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storage

Page 26 of 27 · 646 questions tagged storage.

646 questions · sorted by votes · page 26 of 27

4 votes 5 answers5.1k views
How long does mazdutide stay within specification at 40 °C once reconstituted?

What I have: mazdutide · 40 °C. I can find plenty of assertions about this and almost no reasoning, which is usually a sign that nobody has checked. Assume no…

peptide-stability
peptide-stability

The chemistry of peptide degradation: deamidation, oxidation, hydrolysis, aggregation and fibrillation, and how temperature, pH, ionic strength,…

832 questions
storage
storage

Storage conditions and their evidence base: minus twenty degrees for powder, refrigerated for solution, protection from light, and what the…

646 questions
shelf-life
shelf-life

How long a preparation remains within specification: labelled expiry for a sealed lyophilised vial, beyond-use dating after reconstitution, and…

301 questions
asked by vial_five 15k · 2 months ago
4 votes5 answers4.5k views
How long does mazdutide stay within specification at room temperature once reconstituted?

What I have: mazdutide · room temperature. I would like to understand the steps well enough to explain them to someone else. I have access to a refrigerator with a…

peptide-stability
peptide-stability

The chemistry of peptide degradation: deamidation, oxidation, hydrolysis, aggregation and fibrillation, and how temperature, pH, ionic strength,…

832 questions
storage
storage

Storage conditions and their evidence base: minus twenty degrees for powder, refrigerated for solution, protection from light, and what the…

646 questions
shelf-life
shelf-life

How long a preparation remains within specification: labelled expiry for a sealed lyophilised vial, beyond-use dating after reconstitution, and…

301 questions
asked by triple_agonist_q 37k · 5 months ago
4 votes0 answers4.1k views
What happens to cagrilintide after six weeks at 2–8 °C in solution?

Numbers first: cagrilintide · six weeks · 2–8 °C. I can predict the outcome but I cannot explain it, which means I will get the next case wrong. I would like to know…

peptide-stability
peptide-stability

The chemistry of peptide degradation: deamidation, oxidation, hydrolysis, aggregation and fibrillation, and how temperature, pH, ionic strength,…

832 questions
storage
storage

Storage conditions and their evidence base: minus twenty degrees for powder, refrigerated for solution, protection from light, and what the…

646 questions
shelf-life
shelf-life

How long a preparation remains within specification: labelled expiry for a sealed lyophilised vial, beyond-use dating after reconstitution, and…

301 questions
asked by cap_the_luer 15k · 19 months ago
4 votes5 answers4k views
What is the thermal exposure on a Tianjin to Singapore lane in summer?

What I have: Tianjin · Singapore. I can parse the result. I am less sure what it licenses me to conclude. I have deliberately not looked at anyone else’s…

cold-chain
cold-chain

Keeping material within a temperature window from manufacture to use: phase-change packs versus dry ice, thermal mass, transit-lane temperature…

524 questions
international-shipping
international-shipping

Cross-border movement of research material: transit lanes and their thermal profiles, tracked versus untracked, declaration accuracy, and what…

427 questions
storage
storage

Storage conditions and their evidence base: minus twenty degrees for powder, refrigerated for solution, protection from light, and what the…

646 questions
asked by dead_volume 49k · 5 months ago
4 votes0 answers3.4k views
Is there any published stability data for dulaglutide at 37 °C?

Stated plainly: dulaglutide · 37 °C. This is asserted often enough that I assumed it was established, and then I went looking for the source. I have searched the…

peptide-stability
peptide-stability

The chemistry of peptide degradation: deamidation, oxidation, hydrolysis, aggregation and fibrillation, and how temperature, pH, ionic strength,…

832 questions
storage
storage

Storage conditions and their evidence base: minus twenty degrees for powder, refrigerated for solution, protection from light, and what the…

646 questions
clinical-trials
clinical-trials

Reading the primary literature properly: estimands, intention-to-treat versus per-protocol, confidence intervals, absolute versus relative…

913 questions
asked by kwn_analytical 89k · 10 months ago
4 votes 4 answers3.3k views
Is a mini-fridge good enough for storing reconstituted retatrutide?

What I have: a mini-fridge · retatrutide. This is a planning question. I know what my options are; I do not know how to weigh them. What I want is the minimum viable…

storage
storage

Storage conditions and their evidence base: minus twenty degrees for powder, refrigerated for solution, protection from light, and what the…

646 questions
cold-chain
cold-chain

Keeping material within a temperature window from manufacture to use: phase-change packs versus dry ice, thermal mass, transit-lane temperature…

524 questions
harm-reduction
harm-reduction

Reducing avoidable risk where a decision has already been made: independent verification before use, sterility practice, dose arithmetic checked…

445 questions
asked by otto_brenner 19k · 4 months ago
4 votes 1 answer1.3k views
What happens to mazdutide after six weeks at 30 °C in solution?

