_morishita 19k · 9 months ago
9 votes 3 answers4.2k views
Does a phase-change pack hold a dulaglutide shipment for three days in transit?

What I am working with: dulaglutide · three days. The units are where I keep going wrong, so please be explicit about them. I have sanity-checked the order of…

cold-chain
cold-chain

Keeping material within a temperature window from manufacture to use: phase-change packs versus dry ice, thermal mass, transit-lane temperature…

524 questions
international-shipping
international-shipping

Cross-border movement of research material: transit lanes and their thermal profiles, tracked versus untracked, declaration accuracy, and what…

427 questions
storage
storage

Storage conditions and their evidence base: minus twenty degrees for powder, refrigerated for solution, protection from light, and what the…

646 questions
asked by grainne_ahearn 13k · 2 months ago
9 votes0 answers3.4k views
Does oxidation dominate for oral semaglutide held at 2–8 °C?

The case in front of me: oxidation · oral semaglutide · 2–8 °C. This is one of those things that everyone repeats and nobody derives. This matters practically, not…

peptide-stability
peptide-stability

The chemistry of peptide degradation: deamidation, oxidation, hydrolysis, aggregation and fibrillation, and how temperature, pH, ionic strength,…

832 questions
storage
storage

Storage conditions and their evidence base: minus twenty degrees for powder, refrigerated for solution, protection from light, and what the…

646 questions
hplc
hplc

Reverse-phase high-performance liquid chromatography, the workhorse purity method. Column chemistry, mobile-phase choice, gradient slope,…

466 questions
asked by forty_units 14k · 7 months ago
9 votes 1 answer2.8k views
Is a mini-fridge good enough for storing reconstituted semaglutide?

The specifics, since they change the answer: a mini-fridge · semaglutide. I would like to define my thresholds before I have a result, for obvious reasons. I want a…

storage
storage

Storage conditions and their evidence base: minus twenty degrees for powder, refrigerated for solution, protection from light, and what the…

646 questions
cold-chain
cold-chain

Keeping material within a temperature window from manufacture to use: phase-change packs versus dry ice, thermal mass, transit-lane temperature…

524 questions
harm-reduction
harm-reduction

Reducing avoidable risk where a decision has already been made: independent verification before use, sterility practice, dose arithmetic checked…

445 questions
asked by dermot_kiely 14k · 10 months ago
8 votes 5 answers26k views
How many freeze-thaw cycles will retatrutide at 2 mg/mL tolerate?

Stated plainly: retatrutide · 2 mg/mL. Everything I have found on this is either a forum aside or a product page, neither of which I trust. I am comfortable with the…

freeze-thaw
freeze-thaw

What repeated freezing does to a peptide in solution: ice-crystal shear at the growing front, freeze-concentration of solutes, pH shifts as buffer…

55 questions
peptide-stability
peptide-stability

The chemistry of peptide degradation: deamidation, oxidation, hydrolysis, aggregation and fibrillation, and how temperature, pH, ionic strength,…

832 questions
storage
storage

Storage conditions and their evidence base: minus twenty degrees for powder, refrigerated for solution, protection from light, and what the…

646 questions
asked by Dr_Fatima_Belkacem 52k · 23 months ago
8 votes 5 answers21k views
Does aspartimide formation dominate for liraglutide held at 40 °C?

Conditions: aspartimide formation · liraglutide · 40 °C. I want to know whether this is a real physical effect or an artefact of how it is measured. What prompted the…

peptide-stability
peptide-stability

The chemistry of peptide degradation: deamidation, oxidation, hydrolysis, aggregation and fibrillation, and how temperature, pH, ionic strength,…

832 questions
storage
storage

Storage conditions and their evidence base: minus twenty degrees for powder, refrigerated for solution, protection from light, and what the…

646 questions
hplc
hplc

Reverse-phase high-performance liquid chromatography, the workhorse purity method. Column chemistry, mobile-phase choice, gradient slope,…

466 questions
asked by mz_4113 99k · 2.3 years ago
8 votes 5 answers19k views
Why does dimerisation accelerate at 4 °C rather than proceeding linearly?

What I am working with: dimerisation · 4 °C. The empirical answer seems settled. The explanation does not. If the honest answer is that nobody knows, I would rather…

peptide-stability
peptide-stability

The chemistry of peptide degradation: deamidation, oxidation, hydrolysis, aggregation and fibrillation, and how temperature, pH, ionic strength,…

832 questions
storage
storage

Storage conditions and their evidence base: minus twenty degrees for powder, refrigerated for solution, protection from light, and what the…

646 questions
hplc
hplc

Reverse-phase high-performance liquid chromatography, the workhorse purity method. Column chemistry, mobile-phase choice, gradient slope,…

466 questions
asked by deamidation_watch 43k · 2.1 years ago
8 votes 5 answers18k views
Does hydrolysis dominate for dulaglutide held at 40 °C?

