Page 15 of 39 · 913 questions tagged clinical-trials.
REDEFINE 1 reported mean weight loss of about 22.7% for CagriSema at 68 weeks, which as far as I can tell is the largest figure any phase 3 obesity trial has…
The specifics, since they change the answer: tirzepatide · minus 80 °C. Somebody stated this to me confidently and I would like to check it before repeating it. I…
Numbers first: mazdutide · cagrilintide. I want to know what the trade-off actually is rather than which option is fashionable. I would rather have a defensible…
The particulars: tirzepatide · retatrutide. I am trying to choose between two options that are usually discussed as though only one exists. I am not optimising for…
The particulars: fatigue · ecnoglutide · SURPASS-2. I have the document in front of me and I can read the numbers. What I cannot do is interpret them. I am reasonably…
Concretely: survodutide · survodutide. These are treated as interchangeable and I do not think they are. If both are acceptable I would like to know that, so I can…
Details up front: a GLP-1 receptor agonist · retatrutide. I want to know what the trade-off actually is rather than which option is fashionable. I would rather have a…
What I am working with: early satiety · cagrilintide · SOUL. I have read the primary source rather than the summary, which has left me with more questions. I…
Concretely: STEP 4 · 2 mg. The figures are clear enough; the question is what they mean and what they do not. I can supply the numbers if the specifics change the…
The case in front of me: 2.5 mg · tirzepatide. I want to decide this in advance so that I am not deciding it under pressure later. Assume I will follow the plan I…
Concretely: headache · oral semaglutide · SELECT. The figures are clear enough; the question is what they mean and what they do not. I can supply the numbers if the…
Numbers first: cagrilintide · STEP 5. I can predict the outcome but I cannot explain it, which means I will get the next case wrong. I would like to know how…
Conditions: survodutide · SURPASS-3. I want to know whether this is a real physical effect or an artefact of how it is measured. What prompted the question is an…
Stated plainly: PIONEER-1 · injection-site erythema. I have read the primary source rather than the summary, which has left me with more questions. I understand the…
The specifics, since they change the answer: STEP 1 · survodutide. I want to understand what this actually establishes, as opposed to what it is being used to imply.…
Setup, so nobody has to ask: dulaglutide · minus 80 °C. This is asserted often enough that I assumed it was established, and then I went looking for the source. I…
Conditions: FLOW · oral semaglutide. The figures are clear enough; the question is what they mean and what they do not. I can supply the numbers if the specifics…
Concretely: TRIUMPH-1 · liraglutide. I would like to know the limits of what can be inferred from this. What I am trying to avoid is over-reading a single result,…
The clinician who ordered the panel was not concerned; I would still like to understand it. I would like help reading this properly rather than being told what…
Setup, so nobody has to ask: hair thinning · a GLP-1 receptor agonist · STEP 3. I would like help reading this properly rather than being told what conclusion to…
Concretely: STEP 2 · dizziness · 5 mg. The figures are clear enough; the question is what they mean and what they do not. I can supply the numbers if the specifics…
Setup, so nobody has to ask: SURPASS-2 · cagrilintide. I have read the primary source rather than the summary, which has left me with more questions. I understand the…
I have the full paper rather than the abstract, and the supplementary appendix. I understand the observation; what I do not understand is the mechanism behind it. I…
Numbers first: mazdutide · mazdutide. I have used one of these for a while and I am considering switching, which requires a reason. What I care about is…