Details up front: mazdutide · six weeks · 30 °C. I can predict the outcome but I cannot explain it, which means I will get the next case wrong. I would like to know…

peptide-stability
peptide-stability

The chemistry of peptide degradation: deamidation, oxidation, hydrolysis, aggregation and fibrillation, and how temperature, pH, ionic strength,…

832 questions
storage
storage

Storage conditions and their evidence base: minus twenty degrees for powder, refrigerated for solution, protection from light, and what the…

646 questions
shelf-life
shelf-life

How long a preparation remains within specification: labelled expiry for a sealed lyophilised vial, beyond-use dating after reconstitution, and…

301 questions
asked by ines_delacruz 16k · 3 months ago
4 votes 2 answers1.2k views
Is a mini-fridge good enough for storing reconstituted tirzepatide?

Conditions: a mini-fridge · tirzepatide. The failure mode I am trying to avoid is making this decision emotionally. I have twelve months in view and I would like the…

storage
storage

Storage conditions and their evidence base: minus twenty degrees for powder, refrigerated for solution, protection from light, and what the…

646 questions
cold-chain
cold-chain

Keeping material within a temperature window from manufacture to use: phase-change packs versus dry ice, thermal mass, transit-lane temperature…

524 questions
harm-reduction
harm-reduction

Reducing avoidable risk where a decision has already been made: independent verification before use, sterility practice, dose arithmetic checked…

445 questions
asked by s_bhattacharya 42k · 28 days ago
4 votes0 answers847 views
Does racemisation dominate for retatrutide held at 25 °C?

What I have: racemisation · retatrutide · 25 °C. I suspect the usual explanation for this is wrong, or at least incomplete. I am aware this may have a boring answer.…

peptide-stability
peptide-stability

The chemistry of peptide degradation: deamidation, oxidation, hydrolysis, aggregation and fibrillation, and how temperature, pH, ionic strength,…

832 questions
storage
storage

Storage conditions and their evidence base: minus twenty degrees for powder, refrigerated for solution, protection from light, and what the…

646 questions
hplc
hplc

Reverse-phase high-performance liquid chromatography, the workhorse purity method. Column chemistry, mobile-phase choice, gradient slope,…

466 questions
asked by ines_delacruz 16k · 5 months ago
3 votes 5 answers12k views
Why does hydrolysis accelerate at 37 °C rather than proceeding linearly?

Numbers first: hydrolysis · 37 °C. I can predict the outcome but I cannot explain it, which means I will get the next case wrong. I would like to know how confident…

peptide-stability
peptide-stability

The chemistry of peptide degradation: deamidation, oxidation, hydrolysis, aggregation and fibrillation, and how temperature, pH, ionic strength,…

832 questions
storage
storage

Storage conditions and their evidence base: minus twenty degrees for powder, refrigerated for solution, protection from light, and what the…

646 questions
hplc
hplc

Reverse-phase high-performance liquid chromatography, the workhorse purity method. Column chemistry, mobile-phase choice, gradient slope,…

466 questions
asked by mass_shift_18 14k · 13 months ago
3 votes 5 answers12k views
How many freeze-thaw cycles will cagrilintide at 4 mg/mL tolerate?

What I have: cagrilintide · 4 mg/mL. I would like to understand the steps well enough to explain them to someone else. I have access to a refrigerator with a logger…

freeze-thaw
freeze-thaw

What repeated freezing does to a peptide in solution: ice-crystal shear at the growing front, freeze-concentration of solutes, pH shifts as buffer…

55 questions
peptide-stability
peptide-stability

The chemistry of peptide degradation: deamidation, oxidation, hydrolysis, aggregation and fibrillation, and how temperature, pH, ionic strength,…

832 questions
storage
storage

Storage conditions and their evidence base: minus twenty degrees for powder, refrigerated for solution, protection from light, and what the…

646 questions
asked by assay_blank 39k · 16 months ago
3 votes 5 answers9.2k views
What happens to cagrilintide after sixteen weeks at 2–8 °C in solution?

Numbers first: cagrilintide · sixteen weeks · 2–8 °C. I suspect the usual explanation for this is wrong, or at least incomplete. I am aware this may have a boring…

peptide-stability
peptide-stability

The chemistry of peptide degradation: deamidation, oxidation, hydrolysis, aggregation and fibrillation, and how temperature, pH, ionic strength,…

832 questions
storage
storage

Storage conditions and their evidence base: minus twenty degrees for powder, refrigerated for solution, protection from light, and what the…

646 questions
shelf-life
shelf-life

How long a preparation remains within specification: labelled expiry for a sealed lyophilised vial, beyond-use dating after reconstitution, and…

301 questions
asked by otto_brenner 19k · 13 months ago
3 votes 4 answers7.1k views
What is the thermal exposure on a Qingdao to Poland lane in summer?