Details up front: hydrolysis · dulaglutide · 40 °C. I can predict the outcome but I cannot explain it, which means I will get the next case wrong. I would like to…

peptide-stability
peptide-stability

The chemistry of peptide degradation: deamidation, oxidation, hydrolysis, aggregation and fibrillation, and how temperature, pH, ionic strength,…

832 questions
storage
storage

Storage conditions and their evidence base: minus twenty degrees for powder, refrigerated for solution, protection from light, and what the…

646 questions
hplc
hplc

Reverse-phase high-performance liquid chromatography, the workhorse purity method. Column chemistry, mobile-phase choice, gradient slope,…

466 questions
asked by ines_delacruz 16k · 14 months ago
8 votes5 answers17k views
Is an insulated cool box good enough for storing reconstituted tirzepatide?

The case in front of me: an insulated cool box · tirzepatide. I want to decide this in advance so that I am not deciding it under pressure later. Assume I will follow…

storage
storage

Storage conditions and their evidence base: minus twenty degrees for powder, refrigerated for solution, protection from light, and what the…

646 questions
cold-chain
cold-chain

Keeping material within a temperature window from manufacture to use: phase-change packs versus dry ice, thermal mass, transit-lane temperature…

524 questions
harm-reduction
harm-reduction

Reducing avoidable risk where a decision has already been made: independent verification before use, sterility practice, dose arithmetic checked…

445 questions
asked by Dr_Wren_Halliday 40k · 23 months ago
8 votes 5 answers14k views
Is there any published stability data for tirzepatide at minus 20 °C?

The particulars: tirzepatide · minus 20 °C. Somebody stated this to me confidently and I would like to check it before repeating it. I would accept a well-reasoned…

peptide-stability
peptide-stability

The chemistry of peptide degradation: deamidation, oxidation, hydrolysis, aggregation and fibrillation, and how temperature, pH, ionic strength,…

832 questions
storage
storage

Storage conditions and their evidence base: minus twenty degrees for powder, refrigerated for solution, protection from light, and what the…

646 questions
clinical-trials
clinical-trials

Reading the primary literature properly: estimands, intention-to-treat versus per-protocol, confidence intervals, absolute versus relative…

913 questions
asked by one_ml_bac 12k · 8 months ago
8 votes 5 answers13k views
What happens to ecnoglutide after four weeks at 25 °C in solution?

The case in front of me: ecnoglutide · four weeks · 25 °C. I want to know whether this is a real physical effect or an artefact of how it is measured. What prompted…

peptide-stability
peptide-stability

The chemistry of peptide degradation: deamidation, oxidation, hydrolysis, aggregation and fibrillation, and how temperature, pH, ionic strength,…

832 questions
storage
storage

Storage conditions and their evidence base: minus twenty degrees for powder, refrigerated for solution, protection from light, and what the…

646 questions
shelf-life
shelf-life

How long a preparation remains within specification: labelled expiry for a sealed lyophilised vial, beyond-use dating after reconstitution, and…

301 questions
asked by greta_holzmann 15k · 2.3 years ago
8 votes 5 answers12k views
Is there any published stability data for semaglutide at 4 °C?

Concretely: semaglutide · 4 °C. I want to know whether there is evidence behind this or only repetition. I have checked the obvious registries and monographs without…

peptide-stability
peptide-stability

The chemistry of peptide degradation: deamidation, oxidation, hydrolysis, aggregation and fibrillation, and how temperature, pH, ionic strength,…

832 questions
storage
storage

Storage conditions and their evidence base: minus twenty degrees for powder, refrigerated for solution, protection from light, and what the…

646 questions
clinical-trials
clinical-trials

Reading the primary literature properly: estimands, intention-to-treat versus per-protocol, confidence intervals, absolute versus relative…

913 questions
asked by bridget_nyathi 16k · 9 months ago
8 votes5 answers11k views
Does semaglutide adsorb measurably to the vial wall at 5 mg/mL?

Conditions: semaglutide · 5 mg/mL. Please show the division. I want to check my own against yours. I would like the general form as well as the specific number, so I…

peptide-stability
peptide-stability

The chemistry of peptide degradation: deamidation, oxidation, hydrolysis, aggregation and fibrillation, and how temperature, pH, ionic strength,…

832 questions
content-assay
content-assay

Quantified content: how many milligrams of peptide are actually in the vial, measured against a calibrated reference standard. A separate test…

438 questions
storage
storage

Storage conditions and their evidence base: minus twenty degrees for powder, refrigerated for solution, protection from light, and what the…

646 questions
asked by kwn_analytical 89k · 18 months ago
8 votes 5 answers11k views
Is a domestic freezer good enough for storing reconstituted cagrilintide?