Numbers first: Qingdao · Poland. This is presented as though it settles something, and I am not convinced it does. I have two documents that appear to disagree, which…

cold-chain
cold-chain

Keeping material within a temperature window from manufacture to use: phase-change packs versus dry ice, thermal mass, transit-lane temperature…

524 questions
international-shipping
international-shipping

Cross-border movement of research material: transit lanes and their thermal profiles, tracked versus untracked, declaration accuracy, and what…

427 questions
storage
storage

Storage conditions and their evidence base: minus twenty degrees for powder, refrigerated for solution, protection from light, and what the…

646 questions
asked by bea_castellanos 47k · 11 months ago
3 votes5 answers5.9k views
Does a domestic freezer plus a logger count as a defensible cold chain?

The material is still sealed, so I have not committed to anything yet. I am at the decision point and I would rather think it through than improvise. I would rather…

cold-chain
cold-chain

Keeping material within a temperature window from manufacture to use: phase-change packs versus dry ice, thermal mass, transit-lane temperature…

524 questions
storage
storage

Storage conditions and their evidence base: minus twenty degrees for powder, refrigerated for solution, protection from light, and what the…

646 questions
harm-reduction
harm-reduction

Reducing avoidable risk where a decision has already been made: independent verification before use, sterility practice, dose arithmetic checked…

445 questions
asked by ravenna_pace 13k · 8 months ago
3 votes 5 answers5k views
Is 30 °C an acceptable storage condition for lyophilised ecnoglutide?

The specifics, since they change the answer: 30 °C · ecnoglutide. I would like to know whether this claim survives contact with evidence. If the answer is "nobody has…

storage
storage

Storage conditions and their evidence base: minus twenty degrees for powder, refrigerated for solution, protection from light, and what the…

646 questions
peptide-stability
peptide-stability

The chemistry of peptide degradation: deamidation, oxidation, hydrolysis, aggregation and fibrillation, and how temperature, pH, ionic strength,…

832 questions
shelf-life
shelf-life

How long a preparation remains within specification: labelled expiry for a sealed lyophilised vial, beyond-use dating after reconstitution, and…

301 questions
asked by lane_transit 42k · 33 days ago
3 votes 5 answers4.2k views
Does ecnoglutide adsorb measurably to the vial wall at 3.33 mg/mL?

Concretely: ecnoglutide · 3.33 mg/mL. Please show the division. I want to check my own against yours. I would like the general form as well as the specific number, so…

peptide-stability
peptide-stability

The chemistry of peptide degradation: deamidation, oxidation, hydrolysis, aggregation and fibrillation, and how temperature, pH, ionic strength,…

832 questions
content-assay
content-assay

Quantified content: how many milligrams of peptide are actually in the vial, measured against a calibrated reference standard. A separate test…

438 questions
storage
storage

Storage conditions and their evidence base: minus twenty degrees for powder, refrigerated for solution, protection from light, and what the…

646 questions
asked by threadlock7 14k · 2 months ago
3 votes5 answers3.9k views
Does liraglutide adsorb measurably to the vial wall at 2.5 mg/mL?

For reference: liraglutide · 2.5 mg/mL. I would rather understand the derivation than memorise the outcome. Two people I asked gave two answers that differ by a…

peptide-stability
peptide-stability

The chemistry of peptide degradation: deamidation, oxidation, hydrolysis, aggregation and fibrillation, and how temperature, pH, ionic strength,…

832 questions
content-assay
content-assay

Quantified content: how many milligrams of peptide are actually in the vial, measured against a calibrated reference standard. A separate test…

438 questions
storage
storage

Storage conditions and their evidence base: minus twenty degrees for powder, refrigerated for solution, protection from light, and what the…

646 questions
asked by birk_nordahl 20k · 8 months ago
3 votes 5 answers2.7k views
How long does orforglipron stay within specification at 2–8 °C once reconstituted?

Stated plainly: orforglipron · 2–8 °C. Everything I have found on this is either a forum aside or a product page, neither of which I trust. I am comfortable with the…

peptide-stability
peptide-stability

The chemistry of peptide degradation: deamidation, oxidation, hydrolysis, aggregation and fibrillation, and how temperature, pH, ionic strength,…

832 questions
storage
storage

Storage conditions and their evidence base: minus twenty degrees for powder, refrigerated for solution, protection from light, and what the…

646 questions
shelf-life
shelf-life

How long a preparation remains within specification: labelled expiry for a sealed lyophilised vial, beyond-use dating after reconstitution, and…

301 questions
asked by Dr_Lena_Ostrowska 42k · 34 days ago
3 votes0 answers2.3k views
Is there any published stability data for tirzepatide at 40 °C?