Stated plainly: a domestic freezer · cagrilintide. I am trying to build something sustainable rather than something thorough that I will abandon. I have already…

storage
storage

Storage conditions and their evidence base: minus twenty degrees for powder, refrigerated for solution, protection from light, and what the…

646 questions
cold-chain
cold-chain

Keeping material within a temperature window from manufacture to use: phase-change packs versus dry ice, thermal mass, transit-lane temperature…

524 questions
harm-reduction
harm-reduction

Reducing avoidable risk where a decision has already been made: independent verification before use, sterility practice, dose arithmetic checked…

445 questions
asked by kofi_mensah 12k · 21 months ago
8 votes 5 answers10k views
Does aspartimide formation dominate for tirzepatide held at 25 °C?

The case in front of me: aspartimide formation · tirzepatide · 25 °C. I want to know whether this is a real physical effect or an artefact of how it is measured. What…

peptide-stability
peptide-stability

The chemistry of peptide degradation: deamidation, oxidation, hydrolysis, aggregation and fibrillation, and how temperature, pH, ionic strength,…

832 questions
storage
storage

Storage conditions and their evidence base: minus twenty degrees for powder, refrigerated for solution, protection from light, and what the…

646 questions
hplc
hplc

Reverse-phase high-performance liquid chromatography, the workhorse purity method. Column chemistry, mobile-phase choice, gradient slope,…

466 questions
asked by u100_marks 38k · 9 months ago
8 votes 3 answers9.7k views
What is the thermal exposure on a Xianning to Spain lane in summer?

What I am working with: Xianning · Spain. I would like help reading this properly rather than being told what conclusion to reach. I have the full report including…

cold-chain
cold-chain

Keeping material within a temperature window from manufacture to use: phase-change packs versus dry ice, thermal mass, transit-lane temperature…

524 questions
international-shipping
international-shipping

Cross-border movement of research material: transit lanes and their thermal profiles, tracked versus untracked, declaration accuracy, and what…

427 questions
storage
storage

Storage conditions and their evidence base: minus twenty degrees for powder, refrigerated for solution, protection from light, and what the…

646 questions
asked by Dr_Wren_Halliday 40k · 22 months ago
8 votes5 answers9.5k views
Why does hydrolysis accelerate at room temperature rather than proceeding linearly?

What I have: hydrolysis · room temperature. I can predict the outcome but I cannot explain it, which means I will get the next case wrong. I would like to know how…

peptide-stability
peptide-stability

The chemistry of peptide degradation: deamidation, oxidation, hydrolysis, aggregation and fibrillation, and how temperature, pH, ionic strength,…

832 questions
storage
storage

Storage conditions and their evidence base: minus twenty degrees for powder, refrigerated for solution, protection from light, and what the…

646 questions
hplc
hplc

Reverse-phase high-performance liquid chromatography, the workhorse purity method. Column chemistry, mobile-phase choice, gradient slope,…

466 questions
asked by cal_hennessy 14k · 8 months ago
8 votes5 answers7.9k views
How many freeze-thaw cycles will survodutide at 2 mg/mL tolerate?

The case in front of me: survodutide · 2 mg/mL. I have done this once and I suspect I got away with it rather than got it right. For context: I keep records of every…

freeze-thaw
freeze-thaw

What repeated freezing does to a peptide in solution: ice-crystal shear at the growing front, freeze-concentration of solutes, pH shifts as buffer…

55 questions
peptide-stability
peptide-stability

The chemistry of peptide degradation: deamidation, oxidation, hydrolysis, aggregation and fibrillation, and how temperature, pH, ionic strength,…

832 questions
storage
storage

Storage conditions and their evidence base: minus twenty degrees for powder, refrigerated for solution, protection from light, and what the…

646 questions
asked by shear_at_the_front 15k · 23 months ago
8 votes5 answers7.9k views
Why does aspartimide formation accelerate at 2–8 °C rather than proceeding linearly?

Concretely: aspartimide formation · 2–8 °C. I want to know whether this is a real physical effect or an artefact of how it is measured. What prompted the question is…

peptide-stability
peptide-stability

The chemistry of peptide degradation: deamidation, oxidation, hydrolysis, aggregation and fibrillation, and how temperature, pH, ionic strength,…

832 questions
storage
storage

Storage conditions and their evidence base: minus twenty degrees for powder, refrigerated for solution, protection from light, and what the…

646 questions
hplc
hplc

Reverse-phase high-performance liquid chromatography, the workhorse purity method. Column chemistry, mobile-phase choice, gradient slope,…

466 questions
asked by mz_4113 99k · 23 months ago