The specifics, since they change the answer: tirzepatide · 40 °C. Somebody stated this to me confidently and I would like to check it before repeating it. I would…

peptide-stability
peptide-stability

The chemistry of peptide degradation: deamidation, oxidation, hydrolysis, aggregation and fibrillation, and how temperature, pH, ionic strength,…

832 questions
storage
storage

Storage conditions and their evidence base: minus twenty degrees for powder, refrigerated for solution, protection from light, and what the…

646 questions
clinical-trials
clinical-trials

Reading the primary literature properly: estimands, intention-to-treat versus per-protocol, confidence intervals, absolute versus relative…

913 questions
asked by ellis_thorne 17k · 16 months ago
3 votes 3 answers2.3k views
Is there any published stability data for semaglutide at 37 °C?

Concretely: semaglutide · 37 °C. The claim is plausible, which is exactly why I want to check it. I am able to read a paper if someone points me at one. Is there data…

peptide-stability
peptide-stability

The chemistry of peptide degradation: deamidation, oxidation, hydrolysis, aggregation and fibrillation, and how temperature, pH, ionic strength,…

832 questions
storage
storage

Storage conditions and their evidence base: minus twenty degrees for powder, refrigerated for solution, protection from light, and what the…

646 questions
clinical-trials
clinical-trials

Reading the primary literature properly: estimands, intention-to-treat versus per-protocol, confidence intervals, absolute versus relative…

913 questions
asked by swab_and_wait 15k · 44 days ago
3 votes0 answers1.6k views
What happens to cagrilintide after sixteen weeks at 37 °C in solution?

Details up front: cagrilintide · sixteen weeks · 37 °C. I suspect the usual explanation for this is wrong, or at least incomplete. I am aware this may have a boring…

peptide-stability
peptide-stability

The chemistry of peptide degradation: deamidation, oxidation, hydrolysis, aggregation and fibrillation, and how temperature, pH, ionic strength,…

832 questions
storage
storage

Storage conditions and their evidence base: minus twenty degrees for powder, refrigerated for solution, protection from light, and what the…

646 questions
shelf-life
shelf-life

How long a preparation remains within specification: labelled expiry for a sealed lyophilised vial, beyond-use dating after reconstitution, and…

301 questions
asked by g_paskevicius 44k · 11 months ago
2 votes5 answers16k views
What is the thermal exposure on a Nantong to Japan lane in summer?

The case in front of me: Nantong · Japan. The figures are clear enough; the question is what they mean and what they do not. I can supply the numbers if the specifics…

cold-chain
cold-chain

Keeping material within a temperature window from manufacture to use: phase-change packs versus dry ice, thermal mass, transit-lane temperature…

524 questions
international-shipping
international-shipping

Cross-border movement of research material: transit lanes and their thermal profiles, tracked versus untracked, declaration accuracy, and what…

427 questions
storage
storage

Storage conditions and their evidence base: minus twenty degrees for powder, refrigerated for solution, protection from light, and what the…

646 questions
asked by tobias_maartens 94k · 2.3 years ago
2 votes 3 answers14k views
What happens to ecnoglutide after twelve weeks at 2–8 °C in solution?

Concretely: ecnoglutide · twelve weeks · 2–8 °C. This is one of those things that everyone repeats and nobody derives. This matters practically, not just…

peptide-stability
peptide-stability

The chemistry of peptide degradation: deamidation, oxidation, hydrolysis, aggregation and fibrillation, and how temperature, pH, ionic strength,…

832 questions
storage
storage

Storage conditions and their evidence base: minus twenty degrees for powder, refrigerated for solution, protection from light, and what the…

646 questions
shelf-life
shelf-life

How long a preparation remains within specification: labelled expiry for a sealed lyophilised vial, beyond-use dating after reconstitution, and…

301 questions
asked by yuki_morishita 19k · 23 months ago
2 votes 5 answers12k views
What happens to ecnoglutide after twelve weeks at 4 °C in solution?

The case in front of me: ecnoglutide · twelve weeks · 4 °C. This is one of those things that everyone repeats and nobody derives. This matters practically, not just…

peptide-stability
peptide-stability

The chemistry of peptide degradation: deamidation, oxidation, hydrolysis, aggregation and fibrillation, and how temperature, pH, ionic strength,…

832 questions
storage
storage

Storage conditions and their evidence base: minus twenty degrees for powder, refrigerated for solution, protection from light, and what the…

646 questions
shelf-life
shelf-life

How long a preparation remains within specification: labelled expiry for a sealed lyophilised vial, beyond-use dating after reconstitution, and…

301 questions
asked by harriet_lonsdale 14k · 13 months ago